Identification of contamination sources and delineation of plumes in the geological environment stand as pivotal elements in reconstructing the conceptual site model (CSM) and devising remediation strategies tailored to specific physicochemical trait...
Managing the logistics and safety of an election system, from delivering voting machines to the right locations at the right time to ensuring that voting lines remain reasonable in length is a complex problem due to the scarcity of resources, especia...
Aim: The authors provided an accurate, simple, and noninvasive method for matching the intraoral scan with facial scan of a patient, without the need of a cone beam computed tomography (CBCT). Materials and methods: Three different facial scans were...
Language modeling has evolved from simple rule-based systems into complex assistants capable of tackling a multitude of tasks. State-of-the-art large language models (LLMs) are capable of scoring highly on proficiency benchmarks, and as a result have...
Digital images play an increasingly central role in journalism, legal investigations, and cybersecurity. However, modern editing tools make image manipulation difficult to detect with traditional forensic methods. This research addresses the challeng...
An electric vehicle charging station (EVCS) infrastructure is the backbone of transportation electrification; however, the EVCS has various vulnerabilities in software, hardware, supply chain, and incumbent legacy technologies such as network, commun...
Internet of things (IoT) technologies have recently gained much interest from numerous industries, where devices, machines, sensors, or simply things are linked with each other over open communication networks. However, such an operation environment...
Telemedicine applications are more and more used due to the rapid development of digital imaging and information and communication technologies. Medical information which include digital medical images and patient’s information are extracted an...
We proposed a novel technique for detecting optical filter shift in ROADMs in optical transmission lines by applying machine learning on DP-16QAM constellation data captured just after Analogue-to-Digital Converters (ADCs) in a digital coherent recei...
The quantitative, accurate and efficient acquisition of tree phenotypes is the basis for forest “gene-phenotype-environment” studies. It also offers significant support for clarifying the genetic control mechanisms of tree traits. The app...
Methods: Forty pediatric (0–12 years) B-ALL DNA samples (20 paired Diagnosis-Relapse) and an additional six B-ALL DNA samples (without relapse at 3 years post treatment), as the non-relapse arm, were retrieved from the biobank for advanced genomic an...
A concept for creating a large class of lightweight stream ciphers as Key Stream Generators KSGs is presented. The resulting class-size exceeds 2323 possible different KSGs. If one unknown cipher from the KSG-class is randomly picked-up and stored ir...
Breast cancer tumor draining lymph nodes (TDLNs) display distinct morphologic changes depending on the breast cancer subtype. For triple-negative breast cancers (TNBC), draining LNs display a higher amount of secondary lymphoid follicles, which can b...
Combination antiretroviral therapy (cART) controls but does not eradicate HIV infection; HIV persistence is the principal obstacle to curing infections. The proportion of defective proviruses increases during cART, but the dynamics of this process ar...
Efforts to cure HIV-1 infection require better quantification of the HIV-1 reservoir, particularly the clones of cells harboring replication-competent (intact) proviruses, termed repliclones. The digital droplet PCR assays commonly used to quantify i...
C. canephora exhibits high genetic variability, and to estimate this variability, morphological descriptors associated with coffee quality are used. Bean size is a physical trait of great importance for coffee classification. Manual classification is...
This paper analyzes the systemic threat of election-related Foreign Information Manipulation and Interference (FIMI) and Generative Artificial Intelligence (GAI) across recent Latin American electoral cycles in Guatemala (2023), Ecuador (2025), and H...
To address identity cloning, credential leakage, and delayed authorization in unmanned aerial vehicle (UAV) systems operating in open airspace, we propose a zero-trust authentication and authorization framework. SM9 identity-based mutual authenticati...
To the current data, there have been 6,955,141 COVID-19-related deaths worldwide, reported to WHO. Toll-like receptors (TLRs) implicated in bacterial and virus sensing could be a crosstalk between activation of persistent innate-immune inflammation,...
TRIM28 is a scaffold protein that interacts with DNA-binding proteins and recruits corepressor complexes to cause gene silencing. TRIM28 contributes to physiological functions such as cell growth and differentiation. In the chronic myeloid leukemia c...
Background: Fibroblast activation protein (FAP) is a promising target for cancer diagnosis and therapy, but the specificity and sensitivity of anti-FAP antibodies used for immunohistochemistry (IHC) vary considerably. A head-to-head comparison of com...
Born-digital content is rapidly becoming the norm for literary works, professional reports, academic journal articles, and formal corporate correspondence. From the perspective of digital forensics, there is a need to understand the origin of a docum...
New techniques are on the horizon for the detection of small leukemic clones in both, acute leukemias and myeloproliferative disorders. A promising approach is based on digital polymerase chain reaction (PCR). Digital PCR (dPCR) is a breakthrough tec...
The Ship’s Digital Twin (SDT) is a digital record of a ship’s behaviour or a software clone, which can be used to simulate scenarios that are expensive or hardly feasible to perform on a real object and especially in real time. The purpos...
The goal of this paper is to utilize available big and open data sets to create content for a board and a digital game and implement an educational environment to improve students’ familiarity with concepts and relations in the data and, in the...
The Secret Unknown Cipher (SUC) concept was introduced a decade ago as a promising technique for creating pure digital clone-resistant electronic units as alternatives to the traditional non-consistent Physical Unclonable Functions (PUFs). In this wo...
A meeting among expert pathologists was held in 2019 in Rome to verify the results of the previous harmonization efforts on the PD-L1 immunohistochemical testing by scoring a representative series of non-small cell lung cancer (NSCLC) digital slides....
Screening for elite sugarcane genotypes for canopy cover in a rapid and non-destructive way is important to accelerate varietal/clonal selection, and little information is available regarding canopy cover and leaf production, leaf area, biomass produ...
We introduce a technique to generate and read the digital signature of the networks, channels, and optical devices that possess the fiber-optic pigtails to enhance physical layer security (PLS). Attributing a signature to the networks or devices ease...
The identification of markers for early diagnosis, prognosis, and improvement of therapeutic options represents an unmet clinical need to increase survival in Non-Small Cell Lung Cancer (NSCLC), a neoplasm still characterized by very high incidence a...
Cloning the genes and operons encoding heterologous functions in bacterial hosts is now almost exclusively carried out using plasmid vectors. This has multiple drawbacks, including the need for constant selection and variation in copy numbers. The ch...
The FLT3-ITD mutation is a critical prognostic marker in acute myeloid leukemia (AML) and recent clinical trials demonstrate that FLT3-based measurable residual disease (MRD) is both prognostic and predictive, guiding therapeutic interventions in int...
Diffuse large B cell lymphomas (DLBCL) are the most common neoplasia of the lymphatic system. Circulating cell-free DNA released from tumor cells (ctDNA) has been studied in many tumor entities and successfully used to monitor treatment and follow up...
This article presents a gamified digital twin in Minecraft designed to support practical exercises in digital logic in the Computer Engineering I course at the University of Salamanca. Implemented as a Spigot/Paper server plugin based on the Platform...
Synthetic media are digital artifacts (image, video, audio, text, or multimodal content) that are wholly or partly generated or materially manipulated by artificial intelligence (AI), particularly by deep-learning models. In consequence, their form,...
A subset of ALK+ non-small cell lung cancer (NSCLC) patients relapse on ALK inhibitor (ALKi) treatment due to on-target resistance mutations affecting the tyrosine kinase domain. Objective: In this study, we investigated the presence of minor resista...
Coherent beam combining can be used to scale optical power and enable mechanism-free beam steering using an optical phased array. Coherently combining multiple free-running lasers in a leader-follower laser configuration is challenging due to the nee...
Multiselfing is a form of musicianship where one person digitally clones themself into several single selves, creating layers and a musical collective that would otherwise be impossible without the mediation of technology. There are various kinds of...
Monarch butterflies (Danaus plexippus) throughout the world are commonly infected by the specialist pathogen Ophryocystis elektroscirrha (OE). This protozoan is transmitted when larvae ingest infectious stages (spores) scattered onto host plant leave...
A model describing the wide variety of human behaviours called personality, is becoming increasingly popular among researchers due to the widespread availability of personal big data generated from the use of prevalent digital devices, e.g., smartpho...
TGCTs represent a model of curable disease afflicting especially young men. Defining tumor biological characteristics is crucial to increase current knowledge and tailor the best clinical management. Ki67, a potential prognostic marker, still exhibit...
Intelligent control systems can stabilise operational processes and support the development of digital manufacturing in the food industry. This study presents and examines a digital twin of an industrial bread oven with a hybrid neuro-fuzzy controlle...
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Intratumoral heterogeneity poses a major challenge to making an accurate diagnosis and establishing personalized treatment strategies for cancer patients. Moreover, this heterogeneity might underlie treatment resistance, disease progression, and canc...
The Internet of Things (IoT) connects massive smart devices to collect big data and carry out the monitoring and control of numerous things in cyber-physical systems (CPS). By leveraging machine learning (ML) and deep learning (DL) techniques to anal...
ESR1 mutations in breast cancer are one of the mechanisms of resistance to aromatase inhibitors. These mutations are common in metastatic breast cancer; however, these are rare in primary breast cancer. However, these data have been analyzed mainly i...
Indiscriminate genetic manipulation to improve athletic ability is a major threat to human sports and the horseracing industry, in which methods involving gene-doping, such as transgenesis, should be prohibited to ensure fairness. Therefore, developm...
The rice leaf folder, Cnaphalocrocis medinalis is a major pest of rice and is difficult to control. UDP-N-acetylglucosamine pyrophosphorylase (UAP) is a key enzyme in the chitin synthesis pathway in insects. In this study, the UAP gene from C. medina...
The assessment of programmed death-ligand 1 (PD-L1) combined positive scoring (CPS) in head and neck squamous cell carcinoma (HNSCC) is challenged by pre-analytical and inter-observer variabilities. An educational program to compare the diagnostic pe...
Casuarina equisetifolia L. is a key pioneer tree species for coastal shelterbelt plantations in tropical and subtropical regions. However, long-term reliance on a limited number of superior clones has narrowed its genetic base and reduced stress resi...
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