This article provides a comprehensive narrative review of the history of antiepileptic drugs (AEDs) and their development over time. Firstly, it explores the significant role of serendipity in the discovery of essential AEDs that continue to be used...
About 10 major crops basically feed the world. In fact, there are still a large number of plants that have not been fully explored and utilized because they have been ignored by the market and research. The expansion of food sources in various countr...
Abiotic and biotic stress factors seriously affect plant growth and development. The process of plant response to abiotic stress involves the synergistic action of multiple resistance genes. The ASR (Abscisic acid stress-ripening) gene is a plant-spe...
The aim of this paper is to sketch out the idea for a grand theory in development studies as the necessary research field for fruitful historical interdisciplinary, arguing that Mill’s stage theory provides such a powerful theoretical framework able...
Lithium batteries are electrochemical devices that are widely used as power sources. This history of their development focuses on the original development of lithium-ion batteries. In particular, we highlight the contributions of Professor Michel Arm...
A central contemporary societal discussion in Denmark concerns settlements that have poor connectivity and are geographically distant to main towns and cities. These settlements are called “outskirts.” Historically significant villages in these outsk...
Across many contexts, classrooms are becoming increasingly diverse. New diaspora communities are growing as a consequence of migration caused by conflict and increased global mobility. Despite this, curricula and teaching in general—and history...
Identity development among late adolescent university students and its relationship to family history knowledge was examined in this study. Identity development was examined using Marcia’s individual developmental framework (1988) of exploratio...
The Belgian Association of Hospital Pharmacists (BAHP) is a professional and scientific association representing all pharmacists who work in hospital institutions, whether private or public, university, general or psychiatric. This association was cr...
Epithelial to mesenchymal transition (EMT) is a process that allows epithelial cells to progressively acquire a reversible mesenchymal phenotype. Here, we recount the main events in the history of EMT. EMT was first studied during embryonic developme...
This case report is about a regional land-use planning project in the Netherlands. Initiated by the province of Gelderland and Radboud University (RU), the project aimed to create “Communities of Ownership” (CoO’s), local associations of townspeople...
Sustainable energy development (SED) is a crucial component of the Sustainable Development Goals (SDG), aiming to maintain economic and social progress while protecting the environment and mitigating climate change’s effects. SED serves as a tr...
Throughout history, humans have sought to drink water that is good for their health, according to the knowledge of the time. Hippocrates’ definition of water quality, “good water should be clear, light, aerated, without any perceptible od...
26 October 2025
Life course exposure estimates developed using geospatial datasets must address issues of individual mobility, missing and incorrect data, and incompatible scaling of the datasets. We propose methods to assess and resolve these issues by developing i...
This paper examines how gender shaped the family of Nancy Hood McGee, who belonged to one of Georgia’s antebellum planter families, across four generations. The McGee family had joined the planter class late in the antebellum period, and after the Am...
13 June 2021
Background: Breast cancer is the most common cancer among women. The Korean Genome and Epidemiology Study (KoGES) is a large cohort study that is available to the public. Using this large cohort study, we aimed to unravel the relationship between bre...
Comprehensive analyses of the association between a family history of lung cancer and lung cancer risk are limited, especially in the Korean population. We used baseline data from the Korean Genome and Epidemiology Study, conducted between 2001 and 2...
This paper aims to set out the role Marine Cultural Heritage (MCH) can play in informing responses to global challenges and enhancing the sustainable development of coastal zones. This requires recognition of the importance of MCH as a knowledge base...
The Biomedical Advanced Research and Development Authority, part of the Administration for Strategic Preparedness and Response within the U.S. Department of Health and Human Services, recognizes that the evaluation of medical countermeasures under th...
HER2 is highly expressed in a variety of malignant tumors and affects the prognosis of patients, making it a highly sensitive target for cancer therapy. Since the approval of the first HER2 inhibitor, trastuzumab, in 1998, HER2-targeted drugs have ra...
The mineral resources exploration industry continuously expands the efficiency requirements for geophysical technologies. Due to their relatively inexpensive nature, coupled with the ability to rapidly acquire data over large areas, airborne electrom...
Efavirenz (Sustiva®) is a first-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat human immunodeficiency virus (HIV) type 1 infection or to prevent the spread of HIV. In 1998, the FDA authorized efavirenz for the tre...
This paper presents a review of history matching and oil field development optimization techniques with a focus on optimization algorithms. History matching algorithms are reviewed as a precursor to production optimization algorithms. Techniques for...
This article proposes rethinking communication, development, and social change from a decolonial perspective through the case study of the Ticoya resguardo. It examines how the oral traditions of Indigenous elders construct a history of the territory...
16 August 2021
Colorectal cancer (CRC) is one of the most frequently diagnosed cancers and, as such, is important for public health. The increased incidence of this neoplasm is attributed to non-modifiable controls such as family history and modifiable variable beh...
This study aimed to reveal changes in urban forms by analyzing the modern and contemporary development history of Gangneung City, one of the major cities in the Yeongdong county of Gangwon-do, South Korea; it has been a central city in the Yeongdong...
Although Greece has accomplished wastewater infrastructure construction to a large extent, as 91% of the country’s population is already connected to urban wastewater treatment plants (WWTPs), many problems still need to be faced. These include...
4 October 2017
A high proportion of refugees have been subjected to potentially traumatic experiences (PTEs), including torture. PTEs, and torture in particular, are powerful predictors of mental ill health. This paper reports the development and preliminary valida...
The development of the concept of mental discipline can be understood from three clues, as a puritanical phenomenon, as a phenomenon rooted in the classics, and, on the other hand, as one rooted in faculty psychology. The aim of this research is to e...
Fort Stanwix National Monument, located in Rome, NY, is a historic park with a complex use history dating back to the early Colonial period and through the urban expansion and recent economic revitalization of the City of Rome. The goal of this study...
With the continuous advancement of ocean exploration and development, energy supply for underwater electronic equipment has become a key bottleneck restricting long-term operation. Traditional wired power supply and battery-powered operation suffer f...
As a ubiquitous movement in the ocean, tides are vital for marine life and numerous marine activities such as fishing and ocean engineering. Tidal dynamics are complicated in the East Asian marginal seas (EAMS) due to changing complex topography and...
Liver cirrhosis development is a multifactorial process resulting from a combination of environmental and genetic factors. The aim of the study was to develop accurate non-invasive diagnostic and prognostic models for alcoholic cirrhosis. Consecutive...
This work critically reviews the evolution of reactive sputtering modeling that has taken place over the last 50 years. The review summarizes the main features of the deposition of simple metal compound films (nitrides, oxides, oxynitrides, carbides,...
Animals and plants host diverse communities of microorganisms, and these microbiotas have been shown to influence host life history traits. Much has been said about the benefits that host-associated microbiotas bestow on the host. However, life histo...
Background: Stereotactic radiosurgery (SRS) was originally conceived as a noninvasive alternative to functional neurosurgery by the Swedish neurosurgeon Lars Leksell. This review traces the historical development of stereotactic methods from early me...
Fertilization-initiated development and adult-onset aging are standard features in the life history of eukaryotes. In Paramecium, the number of cell divisions after the birth of a new generation is an essential parameter of sexual phase transition an...
Necrophagous fly species are commonly used as forensic tools to estimate the minimum postmortem interval (PMImin). Many researchers raised necrophagous flies under constant temperature regimes to collect their developmental data. However, in most for...
The origins of veterinary medicine remain a subject of debate. The search for the “first veterinarian” has often led to the application of modern professional concepts to ancient societies. Among the Mesopotamian sources, particular atten...
Understanding a species’ life history is essential for assessing its adaptability and resource trade-offs under environmental stress. Given their diversity and ecological significance, Lepidoptera represent an ideal model system for studying su...
The present study presents a brief discussion regarding the evolution of meteorology from the sixteenth to the twenty-first century, throughout antiquitiy, Aristotle’s legacy, and contemporaneity. Part of the text is dedicated to illustrating the eme...
Multi-centennial C budgets in forested watersheds require information on forest growth, detritus turnover, and disturbances, as well as the transfer to and fate of terrestrial C in aquatics systems. Here, a sediment gravity core was collected from a...
In this paper, representations of Spanish Secondary Education trainee teachers (n = 163) are analyzed with regard to the socio-environmental problematic, end-purposes, and strategies of education for sustainable development (ESD). Likewise, the study...
It has been more than 30 years since the first ordered mesoporous silica molecular sieve (MCM-41) was reported, but the enthusiasm for exploiting mesoporous silica is still growing due to its superior properties, such as its controllable morphology,...
Since 11 September 2001, Islam has been viewed as a threat to global stability rather than as a potential factor for peacebuilding and development. Therefore, most studies on Islam have been framed around security. Although research on the security t...
Background: Children with cow’s milk allergy (CMA) present alterations in their gut microbiome, but any potential sex-dependency of these has not been addressed. Further, whether eliminating milk from children’s diet has similar effects o...
The red abalone Haliotis rufescens is a pivotal marine resource in the context of worldwide abalone aquaculture. However, the species has been listed as critically endangered partly because of the life-history massive mortalities associated with habi...
Background: This scoping review aims to systematically examine the extent of the literature on African health histories throughout the pre-colonial, colonial, post-independence, primary health care (PHC), Millennium Development Goals (MDG), and Susta...
At the beginning of human history, surface water, especially from rivers and springs, was the most frequent water supply source. Groundwater was used in arid and semi-arid regions, e.g., eastern Crete (Greece). As the population increased, periodic w...
Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) using the SEXTANT® system (Medtronic) featured the first generation of commercially available percutaneous pedicle screw (PPS) system in 2001. The innovative system has since be...
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