Search Results (98,065)

Our objective was to investigate the relationship between problematic TikTok use and levels of anxiety, depression, and sleep quality. We also explored differences across sex and generational groups. A cross-sectional study was conducted in Greece using a convenience sample. Participants were classified into three generational groups: Generation Z (1997–2012), Millennials (1981–1996), and Generation X (1965–1980). Problematic TikTok use was assessed with the TikTok Addiction Scale, while anxiety and depression were measured using the Patient Health Questionnaire-4. Sleep quality was evaluated with the Sleep Quality Scale. To account for potential confounding factors, we performed multivariable linear regression analyses. Our results showed a positive association between problematic TikTok use and both anxiety and depression. Multivariable analysis revealed a negative association between problematic TikTok use and sleep quality. In summary, our findings indicate that problematic TikTok use is linked to higher levels of anxiety and depression, as well as poorer sleep quality. These results highlight the need for policymakers, stakeholders, and healthcare professionals to develop and implement targeted interventions aimed at mitigating the negative effects associated with problematic TikTok use. Full article

Structured radiology reporting can improve clinical decision support by standardizing clinical findings into hierarchical formats. However, thousands of questions in structured report templates about clinical findings are prohibitively time-consuming, which can limit clinical adoption. Furthermore, early medical VQA datasets primarily focused on free-text and independent question–answer pairs while a recent dataset, Rad-ReStruct, introduced a hierarchical VQA, but the accompanying model still relies heavily on flattened embedding representations and single-path text–image fusion mechanisms that inadequately handle complex hierarchical dependencies in responses. In this paper, we propose DPA-HiVQA (Dual-Path Cross-Attention for Hierarchical VQA), addressing these limitations through two key contributions: (1) multi-scale image embedding representing global semantic embeddings with patch-level spatial features from domain-specific BioViL encoder; (2) dual-path cross-attention mechanism enabling simultaneous holistic semantic understanding and fine-grained spatial reasoning. Evaluated on the Rad-ReStruct benchmark, the model substantially outperforms the established benchmark baseline with an overall F1-score and Level 3 F1-score improvement by 21.2% and 31.9%, respectively. The proposed model demonstrates that dual-path cross-attention architectures can effectively connect holistic semantic understanding and fine-grained spatial detail, paving the way for practical AI-assisted structured reporting systems that reduce radiologist burden while maintaining diagnostic accuracy. Full article

Prestressed concrete railway sleepers are key structural components that determine the safety, durability, and serviceability of modern railway infrastructure. This study presents a comprehensive investigation of the design, testing, and acceptance of prestressed concrete sleepers in accordance with EN 13230, with particular reference to the requirements applied on the Polish railway network. The analysis integrates normative provisions, analytical calculations, finite element modeling, and experimental verification, including static, dynamic, and fatigue load tests. Special attention is given to the k_t coefficient, which accounts for prestress losses, fatigue degradation, and the development of concrete strength throughout the service life. This coefficient plays a critical role in the acceptance criteria for sleepers during mandatory product testing. The influence of concrete age on the variability of k_t is examined, showing that the highest variability occurs within the first 180 days of curing. Full-scale laboratory tests performed on PS-94 sleepers confirm compliance with standard requirements regarding cracking loads, crack width limits, and ultimate load capacity under both exceptional and fatigue loading conditions. Numerical simulations provide additional insight into stress and displacement distributions in critical cross-sections, supporting the experimental findings. The results indicate that most of prestressing force losses occur during the early service period. This observation supports the application of age-dependent acceptance criteria, which may improve conformity assessment procedures for prestressed concrete railway sleepers in contemporary railway engineering practice. Full article

Background: Elevated anticardiolipin IgG (aCL IgG) has been reported in end-stage renal disease (ESRD), but its association with specific etiologies of kidney failure remains unexplored. The unique pathophysiology of diabetic–hypertensive nephropathy may be associated with a microenvironment that could potentially contribute to antiphospholipid antibody production and thrombotic complications. This study aimed to investigate whether aCL IgG elevation in hemodialysis (HD) patients is associated with combined diabetes–hypertension (DM + HTN) etiology and thrombocytopenia, thereby identifying a clinically distinct potential high-risk subgroup. In this hypothesis-generating study, we focused on within-HD patient comparisons rather than healthy controls. Methods: We enrolled 242 participants: 150 healthy controls (included only to establish local reference ranges) and 92 patients with maintenance HD. The study was conducted from 01 September to 20 November 2025 in Madinah, Saudi Arabia. Serum aCL IgG was measured by chemiluminescence immunoassay (positive ≥ 12 GPL units). Comprehensive hematological and biochemical parameters were analyzed. Multivariable logistic regression identified predictors of aCL positivity. Results: In the HD cohort, 21% demonstrated aCL positivity; this represents a substantially higher rate than the 2% observed in local healthy controls (p < 0.001). This elevation was not uniform across etiologies. Strikingly, 94.7% (18/19) of aCL-positive HD patients had DM + HTN aetiology, compared with only 17.8% of aCL-negative patients (p < 0.001). Thrombocytopenia was significantly more severe in aCL-positive patients (median platelets: 100 vs. 191 × 10⁹/L, p < 0.001). In multivariable analysis, DM + HTN etiology (HTN-alone vs. DM + HTN odds ratio [OR]: 0.0013, 95% confidence interval [CI]: 0.00002–0.0999, p = 0.003; confirmed by Firth’s penalized logistic regression sensitivity analysis, and lower platelet count (OR: 0.92 per 1 × 10⁹/L increase, 95% CI: 0.87–0.98, p = 0.006) independently predicted aCL positivity. Conclusions: These hypothesis-generating findings suggest a potential association between metabolic–vascular disease and antiphospholipid immunity in ESRD. Causality cannot be inferred from this cross-sectional design. At present, routine aCL screening is not recommended outside of research protocols; prospective studies are needed to confirm these associations. Full article

Medical image segmentation plays a crucial role in clinical diagnosis and treatment planning. However, existing segmentation frameworks frequently exhibit high computational complexity and often fail to retain fine-grained structural details—especially along intricate anatomical boundaries such as blood vessels and tumor margins. To overcome these limitations, we propose VMMedSAM-X, an efficient and computationally economical medical image segmentation framework that incorporates structured state space modeling into the Medical Segment Anything Model (MedSAM) architecture. The proposed method adopts a state-enhanced encoder that combines extended long short-term memory (xLSTM) with two-dimensional selective scanning (SS2D) and a dual-path cross-attention mechanism to enhance long-range dependency modeling while maintaining linear computational complexity. Experiments conducted on the $1024\times 1024$ ACDC cardiac MRI dataset show that the proposed encoder reduces floating-point operations from 369.44 G to 17.36 G and achieves a $2.4\times$ improvement in inference speed compared with the Vision Transformer (ViT)-based encoder. Additional evaluations on the SegTHOR and MSD-Lung datasets demonstrate consistent improvements in Dice Similarity Coefficient (DSC) and Intersection over Union (IoU) metrics over MedSAM and Vision Mamba U-Net (VM-UNet) baselines. These results indicate that the proposed framework provides an effective and computationally efficient solution for high-resolution medical image segmentation. Full article

This study aimed to evaluate the aromatic potential of four new Monastrell-derived white grapevine genotypes (MC180, MC69, MT103, MV67) compared with Verdejo over four consecutive seasons (2020–2023), with particular emphasis on both free and glycosidically bound volatile compounds. This approach provided novel insight into the aromatic composition of emerging cultivars under warm climate conditions and their potential suitability for future viticultural use. Free and glycosidically bound volatile compounds were extracted and analyzed using Gas Chromatography–Mass Spectrometry (GC-MS). Differences in aroma profiles were observed among genotypes and seasons. MV67 and MC69 showed higher levels of monoterpenes and volatile phenols, suggesting enhanced floral and complex aromatic potential. Seasonal effects strongly influenced C6 compounds and norisoprenoids, highlighting the importance of climatic conditions in shaping grape aroma. Multifactorial analysis revealed that season had the greatest impact on most compound families, although genotype and its interaction with season were also significant. These results demonstrate that genotype–environment interactions play a key role in determining aromatic composition. The elevated levels of aroma precursors, particularly glycosidically bound compounds, indicate promising enological potential for producing fresh, aromatic white wines. Therefore, these new cultivars represent suitable alternatives for white wine production in warm climates. Full article

Background: Ulcerative Colitis and Crohn’s Disease are the most common forms of inflammatory bowel disease (IBD), with increasing prevalence both globally and in Poland. Many aspects of how a patient’s everyday function and treatment remain underexplored. Methods: This study recruited adult patients with IBD hospitalized in the Department of Digestive Tract Diseases of the Medical University of Lodz, Poland. The data were collected between June and July 2025 using an author-developed questionnaire assessing patients’ opinions on therapy, their expectations, and overall life satisfaction. Results: A total of 87 patients with IBD were included in the analysis. Overall, 59 patients (67.82%) reported strong satisfaction with their current treatment, indicating a generally positive perception of disease management. Higher treatment satisfaction was associated with patients’ perception that their preferences were respected by the gastroenterologist. Further analysis revealed significant associations between different types of treatment, disease activity, and patient-reported outcomes. Those patients who were treated with biological agents more frequently reported complete satisfaction with the treatment (41/52 vs. 18/35; p = 0.014), low-to-moderate disease activity (42/52 vs. 19/35; p = 0.016), and fewer limitations in their social lives (16/52 vs. 20/35; p = 0.026) compared to the remaining group. Furthermore, the study demonstrated that those patients who reported remission were less likely to have their physical activity limited (27/55 vs. 27/32; p = 0.002). There were significantly more patients under 50 years of age than older patients getting biological therapy (48/74 vs. 4/13; p = 0.045). Additionally, women in the studied group had a higher rate of IBD-related surgical interventions compared to men (15/36 vs. 9/51; p = 0.026). Despite the high overall satisfaction with treatment and physician communication, 20 patients (22.99%) admitted to taking additional, non-prescribed medication or dietary supplements. Similarly, 21 (24.14%) patients modified treatment regimens by discontinuing the medication intake or changing the prescribed dose. Furthermore, 57 patients (65.52%) reported that they feared the possibility of surgical intervention. Nonetheless, the majority of patients who underwent surgical treatment (22/24; 91.67%) were satisfied with the results. Reported rates of undergoing regular colorectal cancer screening were also unsatisfactory—4/37 (10.81%) patients with disease duration >8 years, suggesting inadequate awareness. Conclusions: Biological treatment can positively impact multiple aspects of patients’ lives by lowering the disease’s activity. Gastroenterologists should spend more time discussing patients’ preferences and concerns, as well as explaining the colorectal cancer screening rules. Full article

Background/Objective: Mental fatigue (MF) significantly impairs psychomotor performance in dynamic sports; however, its specific impact on closed-skill precision-demanding tasks remains underexplored. This study investigated the acute effects of experimentally induced MF exposure on psychophysiological responses, mood states, and archery shooting performance. Methods: Fifteen well-trained male compound-bow archers participated in a randomized crossover study. Participants completed an MF condition (30 min modified Stroop task) and a control condition (CON; passive viewing of a neutral documentary), separated by a 72 h washout period. Continuous heart rate (HR), archery shooting accuracy, ratings of perceived exertion (RPE), rating scale of mental effort (RSME), state anxiety (VAS-A), mood states, and exercise enjoyment scale (EES) were assessed. Results: The Stroop task successfully induced subjective MF. Consequently, shooting accuracy significantly deteriorated in the MF condition compared to that in the CON condition (p < 0.001; g = 0.731). While HR and VAS-A remained consistent across conditions, the MF condition elicited a significant increase in RPE (p = 0.007; g = 0.836) and RSME (p = 0.010; g = 0.794). Furthermore, MF significantly increased feelings of anger and fatigue while drastically reducing PACES (p < 0.001; g = 1.530). Conclusions: Acute MF significantly degrades fine motor accuracy in precision sports. The pronounced dissociation between elevated RPE and stable peripheral physiological strain suggests that performance decline is driven by top-down cognitive burden rather than physiological limitations. Therefore, systematic monitoring of cognitive load is crucial for optimizing performance in precision sports. Full article

Estimating ground motion parameters at an unsampled site is challenging for seismologists and engineers alike. An attempt is made to apply Kriging interpolation to estimate peak ground accelerations at specific nuclear power plant sites. However, issues such as data quality and Kriging assumptions pose challenges to how practical and reasonable Kriging interpolation results may be in terms of estimating ground motion parameters. Peak ground acceleration data from the 2016 Gyeongju and 2017 Pohang earthquakes were taken from a local seismological agency. Peak ground acceleration, logarithms of the peak ground acceleration, and residuals between the recorded data and global and local ground motion models were used to select and derive empirical variogram models. The leave-one-out cross-validation process suggested estimating peak ground acceleration residuals from a locally developed ground motion model using an Exponential variogram model. Kriging estimates were compared to a site-specific ground motion model. These estimates appeared reasonable at one site but were significantly off at the other site. On the whole, Kriging estimates were lower than ground motion model predictions. When viewed relative to the nearest recordings, Kriging estimates appeared inconsistent across the two earthquake events. A nearest neighbor approach to computing Kriging estimates suggested a minimum of five data points but much more for modeling an empirical variogram. Results also suggest focusing on validation processes more than variogram selection. This suggests caution when applying Kriging for ground motion-related assessments in South Korea. Full article

This article examines The Mark of Cassandra by Chingiz Aitmatov through the emerging framework of Blue Humanities. While most prior studies have approached Aitmatov’s ecological concerns from a land-based ecocritical perspective, this article shifts the focus to his engagement with oceanic themes and marine environments. By combining literary interpretation with ecological philosophy, the study suggests that The Mark of Cassandra goes beyond the limits of traditional environmental fiction. It presents the ocean not only as a setting but as a source of knowledge and ethical reflection. In this way, Aitmatov’s work seems to anticipate current global discussions on climate change, biodiversity loss, and environmental justice. The novel encourages readers to reconsider the human-centered worldview and adopt a more ecocentric approach. Through its marine symbolism and critical stance on human exploitation of nature, the text offers valuable insights into ecological ethics that cross both national and species boundaries. Overall, this article argues that The Mark of Cassandra is an important literary contribution that challenges the usual borders of ecocriticism and calls for a more integrated and holistic understanding of environmental issues. Full article

Political polarization and policy uncertainty have become increasingly consequential for regional economic adjustment, yet their joint role in shaping socioeconomic resilience remains underdeveloped in the literature. This study advances the debate by conceptualizing regional resilience as the outcome of a multi-layer socioeconomic system in which external policy disturbances, institutional fragmentation, and structural adaptive capacity interact over time. Using balanced panel data for 16 Korean regions from 2004 to 2023, the analysis develops an integrated empirical framework that combines panel local projections, threshold estimation, structural moderation tests, dynamic robustness checks, and forward-looking machine-learning prediction. The results show that policy uncertainty is associated with lower regional socioeconomic resilience and that this effect persists over time. More importantly, political polarization does not simply accompany weaker resilience; it amplifies the transmission of uncertainty shocks, especially once institutional fragmentation crosses a critical threshold. Structural conditions further shape this process. Digital transformation, industrial diversification, and financial depth reduce vulnerability, whereas trade exposure intensifies it. These findings indicate that resilience is not determined by economic structure alone, nor by institutional instability in isolation. It emerges from the interaction between disturbance, amplification, and adaptive capacity within a regional system. The predictive analysis reinforces this interpretation. Variables identified as central in the econometric models also carry forward-looking information about future vulnerability states. This study therefore contributes not only by combining methods, but by linking explanation and prediction within a single systems-oriented account of regional resilience. The Korean case shows how institutional coherence and structural adaptability jointly condition resilience under uncertainty. Full article

In this study, the microstructure and mechanical properties of ultrasonic welded joints between large-diameter aluminum wire and Cu (Ni-plated copper) terminals were systematically investigated, to reveal the underlying fracture mechanisms. The cross-sectional morphology, interfacial microstructure, and mechanical properties of the two types of welded joints are investigated. The results indicate that ultrasonic welding produces well-structured Al-Cu and Al-Ni joints. Under the same welding process parameters, the Al-Cu joint exhibits many pores, while the Al-Ni joint has no pores in its microstructure. The interfacial region of the Al-Cu joint presents various morphologies, such as flat bonding, interlocking, and eddy current patterns, whereas the Al-Ni joint interface is flat. No significant atomic diffusion phenomenon occurs between the interfaces of the two types of joints. The tensile strength of the Al-Cu joint is 53 MPa, with fracture modes including ductile fracture and brittle fracture, whereas the tensile strength of the Al-Ni joint is 50 MPa, with a failure mode of pull-out fracture. In working conditions requiring ultrasonic welding of aluminum and copper, nickel-plated copper can be used as a substitute for copper to prevent electrochemical corrosion between aluminum and copper. Full article

Serotoninomics, a nascent emerging discipline within the field of omics, provides a transdisciplinary framework for understanding reproductive toxicology via serotonergic signalling. This research investigates the neuroendocrine effects of permethrin, a commonly used pyrethroid insecticide often considered to pose a low risk to humans, and positions it as a model compound for evaluating reproductive susceptibility beyond conventional endocrine endpoints. It is hypothesized that serotonin, traditionally examined in neuropsychiatric contexts, plays an essential role in gonadal function, hormonal regulation, and emotional resilience. Although permethrins are generally regarded as safe, acute exposure may subtly interfere with serotonergic pathways, potentially resulting in molecular, biochemical, behavioural, and reproductive alterations. These effects could extend beyond immediate exposure, including during gestation, considering permethrins’ ability to cross the placental barrier and influence foetal development. By synthesizing evidence across molecular, organismal, and environmental domains, we advocate for a serotonergic approach to facilitate a more comprehensive assessment of risk and resilience. We emphasize the importance of fostering a transdisciplinary dialogue to redefine reproductive health through the perspectives of serotonergic vulnerability and systemic resilience. Full article

In order to protect the high-sensitivity optical lens of the “magnetic field and velocity field imager” in extreme deep space environments, this paper proposes a new type of dual redundant planetary differential lens cover drive mechanism. In view of the critical vulnerability that traditional single-motor direct drive is prone to sudden mechanical jamming and catastrophic single-point failure (SPF) in severe tasks such as Jupiter exploration, this study constructs a “dual input single output (DISO)” rigid decoupling architecture from the perspective of physical topology. Through theoretical analysis and kinematic modeling, the adaptive decoupling mechanism of the two-degree-of-freedom (2-DOF) system under unilateral mechanical stalling is revealed. Dynamic analysis shows that in the nominal dual-motor synergy mode, the system shows a significant “kinematic load-sharing effect”, thus greatly reducing the sliding friction and gear wear rate. In addition, under the severe dynamic fault injection scenario (maximum gravity deviation and sudden jam superposition of a single motor), the cold standby motor is activated and the dynamic takeover is quickly performed. The high-fidelity transient simulation based on ADAMS verifies that although the fault will produce transient global torque spikes and pulsed internal gear contact forces at the moment, all extreme dynamic loads remain well within the structural safety margin. The output successfully achieved a smooth transition, which is characterized by a non-zero-crossing velocity recovery. This research provides an innovative theoretical basis and a practical engineering paradigm for the design of high-reliability fault-tolerant mechanisms in deep space exploration. Full article

Disinformation is a global challenge that affects areas such as politics, health, economics, and science and is spread rapidly by social media (SM), suggesting the necessity of advancing educational proposals to strengthen critical thinking (CT) and digital literacy (DL). This quantitative, non-experimental, descriptive study identified the self-perception that master’s students (n = 72; at three Spanish universities; October 2024–March 2025) have regarding their DL, along with their CT, in post-truth and fake news settings. A self-administered online questionnaire (53 items) was conducted, covering aspects such as the responsible use of information and platforms, algorithmic perceptions, actions taken to verify this information, and concepts of CT, post-truth, and fake news. The results show that Instagram (97%) and WhatsApp (96%) predominated, with a notable proportion of users (86%) reporting that algorithms influenced them ‘highly’ or ‘moderately’. Despite being aware of disinformation they find on social media (65%) as well as its close link to hate speech (90% who ‘strongly’ or ‘somewhat’ agreed), this knowledge does not fully translate into taking measures to counter it. In fact 61% of respondents report sharing news on at least some occasions, while only 25% are able to identify a professional fact-checking organization. In conclusion, these findings suggest the merit of assessing the prevalence of skills such as Critical Thinking (CT) and strategies like fact-checking among students in other postgraduate education systems. Such assessments could inform the potential promotion of media and digital literacy as cross-curricular skills in education. This approach would help bridge the gap between theoretical knowledge and the active verification needed to counter disinformation. Full article