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19 pages, 2296 KB  
Article
A Method for Compiling the Random Load Spectrum of the Main Shaft Torque of the Vertical Ring-Die Biomass Briquetting Machine Based on Kernel Density Estimation and Copula Function
by Risu Na, Bateer Gao and Bai Qin
Appl. Sci. 2026, 16(13), 6678; https://doi.org/10.3390/app16136678 - 3 Jul 2026
Viewed by 186
Abstract
To address the strong variability, complex cyclic characteristics, and difficulty in characterizing the main shaft torque load of vertical ring-die biomass briquetting machines, this study proposes a random load spectrum generation method based on kernel density estimation (KDE) and a Copula function. The [...] Read more.
To address the strong variability, complex cyclic characteristics, and difficulty in characterizing the main shaft torque load of vertical ring-die biomass briquetting machines, this study proposes a random load spectrum generation method based on kernel density estimation (KDE) and a Copula function. The measured torque time-history signal was processed using wavelet-threshold denoising and rainflow counting to extract cycle mean and cycle amplitude samples. KDE was used to estimate their marginal distributions, and a Copula function was introduced to construct the joint distribution model. The random load spectrum was then reconstructed through two-dimensional probability integration based on the fitted joint density function. The results show that the Frank Copula best describes the dependence structure between the cycle mean and the cycle amplitude. The reconstructed load spectrum agrees well with the measured load spectrum in terms of marginal frequency distribution and main peak intervals, with an RMSE of 6.3161 and an NRMSE of 6.94%. Compared with the KDE-independent baseline model, the proposed KDE–Frank Copula model reduces the RMSE by 12.74%. These results indicate that the proposed method can effectively characterize the statistical features of the random torque load of the main shaft and provide methodological support for load spectrum generation, fatigue life prediction, and reliability design of vertical ring-die biomass briquetting machines. Full article
(This article belongs to the Special Issue Applied Numerical Analysis and Computing in Mechanical Engineering)
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29 pages, 16163 KB  
Article
Structural Prior-Guided Adaptive Wavelet Denoising for Single-Channel Dolphin Whistles
by Ru Wu, Xiang Zhou, Wen Chen, Peibin Zhu and Xiaomei Xu
J. Mar. Sci. Eng. 2026, 14(13), 1185; https://doi.org/10.3390/jmse14131185 - 28 Jun 2026
Viewed by 187
Abstract
The continuous, narrowband time-frequency structure of dolphin whistles is an important information carrier for target detection, behavioral analysis, and ecological monitoring in passive acoustic monitoring. However, ocean noise can easily obscure whistle time-frequency contours, blur their boundaries, and cause local discontinuities, thereby reducing [...] Read more.
The continuous, narrowband time-frequency structure of dolphin whistles is an important information carrier for target detection, behavioral analysis, and ecological monitoring in passive acoustic monitoring. However, ocean noise can easily obscure whistle time-frequency contours, blur their boundaries, and cause local discontinuities, thereby reducing the reliability of subsequent acoustic analysis. Existing denoising methods based on transform-domain thresholding and spectral-domain statistical modeling can attenuate background interference to some extent. However, without explicit structural constraints, these methods still have difficulty achieving a satisfactory balance between noise suppression and preservation of the whistle time–frequency structure. To address this problem, this study proposes a Structural Prior-Guided Adaptive Wavelet Denoising (SPG-AWD) method for single-channel unsupervised scenarios. The proposed method introduces structural priors at two levels: adaptive subband selection and terminal node denoising. At the first level, subband nodes are adaptively split, retained, or suppressed based on stationary wavelet packet recursive decomposition and the distribution of candidate structures. At the second level, a structural mask satisfying local grouped-energy and two-dimensional time–frequency connectivity constraints is extracted, and a continuous whistle-presence probability is obtained through a signed distance transform. This probability is then used to jointly guide local noise power spectral density estimation and protective Wiener gain fusion. Simulation results show that, under real recorded background noise and ship noise conditions, SPG-AWD achieves favorable overall denoising performance when the input SNR is higher than −16 dB, while maintaining a more stable balance between target region energy preservation and non-target region noise suppression. Experiments on real recordings further demonstrate that the proposed method can effectively suppress in-band noise components within the whistle-bearing frequency range, better preserve continuous main frequency contours, and improve the overall perceptibility of whistle contours, confirming its applicability to single-channel dolphin whistle denoising in complex underwater noise environments. Full article
(This article belongs to the Section Ocean Engineering)
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35 pages, 17863 KB  
Article
Wheat Size and Plant Distance Measurement Using LiDAR and Convex Hull Method
by Md Rejaul Karim, Md Nasim Reza, Dae-Hyun Lee and Sun-Ok Chung
Agriculture 2026, 16(11), 1231; https://doi.org/10.3390/agriculture16111231 - 2 Jun 2026
Viewed by 427
Abstract
Interest in light detection and ranging (LiDAR) for the precise monitoring of vegetative growth of grain crops has increased. The study was conducted to estimate wheat size and plant distance using LiDAR and the convex hull method (CHM) compared to the voxel grid [...] Read more.
Interest in light detection and ranging (LiDAR) for the precise monitoring of vegetative growth of grain crops has increased. The study was conducted to estimate wheat size and plant distance using LiDAR and the convex hull method (CHM) compared to the voxel grid method (VGM). A commercial LiDAR system was used for data collection in the middle and late growth stages using static and dynamic scanning. A small number (ten) of data frames, consisting of a region of interest (ROI) of 1 m × 0.9 m for each frame, were selected as data samples. The data processing workflow consisted of data conversion, targeted data frame selection, visualization, region of interest (ROI) segmentation, outlier and untargeted point removal, downsampling, denoising, voxelization, preparation of the convex hull, and 3D PCD density map. To estimate the plant size and distance of wheat, the results obtained using CHM and VGM were compared with measured data results, and both methods were applied for the middle and late growth stages of wheat. The relative accuracy of LiDAR-estimated plant height, canopy volume, plant spacing, and row distances with respect to the measured results were 94%, 87%, 94%, and 87%, respectively, using CHM, and 76%, 72%, 62%, and 71% by VGM for static data scanning; for dynamic scanning, the estimated relative accuracy percentages were 87%, 91%, 94%, and 93%, respectively, using CHM, and 77%, 74%, 75%, and 74%, respectively, using VGM. The same methods were applied to the late growth stage data sets. Between the two methods, CHM provided higher accuracy for static and dynamic data-scanning approaches in the middle and late growth stages because the complex geometry of plants, thin and sparse leaf area, and structure complicated voxelization. Despite several challenges in PCD collection and processing, this study supports size and distance estimation for wheat and similar grains as non-destructive methods. Full article
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24 pages, 3535 KB  
Article
Design of an Integrated Online Testing System for Pressure-Core Characteristics Using an Improved EMD–Wavelet Denoising Algorithm
by Yingjie Liu, Liwen Nan, Qiaoling Gao, Jiawang Chen, Yuankun Chen, Qinghua Sheng, Lieyu Tian and Chenlu Xu
J. Mar. Sci. Eng. 2026, 14(11), 1011; https://doi.org/10.3390/jmse14111011 - 29 May 2026
Viewed by 174
Abstract
Natural gas hydrates are regarded as a vital strategic energy resource for the future owing to their high energy density and clean combustion characteristics. To facilitate research into the physical and mechanical properties of pressure-maintained hydrate samples, this paper presents an integrated multi-parameter [...] Read more.
Natural gas hydrates are regarded as a vital strategic energy resource for the future owing to their high energy density and clean combustion characteristics. To facilitate research into the physical and mechanical properties of pressure-maintained hydrate samples, this paper presents an integrated multi-parameter online analysis system capable of rapidly measuring the P-wave velocity, electrical resistivity, thermal conductivity, and shear strength of core samples under pressure-maintaining conditions. The system comprises hardware acquisition boards based on ZYNQ and ARM platforms, specialized measurement probes, and comprehensive data acquisition and analysis software. To mitigate the susceptibility of P-wave signals to noise interference, an improved denoising algorithm combining Empirical Mode Decomposition (EMD) and wavelet thresholding is proposed. By employing autocorrelation function analysis, the algorithm identifies the transition boundary between noise-dominated and signal-dominated Intrinsic Mode Functions (IMFs), subsequently applying wavelet soft-thresholding to the noise-dominant components. Experimental results demonstrate that the proposed algorithm achieves a superior signal-to-noise ratio (SNR) compared to traditional EMD methods, particularly under low SNR conditions. System validation indicates measurement accuracies of 3.2% for P-wave velocity at 20 °C, 1.76% for electrical resistivity at 25 °C, and within 7% for both thermal conductivity and shear strength. Furthermore, sea trials conducted aboard the “HAIYANG SHIYOU 708” drilling vessel confirm that the system operates stably and effectively fulfills the requirements for deep-sea core parameter characterization. Full article
(This article belongs to the Section Ocean Engineering)
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19 pages, 304 KB  
Review
AI in Musculoskeletal Imaging: An End-to-End Perspective
by Domenico Albano, Mariachiara Basile, Stefano Fusco, Luigi Asmundo, Salvatore Gitto, Carmelo Messina, Alessio Piacentini, Francesco Rizzetto, Caterina Beatrice Monti, Moreno Zanardo, Angelo Vanzulli and Luca Maria Sconfienza
J. Clin. Med. 2026, 15(11), 4077; https://doi.org/10.3390/jcm15114077 - 25 May 2026
Cited by 1 | Viewed by 466
Abstract
Artificial intelligence (AI) is increasingly reshaping musculoskeletal (MSK) imaging across the entire imaging pathway. This narrative review summarizes current AI applications in MSK radiology across four domains: acquisition and reconstruction, detection and triage, characterization and quantification, and prognosis and decision support. AI-based reconstruction [...] Read more.
Artificial intelligence (AI) is increasingly reshaping musculoskeletal (MSK) imaging across the entire imaging pathway. This narrative review summarizes current AI applications in MSK radiology across four domains: acquisition and reconstruction, detection and triage, characterization and quantification, and prognosis and decision support. AI-based reconstruction has enabled faster MRI acquisitions, improved denoising and artifact reduction, and supported low-dose CT imaging while preserving diagnostic quality. Fracture detection and triage currently represent the most mature clinical applications, particularly in emergency settings. AI is also promoting a shift from qualitative interpretation to quantitative imaging phenotyping through automated assessment of body composition, cartilage, bone density, degenerative spine disease, skeletal maturity, and lesion heterogeneity. Emerging applications in prognostic modeling, implant evaluation, and multimodal risk stratification remain promising but less mature. Broader clinical implementation is still limited by restricted interpretability, dataset bias, insufficient prospective validation, regulatory complexity, and unresolved medico-legal issues. Overall, AI should be viewed as a tool to augment, not replace, radiological expertise. Full article
(This article belongs to the Special Issue Clinical Updates in Imaging of Musculoskeletal Diseases)
38 pages, 26491 KB  
Article
A Hierarchical Multi-Scale Denoising Framework for UAV-Derived Digital Subsidence Models in Coal Mining Areas
by Xi Zhang, Jiazheng Han, Zhanjie Feng, Lingtong Meng, Ruihao Cui and Zhenqi Hu
Remote Sens. 2026, 18(9), 1423; https://doi.org/10.3390/rs18091423 - 3 May 2026
Viewed by 512
Abstract
Mining-induced subsidence monitoring is essential for safe coal production and ecological protection in mining areas. UAV photogrammetry has become a widely adopted technique for constructing Digital Subsidence Models (DSuM); however, multi-scale composite noise significantly limits model accuracy and parameter extraction reliability. Taking the [...] Read more.
Mining-induced subsidence monitoring is essential for safe coal production and ecological protection in mining areas. UAV photogrammetry has become a widely adopted technique for constructing Digital Subsidence Models (DSuM); however, multi-scale composite noise significantly limits model accuracy and parameter extraction reliability. Taking the 2S201 working face of Wangjiata Coal Mine in a western arid–semi-arid region as the study area, this study systematically investigates DSuM noise characteristics and proposes a hierarchical multi-scale denoising framework. First, subsidence value interval stratification is employed to analyze the spatial distribution of noise. Based on this analysis, a two-stage strategy is developed. In the first stage, large-scale outliers are identified and removed using an improved DBSCAN algorithm with empirically calibrated and density-adaptive parameter computation. In the second stage, small-scale mixed noise is suppressed through a curvature-adaptive multi-stage denoising method. Validation using 20 ground monitoring points demonstrates that the RMSE decreases from 154 mm to 86 mm after large-scale denoising and further to 59 mm, achieving a 61.5% overall accuracy improvement. The denoised model exhibits enhanced surface continuity, smoother deformation profiles, and clearer subsidence boundaries while preserving overall deformation trends. The proposed framework effectively improves DSuM geometric accuracy and spatial consistency, providing reliable technical support for subsidence monitoring with improved accuracy in complex mining environments. Full article
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20 pages, 1096 KB  
Article
Wavelet Basis Selection in Signal Denoising Based on Wavelet-Coefficient Distribution Shape
by Mladen Tomic and Marko Gulic
Signals 2026, 7(3), 39; https://doi.org/10.3390/signals7030039 - 2 May 2026
Viewed by 765
Abstract
Denoising one-dimensional signals by wavelet shrinkage critically depends on the choice of wavelet basis, yet basis selection is often guided by heuristics rather than explicit statistical criteria. This paper investigates the relationship between wavelet-basis properties and the shape of the probability density function [...] Read more.
Denoising one-dimensional signals by wavelet shrinkage critically depends on the choice of wavelet basis, yet basis selection is often guided by heuristics rather than explicit statistical criteria. This paper investigates the relationship between wavelet-basis properties and the shape of the probability density function (PDF) of the detail coefficients in the coarsest retained detail subband. On this basis, it proposes the shape of this PDF as a criterion for wavelet-basis selection. We hypothesize that, for a fixed decomposition depth, noise model, and shrinkage rule, a basis better matched to the signal’s local regularity produces a narrower and more sharply peaked coefficient PDF in this subband than a mismatched basis and can therefore serve as a data-driven indicator for basis selection. To evaluate the consistency of this proposal, we perform controlled hard-thresholding experiments on six canonical test signals, five wavelet bases, and additive white Gaussian noise. Although the test signals differ significantly in local regularity and features, the relationship between basis suitability and PDF shape is confirmed for each of them. Therefore, the results suggest that the proposed PDF-shape criterion is a valuable indicator for wavelet-basis selection. Full article
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28 pages, 2538 KB  
Article
E-GuidedRE: An Evaluation-Model-Guided Collaborative Framework for Relation Extraction in Specialized Domains
by Yixuan Liu, Jing Zhang, Ruipeng Luan and Xuewen Yu
Symmetry 2026, 18(5), 761; https://doi.org/10.3390/sym18050761 - 29 Apr 2026
Viewed by 612
Abstract
Relation Extraction is crucial for knowledge graph construction, but extracting complex relations in specialized domains like Satellite Navigation Countermeasures (SNCM) remains challenging due to long semantic spans and high relational density. While Large Language Models (LLMs) possess strong semantic understanding, they often suffer [...] Read more.
Relation Extraction is crucial for knowledge graph construction, but extracting complex relations in specialized domains like Satellite Navigation Countermeasures (SNCM) remains challenging due to long semantic spans and high relational density. While Large Language Models (LLMs) possess strong semantic understanding, they often suffer from severe recall deficiency and hallucinations in high-density multi-entity contexts. Conversely, traditional small models generate excessive redundant noise. To address these limitations, this paper proposes an evaluation-model-guided relation extraction method (E-guidedRE). This framework employs a two-stage collaborative mechanism. First, a lightweight evaluation model utilizing a GlobalPointer network with Rotary Position Embedding (RoPE) and a sparse multi-label loss function acts as a structural filter to generate high-coverage candidate entity pairs. Second, these candidates guide the frozen LLM to perform deep semantic discrimination and retrospective denoising. Furthermore, we construct a dedicated SNCM dataset to fill the vertical domain data void. Extensive experiments across five heterogeneous datasets, including general, biomedical, financial, and our self-built SNCM corpus, demonstrate that E-guidedRE exhibits remarkable robustness. In ablation studies on the SNCM dataset, our method improved the F1-score from 36.54% to 54.93% compared to standalone LLM extraction, boosting recall from 27.81% to 47.13%. The proposed paradigm effectively mitigates the LLM’s attention divergence in complex contexts, dynamically balancing precision and recall, and offers a highly reliable technical pathway for knowledge extraction in specialized vertical domains. Full article
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26 pages, 3215 KB  
Article
A Conformer-Based Time–Frequency Decoupling Network for Pig Vocalization Behavior Classification
by Jianping Wang, Yuqing Liu, Siao Geng, Feng Wei, Haoyu Wu, Yuzhen Song, Yingying Lv, Shugang Li and Qian Li
Animals 2026, 16(9), 1337; https://doi.org/10.3390/ani16091337 - 27 Apr 2026
Viewed by 779
Abstract
Continuous monitoring of pig behavior is essential for timely health management and welfare assessment in commercial production systems. Although vision-based methods have been widely studied, their practical application in commercial barns is often limited by variable lighting, frequent occlusion, and high stocking density. [...] Read more.
Continuous monitoring of pig behavior is essential for timely health management and welfare assessment in commercial production systems. Although vision-based methods have been widely studied, their practical application in commercial barns is often limited by variable lighting, frequent occlusion, and high stocking density. Acoustic sensing offers a non-contact alternative that is independent of lighting conditions; however, reliable behavior classification from pig vocalizations remains challenging in commercial environments because of background noise and temporal variability in sound patterns. In this study, an attention-guided acoustic framework, termed ATF-Conformer, was developed for pig vocalization classification under farm conditions. A five-class vocalization dataset was collected from finishing Landrace pigs and multiparous sows on a commercial farm, including cough, scream, estrus, feeding, and normal behavior sounds. The proposed framework combined spectrogram denoising with interactive attention to enhance behavior-related acoustic information, while a time-frequency-decoupled Conformer encoder was introduced to improve feature representation under noisy conditions. Final classification was performed using mask-based temporal pooling with an additive angular margin Softmax objective. In five-fold grouped cross-validation, ATF-Conformer achieved an accuracy of 97.34% ± 0.42 and outperformed several existing acoustic models across multiple evaluation metrics. A similar accuracy of 97.38% was obtained on an independent test set, indicating stable performance across datasets. These results suggest that the proposed method can support continuous, non-invasive pig vocalization-based behavior monitoring and may assist farm owners or workers in pen-level screening of frequent cough or abnormal vocal events, thereby supporting targeted on-site inspection in precision livestock farming. Full article
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24 pages, 3653 KB  
Article
Production History Matching and Multi-Objective Collaborative Optimization of Shale Gas Horizontal Wells Based on an Equivalent Fractal Fracture Model
by Zibo Wang, Yu Fu, Ganlin Yuan, Wensheng Chen and Yunjun Zhang
Processes 2026, 14(8), 1294; https://doi.org/10.3390/pr14081294 - 18 Apr 2026
Viewed by 345
Abstract
Characterizing multiscale fracture networks in shale gas reservoirs remains challenging, while the limited applicability of conventional continuum-based models and insufficient multi-objective coordination often lead to low efficiency in development optimization. To address these issues, this study proposes a production history matching and multi-objective [...] Read more.
Characterizing multiscale fracture networks in shale gas reservoirs remains challenging, while the limited applicability of conventional continuum-based models and insufficient multi-objective coordination often lead to low efficiency in development optimization. To address these issues, this study proposes a production history matching and multi-objective collaborative optimization framework for shale gas horizontal wells based on an equivalent fractal fracture (EFF) model. By integrating fractal theory with intelligent optimization techniques, a multiscale equivalent fractal permeability tensor is constructed, forming a hybrid machine-learning framework that combines physics-based fractal constraints with data-driven learning for efficient representation of complex fracture networks. Microseismic event clouds were converted into continuous fracture-density and fractal-geometry descriptors through denoising, temporal alignment, and spatial interpolation, and these descriptors were mapped to the equivalent fractal fracture model to dynamically update key flow parameters for history matching and parameter inversion. On this basis, a multi-objective collaborative optimization strategy is developed to achieve simultaneous time-varying fracture characterization and dynamic regulation of development parameters. Comparative results indicate that the EFF-based approach yields a production prediction error of 6.8%, slightly higher than the 4.2% obtained using discrete fracture network (DFN) models, while requiring only one-eighteenth of the computational time. Using the net present value (NPV) as the unified objective function, constraints are imposed on bottom-hole flowing pressure, flowback rate and system switching time for optimization. With the optimized pressure drop being more uniform and the gas saturation distribution being more balanced, it is verified that “EFF + NPV” can achieve the coordinated optimization of “production capacity—decline—cost” and enhance the development efficiency. Full article
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15 pages, 2544 KB  
Article
Double Boosting Strategy for Low-Iodine-Dose Dual-Source DECT Follow-Up CT After Intervention with Raw DICOM-Level Deep Learning Iodine Boosting and Low-keV Dual-Energy-Derived Images
by Tae Young Lee, Jong Hwa Lee, Hoonsub So and Ho Min Jang
Tomography 2026, 12(4), 56; https://doi.org/10.3390/tomography12040056 - 13 Apr 2026
Viewed by 774
Abstract
Background/Objectives: We aim to evaluate whether digital imaging and communications in medicine (DICOM)-level deep learning-based iodine-boosting applied to dual-source dual-energy computed tomography (DECT) source DICOM improves image quality in low-iodine-dose abdominal DECT in adults undergoing post-procedure follow-up computed tomography (CT). Methods: [...] Read more.
Background/Objectives: We aim to evaluate whether digital imaging and communications in medicine (DICOM)-level deep learning-based iodine-boosting applied to dual-source dual-energy computed tomography (DECT) source DICOM improves image quality in low-iodine-dose abdominal DECT in adults undergoing post-procedure follow-up computed tomography (CT). Methods: This retrospective study included 43 adults (April–September 2025) who underwent dynamic dual-source DECT using a low-iodine protocol. Three CT reconstructions were compared: mixed images, conventional 50-keV virtual monoenergetic images (VMIs), and 50-keV VMIs generated after applying DICOM-based deep learning iodine-boosting/denoising to the tube-specific dual-energy source DICOM series prior to VMI/iodine-map reconstruction (deep learning-based reconstruction [DLR]-VMI). Iodine material density (IMD) images were compared between the conventional and DLR-processed datasets. Quantitative attenuation and signal-to-noise ratio (SNR) were assessed using paired and repeated-measures tests. Image quality was scored by two readers using a five-point Likert scale. Results: Attenuation varied across CT reconstructions for all regions of interest in both phases (all overall p < 0.001). Liver attenuation increased from 94.9 ± 22.0 Hounsfield units (HU) (VMI) to 114.5 ± 34.6 HU (DLR-VMI) during the arterial phase and from 127.6 ± 25.6 HU to 166.6 ± 39.9 HU during the portal venous phase (both p < 0.001). Liver SNR improved with DLR-VMI compared to VMI (arterial: 9.11 ± 3.62 vs. 6.06 ± 1.90; portal: 12.74 ± 3.56 vs. 7.90 ± 1.82; both p < 0.001). On IMD images, DLR increased HU-equivalent values and liver SNR (arterial: 5.20 ± 2.89 vs. 2.61 ± 1.39; portal: 9.22 ± 2.81 vs. 4.48 ± 1.28; both p < 0.001). Qualitatively, DLR-VMI yielded the highest overall image-quality scores for both reviewers in both phases (Reviewer 1, arterial/portal: 4 (4–5)/5 (4–5); Reviewer 2, arterial/portal: 4 (3–4)/4 (4–4)). DLR also improved the overall image quality of IMD images for both reviewers (all p < 0.001). Conclusions: Raw DICOM-level iodine-boosting DLR applied to dual-source DECT-source DICOM enabled enhanced image quality and improved quantitative and qualitative metrics in low-iodine-dose abdominal DECT. Full article
(This article belongs to the Section Abdominal Imaging)
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19 pages, 1730 KB  
Article
PPI-Diff: De Novo Generation of Peptide Binders via Resolution-Aware Geometric Diffusion
by Benzhi Dong, Sijia Li, Chang Hou and Dali Xu
Biomolecules 2026, 16(4), 528; https://doi.org/10.3390/biom16040528 - 1 Apr 2026
Cited by 1 | Viewed by 857
Abstract
Peptide binders, serving as a critical drug modality bridging small-molecule compounds and protein macromolecules, can effectively mimic the secondary structural elements of natural proteins. Peptides exhibit unique physicochemical advantages when targeting protein protein interaction (PPI) interfaces, which are typically characterized by flat surfaces [...] Read more.
Peptide binders, serving as a critical drug modality bridging small-molecule compounds and protein macromolecules, can effectively mimic the secondary structural elements of natural proteins. Peptides exhibit unique physicochemical advantages when targeting protein protein interaction (PPI) interfaces, which are typically characterized by flat surfaces and extensive contact areas. Recently, diffusion models represented by RFdiffusion have established a new computational paradigm for protein backbone generation by defining a denoising process over the rigid-body transformation group. However, in the de novo design of binders targeting “undruggable” PPI targets, this general paradigm encounters significant adaptability bottlenecks. First, its underlying rigid-body assumption struggles to accurately describe the dynamic induced-fit process of peptides at the binding interface. Second, it lacks sufficient robustness to the experimental resolution heterogeneity inherent in training data. Furthermore, the decoupled two-stage generation of sequence and structure severs the synergy of physicochemical properties, leading to backbones with idealized, singular secondary structures that lack authentic spatial binding capacity and reasonable side-chain physicochemical features. To address these challenges, this study proposes PPI-Diff, a novel generative framework. While preserving the generative capability of diffusion models, PPI-Diff introduces three core mechanisms: (1) a resolution-aware constraint mechanism that maps the measurement precision of experimental data into explicit contextual constraints to dynamically suppress geometric noise from low-resolution samples; (2) an internal-coordinate-driven manifold diffusion model that performs conformational evolution on a Riemannian manifold constructed by dihedral angles, balancing local stereochemical validity with the precise capture of flexible peptide conformations; and (3) a geometry-semantic synergistic modeling mechanism that leverages the evolutionary embeddings of a pre-trained protein language model (ESM-2) as latent variables to align structure generation with biophysical functions. Systematic benchmarking demonstrates that, on a strictly non-homologous test set, the binders generated by PPI-Diff significantly outperform existing baseline models in terms of interface contact density, stereochemical validity, and sequence novelty. Full article
(This article belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
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48 pages, 14824 KB  
Review
Convergence of Multidimensional Sensing: A Review of AI-Enhanced Space-Division Multiplexing in Optical Fiber Sensors
by Rabiu Imam Sabitu and Amin Malekmohammadi
Sensors 2026, 26(7), 2044; https://doi.org/10.3390/s26072044 - 25 Mar 2026
Viewed by 1566
Abstract
The growing demand for high-fidelity, multi-parameter, distributed sensing in critical domains such as structural health monitoring, oil and gas exploration, and secure perimeter surveillance is pushing traditional optical fiber sensors (OFS) to their performance limits. Although conventional multiplexing techniques such as time-division and [...] Read more.
The growing demand for high-fidelity, multi-parameter, distributed sensing in critical domains such as structural health monitoring, oil and gas exploration, and secure perimeter surveillance is pushing traditional optical fiber sensors (OFS) to their performance limits. Although conventional multiplexing techniques such as time-division and wavelength-division multiplexing (TDM, WDM) have been commercially successful, they are rapidly approaching fundamental bottlenecks in sensor density, spatial resolution, and data capacity. This review argues that the synergistic convergence of space-division multiplexing (SDM) and artificial intelligence (AI) represents a paradigm shift, enabling a new generation of intelligent, high-dimensional sensing networks. We comprehensively survey the state of the art in SDM-based OFS, detailing the operating principles and applications of multi-core fibers (MCFs) for ultra-dense sensor arrays and 3D shape sensing, as well as few-mode fibers (FMFs) for mode-division multiplexing and enhanced multi-parameter discrimination. However, the unprecedented spatial parallelism provided by SDM introduces significant challenges, including inter-channel crosstalk, complex signal demultiplexing, and massive data volumes. This paper systematically explores how AI, particularly machine learning (ML) and deep learning (DL), is being leveraged not merely as a tool but as an indispensable core technology to mitigate these impairments. We critically analyze AI’s role in digital crosstalk suppression, intelligent mode demultiplexing, signal denoising, and solving complex inverse problems for parameter estimation. Furthermore, we highlight how this AI–SDM synergy enables capabilities beyond the reach of either technology alone, such as super-resolution sensing and predictive analytics. The discussion is extended to include the critical supporting pillars of this ecosystem, such as advanced interrogation techniques and the associated data management challenges. Finally, we provide a forward-looking perspective on the trajectory of the field, outlining a path toward cognitive sensing networks that are self-calibrating, adaptive, and capable of autonomous decision-making. This review is intended to serve as a foundational reference for researchers and engineers at the intersection of photonics and intelligent systems, illuminating the pathway toward tomorrow’s intelligent sensing infrastructure. Full article
(This article belongs to the Collection Artificial Intelligence in Sensors Technology)
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27 pages, 29264 KB  
Article
Method and Application of Full-Space Deformation Monitoring of Surrounding Rock in Coal Mine Roadway Based on Mobile Three-Dimensional Laser Scanning
by Chao Gao, Dexing He and Xinqiu Fang
Appl. Sci. 2026, 16(7), 3156; https://doi.org/10.3390/app16073156 - 25 Mar 2026
Viewed by 446
Abstract
Deformation monitoring of roadway surrounding rock is the key link to ensure the safety production of the coal mine. The traditional monitoring method can only obtain the displacement information of discrete measuring points, and it is difficult to fully reflect the spatial distribution [...] Read more.
Deformation monitoring of roadway surrounding rock is the key link to ensure the safety production of the coal mine. The traditional monitoring method can only obtain the displacement information of discrete measuring points, and it is difficult to fully reflect the spatial distribution characteristics and evolution law of surrounding rock deformation. Based on the engineering background of the extra-thick coal seam roadway in the Yushupo Coal Mine, Shanxi Province, China, this study proposes a set of full-space deformation monitoring methods for roadway surrounding rock based on explosion-proof mobile 3D laser scanning technology. Firstly, a hierarchical denoising method based on improved statistical filtering is established. The quality of point cloud data is effectively improved by region clipping, a connectivity analysis guided by multi-dimensional geometric features and adaptive density threshold three-level processing strategy. Secondly, a hierarchical point cloud registration method combining physical anchor geometric constraints and deep learning patch guided matching is proposed to reduce the registration error to millimeter level. Finally, the deformation evaluation of surrounding rock is carried out by combining the overall deformation identification with the quantitative analysis of local section slices. The engineering application results show that the deformation of the roadway floor is the most significant during the monitoring period, the maximum deformation is 90.0 mm, and the average deformation is 46.9 mm. The maximum deformation of the roof is 35.0 mm, and the convergence of both sides is asymmetric. Compared with the total station, the results show that the maximum displacement error in each direction does not exceed 5 mm, and the standard deviation is within 1.3 mm, which meets the engineering accuracy requirements of coal mine roadway deformation monitoring. This study provides a complete technical scheme for panoramic and high-precision monitoring of surrounding rock deformation in coal mine roadway. Full article
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28 pages, 31519 KB  
Article
A Directional Nearest Neighbor Distance-Based Algorithm for Signal Photon Extraction from Spaceborne Photon-Counting LiDAR in Shallow Waters
by Shibin Zhao, Zhenwei Shi, Tingting Jin, Boxue Huang, Xiaokai Li and Hui Long
Sensors 2026, 26(5), 1645; https://doi.org/10.3390/s26051645 - 5 Mar 2026
Viewed by 605
Abstract
The Ice, Cloud, and Land Elevation Satellite-2 (ICESat-2) employs a 532 nm laser with strong water-penetration capability, making it well suited for satellite-derived bathymetry in shallow waters; however, the effective denoising of photon-counting data remains essential due to strong solar background and intrinsic [...] Read more.
The Ice, Cloud, and Land Elevation Satellite-2 (ICESat-2) employs a 532 nm laser with strong water-penetration capability, making it well suited for satellite-derived bathymetry in shallow waters; however, the effective denoising of photon-counting data remains essential due to strong solar background and intrinsic instrument noise. To address this challenge, this study proposes a novel photon denoising method, termed the Directional Nearest Neighbor Distance-based Algorithm (DNNDA), for robust extraction of signal photons from shallow-water ICESat-2 data. Unlike existing methods that rely heavily on density or terrain features and often degrade under high-noise conditions, DNNDA systematically exploits both scale-corrected spatial relationships and directional distribution characteristics of photons. By quantitatively characterizing the directional features of photon distributions and embedding this information into a density representation, DNNDA amplifies the density contrast between signal and noise photons, rendering the seafloor signal photons more distinct and easier to extract. An evaluation index was further designed to automate optimal parameter determination. Validation using multiple global ICESat-2 datasets demonstrates that DNNDA achieves superior seafloor photon extraction performance, with F1-scores exceeding 95%. Further regression analysis against high-precision CUDEM data in the Puerto Rico region yields root-mean-square errors below 0.57 m. By jointly correcting scale anisotropy and incorporating directional information, DNNDA enables reliable and adaptive signal photon extraction across local and global scales, providing a robust solution for shallow-water bathymetry in complex, high-noise environments. Full article
(This article belongs to the Section Optical Sensors)
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