Search Results (13,532)

As vital repositories of Beijing’s cultural heritage, Qing Dynasty Qinwang (Prince of the First Rank) mansions offer profound insights into the era’s architectural evolution. Despite its significance, systematic architectural analysis of Prince Jingjin’s Mansion is lacking, with existing research primarily focusing on historical events. To address this gap, the present study focuses on Prince Jingjin’s Mansion as its research subject, utilizing historical document analysis, historical map comparison, field investigation, and space syntax analysis. This study investigates the succession of ownership, historical development, and architectural regulations, and outlines the complete construction process shaped by the evolution of early Qing princely mansion regulations as well as the functional transformation during the late Qing period. Furthermore, the architectural features of the mansion are explored from five perspectives: site selection, functionality, spatial layout, individual buildings, and gardens. The objective of this study is to elucidate the unique characteristics and significance of Prince Jingjin’s Mansion, thereby offering theoretical support for the development of Beijing as a renowned historical and cultural city and for the preservation and adaptive reuse of architectural heritage structures. Full article

Background and Objectives: Sexual dysfunction (SD) is common in multiple sclerosis (MS) but remains under-recognized in routine care. This study aimed to quantify the burden of SD in men and women with relapsing–remitting MS (RRMS), describe sex-stratified patterns across primary/secondary/tertiary domains, and examine associations with fatigue and MS-related health-related quality of life (HRQoL). Materials and Methods: In this cross-sectional observational study, RRMS participants were voluntarily recruited online via a QR code linking to a Google Forms survey. Men completed the International Index of Erectile Function-5 (IIEF-5), and women the Female Sexual Function Index (FSFI). MS-specific SD domains were assessed using the Multiple Sclerosis Intimacy and Sexuality Questionnaire (MSISQ), alongside the Fatigue Severity Scale (FSS) and the Multiple Sclerosis Quality of Life questionnaire (MSQOL-54). Sex differences were tested using parametric/non-parametric methods as appropriate, with false discovery rate (FDR) and Bonferroni adjustments for multiple comparisons. Results: Thirty-seven participants were included (16 men; 21 women). Mean age did not differ by sex (35.9 ± 4.0 vs. 38.9 ± 10.4 years; p = 0.23). All participants reported at least some degree of difficulty across MSISQ domains. Among men, 87.5% screened positive for erectile dysfunction within this sample (mild 37.5%, mild-to-moderate 12.5%, moderate 12.5%, severe 25.0%). When dysfunction type was defined as the highest MSISQ domain score, secondary SD was most frequent in both sexes (75.0% men; 76.2% women; p = 0.49). Women showed higher secondary domain scores at the uncorrected level (p = 0.04), but this did not survive FDR correction. In HRQoL and symptom measures, women reported markedly higher fatigue (FSS 46.1 ± 12.4 vs. 25.5 ± 12.7; p_FDR < 0.001) and poorer physical health indices, including pain-related outcomes. Conclusions: SD has represented a substantial burden within this RRMS sample, with secondary domain predominance in both sexes, highlighting the clinical relevance of symptom-related and functional interference. These findings support the value of multidimensional sexual health assessment in clinical research settings and may be relevant for clinical assessment and future research in MS. Full article

Cylinder–plate combined structures (CPCS) are widely used in aerospace, marine engineering, and offshore platform systems. During service, they are frequently subjected to stochastic excitations induced by turbulent boundary layers, acoustic loads, hydrodynamic disturbances, and broadband operational vibrations. Excessive random vibration responses may significantly reduce structural reliability, accelerate fatigue damage, and compromise operational safety. To address these engineering challenges, a unified stochastic dynamic analysis and vibration suppression framework is established for functionally graded graphene platelet-reinforced composites (FG-GPLRC) CPCS equipped with distributed dynamic vibration absorbers (DVAs). Adopting the First-order Shear Deformation Theory (FSDT), a comprehensive energy functional for the CPCS is established, in which the penalty method is implemented to impose boundary conditions and ensure interface continuity. Subsequently, the Pseudo-excitation Method (PEM) is utilized to convert the stochastic vibration analysis into an equivalent deterministic harmonic problem, and the governing equations are spatially discretized by combining the spectral geometric method (SGM) with the Ritz variational procedure, enabling efficient evaluation of power spectral density (PSD) and root-mean-square (RMS) responses. The reliability of the proposed model is verified through a series of numerical validation comparisons. On this basis, comprehensive parametric investigations are conducted to assess how material properties, structural geometries, and critical DVA parameters influence system behavior. The results demonstrate that the incorporation of distributed DVAs can achieve superior vibration suppression performance. This study provides an efficient and reliable theoretical framework for stochastic vibration analysis and damping design of advanced composite plate–shell coupled structures operating in complex random environments, offering important theoretical support for dynamic optimization design in aerospace and marine engineering applications. Full article

Background: Chronic obstructive pulmonary disease (COPD) is increasingly recognized as a disorder linked to increased cardiovascular risk, often coexisting with coronary artery disease (CAD), yet angiographic data on coronary involvement in COPD remain limited. This study aimed to evaluate whether COPD is associated with a distinct angiographic pattern of CAD, focusing on vessel distribution. Methods: We retrospectively enrolled 94 patients who underwent coronary angiography between 2023 and 2024 for suspected or known CAD. Clinical data, comorbidities, laboratory testing, pulmonary function, electrocardiography, echocardiography, and angiography were collected. Participants were stratified into two groups: COPD (n = 47) and non-COPD (n = 47). Coronary vessels were classified by number, location, and diameter. The normality of continuous variables was assessed using the Shapiro–Wilk test. Non-normally distributed variables were compared using the Mann–Whitney U test, while Fisher’s exact test was used for categorical comparisons. A multivariable logistic regression model was performed to identify independent predictors of left main coronary artery (LMCA) disease at the patient level. The primary endpoint was the association between COPD and CAD severity. Results: Baseline characteristics, including age, sex, BMI, and smoking history, were comparable between groups. The overall extent of CAD, expressed as the number of diseased vessels, did not differ significantly (p = 0.1436). However, vessel-based analysis revealed a distinct pattern: COPD patients showed a significantly higher prevalence of left main coronary artery (LMCA) disease compared to non-COPD patients (14% vs. 4.7%, p < 0.001). At the patient level, LMCA disease was present in 15/47 (31.9%) COPD patients compared with 6/47 (12.8%) non-COPD patients (p = 0.046). Multivariable logistic regression confirmed that COPD was an independent predictor of LMCA disease (OR = 3.56, 95% CI: 1.12–11.29, p = 0.031) after adjustment for age, sex, smoking, diabetes, and chronic kidney disease. Intermediate-caliber vessels were most frequently affected in both groups, while small-caliber branches were less commonly involved in COPD patients. Conclusions: COPD is an independent predictor of LMCA disease despite a similar overall angiographic extent of CAD. These findings suggest a distinct, high-risk coronary phenotype in COPD and highlight the need for enhanced cardiovascular vigilance and integrated cardiopulmonary management in this population. Full article

High-amylose Lueang Patew Chumphon (LPC) rice, a Thai geographical indication variety, represents an underutilized resource for functional food development. This study investigated sweet fermented LPC rice (SFLPC) compared to conventional sweet fermented glutinous rice (SFGR) through comprehensive microbial, chemical, and nutritional characterization. Starter cakes contained Aspergillus sp., Rhizopus stolonifer, and Pediococcus pentosaceus (>99% similarity by ITS/16S rRNA sequencing and MALDI Biotyper). Both varieties demonstrated comparable fermentation with pH reductions to ~3.5 and lactic acid production (~6 g/L). GC-MS analysis with mass spectral library matching and Linear Retention Index (LRI) comparison tentatively annotated twelve volatile compounds. Absolute peak area analysis revealed distinct variety-specific profiles: SFGR was characterized by significantly higher ethyl palmitate (75.89 ± 19.30 vs. 16.80 ± 7.21 × 10⁶, p = 0.008) and isobutyl alcohol (33.09 ± 3.56 vs. 23.53 ± 1.71 × 10⁶, p = 0.014), exclusive ethyl dodecanoate (44.87 ± 20.60 × 10⁶), and exclusive 2,4-di-tert-butylphenol, while SFLPC showed exclusive ethyl acetate formation. Isoamyl alcohol was the dominant volatile in both varieties, with comparable absolute peak areas (273.91 ± 22.65 vs. 267.54 ± 28.78 × 10⁶, ns). SFLPC demonstrated superior mineral retention (2.1-fold phosphorus, 1.9-fold potassium and magnesium) and enhanced antioxidant capacity (IC₅₀: 3.30 vs. 5.20 μg/mL, representing 36% improvement). Degree of gelatinization analysis validated comparable starch gelatinization (32.5–40.1%) despite different cooking methods, confirming volatile differences arose from rice variety rather than processing. These findings demonstrate high-amylose LPC rice as a promising fermented food substrate offering enhanced nutritional properties and volatile compound profiles through traditional fermentation. Full article

Predation risk influences how animals approach predictable food sources where ambush predators may be present. In parids, chick-a-dee calls are used in a wide variety of contexts related to social cohesion and are well known as mobbing signals. Here, we examined whether they are also produced in the absence of visible predators in contexts in which predation risk may nevertheless be latent or uncertain. We tested whether chick-a-dee calls emitted by Willow Tits (Poecile montanus) during feeder approach exhibit acoustic and recruitment characteristics comparable to mobbing calls elicited by predator models. The study included repeated observations of 44 individuals across 11 flocks, enabling within-individual comparisons across habitat contexts. We analyzed call structure, calling duration, and recruitment latency in relation to habitat visibility and dominance status. Calls produced during the feeder approach showed overlapping structural features with mobbing calls and were associated with the recruitment of flock members, particularly in dense habitat. Mixed-effects models confirmed significant effects of habitat structure, predator presentation, and social rank on calling behavior and recruitment dynamics. These patterns are consistent with mobbing-like signaling under conditions of uncertain predation risk. Because predator presence and detection outcomes were not directly measured, our findings provide behavioral evidence compatible with proactive signaling rather than functional confirmation of predator probing. Full article

Evaluating pedestrian comfort in high-density cities requires methods integrating subjective experience with urban morphology. This study develops an integrated framework combining pairwise comparison scoring, semantic segmentation (DeepLabv3+), ensemble learning (Random Forest), and SHAP-based interpretability. EfficientNet-B7 is used to expand pairwise datasets and derive continuous comfort scores across Macau’s street network. Four experiential street types are identified: historical–cultural districts, urban lifestyle areas, natural corridors, and leisure zones. SHAP analysis illustrates stable associations between predicted comfort scores and multi-layered spatial configurations, including cultural legibility and sequencing in historic cores, moderate greenery with functional anchoring in residential areas, and scene coherence in tourism zones. Semantic features serve as effective morphological proxies within the modeling framework. Methodologically, the framework demonstrates how explainable machine learning can be applied to dense Asian cities under observational conditions. Design implications emphasize interface continuity, microclimate adaptation, and functional enrichment, suggesting that pedestrian comfort is closely related to coherent spatial–experiential structures rather than isolated environmental upgrades. Full article

The recent revision of the European Energy Performance of Buildings Directive (EPBD) introduces mandatory whole-life global warming potential (GWP) reporting, creating practical challenges for building life-cycle assessment due to incomplete life-cycle phase coverage in conventional Environmental Product Declarations (EPDs). This study develops and validates an integrated BIM–LCA framework for structured whole-building GWP evaluation through harmonized life-cycle module alignment and cross-tool comparison, with emphasis on the early design stages. The workflow combines rapid BIM-based screening with detailed external LCA validation, establishing a tiered assessment strategy that enables iterative material optimization within the BIM environment prior to expert review. The methodology is applied to two residential construction systems (masonry and timber), and three functional units are evaluated: total whole-building GWP, area-normalized GWP, and material-level contributions. Five comparative scenarios are analyzed, including reference, nationally representative, optimized low-carbon, and European benchmark configurations. The results show progressive GWP reductions ranging from 5% to 30% across scenarios. Although substantial absolute deviations are observed between BIM-integrated and professional LCA tools, scenario-level rankings remain fully consistent across all functional units, confirming the robustness of the screening approach for comparative decision-making. Cross-tool validation focuses on an aligned embodied-carbon scope (A1–A3 plus selected end-of-life modules) to ensure screening robustness, while full whole-life LC-GWP (including B-modules and services) is positioned as the regulatory context for subsequent expert-stage assessment. The framework provides an efficient and transferable decision-support methodology that supports early-stage carbon optimization while preserving methodological transparency for regulatory reporting. Full article

The distinction between signs and expressions is essential to unlock Deleuze’s interpretation of Spinoza. However, during a lecture delivered on 13 January 1981, Deleuze makes a passing remark that complicates this distinction. For Spinoza, Christ’s religion, like political society, is a systems of signs pertaining to the collective imagination that nevertheless is meant to facilitate the transition towards the domain of expressions, that is, to the domain of reason and philosophy. The aim of this paper is to shed light on this ambiguity between signs and expressions in Deleuze’s work on Spinoza. First, I discuss the scattered passages in Spinoza’s oeuvre dealing with the figure of Christ. I then go on to reconstruct Deleuze’s Spinozistic taxonomy of signs. Third, I reconstruct Deleuze’s comparison between Spinoza and Hobbes regarding the emergence of political society from the state of nature. I then propose a close reading of chapter 7 of the Theological-Political Treatise to argue that Christ’s religion, according to Spinoza, should be seen as fulfilling the function of political society in times of crisis. I end with an extensive analysis of Spinoza’s formula “the Spirit of Christ, that is, the idea of God” in light of Deleuze’s reading of the first half of Ethics V. To conclude, I suggest we look at Christ as the conceptual persona of Spinozism. Full article

The Particle swarm optimization (PSO) algorithm has strong universality and fast convergence speed, but when solving complex multimodal optimization problems, it is prone to fall into local optimum due to insufficient population diversity. To address this issue, this paper proposes a dual-population hybrid particle swarm optimization algorithm based on Hooke’s law competition mechanism (HLCM-DHPSO). This algorithm integrates the differential evolution algorithm into the PSO framework, and the two subpopulation sizes dynamically compete for computing resources according to the adaptive mechanism of Hooke’s law. When the algorithm stagnates, HLCM-DHPSO can automatically trace back to historical archives and adjust the inertia weight based on excellent experience data. Meanwhile, HLCM-DHPSO adaptively adjusts the acceleration coefficient through the Sine function to enhance the algorithm’s ability to escape from local optimum. To verify the effectiveness of the HLCM-DHPSO algorithm, it is compared with eight advanced optimization algorithms on the CEC2017 benchmark test set. The experimental results show that HLCM-DHPSO significantly outperforms the comparison algorithms in terms of solution performance, especially in handling high-dimensional and multi-peak complex functions, demonstrating superior global search and optimization capabilities. Full article

For decades, zirconia- and ceramic-based materials have dominated dental crown fabrication due to their durability and aesthetic appeal. However, a fundamental shift is occurring as polymeric alternatives emerge with notable advantages: better adhesive bonding, versatile aesthetics, lower costs, and a lighter weight. The advances in polymer chemistry and additive manufacturing have significantly impacted prosthodontics, allowing the rapid creation of highly customized, patient-specific restorations with a precision previously impossible (achieved through advanced Computer-Aided Design software and standardized 3D-printing equipment) with traditional methods. This review provides a detailed analysis of 3D-printed polymeric dental crowns from various angles. It explores the materials science behind different polymers, compares manufacturing methods, and evaluates the mechanical performance and biocompatibility. Despite the progress, polymeric materials still fall short of matching the mechanical properties of advanced ceramics, especially in compressive strength and wear resistance. Moreover, there is limited long-term clinical data over five to ten years. The lack of standardized testing protocols complicates cross-study comparisons, and the regulatory pathways for patient-specific 3D-printed devices are still developing, creating uncertainty for manufacturers and clinicians. The future prospective looks promising in many ways such as innovations like four-dimensional printing, where materials respond dynamically to environmental stimuli, which could enable crowns that adapt to changing oral conditions. Nanocomposites with functionalized nanoparticles might enhance mechanical properties while maintaining printability. AI-driven design optimization could automate and improve the crown morphology, occlusal contacts, and fit. Incorporating bioactive materials could turn crowns into active therapeutic devices that promote remineralization and combat bacterial colonization. This review summarizes the current knowledge, highlights the key gaps, and suggests steps toward establishing polymeric 3D-printed crowns as viable long-term alternatives capable of competing with or surpassing traditional ceramic options. Full article

Objective: The optimal surgical approach for 1.0–2.0 cm renal stones in solitary kidney patients remains controversial. This retrospective study compared mini-percutaneous nephrolithotomy (mPCNL) and flexible ureteroscopy (f-URS) outcomes in this vulnerable population. Methods: Between June 2018 and April 2024, 50 patients with solitary kidneys and 1.0–2.0 cm renal stones underwent either mPCNL (n = 26) or f-URS (n = 24). Outcomes included 3-month stone-free rate (SFR), complications (Clavien–Dindo classification), and renal function (serum creatinine, eGFR by CKD-EPI equation) at the baseline, 72 h, and 1 month. Results: Stone-free rates were comparable (mPCNL 96.2% vs. f-URS 91.7%, p = 0.157). The f-URS group demonstrated significantly less hemoglobin decline (2.2 ± 0.9 vs. 5.7 ± 2.4 g/dL, p < 0.001) and shorter hospitalization (4.1 ± 1.1 vs. 7.8 ± 1.6 days, p < 0.001). All Grade II complications (8.3%, requiring transfusion) occurred in the mPCNL group. At 1 month, serum creatinine decreased more with f-URS (15.4 ± 7.96 vs. 8.7 ± 4.23 μmol/L, p < 0.001), with greater eGFR improvement (16.7 ± 4.7 vs. 15.4 ± 5.2 mL/min/1.73 m², p = 0.023). Conclusions: In this retrospective cohort, f-URS achieved comparable stone clearance to mPCNL alongside a superior early safety profile and better short-term renal functional preservation. These preliminary findings suggest that f-URS represents a viable nephron-sparing option for this high-risk population. However, these results are considered hypothesis-generating, and further prospective, long-term studies are required to evaluate the durability of these functional benefits. Full article

The Ritz method is applied to an in-plane vibration analysis to obtain accurate frequencies of isotropic annular plates. The method is formulated in a manner that allows all combinations of free boundary conditions, two types of supported (constraining only either radial or circumferential displacement) boundary conditions, and clamped boundary conditions. Admissible functions for the two displacement components are chosen as products of trigonometric functions in the circumferential coordinate and special algebraic polynomials in the radial coordinate, enabling all possible boundary-condition combinations to be satisfied. In the numerical study, after the solution’s accuracy is verified through convergence and comparison tests, extensive and accurate frequency parameters are presented to cover all combinations of the four in-plane boundary conditions along the outer and inner edges of the annular plates. Full article

The advent of drone technology has led to groundbreaking advancements across various industries, including warehousing operations. In recent years, warehouse drones have garnered significant attention due to their potential to revolutionize traditional inventory management and order fulfillment processes. This paper presents a comprehensive review that synthesizes findings from more than 120 research papers on drone-enabled practices in warehouses. The review systematically considers multiple parameters, including drone function (inventory counting, mapping, surveillance, inspection, and intralogistics support), robot platforms used (UAV, UAV-AGV), deployment architecture (single and multi-drone system), validation approach (real-time and simulation), technology and methodology used (modern electronic devices, AI, and IOT), and environmental context (dynamic and static). Furthermore, the paper explores the diverse applications of warehouse drones in inventory management, maintenance and inspection, picking and packaging, goods transportation, security and surveillance, and warehouse layout optimization. The review highlights that most studies still rely on single-UAV systems tested mainly in simulations, with only a few real-time demonstrations of fully autonomous performance inside real warehouses. Although multi-drone approaches are emerging to improve scalability, they continue to struggle with coordination and safety. Research remains largely focused on static environments, with dynamic warehouse conditions receiving far less attention despite their practical importance. The findings of the review are presented with the tabulated results and a comparative table to provide a better understanding of the review work, which helps to identify the existing literature gap. The review presents its findings through clear tables and comparisons, making it easier to understand existing studies and pinpoint the gaps in the current literature. Full article

Background/Objectives: Attention-Deficit/Hyperactivity Disorder (ADHD) shows substantial cognitive heterogeneity, complicating individualized clinical formulation. This study examined whether Cognitive Disengagement Syndrome (CDS), anxiety, and ADHD symptom severity are associated with memory functions and visuospatial skills in children with ADHD. Methods: The sample included 120 children aged 6–12 years with ADHD (ADHD + CDS: n = 40; ADHD-only: n = 80). Memory was assessed with the Oktem Verbal Memory Processes Test (OVMPT) and Wechsler Memory Scale–Visual Reproduction (WMS–VR), and visuospatial skills with WISC-IV Block Design and Judgment of Line Orientation (JLO). ADHD symptoms were rated using combined parent–teacher Turgay-Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition-Based Disruptive Behavior Disorders Scale (T-DSM-IV-S) scores; CDS symptoms with the Barkley Child Attention Scale; and anxiety with the SCARED-Child Form. Group comparisons, correlation analyses, and multivariable linear regression models were conducted. Results: The ADHD + CDS group performed worse on WISC-IV Block Design than the ADHD-only group (p = 0.005). In the ADHD + CDS group, inattention severity showed a strong negative association with WMS–VR short-term memory (r = −0.560, p < 0.001). In the ADHD-only group, inattention severity was negatively associated with OVMPT Spontaneous Recall (ρ = −0.319, p = 0.004) and JLO total score (ρ = −0.348, p = 0.002). Anxiety severity in the ADHD-only group was positively associated with OVMPT Total Learning (ρ = 0.350, p = 0.001), Highest Learning (ρ = 0.370, p = 0.001), and WMS–VR short-term memory (ρ = 0.304, p = 0.006). In regression analyses, the presence of CDS independently and negatively predicted WMS–VR short-term memory (β = −0.187, p = 0.018) and Block Design performances (β = −0.226, p = 0.016). Inattention symptom severity was also independently and negatively associated with Block Design performance (β = −0.243, p = 0.013). Conclusions: CDS status and symptom dimensions contribute to cognitive variability in pediatric ADHD, with CDS showing independent associations with timed visuospatial construction and short-term visual memory. Inattention severity emerged as a robust dimensional predictor of cognitive inefficiency across domains, supporting the clinical utility of symptom-based cognitive profiling in ADHD diagnostic evaluations. In addition, mild anxiety symptoms demonstrated meaningful associations with some learning and memory performances within the ADHD-only group, indicating that affective factors may modulate cognitive outcomes in ADHD. Taken together, these findings support considering CDS status and symptom dimensions jointly when characterizing cognitive variability in ADHD. Full article