Search Results (787)

Lung cancer remains the leading cause of cancer-related mortality worldwide despite advances in screening, navigational bronchoscopy, and systemic therapies. Diagnostic and therapeutic limitations persist, including uncertainty regarding intraprocedural tissue adequacy during biopsy sampling and constraints of existing ablative modalities for tumors located near critical thoracic structures. This review examines two emerging technologies: Full-Field Optical Coherence Tomography-based Dynamic Cell Imaging (DCI) and monopolar biphasic Pulsed Electric Field (PEF) ablation as complementary emerging technologies that may address these gaps. The Van Gogh™ Microscopy System (CellTivity Scientific, Inc.) utilizes DCI to enable real-time visualization of cellular metabolic activity without tissue destruction, providing functional information regarding tissue viability and microstructural morphology. The Aliya^® PEF ablation system (Galvanize Therapeutics, Inc.) delivers biphasic high-voltage electrical pulses that induce non-thermal tumor cell death while preserving extracellular matrix architecture, potentially allowing treatment near sensitive thoracic structures such as airways, vasculature, and pleura. Early preclinical studies and initial clinical experience suggest that DCI can facilitate rapid intraprocedural assessment of biopsy adequacy, while PEF ablation may provide reproducible focal tumor destruction with a favorable safety profile near critical structures. Although the current evidence base remains limited to early-phase studies and feasibility trials, the convergence of real-time biologic tissue assessment with structurally preserving ablation technologies introduces the possibility of integrating diagnostic confirmation and local therapy within a single procedural workflow. This review summarizes the mechanistic rationale, emerging evidence, and potential clinical applications of these technologies and proposes a conceptual “See and Strike” framework within these two emerging technologies. The methodological limitations, workflow considerations, and future research directions required to validate this approach are also discussed. Prospective multicenter trials and long-term oncologic outcomes will be necessary before widespread clinical adoption. Full article

Electrical impedance tomography (EIT) is a promising imaging tool in critical care. Its capacity to provide noninvasive bedside visualization of regional ventilation and perfusion with high temporal resolution makes it an ideal monitoring modality for patients on ventilation. However, its widespread implementation has been hindered by physical limitations in spatial resolution and a lack of robust evidence linking its use to improved clinical outcomes. In recent years, the commercialization of several bedside devices has led to growing clinical experience, gradually yielding concrete evidence regarding its clinical utility. Furthermore, beyond respiratory monitoring, data are increasingly accumulating in non-pulmonary fields, including perfusion, neuro-critical care and gastroenterology. Therefore, the objective of this review is to synthesize emerging evidence regarding the recent clinical applications of electrical impedance tomography and discuss future perspectives. Full article

This work presents a noninvasive imaging method to locate veins using a tuned microwave loop resonator. It offers a low-cost, fast, and effective solution to the challenges in venipuncture. The sensor features a loop resonator with a 5.2 mm radius, incorporating a self-tuning mechanism, and operates at 2.408 GHz with a reflection coefficient of −48.77 dB. It generates localized high-intensity electric fields that penetrate tissues to sufficient depths, enabling the detection of veins based on shifts in resonant frequencies that are induced by the varied dielectric properties of blood vessels. Two-dimensional raster scan simulations of the cephalic and median cubital veins yielded a ∼25 MHz downward resonant-frequency shift between vein and non-vein positions, with the median cubital vein still detectable at depths up to 6 mm. To quantify generalization to real tissues, a decision tree classifier trained on 63 simulation samples and evaluated on 335 in vivo measurements achieved 82.09% classification accuracy (sensitivity 81.25%, specificity 83.02%), demonstrating that the simulation-derived frequency contrast transfers reliably to experimental data despite inter-subject tissue variability. Extensive tests conducted demonstrate the sensor’s effectiveness, producing consistent and distinguishable frequency shifts when the sensor moves on the skin across veins. This technology holds significant promise for improving venipuncture accuracy, minimizing complications, and enhancing patient comfort. Full article

Underwater explosion bubbles generate intense pressure pulses and high-speed re-entrant jets during their expansion and collapse processes, posing significant threats to ships and submerged structures. In practical engineering, plate-like structures with different orientations are widely encountered; therefore, investigating the influence of boundary orientation on bubble dynamics is of great importance. In this study, underwater electrical explosion experiments were conducted using a capacitor discharge voltage of 300 V, with stand-off distances ranging from 1 mm to 30 mm. Two typical boundary configurations were established, namely a vertical plate and a horizontal plate. High-speed imaging was employed to capture the complete bubble evolution process, while coupled Eulerian–Lagrangian (CEL) simulations were performed to analyze bubble dynamics and structural response. The results indicate that, under the vertical plate condition, the maximum bubble diameter decreases monotonically with increasing stand-off distance, whereas the oscillation period exhibits a non-monotonic variation. At a stand-off distance of 5 mm, the maximum bubble diameter in the vertical plate configuration is 40.3% larger than that in the horizontal plate configuration. The reflected shock wave from the elastic boundary modifies the surrounding pressure field, thereby influencing the evolution of the bubble interface. In the presence of a vertical elastic plate, the bubble exhibits a centroid displacement during the expansion phase, and a re-entrant jet directed toward the boundary forms during collapse. In contrast, under the horizontal elastic plate condition, the bubble maintains a nearly axisymmetric evolution, and the re-entrant jet develops along the vertical direction. As the standoff distance between the plate and the charge center increases, the boundary effect gradually weakens, and the bubble morphology approaches that under free-field conditions. This study provides experimental evidence for understanding bubble–structure interaction (BSI) between underwater explosion bubbles and ship plate structures, and offers valuable insights for blast-resistant design of naval structures and the evaluation of underwater explosion loads. Full article

Optical bistability is a nonlinear phenomenon enabling stable switching between two optical states and has important applications in optical communication and photonic neural networks (PNNs). However, conventional bistable devices often suffer from fabrication imperfections and scattering losses, which limit their robustness and dispersionless performance. In this study, we numerically investigate optical bistability from a one-dimensional photonic topological hypercrystal (PhH) composed of alternating hyperbolic metamaterials (HMMs) and dielectric layers. By designing a center-inversed symmetric layered PhH structure and introducing Kerr nonlinearity into the localized dielectric region of maximum electric field intensity at the inversion center, we achieve a robust, angle-insensitive optical bistability for TM polarization through phase variation compensation mechanism. When applied as a nonlinear activation function in PNNs, the bistable PhH exhibits performance comparable to conventional digital activation functions such as ReLU and Sigmoid in image-recognition tasks. Our work paves the way for integrating topological bistable devices into next-generation PNNs. Full article

Current detection technologies of operation current in power systems primarily rely on electromagnetic induction principles and infrared thermal imaging. These methods suffer from inherent limitations such as dependence on external power supplies, susceptibility to interference in complex electromagnetic environments, and high equipment costs. Electrochromic materials, which can directly convert electrical signals into optical signals and enable self-sensing without external power, offer a novel technological pathway for condition monitoring of electrical equipment. However, existing electrochromic materials still face technical challenges in power equipment operating environments, including high response thresholds, poor environmental stability, and short cycle life. Based on the synergistic electrochromic effect of poly(3-hexylthiophene) (P3HT) and fluoran, this study develops a color-changing coating suitable for operating current sensing. Core–shell structured microcapsules with urea-formaldehyde resin as the wall material were prepared via in situ polymerization to effectively encapsulate the P3HT–fluoran composite core material. These microcapsules were uniformly dispersed in an epoxy acrylate/TMPTA ultraviolet-curable resin system to form a current-sensing coating with excellent adhesion and insulation properties. Test results show that the coating, applied on a busbar, undergoes a noticeable color change from red to white within 30 s when a current of 100 A passes through the busbar, with a color difference (ΔE) of 25.3. The coating exhibits adhesion strength exceeding 11.7 MPa, volume resistivity on the order of 10¹³ Ω·m, and a breakdown field strength higher than 85 kV/mm. After 100 cycles, ΔE remains stable, demonstrating good cyclic durability. This research provides a new visual sensing solution for high-current monitoring and shows broad application prospects in the field of power equipment operation status monitoring. Full article

The imaging quality of electrical resistivity tomography (ERT) crucially depends on the electrode array configuration. Although the symmetrical optimized ‘Compare R’ (CR) method improves computational efficiency, restricting the search to the symmetrical data set inherently limits the imaging accuracy. To address this limitation, this paper proposes a multi-step optimized CR method that progressively explores both symmetrical and asymmetrical arrays to extend the search space and further enhance imaging accuracy. Numerical experiments demonstrate that the multi-step optimized array yields the highest average relative model resolution (0.646) and structural similarity index measure (0.668), surpassing the symmetrical optimized array (0.615 and 0.630, respectively). Field experiments on pipeline detection confirm that the proposed array accurately identifies the location and geometry of underground anomalies and achieves superior imaging accuracy. Applications in karst cavity exploration further confirm that the proposed array effectively detects the deep karst caves and the bedrock interfaces, as validated by borehole drilling. Additionally, the detection performance of both optimized arrays is evaluated at different depths. The results indicate that the multi-step optimized array preserves anomaly geometry and resistivity more reliably at greater depths, attributed to the accumulation of asymmetrical data points in deep regions, which results in a significantly higher data density. Full article

The characterisation of subsurface electrical resistivity is a fundamental requirement for geoscientific and engineering applications, including groundwater exploration and structural assessments. This study examines the sequential cooperative inversion of direct current resistivity and frequency-domain electromagnetic data and compares the results to the inverse models obtained from separate (individual) inversions of the datasets. The proposed cooperative framework is applied to both synthetic datasets generated through forward modelling and field data acquired at the Morgenzon Farm site, South Africa, to delineate a dolerite dyke of hydrogeological significance. Individual inversions identified distinct features but exhibit limitations: direct current resistivity highlights a two-layered medium with minor anomalies, while frequency-domain electromagnetic data identify a resistive anomaly. In contrast, the sequential cooperative inversion approach, which uses the output of one dataset to constrain the other, provides improved subsurface imaging results, reduces ambiguity, and enables the integration of complementary information from both methods. The results indicate that resistivity models constrained by inverse frequency-domain electromagnetic data provide improved representation of subsurface geometry and amplitude compared to individual approaches. These findings support the use of a non-destructive testing approach for improved subsurface imaging, facilitating better-informed decision-making in infrastructure projects and resource management. Full article

Transcranial acoustoelectric brain imaging (tABI) is a potential brain activity imaging technique with high spatiotemporal resolution. Precise focus of transcranial ultrasound is critical for realizing millimeter-level spatial resolution in tABI. In this study, a precise focusing simulation platform is proposed by constructing a high-precision 3D skull model from Bama pig computed tomography data and a mathematical model equation by considering the skull’s heterogeneous properties. Then, the delay parameters derived from the simulation platform improve the precision of transcranial ultrasound focusing, enabling precise localization of brain activation sources with tABI. Phantom experimental results demonstrate that the transcranial ultrasound field is precisely focused at the target with a 0.20 mm deviation when delay parameters are obtained from the proposed simulation platform, whereas it exhibits divergence when using delay parameters derived from pure water or homogeneous skull models. Furthermore, using the proposed simulation platform, tABI can accurately identify intracranial electrical signals of distinct frequencies and precisely locate the corresponding activation sources with a spatial deviation of 0.50 mm. These results demonstrate that the proposed simulation platform is a powerful tool for the precise focusing of tABI. Full article

Objectives: Management of unstable pelvic fractures during pregnancy presents a major therapeutic challenge, requiring careful multidisciplinary evaluation to balance maternal benefits and fetal radiation risks. Methods: We report the case of a 32-year-old patient who presented with a pelvic fracture due to a road traffic accident at three months of pregnancy. A left sacroiliac osteosynthesis was performed to treat a left sacroiliac diastasis with pelvic osteosynthesis using a trans-iliosacral approach under cone-beam CT (CBCT) guidance using a very-low-dose protocol. Radiation parameters and fetal dose estimates were calculated in advance in collaboration with a medical physicist. Tight beam collimation, a reduced field of view, and minimization of fluoroscopic checks were applied to keep fetal exposure as low as reasonably achievable. This article aims to demonstrate the feasibility of managing a complex pelvic fracture using interventional radiology and to review the literature on management options and gestational age-dependent fetal risks. Results: The estimated cumulative fetal dose from initial imaging, open surgery, and CBCT-guided osteosynthesis remained below 70 mGy using a pregnant phantom (Duke Organ Dose–Dosewatch–General Electric system), which is below thresholds associated with deterministic effects. The procedure achieved optimal screw positioning with less than 40 s of fluoroscopy. Maternal postoperative recovery was favorable, and follow-up revealed normal fetal development. Conclusions: This case demonstrates that CBCT-guided percutaneous iliosacral screw fixation can be safely performed during pregnancy with meticulous planning, dose-reduction strategies, and multidisciplinary collaboration, maintaining fetal radiation exposure below accepted safety thresholds. Full article

Congenital Long QT Syndrome (LQTS) is a hereditary cardiac channelopathy defined by delayed ventricular repolarization and an elevated risk of life-threatening ventricular arrhythmias. Recent echocardiographic studies using speckle-tracking and strain imaging have identified subtle abnormalities in ventricular and atrial mechanics among LQTS patients, including reduced global longitudinal strain, impaired diastolic function, enlarged left atrial volumes and a consistently negative electromechanical window. These findings challenge the traditional concept of LQTS as solely an electrical disease and support evolving evidence of a subclinical cardiomyopathic phenotype. Left atrial remodeling, although less studied, may represent an underrecognized component of LQTS with potential implications for arrhythmia vulnerability and diastolic dysfunction. This review summarizes current evidence on electromechanical and structural cardiac involvement in congenital LQTS, highlights its diagnostic and clinical implications, and outlines future directions for research in this evolving field. Full article

Van der Waals (vdW) heterostructures are attractive for optoelectronic devices due to their lattice-mismatch tolerance and tunable band structures. Here, we report a gate-tunable Au/MoS₂/WSe₂ dual junction photodetector featuring competing asymmetric built-in electric fields. Spatially resolved photocurrent measurements reveal that selective utilization of these built-in electric fields decouples the transport dynamics of dark and photogenerated carriers. Such decoupling allows for independent modulation of the dark current and photocurrent, enabling the concurrent realization of the ultralow dark current and high photocurrent. Moreover, gate-voltage modulation enhances the photoresponse by ~245%, yielding a detectivity of 1.98 × 10¹² Jones over the 532–940 nm range. Imaging and optical communication further verify the device’s practical potential. These results provide a viable route toward high-sensitivity and electrically reconfigurable broadband photodetectors. Full article

The increasing deployment of shared transmission corridors for High-Voltage Alternating Current (HVAC) and High-Voltage Direct Current (HVDC) systems has intensified the need to evaluate electromagnetic compatibility in hybrid overhead line configurations. This study presents an analytical methodology to estimate the electric field magnitude and magnetic flux density generated by hybrid HVAC–HVDC transmission lines under steady-state operating conditions. The electric field is determined using the Maxwell potential matrix combined with the image method, while the magnetic field is obtained from a formulation based on the Biot–Savart law. Two representative case studies were analyzed with identical electrical operating conditions but different transverse conductor arrangements to evaluate the influence of geometry on the electromagnetic environment of the corridor. The results show that variations in the spatial configuration of the conductors produce noticeable changes in the location and magnitude of the electric and magnetic field maxima across the right-of-way. These findings demonstrate that conductor geometry plays a key role in the electromagnetic behavior of hybrid corridors and should be considered in the design and assessment of HVAC–HVDC transmission systems. Full article

A graphene-based tunable broad-band terahertz (THz) metamaterial absorber is presented, exhibiting strong and stable absorption across a wide frequency range. The device employs an ultra-thin three-layer structure consisting of a metallic reflector, a dielectric spacer, and a patterned graphene metasurface with an asymmetric geometry. Through optimized structural parameters, the absorber achieves broad-band absorption exceeding 90% between 2.45 THz and 6.11 THz with a bandwidth of 3.66 THz, featuring three distinct resonant frequencies at 2.764 THz, 3.534 THz, and 5.41 THz, corresponding to peak absorption efficiencies of 97.26%, 96.96%, and 99.90%, respectively. Impedance matching and electric field analyses confirm that the enhanced absorption arises from the strong coupling of electric and magnetic resonances within the multilayer structure. Moreover, the absorber exhibits polarization-insensitive behavior under varying polarization angles and maintains high absorption stability for both TE and TM modes up to an incident angle of 60°, as verified by simulation results, and allows dynamic tunability through Fermi-level modulation. These characteristics highlight the absorber’s potential for advanced THz imaging, sensing, and stealth applications. Full article

This study investigates subauroral phenomena during the main phase of the 10 May 2024 geomagnetic storm using a combination of ground-based observations from the WD IZMIRAN observatory (magnetometer, ionosonde, and all-sky imager) and Global Self-consistent Model of the Thermosphere, Ionosphere, Protonosphere (GSM TIP) simulations. During 18:00–20:00 UT, we identified the simultaneous occurrence of ionospheric signatures of Polarization Jets (PJ)/Sub-Auroral Ion Drifts (SAID) and Strong Thermal Emission Velocity Enhancement (STEVE) over Kaliningrad, consistent with previously reported PJ/SAID identification from DMSP drift velocity measurements. This identification is supported by: (1) characteristic purple emissions (clearly visible in all three channels) moving rapidly westward; (2) U-shaped structures in ionogram sequences; (3) the reproduction of supersonic westward plasma drifts within a narrow latitudinal band by the first-principles model; and (4) observed and simulated significant Ne depletion. The estimated ion drift velocity from all-sky imaging (assuming an emission altitude of 200 km) is consistent with GSM TIP simulations, which predicted PJ/SAID velocities of ~750 m/s driven by a latitudinally narrow (~3°) but longitudinally extended (>50°) poleward electric field (40 mV/m). Simulations reveal that this PJ/SAID phenomenon causes a reversal of the zonal thermospheric wind at 250 km and induces Ne disturbances across the 200–700 km altitude range. The electron temperature enhancement (up to 1500 K) exhibits a “falling drop” shape, peaking at 350 km, while ion heating exceeds 150 K. The neutral temperature shows a dual response: frictional heating at 120–160 km and localized cooling at 175–250 km due to drop in electron density. Additionally, an increase in atomic oxygen concentration was predicted within the 90–200 km range across the PJ/SAID longitudinal sector. Full article