Search Results (1,622)

Wildfires significantly affect wood properties and usability, yet their impact on hardwood species remains insufficiently understood. This study presents an exploratory characterization of moderately fire-affected pedunculate oak (Quercus robur L.) wood, combining physical, mechanical, chemical, and thermal analyses to evaluate depth-related changes within outer stem zones. Samples were collected from bark and from wood originating approximately 1 cm and 1–2 cm beneath the cambial region to evaluate radial variation associated with moderate surface fire exposure. The oven-dry density of fire-affected wood reached 720 kg·m⁻³, corresponding to values marginally below the literature reference ranges reported for unaffected oak wood. Bending strength decreased to 85.56 MPa, while compressive strength remained within or marginally above the literature reference (71.16 MPa), and Brinell hardness (42.75 MPa) stayed within the typical range for oak. Chemical and elemental analyses revealed degradation of polysaccharides and carbon enrichment in surface layers. FTIR and DSC analyses suggested partial hemicellulose degradation, structural modification of cellulose, and reduced thermal reactivity in outer stem regions. Despite these changes, the higher heating value (19.09–19.56 MJ·kg⁻¹) remained within the literature reference ranges reported for oak wood. The results suggest that under moderate surface fire conditions, fire-induced changes were primarily concentrated in outer stem layers, while inner wood retained properties comparable to the literature reference values for unaffected oak wood. These findings indicate that moderately fire-affected oak wood may remain suitable for selected material or energy-related applications following appropriate quality assessment and removal of thermally altered surface zones. Full article

Background: Group Care (GC) is an antenatal/postnatal care model comprised of a stable group of pregnant people or parent–child dyads receiving care in two-hour group sessions that combine clinical care with interactive discussion and learning. Integrating GC into healthcare systems organised for individual care poses challenges at both site and system levels. This study identified scheduling-related modifications across contexts to understand modification processes. Methods: We used an explanatory sequential design with mixed qualitative methods across seven GC implementation sites in Belgium, Kosovo, and the United Kingdom. A qualitative survey based on the Framework for Reporting Adaptations and Modifications to Evidence-based interventions (FRAME) was completed at each site by multiple stakeholders. Subsequently, in-depth interviews were conducted to further explore modification processes and examine whether changes were sustained or discontinued up to three years post-implementation initiation. Results: Two modifications were identified across countries: (1) combining GC sessions with individual consultations, and (2) integrating GC into digital booking and medical record systems. Guided by FRAME, we identified similarities and differences in the goals, drivers, and impact of these modifications. The dominant one-to-one antenatal care model strongly influenced modifications, making it more difficult to implement GC as a stand-alone model in obstetrician-led systems (Belgium and Kosovo) compared to a midwifery-led system (UK). In both contexts, the dominant model negatively influenced the perceived value of GC, with GC sessions viewed only as education and individual consultations seen as the actual care. Integration in the booking system appeared essential for payment and scheduling arrangements. Conclusions: Integrating GC scheduling into existing care pathways is challenging in systems where one-to-one care is the predominant model. Sustainable integration of GC requires early coordination and shared ownership across areas, including clinical, administrative, and IT. Full article

Living with Loss, an eight-session community-based bereavement program, supports individuals who have lost a loved one to cancer within the past two years. This pilot study sought to document people’s experiences across program delivery and compare levels of hope and coping before and after program completion. Participants (N = 11) completed self-report e-questionnaires (Hope Herth Index and Brief Cope Scale) before and after program completion. Semi-structured individual interviews were conducted before program attendance, at the midpoint and after program completion. Levels of hope and coping were compared using paired-sample t-tests. Digitally recorded interview data were transcribed verbatim and thematically analyzed. Total hope scores significantly increased at program completion. There were no significant pre-post changes in coping subscales. Qualitative data revealed three themes: (1) tangible and intangible program contributions to bereavement processes (i.e., developing coping strategies, perspective changes), (2) an enhanced sense of community post-attendance (i.e., mutual understandings, group-related growth), and (3) distinct preferences for in-person vs. virtual delivery (i.e., depth of interpersonal connections, anticipated instrumental issues including parking restrictions). Preliminary findings suggest that Living with Loss is relevant and beneficial for bereaved participants. Documenting experiences across program delivery serves to further inform program adjustments to better meet participants’ needs and preferences. Full article

Aquavoltaics, which integrates solar photovoltaic infrastructure with aquaculture production, has increasingly been promoted as a possible pathway for supporting low-carbon energy transition and multifunctional land use in coastal regions. In Taiwan, aquavoltaics has been framed as a policy approach that may contribute to renewable energy development, aquaculture continuity, and rural revitalisation. However, its implementation has also raised governance concerns related to land use, environmental uncertainty, and local participation in coastal aquaculture communities. This study examines the governance trade-offs and institutional development of aquavoltaics policy in southern Taiwan through an analytical framework that combines political ecology and the extended explanatory chain model (EECM). Drawing on policy document analysis, field observations, administrative records, and in-depth interviews with 24 stakeholders, the study traces aquavoltaics governance across five interrelated stages: policy discourse, institutional design, local implementation and community response, policy feedback, and institutional diffusion. The findings indicate that Taiwan’s aquavoltaics governance has been shaped by tensions between centralised energy-policy objectives and diverse local aquaculture conditions. Technical requirements, including the 40% shading threshold and the 70% production maintenance requirement, provide administrative clarity but may not fully reflect species-specific practices, pond-management needs, or existing land-tenure arrangements. In the cases examined, aquavoltaics development was associated with changes in land-use relations, spatial competition, and concerns over environmental uncertainty and governance legitimacy. The study also suggests that local stakeholders were not only recipients of top–down policy implementation but also participated in governance adjustment through review procedures, administrative negotiation, adaptive practices, and the mobilisation of local ecological knowledge. By integrating political ecology with the EECM, this study offers a process-oriented perspective for examining aquavoltaics as a socioecological governance issue rather than only a technical energy arrangement. The findings suggest that future aquavoltaics governance may benefit from more context-sensitive assessment, clearer institutional coordination, and greater attention to local knowledge and long-term monitoring. Full article

Microscale physical cues at the cell–extracellular matrix adhesion interface are increasingly being recognized as important regulators of cellular behavior. B16-F10 melanoma-derived cells retain melanogenic activity, including microphthalmia-associated transcription factor (MITF) expression and inducible melanin production, and are widely used for studies of melanogenesis and pigmentation-associated cellular responses. Melanocytic cells are sensitive to the physical characteristics of the surrounding microenvironment, including adhesion-dependent mechanical cues. However, the mechanism by which physical cues derived from the adhesion interface regulate melanoma cell function remains incompletely understood. In this study, we investigated the mechanism by which defined micropatterned substrates modulate melanoma cell morphology, migration, nuclear architecture, and melanogenic activity. Polydimethylsiloxane substrates with pillar- and hole-shaped microstructures (5, 10, and 50 µm diameters and spacings; 10 µm height or depth) were fabricated and coated with fibronectin. B16-F10 melanoma cells cultured on narrow pillar patterns (5 and 10 µm) exhibited restricted cell spreading, shortened protrusions, suppressed migration, and pronounced nuclear deformation compared with flat substrates. These mechanical constraints were accompanied by significant reductions in melanin production and downregulation of melanogenesis-related genes (Mitf, Tyr, and Tyrp1). Comparable trends were observed for Matrigel-coated substrates, indicating that microscale topography exerted consistent effects on B16-F10 melanoma cell responses across the tested extracellular matrix conditions. Collectively, our results demonstrate that surface topography with narrow pillar microstructures is associated with topography-dependent changes in cell behavior and melanogenic activity, providing insights into how microscale topographic confinement influences melanoma cell morphology and melanogenic activity. Full article

Age-related changes in visual perception alter attentional deployment, yet computational models of visual attention have been validated almost exclusively on younger populations. This limits both the theoretical investigation of age-specific mechanisms and practical applications in age-inclusive design, where researchers depend on specialised eye-tracking equipment to observe such differences. Therefore, we present the Elderly Visual Attention Estimation (EVAE) model, a computational framework that predicts early visual attentional orienting in older adults by combining stimulus-driven image features with age-specific top-down priors. The framework models six dimensions of elderly visual attention from cross-age eye-tracking data: colour brightness sensitivity, centre bias, foreground–background differentiation, depth detection, early attentional prior, and sustained-attention spatial prior. On public datasets, EVAE achieves an AUC-Judd of 0.92, which outperforms existing saliency models and deep learning approaches such as DeepGaze II. The framework is optimised for an input resolution of 128 × 96 pixels, producing fixation probability maps that are upsampled to match the original stimulus resolution for practical interface evaluation. Cross-age validation confirms the model’s specificity, as EVAE predicts attentional behaviour in older adults but does not generalise to younger adults. An ablation study shows that image features and top-down spatial priors each contribute independently to prediction accuracy, and that bottom-up saliency alone cannot account for age-related attentional patterns. Centre bias and early attentional prior are the strongest predictors, indicating that visual ageing involves greater reliance on spatial strategies and compensatory processing. As an alternative to hardware-based eye-tracking, EVAE widens the scope of empirical research into older adults’ visual attention and informs the design of accessible digital interfaces. Full article

Drought severely restricts the growth and secondary metabolism of medicinal plants. Blumea balsamifera is a water-sensitive and economically important medicinal species, yet its molecular regulatory mechanisms in response to drought remain largely unclear, which is worthy of in-depth investigation. In this study, four-month-old B. balsamifera seedlings were subjected to three treatments; normal irrigation (CK), drought stress (DS), and rehydration recovery (RW). Leaf photosynthetic parameters, L-Borneol content, and root physiological indices were determined, and transcriptomic and proteomic analyses were integrated to explore its drought response mechanism. Under drought stress, leaf net photosynthetic rate, transpiration rate, and stomatal conductance decreased sharply, while intercellular CO₂ concentration increased; L-Borneol content showed a biphasic change, and root malondialdehyde content accumulated continuously, accompanied by significant increases in antioxidant enzyme activities and osmotic regulator contents. A total of 9917 differentially expressed genes and 736 differentially expressed proteins were identified, which were mainly enriched in phenylpropanoid biosynthesis, photosynthesis and other pathways, with photosynthesis-related genes and proteins coordinately downregulated. B. balsamifera adapts to drought stress by activating the antioxidant defense system, regulating osmotic substances, and reprogramming photosynthetic networks. The key candidate genes obtained provide important targets for drought-tolerant breeding of this species, and their reliability was verified by RT-qPCR. Full article

Background and Objectives: Conventional EEG-derived sedation targets for Entropy monitoring (State Entropy SE 40–60) were established in the context of general anaesthesia and may not be directly applicable to procedural sedation for endoscopic retrograde cholangiopancreatography (ERCP). This study aimed to characterize SE and Response Entropy (RE) trajectories during propofol-based sedation for ERCP and to evaluate their relationships with clinical sedation depth, patient characteristics, and procedural outcomes. Materials and Methods: In this prospective, single-center observational study, 50 consecutive adult patients undergoing elective ERCP under propofol-based sedation were enrolled. SE and RE were recorded at baseline and at serial intra-procedural timepoints. Time-in-zone analysis classified SE values into predefined ranges. Correlations between Entropy indices and MOAA/S scores, patient factors, Aldrete recovery scores, and adverse events were assessed using Spearman’s rank correlation. Results: The median patient age was 72.5 years (IQR 65.0–79.0), and the median ASA score was 3 (IQR 2–3). Following induction, SE declined from a baseline mean of 89.3 ± 1.5 to a mean of 68.8 ± 5.3 at 10 min, the lowest group-level value recorded; the mean individual SE nadir across patients was 67.2 ± 5.3. No SE values below 40 were observed at any timepoint. Mean time spent within the conventional SE 40–60 target range was 3.7% ± 10.6, while mean time within SE 60–85 was 80.7% ± 8.3. SE at 3 min correlated moderately with MOAA/S at 3 min (Spearman rho = 0.430, p = 0.002), with substantial within-category variability. Age showed a strong negative correlation with SE at 3 min (rho = −0.612, p < 0.001), an effect that persisted at 5 min, consistent with deeper early EEG suppression in older patients, which may reflect increased pharmacodynamic sensitivity, age-related changes in spectral substrate, or both. ASA score was associated with SE at 15 min only (rho = −0.299, p = 0.035). Patients who experienced adverse events demonstrated higher SE instability, though differences did not reach statistical significance. Recovery was rapid, with a median Aldrete score of 10 at 15 min. Conclusions: During propofol sedation for ERCP, observed SE values operated predominantly between 60 and 85, well above the conventional general anaesthesia target of 40–60. Older age was the strongest predictor of early sedation depth. These findings suggest that in elderly, high-ASA patients receiving propofol-based multi-drug sedation for ERCP, numerical SE values differ systematically from conventional general anaesthesia-derived target ranges. Whether this reflects true procedure-specific sedation requirements or cohort-specific spectral substrate differences warrants prospective outcome-anchored investigation. Full article

Background/Objectives: The practices that parents use to feed their infants have important implications for life course health and well-being. However, little is known about the infant feeding experiences and decisions of parents with developmental disabilities. This study used a mixed methods design to gain an in-depth understanding of the infant feeding experiences and decisions of parents with developmental disabilities in the United States. Methods: Between July 2024 and June 2025, 18 parents with developmental disabilities completed a one-time quantitative survey, seven of whom also completed three individual qualitative interviews. Analytical procedures included descriptive statistics of quantitative survey data and thematic analysis of qualitative interviews, followed by integration of the two forms of data. All interview participants completed member checking of preliminary themes. Results: Parents with developmental disabilities described varied experiences with breastfeeding, formula feeding, and introducing solid foods to their infants at around six months. Four disability-related factors influenced parents’ decisions across different infant feeding practices: (1) sensitivity to sensory stimuli; (2) demands on executive function; (3) “rigid thinking” about breastfeeding; and (4) medication use. Conclusions: Findings suggest parents with developmental disabilities may benefit from direct and customized support with infant feeding. Changes to improve access to disability-affirming care are warranted. Full article

Age-related changes in the gut significantly impact host health, yet the multi-omics dynamics during the maturation of Tibetan pigs remain unclear. This study aimed to investigate the morphological, microbial, metabolic, and transcriptomic transformations in the intestines of aging Tibetan pigs. We analyzed the ileum and colon of 1-year-old and 3-year-old Tibetan pigs using histological evaluation, 16S rRNA sequencing, metabolomics, and transcriptomics. Aging to 3 years significantly improved ileal architecture, notably increasing the villus height to crypt depth ratio. Older pigs exhibited higher colonic microbial diversity, a decreased Firmicutes to Bacteroidota ratio, and enrichment of homeostasis-associated taxa, including Lactobacillus, Prevotellaceae, and Ruminococcaceae. Metabolomics revealed higher abundance of certain metabolites, including docosahexaenoic and arachidonic acids, enriching lipid metabolism and bile secretion pathways. Transcriptomics identified 2363 differentially expressed genes in the ileum, primarily involved in immune regulation and nutrient digestion. Integrated analysis showed strong positive correlations between enriched microbes (Lactobacillus porci) and up-regulated host genes (UGT2B31, CCL28) governing intestinal homeostasis. The transition from 1 to 3 years of age in Tibetan pigs fosters a synergistic host-microbiome environment, enhancing intestinal barrier function, immune capacity, and metabolic efficiency. Full article

Animal growth involves changes in size with age and is associated with environmental factors. The aim was to conduct a study of a representative group of the Santandereana Creole goat breed to evaluate morphometric allometry according to sex. A sample of 23 males and 76 females, ranged 8–72 and 8–84 months of age respectively, was studied. Morphometric allometry was evaluated using 30 linear characters. A Mann–Whitney test assessed right- and left-side differences in horns (length and perimeter) and ears (length and width). A one-way PERMANOVA, using Gower distances, assessed sex differences. Principal component analysis (PCA) using a var-covar matrix identified the most discriminating traits. A one-way ANCOVA, using loadings at PC1, was performed to compare allometric trends between sexes. Differences between sexes were observed in linear traits (p = 0.0101) and indices (p = 0.0364). No differences were observed between the right and left sides in horns and ears. Differences were observed in size, with body weight, body length, thoracic perimeter, and horn length (right/left) being the most discriminating values reflecting sexual dimorphism of size. The indexes corroborated the larger size of males, especially in relation to skull width, rump length, chest depth, and body weight. Detected differences may reflect variations in the development of skeletal maturity. The indexes confirm that the Santandereana Creole goat is an animal with a tendency for meat production, with larger males and brachycephalic features due to the shape of the head. Discriminatory measures can be considered as parameters of interest for preserving the breed and establishing genetic improvement programs. Full article

This study conducted a comprehensive comparative assessment of the effects of site-specific tillage (SST) and uniform-depth tillage (UDT) on soil physical properties, fuel consumption and CO₂ emissions. The aim was to determine whether using different tillage depths based on variability in soil properties associated with apparent electrical conductivity (ECa) could improve the efficiency of soil management, which would be beneficial for the soil and the environment. Field experiments were conducted using a multifunctional cultivator with three SST depths (10, 14 and 18 cm), which were distributed over variable soil management zones. UDT was applied at a constant depth of 15 cm. The results of the experimental studies showed that SST affected the physical properties of the soil in different management zones with different tillage depths. Reduced tillage depths ensured adequate soil physical properties in areas of lower soil resistance, while deeper tillage was only effective in areas of higher soil resistance. Soil density in the top 0–10 cm soil layer varied within the plant-friendly range of 1.2–1.3 g cm⁻¹ in the region and 1.4–1.5 g cm⁻¹ in the deeper 10–20 cm layer, while total soil porosity responses differed in different management zones. UDT reduced total soil porosity by 3.17% and 3.5% in the top and deeper soil layers, respectively. Changes in total soil porosity due to SST in the 0–10 cm layer depended on tillage depth: it decreased slightly at 10 cm, remained unchanged at 14 cm and increased slightly at 18 cm. In addition, SST reduced fuel consumption and associated CO₂ emissions compared with UDT, with environmental impact related to fuel combustion decreasing by approximately 14%. These findings demonstrate that site-specific tillage, when guided by soil variability, can improve the efficiency and environmental sustainability of tillage operations without compromising soil physical properties. Full article

Background: In this study, we radiologically assessed potential increases in microvascularity, extracellular matrix-related changes, and tissue viscoelasticity following carboxytherapy for periorbital hyperpigmentation (POH). We also analyzed the correlation between radiological changes and clinical outcomes and explored implications for future outpatient selection, as well as the potential to predict treatment success based on radiological–clinical correlations. Materials and Methods: The present study included 78 patients (76 women and 2 men) aged over 18 years with Fitzpatrick skin types I–V and moderate-to-severe infraorbital dark circles who applied for treatment at the Dermatology Department in the Cosmetology Unit of Cerrahpaşa Medical Faculty Hospital. Each patient was given manual, pressure-controlled injections of sterile CO₂ into the upper and lower eyelids for 7 weeks, with one round of treatment per week. We conducted dermatoclinical and radiological evaluations, including measurements of epidermis–dermis thickness and SWE, musculus orbicularis oculi pars pretarsalis thickness, and cSMI vascular index percentage, as well as SOOF tissue SWE (measured in kPa). These analyses were performed on both lower eyelids before treatment and at 1 month and 6 months after treatment. Results: After treatment, VAS scores improved significantly. Grayscale ultrasonography showed significant increases in epidermis–dermis and orbicularis oculi thickness at 1 and 6 months (p < 0.05). SMI presented a significant increase in vascular index at both follow-ups (p < 0.05). SOOF SWE values increased significantly at 1 and 6 months, whereas epidermis–dermis SWE did not. Procedural pain was common, and 25 participants withdrew during the 7-week period due to discomfort. Injection depth was not confirmed by real-time imaging, and adverse events were not graded using a standardized classification system. Therefore, tolerability and procedural safety should be interpreted with caution. Conclusions: Carboxytherapy was associated with improvements in clinical outcomes and radiological parameters among patients who were able to tolerate the procedure, including increased microvascularity on SMI and changes suggestive of extracellular matrix-related alterations. These improvements were maintained at the 6-month follow-up, indicating temporal persistence of the observed findings. However, due to the absence of a control group, the results should be interpreted with caution, and further randomized controlled studies are required to confirm these findings and establish causality. Full article

Soil hydrophysical properties play a key role in processes such as water movement through soil and also affect the amount of water available to plants, thus influencing the sustainability of water management in lowland agricultural landscapes. This study investigated whether the application of calcium sulfate dihydrate (gypsum, CaSO₄·2H₂O) can improve selected hydrophysical properties of a heavy clay agricultural soil from the Eastern Slovak Lowland (Slovakia). In a controlled laboratory experiment, topsoil samples (0–15 cm depth) were treated with four rates of gypsum application (0.5, 1, 2.5 and 10 g core⁻¹; ≈2–40 t ha⁻¹ equivalents) and then repacked in 100 cm³ cores. Gypsum caused a marked apparent shift from “clay” to “silt” in the particle-size analysis, consistent with flocculation and incomplete dispersion rather than a real textural change. Increasing the gypsum dose also led to a gradual increase in saturated hydraulic conductivity (from 0.68 ± 0.21 to 2.00 ± 0.66 cm d⁻¹). Water retention near saturation changed little, but water content at the wilting point decreased at higher doses, increasing plant-available water (maximum ~59% at 2.5 g core⁻¹). Under laboratory conditions, gypsum improved the hydraulic function of the soil, and, at selected doses, increased water availability related to drought, supporting its potential as a structural amendment for enhancing the sustainable management of heavy clay soils. Full article

Top Submerged Lance (TSL) technology is widely used in non-ferrous smelting, yet in-situ bath dynamics remain challenging to quantify because the process operates in a closed, high-temperature, highly turbulent and optically inaccessible environment. The absence of direct diagnostics limits the ability to relate operating conditions to bubble dynamics, gas penetration and bath agitation and constrains validation of multiphase CFD models under realistic conditions. This study introduces a multimodal sensing framework that combines spectral acoustic analysis with lance-mounted inertial motion sensing to characterize dynamic bath behavior across cold-model, laboratory-scale and pilot-scale systems. Water-glycerin experiments establish repeatable acoustic signatures of individual bubble-collapse events, with dominant emission bands in the 300–900 Hz range and higher-frequency components extending into the kilohertz domain. High-temperature laboratory trials using fayalitic slag reproduce these frequency regions while exhibiting depth-dependent attenuation and clear spectral separation between submerged and non-submerged lance operation. Power Spectral Density (PSD) and cumulative spectral power analyses resolve the influence of gas flow rate and lance submersion depth on acoustic spectral power distribution, while inertial measurements capture corresponding increases in vertical lance acceleration associated with back-pressure fluctuations. Pilot-scale trials at 120 Nm³/h air and 13 L/h diesel confirm that shallow lance submersion substantially increases measured acoustic spectral power below 3 kHz, whereas deeper penetration enhances periodic vertical acceleration response measured by the inertial sensor. The combined acoustic-inertial methodology provides a physically interpretable and cross-scale framework for assessing bubble collapse activity, plume interaction and bath agitation under high-temperature TSL conditions. The approach enables frequency-based diagnostics that can be systematically compared with CFD predictions of plume oscillation and collapse-related dynamics. Once baseline frequency ranges are established for a given slag system, the method can support process monitoring and may provide indirect indicators related to changes in surface agitation or foaming tendency, enabling structured data-driven analysis. The framework thus provides a practical bridge between cold-model experiments, high-temperature measurements, multiphase modeling and industrial TSL operation. Full article