Search Results (1,372)

A 12-year-old neutered male domestic shorthair cat presented with recurrent pleural effusion following repeated thoracentesis. Initial analysis of the pleural effusion did not reveal neoplastic cells. Thoracic imaging demonstrated pleural effusion without identifiable nodular lesions. However, abdominal computed tomography and histopathological examination of an ultrasound-guided percutaneous core liver biopsy identified a large hepatic mass, confirmed to be cholangiocarcinoma, with suspected metastases to the spleen. After exclusion of other potential causes, the effusion was suspected to be a paramalignant pleural effusion. Despite palliative management, the disease progressed, and the cat was euthanized 98 days after definitive diagnosis. Postmortem examination revealed widespread metastatic cholangiocarcinoma involving the lungs, spleen, and intercostal muscles. No gross mass lesions were identified in the pulmonary parenchyma. Histological results demonstrated neoplastic cell infiltration within both the pulmonary lymphatic and blood vessels, a finding consistent with lymphovascular spread, which can contribute to the development of pleural effusion. This case show that while the characteristics of neoplasia-associated pleural fluid may vary according to disease stage, cholangiocarcinoma-associated pleural effusion may occur in the absence of cytologic evidence of malignancy, pulmonary nodules on thoracic imaging, or typical hepatobiliary signs. Full article

Punica granatum L. (pomegranate) is one of the oldest medicinal plants known to humankind, valued across ancient civilisations for treating parasitic, microbial, and metabolic diseases. Its exceptionally rich phytochemical composition, dominated by punicalagins, ellagic acid, anthocyanins, flavonoids, piperidine alkaloids, and the unique conjugated fatty acid punicic acid, confers a remarkably broad spectrum of biological activities of direct relevance to contemporary veterinary medicine. While human-health applications have been extensively reviewed, a comprehensive synthesis of veterinary evidence across multiple species remains lacking. This review consolidates current preclinical and field knowledge on the pharmacological effects of pomegranate preparations in poultry, ruminants, swine, fish, companion animals, and laboratory models. In poultry—the most extensively studied taxon—dietary inclusion of pomegranate peel powder or extract consistently enhances growth performance, antioxidant status, and humoral immunity while exerting meaningful anticoccidial activity. The antiparasitic properties are compellingly supported by evidence against gastrointestinal nematodes of ruminants, tapeworms, schistosomes, and protozoa including Giardia, Cryptosporidium, and Leishmania spp., as well as monogenean fish parasites. Broad-spectrum antimicrobial activity extends to major veterinary pathogens such as Salmonella, Escherichia coli, Staphylococcus aureus (including MRSA), and Clostridium perfringens. Rodent models have validated antidiabetic, hepatoprotective, nephroprotective, and reproductive benefits, including improved post-thaw sperm quality and enhanced litter size. The safety profile is generally favourable at conventional doses, although high dietary inclusion elicits anti-nutritional effects from condensed tannins, and potential drug interactions via cytochrome P450 inhibition warrant clinical caution. Despite this substantial evidence, significant translational barriers persist, including extract heterogeneity, absence of pharmacokinetic data in target species, and scarcity of controlled clinical trials. By providing a species- and pathology-driven synthesis, this review identifies critical research priorities and highlights the immense potential of this ancient, accessible, and economically viable phytobiotic as a natural alternative to antibiotic growth promoters and synthetic antiparasitics in veterinary practice. Full article

Feline kobuvirus (FKoV) has been linked to diarrheal disease in cats and has recently emerged in several Asian countries. This study aimed to investigate the epidemiological and genetic characterization of FKoV in domestic cats in northern Vietnam from 2022 to 2025. In total, 244 fecal samples were obtained from both healthy and sick cats in Hanoi, Hungyen, Bacninh, and Ninhbinh in the north of Vietnam. Of 244 fecal samples examined, eight (3.28%) samples were found to be positive for the FKoV genome by using the conventional PCR method. Viral genomes were identified in both healthy and sick cats. The highest FKoV-positive rate was 12.50% in 6–12-month-old cats, significantly higher than those detected in cats aged 3–6 months and >12 months. Eight positive samples were successfully sequenced and characterized for the partial 3D gene and full-length VP1 genes. Results showed that the level of nucleotide identity of the partial 3D gene and full-length VP1 genes among the FKoV strains in this study ranged from 95.86% to 100% and 94.09% to 99.73%, respectively. Phylogenetic analysis revealed that the eight Vietnamese viral strains obtained in this study formed a novel cluster within FKoV and are genetically related to Chinese FKoV strains. Two positive selections were found in the VP1 protein of the Vietnamese FKoV strains. Full article

Background: Bacteria of the genus Providencia are emerging pathogens associated with a wide range of infections, particularly in healthcare settings. In veterinary medicine, infections caused by these organisms are uncommon, and, to date, there have been no reports of carbapenem-resistant Providencia spp. causing infection in companion animals. Methods and Results: This study describes a comprehensive investigation of bacterial endocarditis caused by carbapenem-resistant Providencia rettgeri in a cat, including clinical, imaging, pathological, microbiological, and genomic findings. A 1.5-year-old mixed-breed female cat was admitted to a referral veterinary hospital with an extensive pelvic limb wound and a recent history of laparotomy. During hospitalization, a heart murmur was detected, and echocardiographic examination revealed vegetation-like lesion on the mitral valve. Despite intensive treatment, the patient’s clinical condition progressively deteriorated over a 15-day period, ultimately leading to euthanasia. Necropsy confirmed bacterial endocarditis with evidence of systemic septic embolization. P. rettgeri was isolated from blood collected from both heart ventricles and from an endocardial swab and its identity was confirmed by MALDI-ToF mass spectrometry. Antimicrobial susceptibility testing demonstrated resistance to meropenem. Whole-genome sequencing confirmed the species identification and revealed a Col3M plasmid carrying multiple antimicrobial resistance genes, including the carbapenemase gene bla_NDM-1. Discussion: To the best of our knowledge, this is the first report of carbapenem-resistant Providencia spp. causing infection in a companion animal. This case highlights the emergence of Providencia spp. as potential veterinary pathogens capable of causing severe, invasive and fatal infections. Full article

Companion animals have increasingly become central to human emotional life, yet the literature linking living with companion animals, human–animal interaction, and mental health remains fragmented. This study mapped global research trends on companion animals and mental health from 2000 to 2024 using bibliographic records retrieved from the Web of Science Core Collection (WoSCC). A final dataset of 930 peer-reviewed articles was analyzed with Bibliometrix (RStudio), CiteSpace, and VOSviewer to characterize publication growth, national and institutional collaboration, influential authors and journals, co-cited references, keyword clusters, and citation bursts. Results show a strong nonlinear increase in output after 2015, with the United States as the dominant contributor and Australia and the WoSCC country node labelled England (distinct from Scotland) as important international bridges. Core knowledge clusters center on human–animal interaction, animal-assisted intervention, older adults, child/adolescent development, loneliness, attachment, and post-traumatic stress. Recent burst terms and references indicate a shift from general companion-animal caregiving and physiological stress buffering toward intervention design, vulnerable populations, and pandemic-era mental health. Overall, the field has matured into an interdisciplinary research area with growing methodological sophistication, but future work should strengthen cross-cultural evidence, longitudinal designs, standardized outcome measures, and explicit assessment of animal welfare. Full article

As urban housing becomes increasingly compact and companion animals become more deeply integrated into domestic life, human–cat cohabitation presents design challenges related to spatial efficiency, furniture wear, maintenance, and everyday coexistence. This study examines shared-interface conflicts in compact apartments and proposes an integrated SOR–Kano–FBS pathway for sustainable human–cat shared furniture design. In-home observations, semi-structured interviews, behavioral path recording, and Kano questionnaires were used to identify high-frequency activity contexts and prioritize user requirements. These requirements were translated through the FBS model into functional objectives, behavioral scripts, and structural strategies. The results indicate that ease of cleaning and maintenance, structural stability and user-perceived safety, and dedicated scratching guidance primarily represent must-be requirements. Movement-path separation, centralized storage, and aesthetic integration function as performance-enhancing requirements, whereas shared yet stratified zoning, elevated observation points, and moderate visual connection improve the cohabitation experience. Two conceptual designs—a human–cat shared living-room sofa system and a foldable work/study system—were developed. Their descriptive comprehensive acceptance indices were 0.802 and 0.794, respectively, while a combined conventional-furniture reference set scored 0.520. Because the reference set represented two conventional activity contexts, these values were used only as diagnostic, user-perception-based evidence and not as inferential proof or a direct ranking between the schemes. The findings suggest that the proposed pathway can support design-level sustainability in compact human–cat cohabitation; however, further validation through physical prototypes, long-term in-home testing, and life-cycle assessment is required. Full article

Microplastics (MPs) are widely distributed among humans and companion animals. Fecal samples from members of the university community at the Pontifical Javeriana University in Bogotá, Colombia, and their companion animals (pets) were analyzed to investigate a possible association between MP loads in humans and their dogs and/or cats. Structures compatible with microplastics were detected in the feces of 97.78% of humans and 100% of companion animals. No significant correlation was found between MP loads in humans and their companion animals (p = 0.6846), suggesting that exposure is not determined solely by the shared household environment. If the home were the dominant and exclusive source of exposure, a positive correlation between owners and their companion animals would be expected. Instead, the results indicate the existence of species-specific exposure routes. This exploratory study provides the first report of MP-like structures in fecal samples from humans and their companion animals in Colombia. Full article

The demand for sustainable protein sources for companion animal nutrition has stimulated interest in insect-derived ingredients. Tenebrio molitor larvae meal is a promising alternative to conventional proteins because of its nutritional composition and functional properties. This study evaluated the nutritional quality, in vitro digestibility, chitin digestibility, and antioxidant properties of T. molitor meal using canine- and feline-adapted in vitro digestion models. Chemical composition, amino acid and fatty acid profiles, total, protein, lipid, and chitin digestibility, antioxidant activity (ABTS), and Folin–Ciocalteu reducing capacity were determined. T. molitor meal contained 44.3% crude protein and 21.0% ether extract, with a balanced amino acid profile and a lipid fraction dominated by oleic and linoleic acids. Compared with the fish meal evaluated in this study, T. molitor showed higher total and lipid digestibility in both models, whereas protein digestibility was higher in dogs and comparable in cats. Chitin accounted for approximately 7.6% of the meal and showed negligible apparent digestibility. Water extracts of T. molitor exhibited greater antioxidant activity and reducing capacity than fish meal. These findings support the potential of T. molitor larvae meal as an alternative protein ingredient for companion animal nutrition, although in vivo studies are needed to confirm these observations. Full article

The African esophageal squamous cell carcinoma (ESCC) corridor extends from Ethiopia to the Eastern Cape and contains some of the highest age-standardized ESCC incidence rates reported anywhere, with five-year survival below 5%. The corridor’s heterogeneous incidence (sex ratios from 1:1 to 7:1; tenfold variation between adjacent populations) has resisted single-factor explanation through more than half a century of investigation. We synthesize the multicenter evidence accumulated since the IARC 2018 Group 2A classification of very hot beverages (>65 °C), with particular attention to the African Esophageal Cancer Consortium (ESCCAPE) outputs and to whole-genome sequencing. We argue, on the convergent evidence of animal toxicology, human in vitro mucosa, and population genomics, that thermal exposure acts as a tumor promoter rather than an initiator. On this reading, the corridor’s heterogeneous burden reflects heterogeneous chemical co-exposure profiles operating against a shared thermal-promoter substrate. Extending the comparative margin-of-exposure (MOE) methodology to esophageal squamous carcinogenesis, we present an MOE framework distinguishing genotoxic compounds (within-mode-of-action additive) from thermal exposure (separate companion figure) and apply it to two corridor scenarios. The framework supports a four-lever prevention strategy combining tobacco control, alcoholic-strength reduction in unrecorded spirits, clean-cookstove deployment, and graduated thermal-exposure reduction. Full article

The pet food industry is undergoing a significant transformation, driven by the growing trend of companion animal humanization and increasing concerns over the environmental sustainability of conventional protein and lipid sources. Consumers now seek diets that not only meet basic nutritional requirements but also offer preventive health benefits. Microalgae, including Arthrospira (Spirulina, a kind of cyanobacterium), Chlorella, Schizochytrium, and Euglena gracilis, have emerged as versatile biological platforms capable of addressing both functional and sustainability challenges. These microorganisms produce high-quality proteins, omega-3 long-chain polyunsaturated fatty acids (particularly docosahexaenoic acid, DHA), natural pigments, and immunomodulatory polysaccharides. This review synthesizes findings from peer-reviewed studies on the application of microalgae in pet nutrition, covering dogs, cats, and aquatic companion animals. We examine how algal ingredients influence gut microbiota, for instance, by enriching beneficial genera such as Turicibacter and Peptococcus, enhance vaccine responses and mucosal immunity, support cognitive function in aging pets, and contribute to weight management. Particular attention is given to Euglena gracilis and its paramylon (β-1,3-glucan), a pathogen-associated molecular pattern that engages the Dectin-1 pathway to train innate immunity and has demonstrated antiviral activity through host defense mechanisms. The review also surveys the patent landscape, highlighting trends in palatability enhancement, hypoallergenic formulations, and novel delivery formats. Key challenges remain, including ingredient standardization, safety validation, palatability optimization, and consumer acceptance. We outline a translational roadmap that prioritizes well-designed clinical trials in target species and processing methods that preserve bioactivity. Collectively, the evidence positions microalgae, and Euglena gracilis in particular, as promising candidates for next-generation functional pet foods that deliver health benefits alongside ecological sustainability. Full article

Glomerulosclerosis is not an independent disease entity but rather a common histopathological endpoint shared by diverse glomerular diseases and chronic kidney disorders. It represents the final common pathway of progressive glomerular injury and is a major determinant of chronic kidney disease (CKD) progression. Accordingly, this review focuses on the shared cellular and molecular mechanisms that drive glomerulosclerosis, together with current diagnostic strategies, mechanism-based therapeutic approaches, and future directions toward precision nephrology. We begin by summarizing the structural and functional features of the glomerulus and outlining the key molecular mechanisms that drive sclerosis, including podocyte loss, mesangial matrix expansion, endothelial dysfunction, inflammation, and fibrosis-related signaling pathways. The clinical and pathological classifications of glomerular diseases associated with glomerulosclerosis—ranging from primary and secondary focal segmental glomerulosclerosis (FSGS) to diabetic, hypertensive, and immune-mediated forms—are discussed in detail. We further review current diagnostic approaches, including renal biopsy patterns, emerging biomarkers, and novel imaging and digital pathology tools that enable earlier and more precise assessment of disease severity. Recent advances in treatment are summarized across conservative, immunologic, and targeted therapeutic categories, with emphasis on SGLT2 inhibitors, endothelin receptor antagonists, immunomodulatory agents, and antifibrotic compounds. Finally, we highlight rapidly evolving therapeutic and technological advances, including podocyte-directed interventions, APOL1-targeted therapies, RNA- and gene-based therapeutics, and artificial intelligence-driven precision nephrology. These emerging approaches are reshaping the management paradigm of glomerular diseases by enabling molecular disease stratification and personalized treatment strategies. Despite substantial progress, significant unmet needs remain, particularly concerning early detection, individualized treatment selection, and the marked heterogeneity of disease mechanisms across patient populations. Overall, this review provides an integrated framework for understanding glomerulosclerosis as a shared pathological endpoint of diverse glomerular diseases and highlights emerging mechanism-based therapeutic strategies that support the transition toward precision nephrology. Full article

Monoclonal antibodies are emerging as advanced therapies in companion-animal medicine, with approved or clinically evaluated applications in canine and feline osteoarthritis pain, canine atopic dermatitis, and selected infectious-disease and oncological settings. This critical narrative review integrates peer-reviewed studies, regulatory records, product information, and publicly available therapeutic-antibody sequence resources to examine target biology, species adaptation, Fc function, developability, and clinical implementation. Anti-NGF and anti-IL-31 products demonstrate the clinical value of long dosing intervals, whereas oncology and infectious-disease programmes remain subject to indication-specific efficacy and safety requirements. Canine and feline IgG subclasses, Fc-receptor and FcRn biology, incomplete feline framework resources, manufacturing economics, and owner-funded care all influence candidate design and deployment. Emerging bispecific antibodies, antibody–drug conjugates, VHHs, mRNA-based approaches, and AI-assisted strategies are most relevant when they address a defined veterinary use case. We propose a translational framework linking target validation, species-adapted engineering, species-matched assays, manufacturability, regulatory evidence, and real-world deployment. Full article

Giardia duodenalis, a member of the genus Giardia, is a common intestinal protozoan parasite in humans and some farm, companion, and wild animals. Due to the uniform morphology of the parasites sampled from a wide range of hosts, the taxonomy of the genus Giardia has been the subject of debate for more than a century. The confusion generated by this controversy, and the technological limitations to carry out the necessary research to clarify the matter, led to an insufficient understanding of the epidemiology of the infection, mainly in aspects related to host specificity and zoonotic transmission. The results of molecular and epidemiological studies conducted over the last four decades, which are reviewed in this paper, allow us to conclude that zoonotic transmission of Giardia duodenalis infection is possible. Concurrently, these findings suggest that most Giardia infections are host-specific, rendering zoonotic transmission relatively uncommon. Nevertheless, from a public health perspective, such transmission remains a critical concern for vulnerable groups, particularly children and immunocompromised individuals. In these populations, even infrequent zoonotic events can lead to severe clinical outcomes, including chronic diarrhea, malabsorption, and failure to thrive. Full article

Animal abuse directly compromises companion-animal welfare, causing pain, injury, neglect, and, in many cases, death. Although veterinary case series and welfare surveys offer clinical perspectives, far less is known about how abuse is documented in criminal-court decisions. This study analyzed 501 publicly available judgments issued under the South Korean Animal Protection Act between 2003 and 2025 to characterize the species involved, the abusive acts described, sentencing outcomes, and the visibility of veterinary information. Dogs were the predominant victims (63.9%), followed by a heterogeneous group of other or unspecified species (22.1%) and cats (14.0%). Blunt-force trauma (beating, kicking, or hitting with objects) was the most common coded act (92.0%), whereas neglect-related death (3.0%), asphyxiation (2.6%), and sharp-force trauma (2.4%) were recorded far less frequently. Most offenders received monetary fines (64.5%), with custodial sentences imposed in 14.1% of cases. Veterinary information was not consistently visible in the public legal record; a minimum of 7 of 501 decisions (1.4%) contained an unambiguous, explicit reference to veterinary involvement, and this floor estimate likely understates the true frequency, because many appellate summaries omitted the factual detail needed to determine whether veterinary records or expert opinions had been presented at earlier stages. The results therefore characterize how prosecuted abuse is represented in publicly accessible court records rather than the full spectrum of animal abuse or the severity of suffering experienced by the animals. When situated within the limited but growing international literature, the South Korean findings resemble other judgment-based datasets in foregrounding overt violence more readily than chronic or diffuse forms of welfare harm. Full article

Toxocara spp. infection is a neglected zoonotic disease associated with exposure to companion animals and contaminated environments. However, information regarding its seroprevalence and associated risk factors among cat owners in Thailand, particularly in remote island communities, remains limited. This cross-sectional study aimed to determine anti-Toxocara spp. IgG seropositivity and identify associated risk factors among cat owners in Koh Yao District, Phang Nga Province, Thailand. A total of 291 cat owners participated in the study. Sociodemographic characteristics, health-related behaviors, serum anti-Toxocara spp. IgG antibodies, and hematological parameters were collected. Univariate and multivariable logistic regression analyses were performed to identify factors associated with seropositivity. The overall prevalence of anti-Toxocara spp. IgG seropositivity was 34.36%. In the univariate analysis, failure to wash hands after cat contact was significantly associated with higher odds of seropositivity (odds ratio [OR] = 1.96, 95% confidence interval [CI]: 1.16–3.33; p = 0.011). This association remained significant in the multivariable logistic regression model. These findings indicate substantial exposure to Toxocara spp. among cat owners in this island community and highlight the importance of personal hygiene, particularly handwashing after cat contact, in reducing exposure to infective Toxocara eggs. Targeted health education programs and preventive interventions should be strengthened to reduce the risk of Toxocara spp. exposure in endemic communities. Full article