Search Results (1,378)

Background/Objectives: The vestibular labyrinth is classically viewed as a sensor of low-frequency head motion—linear acceleration for the otoliths and angular velocity/acceleration for the semicircular canals. However, there is now substantial evidence that air-conducted sound (ACS) can also activate vestibular receptors and afferents in mammals and other vertebrates. This sound sensitivity underlies sound-evoked vestibular-evoked myogenic potentials (VEMPs), sound-induced eye movements, and several clinical phenomena in third-window pathologies. The cellular and biophysical mechanisms by which a pressure wave in the cochlear fluids is transformed into a vestibular neural signal remain incompletely integrated into a single framework. This study aimed to provide a narrative synthesis of how ACS activates the vestibular labyrinth, with emphasis on (1) the anatomical and biophysical specializations of the maculae and cristae, (2) the dual-channel organization of vestibular hair cells and afferents, and (3) the encoding of fast, jerk-rich acoustic transients by irregular, striolar/central afferents. Methods: We integrate experimental evidence from single-unit recordings in animals, in vitro hair cell and calyx physiology, anatomical studies of macular structure, and human clinical data on sound-evoked VEMPs and sound-induced eye movements. Key concepts from vestibular cellular neurophysiology and from the physics of sinusoidal motion (displacement, velocity, acceleration, jerk) are combined into a unified interpretative scheme. Results: ACS transmitted through the middle ear generates pressure waves in the perilymph and endolymph not only in the cochlea but also in vestibular compartments. These waves produce local fluid particle motions and pressure gradients that can deflect hair bundles in selected regions of the otolith maculae and canal cristae. Irregular afferents innervating type I hair cells in the striola (maculae) and central zones (cristae) exhibit phase locking to ACS up to at least 1–2 kHz, with much lower thresholds than regular afferents. Cellular and synaptic specializations—transducer adaptation, low-voltage-activated K⁺ conductances (K_LV), fast quantal and non-quantal transmission, and afferent spike-generator properties—implement effective high-pass filtering and phase lead, making these pathways particularly sensitive to rapid changes in acceleration, i.e., mechanical jerk, rather than to slowly varying displacement or acceleration. Clinically, short-rise-time ACS stimuli (clicks and brief tone bursts) elicit robust cervical and ocular VEMPs with clear thresholds and input–output relationships, reflecting the recruitment of these jerk-sensitive utricular and saccular pathways. Sound-induced eye movements and nystagmus in third-window syndromes similarly reflect abnormally enhanced access of ACS-generated pressure waves to canal and otolith receptors. Conclusions: The vestibular labyrinth does not merely “tolerate” air-conducted sound as a spill-over from cochlear mechanics; it contains a dedicated high-frequency, transient-sensitive channel—dominated by type I hair cells and irregular afferents—that is well suited to encoding jerk-rich acoustic events. We propose that ACS-evoked vestibular responses, including VEMPs, are best interpreted within a dual-channel framework in which (1) regular, extrastriolar/peripheral pathways encode sustained head motion and low-frequency acceleration, while (2) irregular, striolar/central pathways encode fast, sound-driven transients distinguished by high jerk, steep onset, and precise spike timing. Full article

This research examines the underlying processes of public stigma toward visible facial differences (VFDs) by focusing on gaze behavior. Past research showed that a VFD influences the visual processing of faces, leading to increased attention to the VFD area at the expense of internal features (i.e., eyes, nose, mouth). Since these features primarily convey affective information, this pre-registered study investigates whether this bias also affects pain perception. In an eye-tracking task, participants (N = 44) viewed faces that either did or did not display a VFD located in a peripheral area of the face, and that either did or did not express pain, while their gaze behavior was being recorded. Participants then rated perceived pain intensity for each face. Results showed that VFDs diverted attention toward peripheral features and away from internal, pain-relevant features of the face. Surprisingly, participants rated faces with VFDs as experiencing more pain, regardless of whether pain was actually expressed. This suggests that, despite gazing less at facial expressions, observers inferred pain based on task-irrelevant features, likely stereotypes related to the VFD. These findings provide insights into how people with VFDs are perceived and how their emotions are interpreted. Full article

Articles are among the most frequently encountered words during reading; however, it is not clear how deeply they are usually processed. This study examines whether native Spanish speakers use parafoveal article–noun agreement information to guide eye movements during reading. Using the gaze-contingent boundary paradigm, we manipulated the parafoveal preview of articles across two experiments. In Experiment 1, we manipulated gender agreement between the previews readers received of definite articles and the subsequent nouns (e.g., la mesa vs. el* mesa). In Experiment 2, we manipulated grammatical gender and number agreement between parafoveal article previews and the subsequent nouns jointly (e.g., los* mesa vs. una mesa). We found no evidence that parafoveal article–noun gender or number agreement affected article skipping probability, suggesting that initial parafoveal processing of articles does not extend to their grammatical properties. However, we observed increased total viewing time on the noun following mismatching previews, suggesting that, while the decision of whether to skip an article is taken largely without considering the grammatical properties of the upcoming words, readers do need more time to recover from the grammatical mismatch afterwards. We discuss the results in the context of current models of eye-movement control during reading. Full article

Gaze behavior is a critical component of social interaction, reflecting emotional recognition and social regulation. While previous research has emphasized either situational influences (e.g., deception) or stable individual differences (e.g., attachment avoidance) on gaze patterns, studies exploring how these factors interact to shape gaze behavior in interpersonal contexts remain scarce. In this vein, the aim of the present study was to experimentally determine whether the gaze direction of individuals differs, with respect to their avoidant orientation, under changing situational conditions, including truthful and deceptive communication towards a counterpart. Using a within-person experimental design and the eye-tracking methodology, 31 participants took part in both rehearsed and spontaneous truth-telling and lie-telling tasks. Consistent with expectations, higher attachment avoidance was associated with significantly fewer fixations on emotionally expressive facial regions (e.g., mouth, jaw), and non-significant but visually consistent increases in fixations on the upper face (e.g., eyes) and background. These findings indicate that stable dispositional tendencies, rather than situational demands such as deception, predominantly shape gaze allocation during interpersonal interactions. They further provide a foundation for future investigations into the dynamic interplay between personality and situational context in interactive communicative settings. Full article

Background: Keratoconus (KC) is a progressive corneal ectasia and a leading cause of corneal transplantation in young adults. Once regarded as a biomechanical disorder, KC is now recognized as a complex disease driven by genetic predisposition, epigenetic modulation, and environmental triggers. Advances in genomics and transcriptomics have begun to elucidate the molecular mechanisms underlying corneal thinning and ectasia. Objectives: This review synthesizes two decades of evidence on the genetic and epigenetic architecture of keratoconus, highlights key molecular pathways implicated by these findings, and discusses translational implications for early diagnosis, risk prediction, and novel therapeutic strategies. Methods: A narrative review was conducted of peer-reviewed human, animal, and in vitro studies published from 2000 to 2025, with emphasis on genome-wide association studies (GWAS), sequencing data, methylation profiling, and non-coding RNA analyses. Findings were integrated with functional studies linking genetic variation to molecular and biomechanical phenotypes. Results: Genetic studies consistently implicate loci such as ZNF469, COL5A1, LOX, HGF, FOXO1, and WNT10A, alongside rare variants in Mendelian syndromes (e.g., brittle cornea syndrome, Ehlers–Danlos spectrum). Epigenetic research demonstrates altered DNA methylation, dysregulated microRNAs (e.g., MIR184, miR-143, miR-182), and aberrant lncRNA networks influencing extracellular matrix remodeling, collagen cross-linking, oxidative stress, and inflammatory signaling. Gene–environment interactions, particularly with eye rubbing and atopy, further shape disease expression. Translational progress includes polygenic risk scores, tear-based biomarkers, and early preclinical studies using RNA-based approaches (including siRNA and antisense oligonucleotides targeting matrix-degrading and profibrotic pathways) and proof-of-concept gene-editing strategies demonstrated in corneal cell and ex vivo models. Conclusions: Keratoconus arises from the convergence of inherited genomic risk, epigenetic dysregulation, and environmental stressors. Integrating multi-omic insights into clinical practice holds promise for earlier detection, precision risk stratification, and development of targeted therapies that move beyond biomechanical stabilization to disease modification. Full article

Smart virtual reality (VR) systems are becoming central to media production education, where immersive practice, real-time feedback, and hands-on simulation are essential. This review synthesizes the integration of artificial intelligence (AI) into human-centered, interactive VR learning for television and media production. Searches in Scopus, Web of Science, IEEE Xplore, ACM Digital Library, and SpringerLink (2013–2024) identified 790 records; following PRISMA screening, 94 studies met the inclusion criteria and were synthesized using a systematic scoping review approach. Across this corpus, common AI components include learner modeling, adaptive task sequencing (e.g., RL-based orchestration), affect sensing (vision, speech, and biosignals), multimodal interaction (gesture, gaze, voice, haptics), and growing use of LLM/NLP assistants. Reported benefits span personalized learning trajectories, high-fidelity simulation of studio workflows, and more responsive feedback loops that support creative, technical, and cognitive competencies. Evaluation typically covers usability and presence, workload and affect, collaboration, and scenario-based learning outcomes, leveraging interaction logs, eye tracking, and biofeedback. Persistent challenges include latency and synchronization under multimodal sensing, data governance and privacy for biometric/affective signals, limited transparency/interpretability of AI feedback, and heterogeneous evaluation protocols that impede cross-system comparison. We highlight essential human-centered design principles—teacher-in-the-loop orchestration, timely and explainable feedback, and ethical data governance—and outline a research agenda to support standardized evaluation and scalable adoption of smart VR education in the creative industries. Full article

Understanding the influence of the morphological mechanisms of Mei Gui chairs on the emotional preferences of female users is crucial for achieving perceptual resonance in design. This study aims to investigate/explore the relationship between user preferences and design features to create furniture with greater emotional resonance. (1) Background: To develop a scientifically validated model for predicting user preferences in Mei Gui chair design by emotional factors and morphological mechanisms. (2) Methods: (a) Data Collection: Establish a dataset of Mei Gui chair morphological mechanisms based on the visual sequences of female users using the KJ method, factor analysis, K-means clustering, and triangular fuzzy numbers. (b) Preference Analysis: Use Eye-tracking Technology to identify female users’ preference areas for Mei Gui chair morphology and construct a morphological element preference library. (c) Feature Classification: Categorize the extracted feature elements into five classes. (d) Neural Activation Analysis: Utilize near-infrared brain functional imaging technology to conduct paired-sample T-tests on the five classes of features, identifying preferred backrest characteristics. (e) Model Validation: Integrate three factors (elegance, delicacy, comfort) into the final design scheme and compare the performance of the proposed EMD-KPCA-LSTM model with traditional BP neural network, SVM, and CNN models. (3) Results: The EMD-KPCA-LSTM model outperforms traditional models in capturing the relationship between user preferences and morphological mechanism design features, demonstrating higher predictive accuracy, better generalization ability, and stronger robustness. (4) Conclusions: The proposed model effectively integrates user preferences with Mei Gui chair design, providing a scientifically validated method for perceptual prediction in furniture design. Full article

Background: Active-fluidics phacoemulsification can maintain anterior chamber stability at lower intraoperative intraocular pressure (IOP) levels. However, whether reducing IOP alone—without additional stabilizing technologies such as the Active Sentry handpiece—can decrease surgical invasiveness during Eight-Chop phacoemulsification remains unclear. Methods: In this prospective fellow-eye comparative study, 56 non-diabetic patients (112 eyes) underwent Eight-Chop technique phacoemulsification using the Centurion Vision System with active fluidics. One eye was randomly assigned to a standard-IOP setting (55 mmHg; high-IOP group) and the fellow eye to a reduced-IOP setting (28 mmHg; low-IOP group). Intraoperative parameters—including operative time, phaco time, aspiration time, cumulative dissipated energy (CDE), and irrigation volume—were recorded. Postoperative outcomes included aqueous flare (laser flare photometry), corneal endothelial cell density (CECD) and CECD loss, corneal morphology (central corneal thickness [CCT], coefficient of variation [CV], percentage of hexagonal cells [PHC]), and IOP. Linear mixed-effects models with patient ID as a random effect were used for all paired-eye comparisons. Results: Lowering the intraoperative IOP did not reduce surgical invasiveness. Phaco time was significantly longer in the low-IOP group (16.2 ± 5.22 s vs. 13.9 ± 4.40 s; p = 0.001), and aspiration time was also longer (75.0 ± 18.3 s vs. 69.0 ± 17.9 s; p = 0.033). No significant differences were found in operative time (5.08 ± 1.10 min vs. 4.82 ± 1.13 min; p = 0.082), CDE (5.93 ± 1.87 vs. 5.56 ± 1.90; p = 0.099), or irrigation volume (26.6 ± 7.71 mL vs. 25.2 ± 7.35 mL; p = 0.214). Postoperative outcomes were similarly comparable. Aqueous flare showed no significant differences at any time point (e.g., day 1: 14.8 ± 5.10 vs. 14.5 ± 4.76 ph/ms; p = 0.655). Mean CECD loss remained small in both groups and did not differ significantly (7 weeks: −0.82 ± 1.05% vs. −0.98 ± 1.16%, p = 0.460; 19 weeks: −0.93 ± 1.38% vs. −1.28 ± 1.69%, p = 0.239). Corneal morphological parameters (CCT, CV, PHC) and postoperative IOP also showed no significant differences between settings. Conclusions: In this fellow-eye comparative study, lowering intraoperative intraocular pressure from conventional to near-physiologic levels under active-fluidics control did not reduce surgical invasiveness during Eight-chop phacoemulsification. No additional benefits were observed in terms of endothelial cell preservation, postoperative inflammation, or overall surgical performance. These findings indicate that, when chamber stability is already ensured by a low-invasive fragmentation strategy, further reduction in intraoperative IOP alone does not confer measurable short-term clinical advantages. Full article

Aeromycoflora present in the library environment is known to play a significant role in triggering allergies and contributing to the deterioration of both cellulosic and non-cellulosic materials within the intramural setting of the Midnapore College Library. Fungal spores not only accelerate the aging and degradation of books but also pose considerable health risks to students, library visitors, and staff. In total, 480 fungal colonies belonging to 15 genera and 28 species were recorded using the culture plate exposure method. The predominant taxa included Aspergillus/Penicillium, Alternaria alternata, Alternaria solani, Cladosporium cladosporioides, Curvularia lunata, Penicillium oxalicum, Epicoccum sp., Fusarium solanii, Fusarium oxysporum, Periconia sp., Rhizopus sp., and other Penicillium species. Many of these fungi are well-documented allergens and have been reported to cause adverse health manifestations—such as respiratory discomfort and skin irritation—among students, teaching staff, and book handlers exposed to airborne mycobiota. The present study aimed to investigate the aeromycological diversity within the Midnapore College Library and to conduct immuno-clinical assessments to identify specific serum IgE using both in vivo and in vitro diagnostic techniques. Individuals frequently visiting the library reported symptoms including eye irritation, headaches, itchy skin, sore throat, and severe asthma. Spearman’s rank correlation analysis revealed a significant association between total and dominant spore concentrations and the health status of affected individuals. Clinico-immunological evaluations confirmed the allergenicity of Aspergillus fumigatus, with 39.5% of atopic individuals showing positive reactions in skin prick tests (SPT). Additionally, three novel sero-reactive proteins were identified, offering valuable insights for local clinicians in diagnosing and managing fungal-induced allergic conditions. Full article

Traffic police officers represent a critical occupational group with high vulnerability to vehicular air pollution, a severe environmental health threat in rapidly urbanizing metropolises such as Addis Ababa. This cross-sectional study explored occupational exposure, protective practices, health risks, perceptions, and awareness of air-quality-associated health risks among 120 traffic police officers in Addis Ababa. The officers were mostly male (80%) and married (93.3%), with the majority (62.6%) having served for more than ten years. While vehicle emissions were consistently recognized as the main source of air pollution, critical knowledge gaps were identified, i.e., only 24.2% had received pollution-related training, fewer than half (45.8%) were aware of government policies, and just 9.2% reported collaboration with environmental authorities. Awareness of the Air Quality Index (AQI) was generally low, and regular monitoring of AQI was limited. Self-reported health symptoms were highly prevalent among participants, with cough (75.0%), eye irritation (61.7%), sneezing (58.3%), and runny nose (55.8%) being the most frequently reported. Notably, sneezing, runny nose, eye irritation, and psychological stress showed significant association with perceived pollution levels at the workplace (p < 0.05), while blood pressure, cough, difficulty concentrating, and sleep loss were not significantly associated (p > 0.05). A higher prevalence of symptoms was generally observed in groups experiencing moderate-to-very high levels of pollution. Protective measures were applied inconsistently; while 63.3% of participants reported using masks, their beliefs about the effectiveness of using masks varied. Relocation (60%) and use of face covers/glasses (13.3%) were less commonly practiced. Overall, traffic police officers are exposed to occupational air pollution, which is associated with various health symptoms. These findings highlight the need for enhanced training, clearer communication of policies, stronger institutional engagement, the provision of standardized protective masks, and the promotion of AQI utilization to reduce occupational health risks and safeguard the wellbeing of traffic police officers in Addis Ababa. Full article

Background: Eye tracking technology can be utilized to identify early markers of autism. Several neurodivergent features of social attention have been revealed by eye tracking studies in ASD toddlers. Our aim was to develop stimulus material that elicits highly distinctive gaze patterns in toddlers at low and high risk for autism as indicated by ADOS (i.e., scoring below and above the ADOS cut-off point). Additionally, we sought to identify the variables most effective in differentiating between these groups. Methods: In our research, we analyzed the data of 74 toddlers between 12 and 30 months. Children were divided into two groups based on their ADOS scores: the lower ADOS (lrADOS) group included those scoring below the ADOS cut-off point (n = 42; mean age = 22.5 ± 5.0 months), while the higher ADOS (hrADOS) group comprised children scoring above the cut-off (n = 32; mean age = 23.3 ± 4.8 months). We recorded eye gaze data during the presentation of dynamic social attention stimuli with a self-developed eye tracking device. We used two types of social attention stimuli: joint attention (ostensive) and preferential looking paradigm. We analyzed the area of interest based on the gaze–time ratio. To ensure sufficient robustness, we selected gaze retention interval (GRI) variables characterized by broader spatial and temporal parameters compared to traditional fixation-based measures. Results: As anticipated, we observed significant differences between the two groups across most variables. Typically, within the preferential paradigm, the distinct indicators of the social domain were higher on average in the lrADOS group compared to the hrADOS group, while the non-social domain exhibited the opposite trend. The results of correlations with ADOS scores indicated that the social ratio in the preferential paradigm exhibited the strongest negative correlation. Notably, there were higher effect sizes within the hrADOS group in comparison to the lrADOS group when correlation with ADOS scores was tested separately for each group. Conclusions: We developed stimulus materials and eye tracking variables that, thanks to their robustness, appear promising even when dealing with noisy eye tracking data typical of young children. In the preferential paradigm, beyond AOI ratio measures, GRI variables show promise in distinguishing between toddler groups with higher vs. lower ADOS scores. Furthermore, they may be related to severity based on their marked and significant correlations with ADOS scores. Especially when used in combination, these variables appear well-suited to capturing characteristics indicative of an elevated likelihood of autism. Full article

We survey recent advances in second-language (L2) Mandarin lexical tones research and show how an interpretable computational approach can deliver parameter-aligned feedback across perception–production (P ↔ P). We synthesize four strands: (A) conventional evaluations and tasks (identification, same–different, imitation/read-aloud) that reveal robust tone-pair asymmetries and early P ↔ P decoupling; (B) physiological and behavioral instrumentation (e.g., EEG, eye-tracking) that clarifies cue weighting and time course; (C) audio-only speech analysis, from classic F0 tracking and MFCC–prosody fusion to CNN/RNN/CTC and self-supervised pipelines; and (D) interpretable learning, including attention and relational models (e.g., graph neural networks, GNNs) opened with explainable AI (XAI). Across strands, evidence converges on tones as time-evolving F0 trajectories, so movement, turning-point timing, and local F0 range are more diagnostic than height alone, and the contrast between Tone 2 (rising) and Tone 3 (dipping/low) remains the persistent difficulty; learners with tonal vs. non-tonal language backgrounds weight these cues differently. Guided by this synthesis, we outline a tool-oriented framework that pairs perception and production on the same items, jointly predicts tone labels and parameter targets, and uses XAI to generate local attributions and counterfactual edits, making feedback classroom-ready. Full article

Background: Body dysmorphic disorder (BDD) is a psychiatric condition characterized by a preoccupation with perceived appearance flaws. It is highly prevalent among aesthetic surgery candidates and can negatively impact surgical outcomes. The Body Dysmorphic Disorder Questionnaire (BDDQ) is used for BDD screening, but objective validation is limited. This study aimed to determine whether individuals screening positive for BDD exhibit different visual perception patterns of their own and model faces compared to controls, using eye-tracking technology. Methods: We conducted a cross-sectional study among 79 participants, including psychiatric patients and medical students. Participants completed the BDDQ and underwent eye-tracking while evaluating standardized photographs of models and their own faces. Gaze fixation patterns were recorded across pre-defined facial areas of interest. Perception and aesthetic assessment differences between the BDDQ-positive and BDDQ-negative groups were studied. Results: Participants focused most frequently on the nose, eyes and eyebrows. Compared to model faces, more attention was directed toward their own chin and cheeks. However, BDDQ screening results did not significantly influence fixation patterns or eye-tracking metrics. Psychiatric patients, regardless of BDDQ status, exhibited more numerous and shorter fixations than students. All participants rated model faces as significantly more attractive (i.e., higher aesthetic rating) than their own, with the largest difference observed in the BDDQ-positive group. Conclusions: While individuals screening positive for BDD reported lower self-attractiveness, eye-tracking patterns did not differ significantly from those of healthy participants. These findings suggest that BDDQ remains a useful screening tool for subjective dissatisfaction but may not correspond to objective differences in facial visual processing. Full article

This study provides a chronological analysis of how Extended Reality (XR) interaction techniques have evolved from early controller-centered interfaces to natural hand- and gaze-based input and, more recently, to multimodal input, with a particular focus on the role of XR devices. We collected 46 user study–based XR interaction papers published between 2016 and 2024, including only studies that explicitly defined their interaction techniques and reported quantitative and/or qualitative evaluation results. For each study, we documented the XR hardware and software development kits (SDKs) used as well as the input modalities applied (e.g., controller, hand tracking, eye tracking, wrist rotation, multimodal input). These data were analyzed in relation to a device and SDK timeline spanning major platforms from the HTC Vive and Oculus Rift to the Meta Quest Pro and Apple Vision Pro. Using frequency summaries, heatmaps, correspondence analysis, and chi-square tests, we quantitatively compared input modality distributions across device generations. The results reveal three distinct stages of XR interaction development: (1) an early controller-dominant phase centered on the Vive/Rift (2016–2018), (2) a transitional phase marked by the widespread introduction of hand- and gaze-based input through the Oculus Quest, HoloLens 2, and the Hand Tracking SDK (2019–2021), and (3) an expansion phase in which multisensor and multimodal input became central, driven by MR-capable devices such as the Meta Quest Pro (2022–2024). These findings demonstrate that the choice of input modalities in XR research has been structurally shaped not only by researcher preference or task design but also by the sensing configurations, tracking performance, and SDK support provided by devices available at each point in time. By reframing XR interaction research within the technological context of device and SDK generations—rather than purely functional taxonomies—this study offers a structured analytical framework for informing future multimodal and context-adaptive XR interface design and guiding user studies involving next-generation XR devices. Full article

End-to-end (E2E) autonomous driving offers a promising alternative to traditional modular pipelines by mapping raw sensor data directly to vehicle controls, thereby mitigating error propagation. However, prevalent approaches largely rely on dense Bird’s-Eye-View (BEV) feature maps, which incur high computational overhead and necessitate complex post-processing for trajectory generation. To address these limitations, we propose HiPro-AD, a proposal-centric sparse E2E planning framework that fundamentally diverges from dense BEV paradigms. HiPro-AD integrates an efficiency-oriented IM-ResNet-34 encoder with a novel STFormer. This transformer dynamically fuses multi-view spatial features and historical temporal context via a proposal-anchored mechanism, focusing computation strictly on regions relevant to sparse trajectory proposals. Furthermore, trajectory selection is refined by a Pairwise Ranking Scorer, which identifies the optimal plan from diverse candidates based on relative quality. On the NAVSIM benchmark, HiPro-AD achieves a PDMS of 92.6 using only camera input, surpassing prior dense BEV and multimodal methods. On the closed-loop Bench2Drive benchmark, it attains a 37.31% success rate and a driving score of 65.48 with a latency of 67 ms, demonstrating real-time capability. These results validate the efficiency and robustness of our sparse paradigm in complex driving scenarios. Full article