Search Results (30)

Coronary artery disease (CAD) and peripheral artery disease (PAD) are associated with increased blood viscosity, which contributes to vascular inflammation and impaired microcirculation. Blood viscosity plays a crucial role in disease progression, influencing endothelial function and tissue perfusion. Sarpogrelate hydrochloride, a serotonin receptor antagonist, has antiplatelet and vasodilatory properties that may improve microvascular function and blood rheology. This randomized, parallel-group, open-label, single-center, phase IV clinical trial enrolled 68 patients with both CAD and PAD. The participants were randomized in a 1:1 ratio to receive either aspirin monotherapy (100 mg) or aspirin (100 mg) plus sarpogrelate (300 mg) for 12 weeks. The primary outcome was the change in blood viscosity from baseline to week 12, assessed using the scanning capillary technique. Secondary outcomes included erythrocyte deformability, flow-mediated dilation (FMD), and tissue oxygen delivery index (tODI), which collectively provide insights into microvascular function and oxygen transport efficiency. Elevated blood viscosity is a key factor in cardiovascular disease progression, yet conventional antiplatelet therapy has shown limited effects on hemorheology. Sarpogrelate, by targeting serotonin-mediated pathways, may enhance microcirculatory function and optimize vascular health. These effects could lead to better oxygen delivery and overall vascular health, thereby optimizing cardiovascular outcomes. By integrating hemorheological and vascular markers, this study aims to provide evidence on the potential benefits of combination therapy. Findings could inform optimized antiplatelet strategies to improve vascular health and reduce cardiovascular risk in patients with CAD and PAD. Full article

This study systematically performs multi-scale numerical investigation of supercritical CO₂-energized fracturing, widely employed for enhanced oil recovery (EOR) in tight oil and gas reservoirs. Two distinct models, spanning from core scale to field scale, are designed to explore the diffusion patterns of CO₂ into the matrix and its impact on crude oil production at varying scales. The core-scale model employs discrete grid regions to simulate the interaction between fractures and the core, facilitating a comprehensive understanding of CO₂ diffusion and its interaction with crude oil. Based on the core-scale numerical model, the wellbore treatment process is simulated, investigating CO₂ distribution within the core and its influence on crude oil during the well treatment phase. The field-scale model employs a series of grids to simulate fractures, the matrix, and the treatment zone. Additionally, a dilation model is employed to simulate fracture initiation and closure during CO₂ fracturing and production processes. The model explores CO₂ diffusion and its interaction with crude oil at different shut-in times and various injection rates, analyzing their impact on cumulative oil production within a year. The study concludes that during shut-in, CO₂ continues to diffuse deeper into the matrix until CO₂ concentration reaches an equilibrium within a certain range. At the core scale, CO₂ penetrates approximately 4 cm into the core after a 15-day shut-in, effectively reducing the viscosity within a range of about 3.5 cm. At the field scale, CO₂ diffusion extends up to approximately 4 m, with an effective viscosity reduction zone of about 3 m. Results suggest that, theoretically, higher injection rates and longer shut-in times yield better EOR results. However, considering economic factors, a 20-day shut-in period is preferred. Different injection rates indicate varying fracture conduction capabilities upon gas injection completion. Full article

Background and Aim: Patients with cyanosis secondary to congenital heart disease (CHD) are characterized by erythrocytosis and increased blood viscosity, which contribute to endothelial dysfunction, increased arterial stiffness, and impaired vascular function, which may affect the final clinical presentation. Asymmetric dimethylarginine (ADMA) and e-selectin (e-sel) are valuable biomarkers for endothelial and vascular dysfunction. Their concentration levels in blood serum have the potential to be an accessible tool that reflects the severity of the disease. We aimed to assess e-sel and ADMA levels and their relationship with the clinical status and endothelial and vascular function. Methods: A cross-sectional study, including 36 adult CHD cyanotic patients [(17 males) (42.3 ± 16.3 years)] with an arterial blood oxygen saturation less than 92% and 20 healthy controls [(10 males) (38.2 ± 8.5 years)], was performed. All the patients underwent a clinical examination, blood testing, and cardiopulmonary tests. Their endothelial function was assessed using the intima media thickness and flow-mediated dilatation. Vascular function, using applanation tonometry methods, was determined using the aortic systolic pressure, aortic pulse pressure, augmentation pressure, augmentation index, pulse pressure amplification, and pulse wave velocity. Results: The concentrations of e-sel and ADMA were significantly higher in the patients with CHD. The E-sel levels correlated positively with red blood cells, hemoglobin concentration, hematocrit, and augmentation pressure; they correlated negatively with blood oxygen saturation, the forced expiratory one-second volume, forced vital capacity, and oxygen uptake. The ADMA levels were found to correlate only with age. Conclusions: The E-sel level, unlike ADMA concentration, reflects the severity of erythrocytosis and hypoxia and, thus, the physical status of patients with cyanotic CHD. Full article

Four-pile caps made from concrete are essential elements for the force transfer from the superstructure to piles or pipes. Due to the difficulties in carrying out full-scale tests and all the instrumentation involved, the use of numerical models as a way to study the mechanical behavior of these elements presents itself as a good alternative. Such numerical studies usually provide useful information for the update and improvement of normative standards and codes. The concrete damaged plasticity (CDP) constitutive model, which combines damage and plasticity with smeared-crack propagation, stands out in the simulation of reinforced concrete. This model is composed of five parameters: dilatation angle (ψ), eccentricity (ϵ), ratio between biaxial and uniaxial compressive strength (σ_bo/σ_co), failure surface in the deviator plane normal to the hydrostatic axis (K_c), and viscosity (μ). For unidimensional elements, the values of the CDP parameters are well defined, but for volumetric elements, such as concrete pile caps, there is a gap in the literature regarding the definition of these values. This fact ends up limiting the use of the CDP on these structural elements due to the uncertainties involved. Therefore, the aim of this research was to calibrate two numerical models of concrete four-pile caps with different failure modes for the evaluation of the sensitivity of the CDP parameters, except for ϵ, which remained constant. As a result, the parameters σ_bo/σ_co and K_c did not significantly influence the calibration of the force × displacement curves of the simulated structures. Values of ψ and μ equal to 36° and 1 × 10⁻⁴, respectively, are recommended for “static” analysis, while for “quasi-static” analysis, ψ values ranging between 45° and 50° are suggested according to the failure mode. The results also showed to be sensitive to the constitutive relation of concrete tensile behavior in both modes of analysis. For geometric parameterization, the “static” analysis is recommended due to the lower coefficient of variation (3.29%) compared to the “quasi-static” analysis (19.18%). This conclusion is supported by the evaluation of the ultimate load of the numerical models from the geometrically parametric study compared to the results estimated by an analytical model. Full article

A solvent in suspension often has non-Newtonian properties. To date, in order to determine these properties, many constitutive equations have been suggested. In particular, power-law fluid, which describes both dilatant and pseudoplastic fluids, has been used in many previous studies because of its simplicity. Then, the Herschel–Bulkley model is used, which describes fluid with yield stress. In this study, we considered how a non-Newtonian solvent affected the equilibrium position of a particle and relative viscosity using the regularized lattice Boltzmann method for fluid and a two-way coupling scheme for the particle. We focused on these methods so as to evaluate the non-Newtonian effects of a solvent. The equilibrium position in Bingham fluid was closer to the wall than that in Newtonian or power-law fluid. In contrast, the tendency of relative viscosity in Bingham fluid for each position was similar to that in power-law fluid. Full article

In order to explore the interface adsorption mechanism of hydroxyl-substituted alkylbenzene sulfonates, the interfacial tension relaxation method was used to investigate the dilational rheology properties of sodium 2-hydroxy-3-octyl-5-octylbenzene sulfonate (C₈C₈OHphSO₃Na) and sodium 2-hydroxy-3-octyl-5-decylbenzene sulfonate (C₈C₁₀OHphSO₃Na) at the gas–liquid interface and oil–water interface. The effect of the length of the hydroxyl para-alkyl chain on the interfacial behavior of the surfactant molecules was investigated, and the main controlling factors of the interfacial film properties under different conditions were obtained. The experimental results show that for the gas–liquid interface, the long-chain alkyl groups adjacent to the hydroxyl group in the hydroxyl-substituted alkylbenzene sulfonate molecules tend to extend along the interface, showing strong intermolecular interaction, which is the main reason why the dilational viscoelasticity of the surface film is higher than that of ordinary alkylbenzene sulfonates. The length of the para-alkyl chain has little effect on the viscoelastic modulus. With the increase in surfactant concentration, the adjacent alkyl chain also began to extend into the air, and the factors controlling the properties of the interfacial film changed from interfacial rearrangement to diffusion exchange. For the oil–water interface, the presence of oil molecules will hinder the interface tiling of the hydroxyl-protic alkyl, and the dilational viscoelasticity of C₈C₈ and C₈C₁₀ will be greatly reduced relative to the surface. The main factor controlling the properties of the interfacial film is the diffusion exchange of surfactant molecules between the bulk phase and the interface from the beginning. Full article

In this article, electro-osmotic thrusters (EOTs), which are full of non-Newtonian power-law fluids with a flow behavior index n of the effective viscosity, are theoretically investigated in a microchannel. Different values of the flow behavior index represent two kinds of non-Newtonian power-law fluids, pseudoplastic fluids (n < 1) and dilatant fluids (n > 1), which have not yet been considered to be used as propellants in micro-thrusters. Analytical solutions of the electric potential and flow velocity are obtained using the Debye–Hückel linearization assumption and the approximate scheme of hyperbolic sine function. Then, thruster performances of power-law fluids, including specific impulse, thrust, thruster efficiency, and thrust-to-power ratio, are explored in detail. Results show that these performance curves strongly depend on the flow behavior index and electrokinetic width. It is noted that the non-Newtonian pseudoplastic fluid is most suitable as a propeller solvent in micro electro-osmotic thrusters owing to its improving or optimizing deficiencies in the performances of the existing Newtonian fluid thrusters. Full article

To control the semisolid processing of aluminum alloys produced by the additive manufacturing technique, an exhaustive knowledge of their rheological behavior is required. In the semisolid state, metallic materials can show rheological characteristics similar to those of polymers, so semisolid state shaping is one of the currently considered routes for additive manufacturing with metallic materials. In this work, an approximation of the rheological control of the A356 aluminum alloy for its subsequent 3D manufacturing was carried out at a very low shear rate. A continuous cooling rheometer was designed and used, evaluating the influence of different process parameters on the viscosity variation of the aluminum alloy in the semisolid state. The results show an anomalous flow variation, indicating dilatant, and not thixotropic behavior, for very low shear rates. Full article

The effectiveness of inhalation therapy depends on aerosol size distribution, which determines the penetration and regional deposition of drug in the lungs. As the size of droplets inhaled from medical nebulizers varies depending on the physicochemical properties of the nebulized liquid, it can be adjusted by adding some compounds as viscosity modifiers (VMs) of a liquid drug. Natural polysaccharides have been recently proposed for this purpose and while they are biocompatible and generally recognized as safe (GRAS), their direct influence of the pulmonary structures is unknown. This work studied the direct influence of three natural VMs (sodium hyaluronate, xanthan gum, and agar) on the surface activity of the pulmonary surfactant (PS) measured in vitro using the oscillating drop method. The results allowed for comparing the variations of the dynamic surface tension during breathing-like oscillations of the gas/liquid interface with the PS, and the viscoelastic response of this system, as reflected by the hysteresis of the surface tension. The analysis was done using quantitative parameters, i.e., stability index (SI), normalized hysteresis area (HAn), and loss angle (φ), depending on the oscillation frequency (f). It was also found that, typically, SI is in the range of 0.15–0.3 and increases nonlinearly with f, while φ slightly decreases. The effect of NaCl ions on the interfacial properties of PS was noted, which was usually positive for the size of hysteresis with an HAn value up to 2.5 mN/m. All VMs in general were shown to have only a minor effect on the dynamic interfacial properties of PS, suggesting the potential safety of the tested compounds as functional additives in medical nebulization. The results also demonstrated relationships between the parameters typically used in the analysis of PS dynamics (i.e., HAn and SI) and dilatational rheological properties of the interface, allowing for easier interpretation of such data. Full article

In order to explore the mechanism responsible for the interactions in the surfactant–polymer composite flooding and broaden the application range of the binary system in heterogeneous oil reservoirs, in this paper, the influences of different surfactants on the viscosity of two polymers with similar molecular weights, partially hydrolyzed polyacrylamide (HPAM) and hydrophobically modified polyacrylamide (HMPAM), were studied at different reservoir environments. In addition, the relationship between the surfactant–polymer synergistic effects and oil displacement efficiency was also investigated. The experimental results show that for HPAM, surfactants mainly act as an electrolyte to reduce its viscosity. For HMPAM, SDBS and TX-100 will form aggregates with the hydrophobic blocks of polymer molecules, reducing the bulk viscosity. However, zwitterionic surfactant aralkyl substituted alkyl sulfobetaine BSB molecules can build “bridges” between different polymer molecules through hydrogen bonding and electrostatic interaction. After forming aggregates with HMPAM molecules, the viscosity will increase. The presence of two polymers all weakened the surfactant oil–water interfacial membrane strength to a certain extent, but had little effect on the interfacial tension. The synergistic effect of the “bridge” between HMPAM and BSB under macroscopic conditions also occurs in the microscopic pores of the core, which has a beneficial effect on improving oil recovery. Full article

Micro visualization has become an important means of solving colloid and interface scientific problems in enhanced oil recovery. It can establish a relationship between a series of performance evaluations of an oil-water interface under macroscopic dimensions and the actual application effect in confined space, and more truly and reliably reflect the starting and migration behavior of crude oil or emulsion in rock pores. In this article, zwitterionic surfactant alkyl sulfobetaine (ASB) and anionic extended surfactant alkyl polyoxypropylene sulfate (A145) were employed as flooding surfactants. The macroscopic properties of the surfactant solutions, such as the oil-water interfacial tension (IFT), the interfacial dilational rheology and the viscosity of crude oil emulsions, have been measured. At the same time, we link these parameters with the oil displacement effect in several visual glass models and confirm the main factors affecting the migration ability of emulsions in micro-scale pores. The experimental results show that ASB reduces the IFT through mixed adsorption with crude oil fractions. The flat arrangement of the large hydrophilic group of ASB molecules enhances the interactions between the surfactant molecules on the oil-water interface. Compared with sulfate, betaine has higher interfacial membrane strength and emulsion viscosity. A145 has a strong ability to reduce the IFT against crude oil because of the larger size effect of the PO chains at the oil side of the interface. However, the membrane strength of A145 is moderate and the emulsion does not show a viscosity-increasing effect. During the displacement process, the deformation ability of the front emulsions or oil banks is the main controlling factor of the displacement efficiency, which is determined by the membrane strength and emulsion viscosity. The strong interfacial membrane strength and the high emulsion viscosity are not conducive to the migration of droplets in pore throats and may result in low displacement efficiency. Full article

In this paper, we study the simple shear flows of a class of dilatant fluids with a limited shear rate. This class of fluids is characterized by shear thickening behavior in which the apparent viscosity tends to infinity as the modulus of the stress approaches a finite threshold. The apparent viscosity function is a logarithmic type with two material parameters. We considered this specific form because it fits very well with the flow curves of some granular suspensions for specific values of the material parameters. Despite the nonlinearity of the constitutive law, it is possible to determine explicit steady-state solutions for a simple shear flow, namely (i) the channel flow; (ii) the flow between coaxial cylinders, and (iii) the flow down an inclined plane. We performed a two-dimensional linear stability analysis to investigate the onset of possible instabilities of the steady basic flow, putting into evidence the dependency of the critical Reynolds number on the material parameters. Full article

Tropomyosin (Tpm) mutations cause inherited cardiac diseases such as hypertrophic and dilated cardiomyopathies. We applied various approaches to investigate the role of cardiac troponin (Tn) and especially the troponin T (TnT) in the pathogenic effects of Tpm cardiomyopathy-associated mutations M8R, K15N, A277V, M281T, and I284V located in the overlap junction of neighboring Tpm dimers. Using co-sedimentation assay and viscosity measurements, we showed that TnT1 (fragment of TnT) stabilizes the overlap junction of Tpm WT and all Tpm mutants studied except Tpm M8R. However, isothermal titration calorimetry (ITC) indicated that TnT1 binds Tpm WT and all Tpm mutants similarly. By using ITC, we measured the direct K_D of the Tpm overlap region, N-end, and C-end binding to TnT1. The ITC data revealed that the Tpm C-end binds to TnT1 independently from the N-end, while N-end does not bind. Therefore, we suppose that Tpm M8R binds to TnT1 without forming the overlap junction. We also demonstrated the possible role of Tn isoform composition in the cardiomyopathy development caused by M8R mutation. TnT1 dose-dependently reduced the velocity of F-actin-Tpm filaments containing Tpm WT, Tpm A277V, and Tpm M281T mutants in an in vitro motility assay. All mutations impaired the calcium regulation of the actin–myosin interaction. The M281T and I284V mutations increased the calcium sensitivity, while the K15N and A277V mutations reduced it. The Tpm M8R, M281T, and I284V mutations under-inhibited the velocity at low calcium concentrations. Our results demonstrate that Tpm mutations likely implement their pathogenic effects through Tpm interaction with Tn, cardiac myosin, or other protein partners. Full article

In the simulation of compressible turbulent flows via a high-order flux reconstruction framework, the artificial viscosity model plays an important role to ensure robustness in the strongly compressible region. However, the impact of the artificial viscosity model in under-resolved regions on dissipation features or resolving ability remains unclear. In this work, the performance of a dilation-based (DB) artificial viscosity model to simulate under-resolved turbulent flows in a high-order flux reconstruction (FR) framework is investigated. Comparison is conducted with results via several typical explicit subgrid scale (SGS) models as well as implicit large eddy simulation (iLES) and their impact on important diagnostic quantities including turbulent kinetic energy, total dissipation rate of kinetic energy, and energy spectra are discussed. The dissipation rate of kinetic energy is decomposed into several components including those resulting from explicit SGS models or Laplacian artificial viscosity model; thus, an explicit evaluation of the dissipation rate led by those modeling terms is presented. The test cases consist of the Taylor-Green vortex (TGV) problem at $Re=1600$, the freely decaying homogeneous isotropic turbulence (HIT) at $M{a}_{t0}=0.5$ (the initial turbulent Mach number ), the compressible TGV at Mach number 1.25 and the compressible channel flow at $R{e}_b=$ 15,334 (the bulk Reynolds number based on bulk density, bulk velocity and half-height of the channel), Mach number 1.5. The first two cases show that the DB model behaves similarly to the SGS models in terms of dissipation and has the potential to improve the insufficient dissipation of iLES with the fourth-order-accurate FR method. The last two cases further demonstrate the ability of the DB method on compresssible under-resolved turbulence and/or wall-bounded turbulence. The results of this work suggest the general suitability of the DB model to simulate under-resolved compressible turbulence in the high order flux reconstruction framework and also suggest some future work on controlling the potential excessive dissipation caused by the dilation term. Full article

In this study, the effect of different types of aluminosilicates on the thermo-mechanical properties of metakaolinite-based geopolymer binders and composites was examined. The metakaolinite-based geopolymer binders and composites were produced from three different types of aluminosilicates (one metakaolin and two calcined claystones) and a potassium alkaline activator. Chamotte was added as a filler, amounting to 65% by volume, to create geopolymer composites. Geopolymer binders were characterized by X-ray diffraction, rotary rheometer and scanning electron microscopy. The mechanical properties, thermal dilatation and thermal conductivity were investigated on geopolymer composites with three different aluminosilicates before and after exposure to high temperatures (up to 1200 °C). The results showed that the geopolymer binders prepared from calcined claystones had a lower dynamic viscosity (787 and 588 mPa·s) compared to the geopolymer binders prepared from metakaolin (1090 mPa·s). Geopolymer composites based on metakaolin had lower shrinkage (0.6%) and higher refractoriness (1520 °C) than geopolymers from calcined claystones (0.9% and 1.5%, 1500 °C and 1470 °C). Geopolymers based on calcined kaolinitic claystones are a promising material with higher compressive (95.2 and 71.5 MPa) and flexural strength (12.4 and 10.7 MPa) compared to geopolymers based on metakaolin (compressive strength 57.7 MPa). Full article