Search Results (10,823)

Background: Multidrug-resistant bacteria have quadrupled globally, impacting effective treatment of infectious diseases. A growing concern is that many Gram-negative and Gram-positive bacteria harbor genes conferring resistance to various antibiotics including colistin. The alarming emergence of colistin resistance is exacerbated by the growing threat of MDR Salmonella species and Listeria monocytogenes (LMO), which pose an escalating risk to global public health. Materials and Methods: In the present study, red meat samples were collected from randomly selected key retail markets in the Eastern Cape province, South Africa, and were evaluated for the incidence of LMO and the Salmonella species using standard culture-based and molecular methods. The confirmed isolates were subjected to antibiotic susceptibility testing. Results: This study demonstrated the occurrence of multidrug-resistant LMO (62%) and Salmonella species (spp.) (58%) in the red meat specimen. There were high resistance rates in both LMO and Salmonella isolates, with LMO exhibiting resistance to penicillin (89%), colistin (81%), nitrofurantoin (78%), and erythromycin (29%), while Salmonella showed resistance to trimethoprim (96.87%), tetracycline, and colistin (90.62%). Antibiotic resistance genes were also detected including BlaTem, erm, Sul1, Sul2 and mcr 1–6. Notably, Salmonella did not harbor any mcr genes that were screened in this study, whereas Listeria isolates harbored the mcr 2 (10%), 3 (7%), 4 (10%), and 6 (3%), with mcr 5 being the most prevalent with 57%. Conclusions: These findings highlight a threat to food security and public health, emphasizing the need for sturdier food handling procedures to ensure safety, enhanced antimicrobial stewardship, and alternative therapeutic strategies to combat antibiotic-resistant pathogens. Full article

Direct ink writing (DIW) has emerged as a promising method for fabricating flexible electronics. Copper nanowires are a key material for the conductive inks required for this technology. However, copper nanowires suffer from significant challenges, including low aspect ratios, poor oxidation resistance, and difficulty in printing. In this study, a liquid-phase reduction method was used to synthesize copper nanowires with a high aspect ratio (up to 2884) and excellent oxidation resistance. The conductive ink was prepared using ethylene glycol, isopropanolamine (MIPA), and ethanol as solvents. Rheological dynamics simulations were used to investigate the influence of printing parameters on ink printing accuracy, ultimately achieving precise control of the printing process. High-precision copper nanowire flexible circuits with a low resistivity of 2.11 μΩ·cm were fabricated under thermal sintering conditions using the DIW method. These circuits exhibited excellent adhesion, flexural behavior, and water resistance, demonstrating significant practical significance for the low-cost fabrication of high-precision flexible electronic devices. Full article

The global lithium supply balance has been under pressure since the recent increase in demand for electric vehicles. Conventional techniques for lithium extraction from natural resources are solar evaporation and hard-rock mining, which both have their limitations in view of sustainability. The question arises whether these methods will suffice for a responsible supply to provide the necessary materials for the emerging green economy. While new technologies for the valorization of lithium from unconventional resources like geothermal brines, salt lakes and seawater are in the pipeline, they are yet to be proven on an industrial scale. Membrane technology, ion-exchange adsorption and electrochemical methods are the current focus of several players in the pilot stage of their announced lithium carbonate or hydroxide production process. These technologies have various advantages and disadvantages in terms of energy consumption, selectivity and process costs, and the optimal choice remains dependent on local factors such as brine composition, energy availability and reagent cost. There are currently several DLE projects in the pilot phase, which is a significant step towards more sustainable lithium supply. Proving the economic and technical viability of these methods for extracting lithium from unconventional sources would increase the amount of globally proven reserves while diversifying and de-risking the supply chain, which is currently heavily dominated by a small number of countries. Full article

The use of food packaging derived from petroleum-based polymers has developed significant environmental problems, as these materials require centuries to degrade and release hazardous pollutants. Consequently, the food industry is shifting toward biodegradable alternatives developed from agro-industrial by-products, such as proteins, polysaccharides, and lipids. Whey protein is a by-product of the cheese industry, which is emerging as a promising material for producing edible and biodegradable films with effective barrier properties. Whey-based films can be incorporated with bioactive compounds, particularly phenolic compounds. These substances, naturally present in fruits, legumes, and vegetable waste, possess potent antimicrobial and antioxidant activities that are essential for extending the shelf life of perishable foods. This review provides a systematic evaluation of how the incorporation of phenolic compounds influences the physicochemical and bioactive properties of whey-based films. Thus, an analysis of film-forming methods, the interaction between protein matrices and phenolic compounds, and a critical discussion of the challenges remaining for their industrial application as active food packaging were evaluated. The discussion focuses on how the incorporation of phenolic extracts influences the physicochemical, mechanical, and barrier properties of the films, as well as their antioxidant and antimicrobial efficiency. The novelty of this review lies in its comprehensive focus on the sustained release of phenolic compounds from a whey protein film and their application in real food systems. By utilizing these natural additives, the industry can provide sustainable alternatives to synthetic preservatives. Active whey protein packaging represents a viable strategy to inhibit food spoilage, prevent lipid oxidation, and maintain sensory quality, while reducing the environmental problems. Full article

Background/Objectives: In the Emergency Department (ED), non-critical patients are classified as Triage Level (TL) 3 on arrival if they are assessed as having a high-level of complexity (HLC), or as TL4–5 if they are assessed as having a low-to-mild level of complexity (LLC). These levels are based on the estimated resources needed. This study aimed to identify the characteristics associated with an HLC or LLC by considering a group of variables from the presentation profile (PP) and clinical diagnostic workload (CDW), assessing ex post whether the assignment of complexity levels based on a priori estimation of the number of resources needed can be considered adequate. Materials and Methods: This retrospective multicentre study involved four first-level EDs and included patients between 2023 and 2024. Outcome Measures: The variables tested in a logistic model were those of the PP (age, sex, chief complaint, National Early Warning Score (NEWS), Numeric Rating Scale (NRS) and those of the CDW (diagnostic tests, interventions and therapy, assistance, and ED length of stay). Results: Of the 335,507 subjects considered, the average age was 59 years (interquartile range [IQR], 25), with 43.3% of cases classified as TL3. An NRS ≥ 7, ECG, urgent laboratory tests, NEWS > 6, need for a stretcher, and male gender were associated with TL3, whereas obstetric–gynaecological complaints, environmental complaints, skin-presenting complaints, and intramuscular therapy were associated with TL4–5. Conclusions: In non-critical patients a defined group of features were associated with different levels of complexity, going beyond the standard criterion based on the resources needed. These results could help clinicians improve the appropriateness of ED care pathways. Full article

Modern high-speed train compartments contain intricate internal configurations. In the event of a fire emergency, the propagation velocity of flames through the passenger cabin is determined by multiple factors, including compartment design, ignition source characteristics, and airflow conditions. This study employed computational fluid dynamics (CFD) and large eddy simulation (LES) to investigate the effects of fire source power, fire source location, and longitudinal ventilation velocity on the rate of flame progression. Unlike simplified homogeneous fuel models, this study incorporates the specific heterogeneous material layout of the CR400AF to capture realistic flame spread dynamics. The simulation results reveal that, under forward ventilation conditions, the magnitude of fire power has a minimal influence on flame propagation speed. However, stronger fire sources lead to earlier initiation of flame spread along the carriage. Central positioning of the ignition source results in bidirectional flame movement toward both ends of the carriage, with faster propagation rates than those of fires originating at the extremities. Longitudinal airflow patterns significantly influence the fire dynamics. When the airflow speed within the tunnel remains below 3 m/s, the impact of longitudinal ventilation on fire propagation speed in the train is minimal under forward ventilation conditions. Conversely, in reverse-ventilation scenarios, the rate of flame advancement shows a positive correlation with increasing ventilation speed. Nevertheless, once tunnel ventilation velocities exceed 3 m/s, combustion propagation within high-speed rail carriages becomes impossible due to intact windows, which create oxygen-deficient conditions that prevent the development of fire. This paper investigates the heat release rate and spread process of vehicle fires. It comprehensively considers the effects of fire source power, fire source location, and longitudinal ventilation rate on the rate of spread. The research results provide data support for the fire-resistant design of rail transit vehicles and for the formulation of emergency evacuation strategies for different fire scenarios, which are vital for enhancing rail vehicle fire safety and ensuring personnel evacuation safety. Full article

This paper reviews constitutive models used to predict concrete spalling under elevated temperatures, with emphasis on fire exposure and concrete linings in deep geological repositories for spent fuel and nuclear waste. The review synthesizes (1) how material composition (ordinary Portland cement concrete, geopolymer concrete, and fiber-reinforced systems using polypropylene and steel fibers) affects spalling resistance; (2) how coupled environmental and mechanical actions (temperature, moisture, stress state, chloride ingress, and radiation) drive damage initiation and spalling; and (3) how constituent-scale characteristics (microstructure, porosity, permeability, elastic modulus, and water content) govern thermal–hydro–mechanical–chemical (THMC) transport and damage evolution. We compare major constitutive modeling frameworks, including plasticity–damage models (e.g., concrete damage plasticity), statistical damage approaches, and fully coupled THM/THMC formulations, and highlight how key parameters (e.g., water-to-binder ratio, temperature-driven pore-pressure gradients, and crack evolution laws) control predicted spalling onset, depth, and timing. Several overarching challenges emerge: lack of standardized experimental protocols for spalling tests and assessments, which limits cross-study benchmarking; continued debate on whether spalling is dominated by pore pressure, thermo-mechanical stress, or their interaction; limited integration of multiscale and constituent-level material characteristics; and high data and computational demands associated with advanced multi-physics models. The paper concludes with targeted research directions to improve model calibration, validation, and performance-based design of concrete systems for high-temperature and repository applications. Full article

Functional coatings for food packaging offer innovative approaches to extend shelf life, preserve quality and introduce active properties such as antimicrobial or antioxidant effects. These coatings include natural bio-based films (e.g., polysaccharide or protein-based) and synthetic polymers enhanced with additives or nanomaterials. Despite their advantages (e.g., improved barrier properties, spoilage inhibition, or intelligent sensing) they also pose safety concerns. Migration of chemical constituents and additives into food can lead to toxicological risks, such as cytotoxicity or endocrine disruption. Non-intentionally added substances (NIASs) and nano-sized components further complicate safety assessments. This review outlines the main types of functional coatings, their active mechanisms, and associated safety issues. Particular focus is placed on migration phenomena, chemical interactions and health risks from common migrants including plasticizers, monomers, nanoparticles and essential oils. The EU Packaging and Packaging Waste Regulation (Regulation (EU) 2025/40), adopted in December 2024 and published in the Official Journal in January 2025, introduces comprehensive sustainability and substance-restriction requirements, including strict criteria for food packaging materials that will apply from 12 August 2026. Emerging challenges include the assessment of bio-based and recycled coatings and the toxicology of nanomaterials. Balancing functionality with safety remains crucial for next-generation, sustainable and health-compliant food packaging. Full article

Recently, near-net-shape rolling has emerged as a key manufacturing technology for producing high-precision, fatigue-resistant bearing rings with irregular cross-sections, particularly for the production of Wind Turbine Shaft Bearings (WTSBs). The deformation behavior of the material during this rolling process is governed by temperature and rolling speed. Therefore, based on a thermomechanical coupled analysis, a simulation model for the deformation process of GCr15SiMn profiled rings during variable-speed rolling was developed in this study. The model was experimentally validated, confirming a dimensional error of less than 3‰. And then, the distribution of strain and temperature were analyzed during the rolling of the profiled ring. As the initial temperature increased from 1040 °C to 1160 °C, the standard deviation of strain (SDP) decreased from 6.12 to 4.05. Correspondingly, the standard deviation of temperature (SDT) was raised from 4.32 to 4.74. When the drive roll speed was increased from 2.5 rad/s to 4.0 rad/s, the SDP was reduced from 4.24 to 3.42. In addition, the SDT decreased from 4.42 to 3.21. The research indicates that SDP is primarily affected by initial temperature, whereas SDT is significantly influenced by drive roller speed. On the one hand, this study provides a clearly defined optimization framework, parameter ranges for achieving optimal uniformity in GCr15SiMn material (temperature of 1100–1130 °C, speed of 3.0–3.5 rad/s), and their anticipated benefits (an SDP reduction of 32% and an SDT reduction of 15%). On the other hand, it also establishes quantifiable industrial control targets, defining key quality assurance values (SDP ≤ 5.0, SDT ≤ 4.5). The rolling stability and precision can be improved through the selection of optimized rolling temperatures and speeds. This finding provides a theoretical foundation and technical framework for improving the rolling process stability of profiled cross-section bearing rings. Furthermore, this study is of positive significance for reducing the manufacturing costs of high-performance WTSBs. Full article

Sub-terahertz (sub-THz) frequencies are in the spotlight in the ongoing development of sixth-generation (6G) wireless communication systems, offering ultra-high data rates and low latency for rapidly emerging applications. However, employment of sub-THz frequencies introduces strict propagation challenges, including free-space path loss and atmospheric absorption, which limit coverage and reliability. To address these issues, highly directional links are required. The conventional beam-shaping solutions such as refractive lenses and parabolic mirrors are bulky, heavy, and costly, making them less attractive for compact systems. Diffractive optical elements (DOEs) offer a promising alternative by enabling precise wavefront control through phase modulation, resulting in thin, lightweight components with high focusing efficiency. Employing the fused deposition modelling (FDM) using high-impact polystyrene (HIPS) allows cost-effective fabrication of DOEs with minimal material waste and high diffraction efficiency. This work investigates the beam-shaping performance of the FDM-printed structures comparing DOEs and spherical refraction-based structures, wherein both are aiming for application in sub-THz communication systems. DOEs exhibit clear advantages over classically employed solutions. Full article

Hydrogen is a key energy carrier for achieving carbon neutrality, yet its widespread deployment is hindered by challenges associated with efficient hydrogen production, safe and reversible hydrogen storage, and hydrogen-induced embrittlement. Severe plastic deformation processes, particularly high-pressure torsion (HPT), have emerged as a powerful approach capable of addressing these challenges through extreme grain refinement, defect engineering, phase stabilization far from equilibrium, and synthesis of novel materials. This article reviews the impact of HPT on hydrogen-related materials, covering hydrogen production, hydrogen storage, and hydrogen embrittlement resistance. For hydrogen production, HPT enables the synthesis of nanostructured, defect-rich, and compositionally complex compounds, including high-entropy oxides and oxynitrides, which exhibit enhanced hydrolytic, electrocatalytic, photocatalytic, photoelectrocatalytic, and photoreforming performance. For hydrogen storage, HPT fundamentally modifies hydrogenation activation and kinetics, and modifies thermodynamics by hydrogen binding energy engineering, enabling reversible hydrogen storage at room temperature in systems such as Mg-based and high-entropy alloys. For hydrogen embrittlement resistance, HPT under optimized conditions suppresses hydrogen-assisted fracture by engineering ultrafine grains and defects (vacancies, dislocations, Lomer–Cottrell locks, D-Frank partial dislocations, stacking faults, twins, and grain boundaries) that control hydrogen diffusion, trapping, and strain localization. By integrating insights across these three domains, this article highlights HPT as a transformative strategy for developing next-generation hydrogen materials and identifies key opportunities for future research at the intersection of severe plastic deformation and hydrogen technologies. Full article

Two-dimensional (2D) materials offer exceptional electrical, optical, and mechanical properties but face challenges in terms of scalability, stability, and integration. Hybridizing 2D materials with polymers provides an effective route to overcome these limitations by enabling tunable interfaces, mechanical compliance, chemical functionality, and three-dimensional device processability. This review summarizes the fundamental structural configurations of 2D–polymer hybrids, including embedded composites, stacked heterostructures, covalently functionalized interfaces, polymer-encapsulated layers, and fiber–network architecture, and describes how their interfacial interactions dictate charge transport, environmental robustness, and mechanical behavior. We also highlight major fabrication strategies, such as solution dispersion, in situ polymerization, and vapor-phase deposition. Finally, we discuss emerging applications in sensors, optoelectronics, neuromorphic systems, and energy devices, demonstrating how synergistic coupling between 2D materials and functional polymers enables enhanced sensitivity, programmable electronic states, broadband photodetection, and improved electrochemical performance. These insights provide design guidelines for future multifunctional and scalable 2D–polymer hybrid platforms. Full article

Paper-based analytical devices have emerged as a versatile and cost-effective platform for on-site chemical and biological analysis. The integration of fluorescence detection with smartphone imaging has significantly enhanced the analytical performance and portability of these systems, enabling sensitive, rapid, and user-friendly detection of diverse analytes. This review highlights recent advancements in paper-based fluorescence sensing technologies, focusing on their design principles, materials, and detection strategies. Emphasis is placed on the use of nanomaterials, quantum dots, and carbon-based fluorophores that improve sensitivity and selectivity in food, bioanalytical, and environmental applications. The role of smartphones as optical detectors and data processing tools is explored, underscoring innovations in image analysis, calibration algorithms, and app-based quantification methods. Full article

Driven by the imperative for enhanced battery safety, solid electrolytes have emerged as a leading strategy in next-generation energy storage technologies. Beyond conventional polymer, oxide, and sulfide systems, chloride-based inorganic solid electrolytes have recently garnered significant attention due to their unique combination of high ionic conductivity, favorable electrochemical stability, and processability. This work presents a comprehensive review of chloride solid electrolytes, examining their crystal structures, synthesis approaches, ionic transport mechanisms, and physicochemical stability under operational conditions. Furthermore, we discuss critical considerations for integrating these materials into practical all-solid-state batteries (ASSBs), including performance across wide temperature ranges, scalable cell fabrication methods, and cost-effectiveness. By bridging fundamental material properties with device-level engineering challenges, this review aims to provide a roadmap for future research and development, highlighting the substantial promise of chloride electrolytes in enabling safe, high-performance solid-state batteries. Full article

Objective: To synthesize current evidence on the relationships between adolescent idiopathic scoliosis (AIS), stress-related mechanisms, neuroanatomical asymmetry, and mental disorders, and to propose an integrative conceptual framework describing their interaction. Materials and Methods: A comprehensive literature review was conducted using the PubMed, Web of Science, and Scopus databases. Search terms targeted the etiology and pathogenesis of adolescent idiopathic scoliosis, hemispheric lateralization, stress responses, body schema disturbances, and associated mental disorders. The review was reported in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) recommendations. A structured qualitative synthesis of 225 relevant publications was performed. Results: The analyzed studies revealed several complementary conceptual approaches to AIS pathogenesis. Emerging evidence suggests that atypical hemispheric lateralization, potentially associated with right-hemisphere (RH) dysfunction, may contribute to susceptibility to AIS. Such patterns of lateralization have been linked to specific stress-related coping strategies, including harm avoidance, as well as to disturbances of body schema and an increased prevalence of certain mental disorders. Gender-related differences in stress responses and in the development and progression of AIS were consistently reported across studies. Collectively, these findings support the hypothesis that neuropsychological and stress-related mechanisms, including phenomena described as the “distorting mirror effect”, may contribute to the persistence and progression of spinal deformity in vulnerable individuals. Conclusions: AIS appears to be a multifactorial condition in which atypical neuroanatomical asymmetry, stress-related processes, and altered body representation interact. This integrative perspective generates hypotheses suggesting that prevention and treatment strategies for AIS could benefit from incorporating approaches aimed at modulating stress responses and enhancing brain neuroplasticity. Further interdisciplinary studies integrating clinical, neuroimaging, and neurobiological methods are warranted to clarify underlying mechanisms. Full article