Search Results (8,972)

Small-scale inland fisheries in the Amazon are critical for food security, yet their sustainability is increasingly threatened by overexploitation and environmental degradation. In data-limited contexts such as the northern Ecuadorian Amazon, the absence of continuous monitoring constrains the development of adaptive management strategies. This study develops an integrated socio-ecological baseline to support the establishment of fisheries agreements in five Indigenous communities of the Napo and Aguarico rivers. Through a participatory monitoring approach, we generated reproductive parameters (gonadosomatic index, fecundity, size at first maturity), population structure metrics, and length–weight relationships for key subsistence species across three hydrological phases. Reproductive investment exhibited marked seasonality, with peak gonadosomatic indices during rising waters in most species, identifying a critical period for protection. Life-history strategies ranged from high-fecundity periodic strategists to low-fecundity equilibrium species, implying differentiated vulnerability to harvesting. Community perceptions prioritized large migratory catfish and floodplain habitats, aligning with biological indicators of vulnerability. High performance in technical training demonstrated the feasibility of long-term local monitoring systems. By linking biological indicators with local ecological knowledge, this study proposes a pathway from baseline assessment to adaptive co-management. The framework presented here provides a transferable model for strengthening sustainability, governance, and food security in tropical small-scale fisheries facing persistent data limitations. Full article

Modern performance-based bridge design seeks to control damage in specific failure modes in order to balance safety and economy, particularly in high-seismic regions where inelastic and ductile deformation is expected to occur, both in the structure and soil, allowing potential reduction in seismic demand through fuse elements. In short-span bridges, abutments strongly influence longitudinal response, whereas transverse performance depends largely on seismic components such as shear keys and other energy-dissipation devices. Thus, performance assessment requires explicit representation of their hysteretic behavior. This study presents a numerical evaluation of the damping provided by common elements in typical bridge systems, using as reference damage observations from bridges affected by recent interface earthquakes in Mexico. Three-dimensional finite-difference models were developed, and nonlinear response-history analyses were performed to simulate ductile behavior and energy dissipation. The Sig3 hysteretic model available in FLAC^3D was used for abutments and foundation soils, while shear keys were represented as nonlinear springs. The results established a relationship between plastic deformation and energy dissipation, showing that incorporating the hysteretic behavior of both soil and sacrificial structural components enhanced the seismic bridge performance assessment, and led to more reliable and cost-efficient designs when inelastic deformation capacity was explicitly included in the numerical simulations. Full article

Background/Objectives: The pre-diagnosis dietary intake in newly diagnosed multi-ethnic paediatric inflammatory bowel disease (PIBD) is not well understood. This study aimed to describe the pre-diagnosis diet and environmental factors in children with newly diagnosed PIBD attending a single Australian tertiary children’s hospital. Methods: A pilot cross-sectional study was conducted from February 2022 to February 2023 involving children with newly diagnosed PIBD. Results: Of 56 children confirmed with PIBD, 54% had Crohn’s disease (CD)—mean ± SD age, 11.55 years ± 2.84—and 46% had Ulcerative Colitis (UC)—11.50 years ± 2.94 (45%, non-Caucasian). More Caucasians had an IBD family history (48.3% vs. 20%; p = 0.02 *). Non-Caucasian children demonstrated significantly lower mean serum vitamin D levels than Caucasian children (42.5 vs. 69 nmol/L; p ≤ 0.001 ***). Most children across ethnicities for both IBD subtypes had ‘regular’ intakes of red meat, whereas more Caucasian children had ‘regular’ intakes of processed/deli meat (72% vs. 39%; p = 0.02 *). A total of 64% of non-Caucasian children with CD reported a usual pre-diagnosis diet that differed from the traditional diet, compared to 42% with UC (p = 0.29). When eating out, fast foods were chosen regularly by most children with PIBD. Pre-diagnosis dietary intake data indicated that most with PIBD ‘rarely/never’ had whole-food sources of plant protein and had ‘infrequent’ intake of rice. Plant food diversity was low (mean 11 types/week). Conclusions: The significantly lower likelihood of IBD family history, along with relatively lower vitamin D levels, and the predominance of a Western-style dietary pattern among non-Caucasian children are compatible with the hypothesis that non-genetic factors may be important in PIBD, warranting further investigation into diet and environmental factors in this group. Further investigation of the pre-disease modifiable non-genetic factors contributing to the development of PIBD in the migrant population group is recommended. The finding across ethnicities of low pre-diagnosis plant food diversity was novel; however, due to the lack of healthy controls and the use of a novel but non-validated exposome tool, causality associations should be interpreted cautiously. Full article

Apolygus lucorum (Meyer-Dür) is a phytozoophagous crop pest. While the effects of plant-based diets on its development and reproduction have been extensively studied, the combined effects of plant- and prey-based diets on these traits remain poorly understood. This study systematically evaluated the effects of plant-only, prey-only, and mixed plant–prey diets on A. lucorum nymphal survival and development, as well as adult longevity and fecundity, under controlled laboratory conditions. The results demonstrate that diet composition significantly affected nymphal survival and developmental progression. Nymphs fed exclusively on prey (Aphis gossypii Glover or Bemisia tabaci (Gennadius) nymphs) failed to complete juvenile development. Although a diet of Helicoverpa armigera (Hübner) eggs alone enabled some individuals to reach adulthood, survival rates were significantly lower than those in mixed-diet treatments. Mixed feeding markedly improved nymphal survival, with the highest rates observed in groups fed green beans + H. armigera eggs and cotton leaves + B. tabaci nymph combinations (both 64.45%). The developmental duration was also influenced. Mixed diets, particularly green beans + H. armigera eggs, significantly shortened each instar and the total developmental time (11.04 ± 0.17 d), whereas a diet of cotton leaves alone prolonged development (19.45 ± 0.24 d). Adult longevity and reproductive output were likewise diet-dependent. The longest lifespans were recorded in adults fed green beans alone or green beans + H. armigera eggs, while the shortest lifespan was observed for those fed only cotton leaves. Successful oviposition was only achieved following four dietary treatments: green beans alone, green beans + H. armigera eggs, H. armigera eggs alone, and cotton leaves + H. armigera eggs. Among these, the green bean + H. armigera egg diet yielded the best reproductive performance, featuring the shortest pre-oviposition period (5.82 ± 0.60 d), the longest oviposition period (19.41 ± 1.68 d), and the highest mean fecundity per female (238.35 ± 25.51 eggs). This underscores the reproductive advantage of a mixed plant–prey diet. This study clarifies how dietary conditions shape the survival, development, and reproduction of A. lucorum, highlighting its strong reliance on nutritional quality for key life-history traits. These findings offer valuable insights into the ecological adaptations underlying the feeding behavior of this insect. Full article

Classical homogenization theory treats critical exponents as universal quantities depending only on spatial dimension, but recent evidence shows that this assumption fails for continuum composites once the mechanism of randomness generation is taken into account. We synthesize three complementary frameworks—structural approximation, structural sums, and self-similar renormalization—to develop a unified geometric theory of criticality in random composites. Dilute-regime expansions for the effective conductivity and shear modulus are expressed in terms of structural sums whose ensemble statistics depend sensitively on the randomness protocol. To bridge the dilute and critical regimes, we employ self-similar factor approximants, iterated-root approximants, additive approximants, and renormalization schemes based on minimal-difference and minimal-sensitivity conditions, combined with Borel summation. For maximally disordered protocols $\mathcal{P}\left(\tau \right)$, the conductivity index s and the elasticity index S fall within comparable numerical ranges, indicating a shared geometric origin and spectral response to the continuous breaking of translational symmetry. A regular periodic arrangement of inclusions ($\tau =0$) possesses full discrete translational symmetry; as a stochastic protocol $\mathcal{P}\left(\tau \right)$ is applied ($\tau$ increases), this symmetry is gradually degraded until statistical chaos is reached. For instance, the parameter $\tau$ can be considered as a time of stirring. During this evolution, the system traverses a continuous spectrum of critical indices, $s=s\left[\mathcal{P}\right(\tau \left)\right],$ which encodes the geometric and topological memory of the initial ordered state. It is established that the classical “universality” of percolation corresponds to a fixed point $\tau$ within a broader manifold of protocol-dependent critical behaviors. The framework developed here provides a coherent basis for inverse design, diagnostics, and classification of random composites by their disorder history, offering a geometric alternative to the universality paradigm. Full article

Background/Objectives: This study aimed to investigate the impact of allergic diseases (AD) or obstructive sleep apnea (OSA) risk, as a host factor, on the development of severe Mycoplasma pneumoniae Pneumonia (SMPP) in children by analyzing the clinical data of pediatric patients with Mycoplasma pneumoniae Pneumonia (MPP). Methods: This retrospective study enrolled children hospitalized with Mycoplasma pneumoniae pneumonia (MPP) at Shanghai Ninth People’s Hospital from November 2024 to November 2025. Patients were classified into severe (SMPP) and mild (MMPP) groups. Demographic, clinical, laboratory, and questionnaire data were collected and compared between groups. Univariate and multivariate logistic regression analyses were performed to identify independent predictors of SMPP and construct a nomogram. The model was validated for discrimination, calibration, and clinical utility using ROC curves, calibration plots, and decision curve analysis, with internal validation by bootstrap resampling. Results: Among the 150 enrolled children with MPP, 35 (23.3%) were classified as severe (SMPP) and 115 (76.7%) as mild (MMPP). Patients with SMPP exhibited significantly higher frequencies of allergic diseases, prolonged fever and steroid use, elevated inflammatory markers (CRP, LDH, D-dimer, ferritin, ALT), and higher PSQ and RQLQ scores (all p < 0.05). Disease severity was positively correlated with these clinical, laboratory, and questionnaire-based parameters. Multivariate logistic regression identified allergic diseases, PSQ score, LDH, and ferritin as independent predictors of SMPP. A nomogram incorporating these four factors demonstrated good predictive performance, with an internally validated C-index of 0.827, satisfactory calibration (Hosmer–Lemeshow p = 0.116), and clinical utility within a 0–25% threshold probability range on decision curve analysis. Conclusions: Children with MPP and comorbid AD or OSA risk are more likely to develop SMPP. Among children aged 6–12 years, RQLQ score is positively correlated with the severity of MPP. AD, PSQ score, LDH, and ferritin are independent risk factors for SMPP. Clinicians should be alert to the development of SMPP when children with MPP present with a history of AD, PSQ score >3.5, LDH >327.50 U/L, or ferritin >120.05 ng/mL. The visual nomogram model constructed by combining these risk factors demonstrates improved predictive performance for SMPP, with high predictive efficacy and accuracy. It has great clinical value and can be used for individualized risk assessment and early intervention. However, our proposed nomogram requires external validation prior to broader implementation. Full article

Children are some of the most vulnerable members of society who must be protected at all costs. Zimbabwe has a long history of disjointed formal and indigenous social protection systems, which have resulted in the exclusion of many children, leading to high levels of child abuse, neglect, exploitation and violence. In policy and practice, there is a strong bias towards the ineffective statist formal system, yet the indigenous social protection system is the mainstay for the protection of most children. The study aimed to explore how asset-based community development can be used as a strategy to integrate the fragmented formal and indigenous social protection systems for sustainable child protection. An explanatory sequential mixed-methods research design was employed, collecting both quantitative and qualitative data from 76 participants. The study findings indicate that asset-based community development by positioning the indigenous social protection system at the centre of the social protection framework provides a blueprint for a community-led and integrated social protection system, which can translate into effective child protection. This system, which utilises a wider network of community and external resources, can counteract the limits of fragmented social protection and sustainably promote child protection among impoverished households in Zimbabwe and similar contexts. The recommendation is that asset-based community development should be promoted as a strategy towards integrated social protection and sustainable child protection. Full article

Background/Objectives: Sleep disturbances have an impact on children’s physical and psychological development, yet little is known about the changes and factors influencing sleep after PICU discharge. To explore the trajectory of changes in sleep quality of critically ill children and to identify factors affecting sleep quality three months after Pediatric Intensive Care Unit (PICU) discharge. Methods: A longitudinal observation study was conducted between November 2022 and November 2023 at a tertiary children’s hospital. The Children’s Sleep Habits Questionnaire (CSHQ) was used at six time points: PICU-admission (T0), 1 week (T1), 2 weeks (T2), 1 month (T3), 2 months (T4), and 3 months (T5) after PICU discharge. The CSHQ is a 33-item parent-report outcome measure evaluating sleep problems. Total scores range between 33 and 99 points. A score of ≤41 indicates normal sleep; a score of >41 indicates sleep disturbance. Data were analyzed using the latent category growth model, univariate analysis, and multifactorial logistic regression. Results: Parents of 237 children completed all follow-up surveys. Prevalence of sleep disorders at T0-T5 of children with a score >41 were 46.5%, 83.5%, 69.7%, 54.3%, 50.2%, and 51.7%, respectively. General linear modeling revealed significant changes in CSHQ scores over time (F = 63.77, p < 0.05). The trajectories of identifying sleep changes were divided into three latent categories: High Sleep Disorder Group (n = 15, 6.33%), Moderate Sleep Disorder Group (n = 110, 45.2%), and No Sleep Disorder Group (n = 115, 48.52%). The trajectories were significantly different among preschool age, baseline sleep habit scores, surgery, and length-of-stay in pediatric wards (p < 0.05). The child’s age and surgical history were independent factors of sleep disturbance. Conclusions: The observed peak in sleep disturbances at 1-month post-PICU suggests that this period may be a critical window to develop and implement targeted interventions to improve sleep. The persistent sleep disorders highlight the need for long-term monitoring. Full article

The number and variety of images of reading in the Investigations suggest that, for Wittgenstein, reading is an essential part of our natural history and of the human form of life. Further, his treatments of reading show that different forms of reading express and sustain different forms of life. This essay explores what the Investigations reveals as the existential stakes of different modes of reading. Beginning with Wittgenstein’s opening engagement with Augustine, it argues that in the Investigations, as in the Confessions, different modes of reading both bespeak, and open us to, blessed or cursed forms of life. It then develops extended interpretations of individual passages in order to detail some specific shapes of, and conditions governing, modes of reading tied to these blessed or cursed forms of life. Finally, given these existential stakes of reading, it examines how the Investigations itself asks to be read and outlines specific ways in which its notorious difficulty and obscurity are essential to achieving its philosophical aims and, in particular, to promoting an ongoing practice of reading through which we are able to awaken to the wonder of our lives in language. Full article

The perennial grass timothy (Phleum pratense) is an important forage crop in cold temperate regions. It forms three types of tillers: vegetative (VEG), generative (GEN), and non-flowering elongated (ELONG). To understand the influence of plant development and tiller formation on biomass production and the diversity in these traits, a total of 246 wild and domesticated accessions of timothy and the related species, P. nodosum and P. alpinum, were investigated. The length of different plant developmental stages and the formation of different tiller types were studied to test the hypotheses: (1) the proportion (%) of different tiller types affects biomass and is influenced by the lengths of the different plant developmental stages, (2) domestication and breeding have affected the length of developmental stages and proportions of tiller types. While timothy cultivars did not differ significantly from wild accessions in biomass, wild accessions had higher VEG%, which increased with latitude of accession origin. P. nodosum cultivars produced the highest number of ELONG of all accessions and species, and the ELONG% showed a strong positive correlation with biomass. Timothy cultivars showed later emergence and tillering, and reached stem elongation and heading earlier than wild accessions, suggesting that delayed tillering, but an overall faster development, has been favoured during breeding. The time between tillering and stem elongation showed a positive correlation with VEG%. This study reveals large diversity in developmental and tiller traits among accessions, reflecting differences in their domestication and breeding history, and highlighting the importance of considering early developmental traits and ELONG formation for yield and quality in further pre-breeding research. Full article

The new-generation aeration blower, which uses a high-speed permanent-magnet synchronous motor supported by elastic-foil thrust bearings, represents the future development trend of high-end sewage treatment turbomachinery. An axial load tester was designed for the elastic-foil thrust bearings in this study. Firstly, the relationship between the axial load and the elastic-foil thrust bearing parameters was first established. An axial load tester was designed. Secondly, finite-element simulation and strain calibration of the axial load tester were performed to estimate the linear relationship between the strain and the axial load. Then, the time histories of axial load for the high-speed permanent-magnet synchronous motor were further obtained at a rotational speed of 15,000 rpm during the operation tests. Finally, the load spectrum was compiled by fitting the test data to a function. The results showed that the amplitude and frequency of the load spectrum obeyed an exponential decay function. It can be used for the life test of elastic-foil thrust bearings in the future. The method for obtaining the axial load in the direct-driven turbomachinery was proposed. The axial load tester proposed in the present study, based on operation tests, proves valuable for improving the performance of the high-speed permanent magnetic synchronous motor and the elastic-foil thrust bearing. Full article

Persistent post-endometrial ablation uterine bleeding indicates that no method of EA eliminates the entire endometrium, and post-EA hysteroscopy shows a distorted and scarred uterine cavity in the majority of patients. These observations raise concerns regarding presentation, assessment and stage of potential post-ablation endometrial cancer (PAEC), developing in residual endometrium pockets. To better understand these concerns, a literature search was conducted, from the introduction of EA in the 1980s through 2025, to capture reports of endometrial cancer (EC) associated with or following EA using multiple data bases, imputing search terms of EC following EA and possible combinations of first- and second-generation EA techniques associated with EC. Upon review of all publications, we identified 86 ECs associated with EA, described in 20 case reports (N = 20), four case series (N = 18), eleven cohort studies (N = 21), one registry (N = 27) and five reviews. Based on 12 relevant studies at a median follow-up of 8.5 years (range 1.9–25), 43 EC were identified in 39,795 women with a history of EA, with a summary incidence of 0.11% (range 0.0–1.59%). Although the studies and data are very heterogeneous, it appears that EA may afford a protective effect in reducing the risk of EC in the short term. The mechanistic effect is likely due to a quantitative reduction in the endometrium that can potentially become malignant, and/or due to the elimination of occult pre- or malignant endometrial elements which are vulnerable to EA. Moreover, based on 25 evaluable cases, the mode and time to presentation, the diagnostic work-up (including endometrial biopsy and hysteroscopy), and the stage of PAEC appear not to be altered by EA. Full article

Starvation is a fundamental physiological stressor that triggers conserved adaptive responses across species, however, its effects are shaped by both developmental stage and prior nutritional history. This study aimed to investigate the effects of acute nutrient deprivation in Artemia franciscana, comparing newly hatched nauplii and adult individuals previously exposed to reduced caloric intake during development. Organisms were subjected to starvation for 24, 48, and 72 h, and mortality, morphometric parameters, and locomotor activity were assessed, complemented by in silico analysis of starvation-related pathways. Starvation induced distinct responses between groups, with markedly higher mortality in adults compared to nauplii. While these differences reflect developmental stage-associated responses, they are also influenced by prior nutritional history. Body length was significantly reduced under starvation in both developmental stages, while antennal length remained largely unchanged. Locomotor activity, including distance travelled and swimming velocity, was consistently decreased, indicating energy-conserving behavioral adaptation. Partial recovery of locomotor performance and antennal length was observed following restoration of feeding. Bioinformatic analysis suggested the presence of conserved autophagy-related genes and enrichment of pathways associated with autophagy and TOR signaling. However, these findings should be interpreted as hypothesis-generating, given the reliance on a proxy species for pathway inference. These findings indicate that starvation responses in A. franciscana are shaped by an interaction between developmental stage and prior nutritional history, supported by conserved stress–response pathways, highlighting the potential of this model for studying metabolic stress responses. Full article

Characterizing multiscale fracture networks in shale gas reservoirs remains challenging, while the limited applicability of conventional continuum-based models and insufficient multi-objective coordination often lead to low efficiency in development optimization. To address these issues, this study proposes a production history matching and multi-objective collaborative optimization framework for shale gas horizontal wells based on an equivalent fractal fracture (EFF) model. By integrating fractal theory with intelligent optimization techniques, a multiscale equivalent fractal permeability tensor is constructed, forming a hybrid machine-learning framework that combines physics-based fractal constraints with data-driven learning for efficient representation of complex fracture networks. Microseismic event clouds were converted into continuous fracture-density and fractal-geometry descriptors through denoising, temporal alignment, and spatial interpolation, and these descriptors were mapped to the equivalent fractal fracture model to dynamically update key flow parameters for history matching and parameter inversion. On this basis, a multi-objective collaborative optimization strategy is developed to achieve simultaneous time-varying fracture characterization and dynamic regulation of development parameters. Comparative results indicate that the EFF-based approach yields a production prediction error of 6.8%, slightly higher than the 4.2% obtained using discrete fracture network (DFN) models, while requiring only one-eighteenth of the computational time. Using the net present value (NPV) as the unified objective function, constraints are imposed on bottom-hole flowing pressure, flowback rate and system switching time for optimization. With the optimized pressure drop being more uniform and the gas saturation distribution being more balanced, it is verified that “EFF + NPV” can achieve the coordinated optimization of “production capacity—decline—cost” and enhance the development efficiency. Full article

Objective: This study investigates the prognostic value and clinical utility of the neutrophil percentage-to-albumin ratio (NPAR) in patients with resected non-small-cell lung cancer (NSCLC). Methods: We retrospectively included 335 patients with NSCLC who underwent lung resection at our institution between January 2017 and October 2018. Optimal cutoffs for preoperative and postoperative day 1 (D1) NPAR were determined using X-tile (version 3.6.1; Yale University, New Haven, CT, USA) to define high and low groups. Overall survival (OS) was evaluated using Kaplan–Meier analysis and Cox proportional hazards models. A perioperative NPAR trajectory (low–low, low–high, high–low, high–high) was constructed to characterize dynamic risk patterns. To mitigate potential bias associated with postoperative measurements, a D1 landmark analysis was performed. A nomogram was developed based on the multivariable model and assessed by calibration at 1, 3, and 5 years. Incremental clinical value beyond TNM stage and surgical approach was evaluated using decision curve analysis (DCA), as well as by 5-year continuous net reclassification improvement (NRI) and integrated discrimination improvement (IDI). Results: The optimal cutoffs for preoperative and postoperative D1 NPAR were 14.5 and 23.1, respectively. In univariate analyses, sex, smoking history, preoperative NPAR, postoperative D1 NPAR, pathologic type, TNM stage, surgical approach, and adjuvant therapy were associated with OS (all p < 0.01). In multivariable Cox regression, high preoperative NPAR (HR 1.896, 95% CI 1.135–3.168; p = 0.014) and high postoperative D1 NPAR (HR 1.905, 95% CI 1.097–3.305; p = 0.014) were independent risk factors, along with TNM stage (Stage II: HR 2.824, 95% CI 1.209–6.595; p = 0.016; Stage III: HR 9.470, 95% CI 4.935–18.171; p < 0.001) and open surgery (HR 2.350, 95% CI 1.341–4.117; p = 0.003). Trajectory analysis further stratified risk, with the high–high group showing the poorest survival (adjusted HR 3.48, 95% CI 1.43–8.47; p = 0.006). The association of postoperative NPAR persisted in the D1 landmark analysis (HR 1.836, 95% CI 1.071–3.148; p = 0.027). Adding NPAR to TNM stage and surgical approach improved 5-year risk reclassification (continuous NRI 0.377, 95% CI 0.094–0.659; IDI 0.028, 95% CI −0.002–0.054) and increased net benefit on DCA. The nomogram demonstrated acceptable calibration at 1, 3, and 5 years. Conclusions: This study demonstrates that NPAR serves as an independent prognostic marker for long-term outcomes in patients with NSCLC. The use of NPAR offers clinicians a comprehensive and precise tool for assessing patient prognosis. Full article