Search Results (124)

Background/Objectives: Possessing red and white ecotypes, and utilized in traditional Guyanese medicine, Doliocarpus dentatus’ red ecotype is preferred locally for its purported superior therapeutic efficacy. Although therapeutic metabolites were detected in D. dentatus previously, phytohormones remain largely unexplored, until now. Cytokinins, phytohormones responsible for plant cell division, growth and differentiation, are gaining traction for their therapeutic potential in human health. This study screened and quantified endogenous cytokinins and correlated detected cytokinins with selected secondary metabolites. Methods: Liquid chromatography–mass spectrometry was used to acquire phytohormone and metabolite data. Bioinformatics tools were used to assess untargeted metabolomics datasets via statistical and pathway analyses, and chemical groupings of putative metabolites. Results: In total, 20 of the 35 phytohormones were detected and quantified in both ecotypes, with the red ecotype displaying higher free base and glucoside cytokinin concentrations and exhibited 6.2 times the total CK content when compared to the white ecotype. Pathway analysis revealed flavonoid and monoterpenoid biosynthesis in red and white ecotypes, respectively. Positive correlations between specific cytokinins and alkaloids, and between trans-Zeatin and isopentenyladenosine riboside with phenolic compounds were observed. Conclusions: These results suggest that the red ecotype’s elevated cytokinin levels coupled with flavonoid biosynthesis enrichment support its preference in Guyanese traditional medicine. Full article

Wireless power transfer (WPT) systems for autonomous underwater vehicles (AUVs) are gaining traction in marine exploration due to their operational convenience, safety, and flexibility. Nevertheless, disturbances from ocean currents and marine organisms frequently induce rotational, axial, and air-gap misalignments, significantly degrading the output power stability. To mitigate this issue, this paper proposes a novel reconfigurable WPT system utilizing coaxial antipodal dual DD (CAD-DD) coils, which strategically switches between a detuned S-LCC topology and a detuned S-S topology at a fixed operating frequency. By characterizing the output power versus the coupling coefficient (P-k) profiles under both reconfiguration modes, a parameter design methodology is developed to ensure stable power delivery across wide coupling variations. Experimental validation using a 1.2 kW AUV charging prototype demonstrates remarkable tolerance to misalignment: ±30° rotation, ±120 mm axial displacement, and 20–50 mm air-gap variation. Within this range, the output power fluctuation is confined to within 5%, while the system efficiency exceeds 85% consistently, peaking at 91.56%. Full article

With the electrification of generator sets, electric locomotives, new energy vehicles, and other industries, AC motors subject bearings to an electric field environment, leading to galvanic corrosion due to the use of variable frequency power supply drives. The phenomenon of bearing discharge breakdown in subway traction motors is a critical issue in understanding the relationship between shaft current strength and the extent of bearing damage. This paper analyzes the mechanism of impulse discharge that leads to galvanic corrosion damage in bearings at a microscopic level and conducts electric thermal coupling simulations of the traction motor bearing discharge breakdown process. It examines the temperature rise associated with lubricant film discharge breakdown during the dynamic operation of the bearing and investigates how breakdown channel parameters and operational conditions affect the temperature rise in the micro-region of bearing lubrication. Ultimately, the results of the electric thermal coupling simulation are validated through experimental tests. This study revealed that in an electric field environment, the load-bearing area of the outer ring experiences significantly more severe corrosion damage than the inner ring, whereas non-bearing areas remain unaffected by electrolytic corrosion. When the inner ring reaches a speed of 4500_rpm, the maximum widths of electrolytic corrosion pits for the outer and inner rings are measured at 89 um and 51 um, respectively. Additionally, the highest recorded temperatures for the breakdown channels in the outer and inner rings are 932 °C and 802 °C, respectively. Furthermore, as the inner ring speed increases, both the width of the electrolytic corrosion pits and the temperature of the breakdown channels rise. Specifically, at inner ring speeds of 2500_rpm, 3500_rpm, and 4500_rpm, the widths of the electrolytic pits in the outer ring raceway load zone were measured at 34 um, 56 um, and 89 um, respectively. The highest temperatures of the lubrication film breakdown channels were recorded as 612 °C, 788 °C, and 932 °C, respectively. This study provides a theoretical basis and data support for the protective and maintenance practices of traction motor bearings. Full article

Tracking the state of the health of electrical insulation in high-power electric machines has always been a topic of great interest due to the high cost of downtime associated with unexpected failures. Over the years, there have been continuous efforts to develop and improve upon methods for testing and categorizing the health and expected lifetime of stator insulation. Methods such as partial discharge, surge, and dissipation factor testing are common examples. With the increasing use of high-specific-power electric machines in new applications such as traction and wind power generation, coupled with the increasing use of wide-bandgap semiconductor device-based inverters, some traditional methods for insulation health tracking may need adjustments or be combined with newer methods to remain accurate and useful. This paper outlines a review of the traditional insulation health tracking methods and newer methods and improvements that have been proposed to address the concerns and shortcomings of traditional methods. Full article

The rapid expansion of the urban rail network has increased concerns regarding stray current generated by the DC traction power supply system. This stray current, which arises from inadequate insulation between the rail and the ground, can cause electrochemical corrosion and operational challenges to nearby buried metallic infrastructures. A portion of stray current entering utility transformers may induce DC bias risk, thereby affecting the stability and reliability of distribution networks. This review studies the trends in utility transformer-related DC bias caused by metro stray current. Various modeling approaches and suppression measures are discussed, with an emphasis on comprehensively understanding stray current distribution behavior, the DC bias coupling loop, and its impacts. This review underscores the need for a thorough evaluation of existing DC bias suppression measures, and more effective and efficient measures must be developed to enhance the resilience of distribution networks. The gaps in current research are highlighted, and further studies are advocated, particularly those focusing on dynamic metro conditions, supported by advanced modeling, field applications, and interdisciplinary collaboration, to address the challenges of DC bias in urban rail environments. Full article

Despite significant advances in understanding neuronal development, a fully quantitative framework that integrates intracellular mechanisms with environmental cues during axonal growth remains incomplete. Here, we present a unified biophysical model that captures key mechanochemical processes governing axonal extension on micropatterned substrates. In these environments, axons preferentially align with the pattern direction, form bundles, and advance at constant speed. The model integrates four core components: (i) actin–adhesion traction coupling, (ii) lateral inhibition between neighboring axons, (iii) tubulin transport from soma to growth cone, and (iv) orientation dynamics guided by substrate anisotropy. Dynamical systems analysis reveals that a saddle–node bifurcation in the actin adhesion subsystem drives a transition to a high-traction motile state, while traction feedback shifts a pitchfork bifurcation in the signaling loop, promoting symmetry breaking and robust alignment. An exact linear solution in the tubulin transport subsystem functions as a built-in speed regulator, ensuring stable elongation rates. Simulations using experimentally inferred parameters accurately reproduce elongation speed, alignment variance, and bundle spacing. The model provides explicit design rules for enhancing axonal alignment through modulation of substrate stiffness and adhesion dynamics. By identifying key control parameters, this work enables rational design of biomaterials for neural repair and engineered tissue systems. Full article

To address the coupled fault diagnosis challenge between temperature sensors and equipment in traction converter cooling systems, this paper proposes a dual-level intelligent diagnostic architecture. This method achieves online sensor fault isolation and early equipment anomaly warning by leveraging spatiotemporal correlation modeling of multimodal sensor data and ensemble learning-based prediction. At the first level, it integrates multi-source parameters such as outlet temperature and pressure to establish dynamic prediction models, which are combined with adaptive threshold mechanisms for detecting various sensor faults including offset, open-circuit, and noise interference. At the second level, it monitors the status of temperature sensors through time-series analysis of inlet temperature data. Verified on an edge computing platform, the proposed method effectively resolves the coupling misdiagnosis between sensor distortion and equipment faults while maintaining physical interpretability, thereby significantly enhancing diagnostic robustness under complex operating conditions. Full article

MicroRNAs (miRNAs) are pivotal modulators of tumor progression and immune function. Given the central role of the immune system in recognizing and eliminating malignant cells, understanding how miRNAs influence immune responses has become essential for advancing cancer therapy. This review explores the emerging roles of miRNAs in orchestrating cancer immunology, emphasizing their regulation of tumor immune surveillance, immune equilibrium, immune evasion, and immunometabolism. We further illustrate how specific miRNAs modulate the tumor microenvironment by shaping immune cell phenotypes, cytokine networks, and antigen presentation. Some miRNAs enhance cytotoxic T lymphocyte activity, while others promote immune escape by expanding regulatory T cells and myeloid-derived suppressor cells. miRNAs also regulate immune checkpoints (e.g., PD-L1 and CTLA-4), metabolic reprogramming, and stress responses that collectively influence tumor immunogenicity. Additionally, miRNAs are gaining traction as biomarkers for immune activity and predictors of immunotherapy response. Therapeutically, miRNA mimics and inhibitors can enhance anti-tumor immunity, particularly when combined with advanced delivery platforms or immune checkpoint inhibitors. However, challenges such as delivery specificity, off-target effects, and the context-dependent nature of miRNA activity remain significant barriers to clinical translation. Despite shortcomings, miRNAs represent a class of immune regulators with substantial therapeutic potential. Accelerated progress in miRNA-guided therapies is anticipated through deepening insights into miRNA regulatory networks, coupled with integrative multi-omics and AI-driven analytical frameworks. Altogether, miRNAs are a promising frontier in next-generation cancer immunotherapy and precision oncology. Full article

The winch traction system for shipboard aircraft, when operating in a marine environment, is subjected to additional forces and moments due to the complex motion of the hull. These loads pose significant threats to the safety of the aircraft during the traction process. To address the safety issues under complex sea conditions, this paper adopts harmonic functions to describe the rolling, pitching, and heaving motions of the hull. A theoretical analytical model of the three-winch traction system, considering the intricate coupling motions of the ship, is established. Unlike previous studies that often simplify ship motion or focus on single-component modeling, this work develops a complete, whole-system dynamic model integrating the winch system, rope, aircraft structure, and ship interaction. The dynamic characteristics of the small-deck winch traction system are investigated, with particular focus on the influence of the rear winch position, driving trajectory, and ship motion on the system’s dynamics and safety. This research is innovative in systematically exploring the dynamic safety behavior of a three-winch traction system operating under small-deck conditions and complex sea states. The results show that as the distance between the two rear winches increases, the lateral force on the tire decreases. Additionally, as the aircraft’s turning angle increases, the front winch rope force also increases. Moreover, with higher sea condition levels and wind scales, the maximum lateral force on the tires increases, leading to a significant reduction in the stability and safety of the winch traction system. This is particularly critical when the sea condition level exceeds 3 and the wind scale exceeds 6, as it increases the risk of tire sideslip or off-ground events. This research has substantial value for enhancing the safety and stability of winch traction systems on small decks, and also provides a theoretical basis for traction path design, winch position optimization, and the extension of the service life of key system components, demonstrating strong engineering applicability. Full article

This paper focused on the motion control of an underwater vehicle installed on a linear guide system, which is driven by two electric winches with wire ropes. The vehicle is subject to complex nonlinear time-varying disturbances and actuator input saturation effects during motion. A coupled dynamic model, incorporating an underwater vehicle, winches, and wire ropes, was established. Particular attention was paid to the nonlinear time-varying hydrodynamic disturbances acting on the underwater vehicle. The Kelvin–Voigt model was introduced to characterize the nonlinear dynamic behavior of the wire ropes, enabling the model to capture the dynamic response characteristics of traction forces. To tackle cross-coupling within the towing system, a differential tension coordination control method was proposed that simultaneously regulates system tension during motion control. For the vehicle dynamics model, a nonsingular fast-terminal sliding-mode (NFTSM) controller was designed to achieve high-precision position tracking control. An auxiliary dynamic compensator was incorporated to mitigate the impact of actuator input saturation. To handle time-varying disturbances, a fuzzy adaptive nonlinear disturbance observer (FANDO) is developed to perform feedforward compensation. Stability proof of the proposed algorithms was provided. Extensive numerical simulations demonstrate the effectiveness of the control strategies. Compared to the NFTSM without the disturbance observer the absolute mean value of the tracking error decreased by 76%, the absolute maximum value of the tracking error decreased by 67%, and the mean square error decreased by 93.5%. Full article

Given the endoscopic possibilities and the need to improve AI in sheep, the aim of this study was to develop a transcervical endoscopic technique for accessing the uterus in sheep. The study was conducted on 35 ewes divided according to the uterus accessing technique applied for artificial insemination (AI). In a pilot study, two techniques were tested using a rigid endoscope coupled to a protective sheath totaling 3 mm, in a group of ewes not subjected to fixed-time artificial insemination (FTAI) protocol and those subjected to the protocol (EPG, n = 5 and EPGp, n = 10). After the pilot study, two additional techniques were tested in synchronized ewes for FTAI: a control group with cervical traction (CG, n = 10) and an AI group using vaginoscopy with a multiport for the passage of a rigid endoscope (EVG, n = 10). The EPG and EPGp showed 100% (5/5) and 10% (1/10) cervical passage rates, respectively. The EPGp had 90% (9/10) superficial cervical inseminations, 10% (1/10) intrauterine inseminations, and a 10% (1/10) pregnancy rate. In CG and EVG, 3.5 ± 3.3 and 1.6 ± 1.2 cervical rings were passed, respectively. Additionally, semen deposition resulted in 20% (2/10) intrauterine inseminations and 80% (8/10) deep cervical inseminations for CG, while EVG had 20% (2/10) intrauterine inseminations and 80% (8/10) superficial cervical inseminations. The pregnancy rate was 20% (2/10) for both CG and EVG. The EPG technique proved efficient for hysteroscopy; however, EPGp was not efficient for AI due to the presence of typical estrus mucus. Nevertheless, it laid the foundation for the development of EVG, which showed promise in gynecological evaluations, enabling intrauterine AI and a complete gynecological assessment. Full article

Nature-based Solutions (NbSs) bridge ecological conservation and human well-being. As the concept gains global traction, its potential for cultural heritage preservation is drawing increasing interest. This study explores the localized application of NbSs in Chinese villages, focusing on two core questions: its compatibility with traditional Chinese construction wisdom and its practical pathways for localization. A literature review reveals strong theoretical alignment between NbS principles and indigenous building practices. This study develops a dual quantitative framework—comprising an NbS evaluation system and a cultural value assessment system—for coupling coordination analysis. Results show a strong interdependence between the integration of NbS principles and village cultural value, with traditional villages (0.7806) achieving a better balance between ecological protection and cultural heritage than non-traditional villages (0.5953), validating the alignment of global NbS principles with local building wisdom. Based on gray relational analysis, disaster risk management and local governance are identified as key NbS dimensions shaping cultural integrity and knowledge continuity. An integrated indicator system combining ecological and cultural metrics is proposed. This study confirms the alignment between global principles and local wisdom, offering an NbS localization framework with insights for heritage conservation. Full article

Modern powertrain configurations for electric vehicles introduce the possibility to actuate the wheel directly by means of in-wheel motors. These machines enable stiffer and more efficient traction, with the possibility of introducing pitch motion control due to the intrinsic coupling between longitudinal, vertical, and pitch dynamics. This paper proposes a pitch rate attenuation control exploiting a Lyapunov function that attempts to cancel the pitch rate dynamics from the model. Unlike previous works, this pitch control is performed exclusively with the traction machine; it does not rely on controllable suspension systems. The controller formulation guarantees global stability of the vehicle. Furthermore, it considers the nonlinearity of the plant introduced by the dependency on the pitch angle. To facilitate the feedback of the road profile needed by the Lyapunov controller, two Kalman filters are included in the control law. This work implements the described strategy on a half car model. Simulations examine different speed and road conditions. It is demonstrated that the control strategy can blend longitudinal and pitch rate attenuation torque commands using a rear in-wheel motor, attaining a reduction of up to $41\%$ for chassis pitch rate and $36\%$ for pitch acceleration. Full article

The lubrication behavior and mechanical characteristics of the main bearing area of an aero-engine main shaft bearing determine the reliability and life of the main shaft bearing. In aero-engine main shaft bearings, the lubricant not only plays the role of lubrication but also affects the dynamic characteristics of the bearing; therefore, if the lubricant drag force is insufficient, it will lead to rolling body slipping. Slipping not only affects the reliability of the bearing operation but also will make the temperature of the contact area instantaneously increase, leading to the occurrence of gluing, scraping and other lubrication failure phenomena in the main bearing area. A lubricant under the shear conditions of traction characteristics is actually the external manifestation of rheological properties. Rheological properties are one of the elastic fluid power lubrication theories and are an important part of the study. Elasto-hydrodynamic lubrication theory of the oil film pressure, film thickness and temperature and solid domains interact to form a thermal–fluid–solid coupling relationship; this coupling relationship affects the main bearing area of the lubrication behavior and mechanical properties, thus affecting the lubrication state of the bearings and dynamic characteristics. With the continuous improvement of aero-engine performance requirements for main shaft bearings, it is of great significance to carry out a coupling study of the lubrication behavior and mechanical properties of the bearing contact zone under heavy load, high speed and high temperature conditions to improve the service performance, reliability and life of the bearings. Full article

To address the issue of inaccurate power flow calculations in the asymmetric coupling system of a power grid and traction network, this paper proposes a dynamic power flow calculation method for the “renewable energy–power grid–transportation network” asymmetric coupled system. First, by utilizing the asymmetric characteristics of the traction transformer, the dynamic asymmetric nodal admittance matrix for the “renewable energy–power grid–transportation network” coupled system is established, which facilitates the construction of the mixed power flow equations for the coupling of the power grid and transportation network. Next, when analyzing the asymmetric coupling system of renewable energy, power grid, and transportation network in mountainous areas, it is necessary to allocate the power of electric multiple units (EMUs) to the three-phase (A, B, C) power distribution. To address this, a three-phase power balancing strategy is proposed, incorporating both the single-phase loads of EMUs and the output of renewable energy sources. Thus, a three-phase power balance strategy is proposed, incorporating the single-phase load of traction load units and renewable energy output. Finally, a simulation study is conducted using a real system of a regional power grid and traction network as a case example, demonstrating the suitability and effectiveness of the proposed model. Full article