Search Results (87)

Background: Sodium–glucose cotransporter 2 (SGLT2) inhibitors have transformed type 2 diabetes mellitus (T2DM) management by promoting glucosuria, lowering glycated hemoglobin (HbA1c), blood pressure, and weight; however, their use is limited by genitourinary infections and ketoacidosis. Phytocannabinoids—bioactive compounds from Cannabis sativa—exhibit multi-target pharmacology, including interactions with cannabinoid receptors, Peroxisome Proliferator-Activated Receptors (PPARs), Transient Receptor Potential (TRP) channels, and potentially SGLT2. Objective: To evaluate the potential of phytocannabinoids as novel modulators of renal glucose reabsorption via SGLT2 and to compare their efficacy, safety, and pharmacological profiles with synthetic SGLT2 inhibitors. Methods: We performed a narrative review encompassing the following: (1) the molecular and physiological roles of SGLT2; (2) chemical classification, natural sources, and pharmacokinetics/pharmacodynamics of major phytocannabinoids (Δ⁹-Tetrahydrocannabinol or Δ⁹-THC, Cannabidiol or CBD, Cannabigerol or CBG, Cannabichromene or CBC, Tetrahydrocannabivarin or THCV, and β-caryophyllene); (3) in silico docking and drug-likeness assessments; (4) in vitro assays of receptor binding, TRP channel modulation, and glucose transport; (5) in vivo rodent models evaluating glycemic control, weight change, and organ protection; (6) pilot clinical studies of THCV and case reports of CBD/BCP; (7) comparative analysis with established synthetic inhibitors. Results: In silico studies identify high-affinity binding of several phytocannabinoids within the SGLT2 substrate pocket. In vitro, CBG and THCV modulate SGLT2-related pathways indirectly via TRP channels and CB receptors; direct IC₅₀ values for SGLT2 remain to be determined. In vivo, THCV and CBD demonstrate glucose-lowering, insulin-sensitizing, weight-reducing, anti-inflammatory, and organ-protective effects. Pilot clinical data (n = 62) show that THCV decreases fasting glucose, enhances β-cell function, and lacks psychoactive side effects. Compared to synthetic inhibitors, phytocannabinoids offer pleiotropic benefits but face challenges of low oral bioavailability, polypharmacology, inter-individual variability, and limited large-scale trials. Discussion: While preclinical and early clinical data highlight phytocannabinoids’ potential in SGLT2 modulation and broader metabolic improvement, their translation is impeded by significant challenges. These include low oral bioavailability, inconsistent pharmacokinetic profiles, and the absence of standardized formulations, necessitating advanced delivery system development. Furthermore, the inherent polypharmacology of these compounds, while beneficial, demands comprehensive safety assessments for potential off-target effects and drug interactions. The scarcity of large-scale, well-controlled clinical trials and the need for clear regulatory frameworks remain critical hurdles. Addressing these aspects is paramount to fully realize the therapeutic utility of phytocannabinoids as a comprehensive approach to T2DM management. Conclusion: Phytocannabinoids represent promising multi-target agents for T2DM through potential SGLT2 modulation and complementary metabolic effects. Future work should focus on pharmacokinetic optimization, precise quantification of SGLT2 inhibition, and robust clinical trials to establish efficacy and safety profiles relative to synthetic inhibitors. Full article

Antarctic navigation encounters substantial challenges due to the dynamic and perilous characteristics of sea ice, which pose threats to vessel safety and operational efficiency. Existing risk assessment methodologies frequently lack real-time adaptability, while strategies for icebreaker convoys remain insufficiently quantified. To address these deficiencies, this study introduces an integrated framework that combines satellite-based sea ice monitoring, operational risk prediction, and icebreaker escort optimization. First, polar research routes and hydrographic conditions are systematically analyzed to enhance navigation planning. Second, a risk assessment system is developed by leveraging satellite-derived sea ice density and thickness data, facilitating a near-real-time hazard assessment (subject to satellite data latency) evaluation with 96.3% accuracy in ice type classification and a 15% improvement in risk prediction precision compared to conventional methods. Finally, kinematic safety criteria for icebreaker-escorted convoys are established, specifying speed-dependent distance thresholds to minimize collision risks, achieving optimal speeds of 1.4–2.3 knots for PC3-class vessels and 10–20% speed improvements for escorted vessels in cleared channels. The findings offer actionable insights into polar route optimization, risk mitigation, and safe ice navigation protocols, thereby directly supporting operational decision making in Antarctic waters. Full article

Ironic remarks are often pronounced with a distinctive intonation. It is not clear whether children rely on acoustic cues to attribute an ironic intent. This question has been only indirectly tackled, with studies that manipulated the intonation with which the final remark is pronounced within an irony comprehension task. We propose a new task that is meant to assess whether children rely on prosody to infer speakers’ sincere or ironic communicative intentions, without requiring meta-linguistic judgments (since pragmatic awareness is challenging for young children). Children listen to evaluative remarks (e.g., “That house is really beautiful”), pronounced with sincere or ironic intonation, and they are asked to identify what the speaker is referring to by selecting one of two pictures depicting an image corresponding to a literal interpretation (a luxury house) and one to its reverse interpretation (a hovel). We tested eighty children aged 3 to 11 years and found a clear developmental trend, with children consistently responding above the chance level from age seven, and there was no correlation with the recognition of emotions transmitted through the vocal channel. Full article

Single image dehazing is a fundamental task in computer vision, aiming to recover a clear scene from a hazy input image. To address the limitations of traditional dehazing algorithms—particularly in global feature association and local detail preservation—this study proposes a novel Transformer-based dehazing model enhanced by an interactive channel attention mechanism. The proposed architecture adopts a U-shaped encoder–decoder framework, incorporating key components such as a feature extraction module and a feature fusion module based on interactive attention. Specifically, the interactive channel attention mechanism facilitates cross-layer feature interaction, enabling the dynamic fusion of global contextual information and local texture details. The network architecture leverages a multi-scale feature pyramid to extract image information across different dimensions, while an improved cross-channel attention weighting mechanism enhances feature representation in regions with varying haze densities. Extensive experiments conducted on both synthetic and real-world datasets—including the RESIDE benchmark—demonstrate the superior performance of the proposed method. Quantitatively, it achieves PSNR gains of 0.53 dB for indoor scenes and 1.64 dB for outdoor scenes, alongside SSIM improvements of 1.4% and 1.7%, respectively, compared with the second-best performing method. Qualitative assessments further confirm that the proposed model excels in restoring fine structural details in dense haze regions while maintaining high color fidelity. These results validate the effectiveness of the proposed approach in enhancing both perceptual quality and quantitative accuracy in image dehazing tasks. Full article

This paper presents a new high-speed RGB image transmission system over Free-Space Optics (FSO) channel employing Optical Code Division Multiple Access (OCDMA) with Permutation Vector (PV) codes. Four RGB images are transmitted simultaneously at 10 Gbps per image, achieving a total capacity of 40 Gbps. The system’s performance is evaluated under various atmospheric conditions, including three fog levels and real-world visibility data from Alexandria city, Egypt. Image Quality Assessment (IQA) metrics, including Signal-to-Noise Ratio (SNR), Root Mean Square Error (RMSE), Peak Signal-to-Noise Ratio (PSNR), correlation coefficients, and Structural Similarity Index Measure (SSIM), are evaluated for both unfiltered and median-filtered images. The results show significant degradation in image quality due to transmission distance and atmospheric attenuation. In Alexandria’s clear atmospheric conditions, the system achieves a maximum transmission range of 15 km with acceptable visual quality, while the range is reduced to 2.6 km, 1.6 km, and 1 km for Low Fog (LF), Medium Fog (MF), and Heavy Fog (HF), respectively. At these distances, the RGB images achieve minimum SNR, RMSE, and SSIM values of 7.27 dB, 47.66, and 0.20, respectively, with further improvements when applying median filtering. Full article

Middle rock pillars (MRPs) play a crucial role in the stability of bifurcated small clear-distance tunnels. Assessing the stability of the MRP is a key challenge in design and construction. This study focuses on the bifurcated small clear-distance section of the Xiamen Haicang Shugang evacuation channel underground interchange tunnels. The stability criteria for the MRP during both the early design and later construction stages were analyzed by using the strength reduction method (SRM) via numerical simulations. In the design stage, the SRM was applied to determine the stability limit state of the MRP. Relationships between rock mass density, cohesion, and elastic modulus were identified, and these parameters were combined with basic cohesion values for an initial stability assessment. During the construction stage, the full excavation process was analyzed by examining the distribution and changes in the plastic zone of the rock mass. Two key construction stages, a 10 m excavation on the main line upper step and a 10 m excavation on the ramp upper step, were identified as points where the plastic zone of the MRP began to form on the sidewall and the center, respectively. Multiple linear regression was used to determine the displacement, stress, and plasticity criteria for MRP stability. A comprehensive criteria formula incorporating the width–span ratio, tunnel vault settlement, and horizontal clearance convergence was developed, providing technical guidance and a scientific basis for similar projects. Full article

Peripheral nerve injuries are a significant concern in surgical procedures, often leading to chronic pain and functional impairment. Despite advancements in imaging, preoperative and intraoperative visualization of peripheral nerves remains a challenge. This study introduces and evaluates a novel tri-iodinated lidocaine-based contrast agent for computed tomography neurography, aiming to enhance the intraoperative visibility of peripheral nerves in vivo. A tri-iodinated lidocaine analogue was synthesized and characterized for its radiodensity, sodium channel binding and nerve affinity. Sodium channel affinity was performed using molecular docking. In vitro contrast enhancement was assessed by comparing the agent’s Hounsfield unit (HU) values with those of Omnipaque, a clinically approved contrast medium. In vivo imaging was conducted on rat sciatic nerves using micro-CT, followed by ex vivo validation. Nerve conduction blockade was assessed via electrical stimulation and histological analysis was performed to evaluate neurotoxicity. Experimental results revealed the tri-iodinated lidocaine analogue to have similar or higher affinity toward voltage-gated sodium channels than the parent lidocaine and a radiodensity comparable to the commercial CT contrast agent Omnipaque in vitro. In vivo, the contrast agent provided CT visualization of the sciatic nerve, with a significant increase in HU values compared to untreated nerves. Electrical stimulation confirmed transient nerve conduction blockade without observable histological damage, supporting its dual role as an imaging and nerve-blocking agent. This study presents a novel tri-iodinated lidocaine-based contrast agent that enables clear CT visualization of peripheral nerves while maintaining reversible nerve inhibition. These findings support its potential application in preoperative planning and intraoperative nerve protection to reduce surgical nerve injuries. Further studies are warranted to optimize imaging conditions and evaluate its clinical feasibility. Full article

The rapid growth of the Internet of Things (IoT) has significantly expanded the deployment of resource-constrained devices, introducing new security and privacy challenges. To address these concerns, the National Institute of Standards and Technology (NIST) concluded a multi-year effort by announcing ASCON as the new lightweight cryptography standard in 2023. ASCON’s cipher suite includes both Authenticated Encryption with Associated Data (AEAD) and hashing functions, ensuring authenticity, confidentiality, and broad applicability. Since its standardization, there has been a significant research effort focused on enhancing ASCON’s performance under diverse application constraints as well as assessing its vulnerability to advanced side-channel attacks. This study offers a comprehensive overview of current ASCON hardware implementations on FPGA and ASIC platforms, examining key design trade-offs. Additionally, it examines the latest side-channel attacks on ASCON were examined. These attacks exploited weaknesses in the hardware implementations rather than in the algorithm itself. Being highly efficient, they could breach both unprotected and protected implementations. This survey also reviews the proposed countermeasures against these powerful attacks and analyzes how their associated overhead conflicts with the performance demands of real-world ASCON applications. The synthesis of these findings offers clear guidelines for designers seeking to implement ASCON. At the same time, areas requiring further investigation are identified. As ASCON sees ever more widespread deployment, this review serves as a reference for understanding the current state of research and guiding future developments toward efficient and secure implementations. Full article

Alveolar active sodium transport is essential for clearing edema from airspaces, in a process known as alveolar fluid clearance (AFC). Although it has been reported that atrial natriuretic peptide (ANP) attenuates AFC, little is known about the underlying molecular effects of natriuretic peptides (NPs). Therefore, we examined the contribution of NPs to AFC and their effects as mediators of active sodium transport. By using the isolated liquid-filled lungs model, we investigated the effects of NPs on AFC. The expression of NPs, Na⁺, K⁺-ATPase, and Na⁺ channels was assessed in alveolar epithelial cells. Congestive heart failure (CHF) was induced by using the aortocaval fistula model. ANP and brain NP (BNP) significantly reduced AFC rate from 0.49 ± 0.02 mL/h in sham rats to 0.26 ± 0.013 and 0.19 ± 0.005 in ANP and BNP-treated groups, respectively. These effects were mediated by downregulating the active Na⁺ transport components in the alveolar epithelium while enhancing the ubiquitination and degradation of αENaC in the lungs, as reflected by increased levels of Nedd4-2. In addition, AFC was reduced in compensated CHF rats treated with ANP, while in decompensated CHF, ANP partially restored AFC. In conclusion, NPs regulate AFC in health and CHF. This research could help optimize pharmacological treatments for severe CHF. Full article

In light of global climate change and sustainable agricultural growth, it is critical to look at producers’ green production methods. Enhancing the quality of agricultural goods and reducing agricultural pollution are the main goals of future agricultural growth, and this is accomplished by farmers using green production methods. Regarding the research data of 364 vegetable farmers, this study uses structural equation modeling and a mediation effect model to empirically assess the effect of livelihood capital and farmers’ cognition on their green behavior. The results show that (1) natural capital, human capital, financial capital, and social capital in the livelihood capital of vegetable growers may significantly impact producers’ green production behavior. It is not immediately clear how physical capital affects the way green manufacturing practices work. (2) Natural capital and green production behavior are completely mediated by environmental and policy cognition, while human capital and green production behavior are partly mediated by environmental and policy cognition. Human and natural capital indirectly influence farmers’ sustainable production techniques via these activities. Financial and social capital directly influence farmers’ sustainable production methods, with no mediation effect seen. (3) Farmers’ green production behavior is more significantly influenced by their cognitive behavior than by their livelihood capital. Accordingly, it is recommended that environmental education and policy promotion be strengthened, that farmers’ livelihood capital be accumulated via a variety of channels, that farmers’ subsidies for green production be increased, and that farmers’ knowledge of green production be improved. The cognitive level of farmers should also be raised. In addition to providing theoretical justification for analyzing farmers’ green production practices within the framework of sustainable agricultural development, this study also acts as a guide for pertinent government agencies to help farmers choose more ecologically friendly farming methods. Full article

To address the severe spectrum shortage in mobile networks, the 3rd Generation Partnership Project (3GPP) standardized Long Term Evolution (LTE)-License Assisted Access (LAA) technology. The LTE-LAA system ensures efficient coexistence with other existing unlicensed systems by incorporating listen-before-talk functionality and conducting random backoff operations similar to those in the IEEE 802.11 distributed coordination function. In this paper, we propose an analytical model to calculate the throughput of each system in a scenario where a single LTE-LAA system shares an unlicensed channel with multiple wireless local area network (WLAN) systems. The LTE-LAA system is utilized for supplementary downlink transmission from the LTE-LAA eNodeB (eNB) to LTE-LAA devices. Our proposed analytical model uses a Markov chain to represent the random backoff operations of the LTE-LAA eNB and WLAN nodes under non-saturated traffic conditions and to calculate the impact of the clear channel assessment (CCA) performed by the LTE-LAA eNB. Through numerical results, we demonstrate how the throughput of both the LTE-LAA and WLAN systems is determined by the contention window size and CCA threshold of the LTE-LAA eNB. Full article

To support the coexistence of long-term evolution (LTE)-license-assisted access (LAA) and wireless local area network (WLAN) in unlicensed bands, the load-based listen-before-talk (LB-LBT) scheme has been developed, incorporating channel sensing and backoff functions similar to those used in WLAN. In the LB-LBT scheme, the contention window size and clear channel assessment (CCA) threshold of the LTE-LAA eNodeB (eNB) significantly influences its transmission probability and the interference caused by concurrent WLAN transmissions outside the CCA range. However, most existing LB-LBT schemes use fixed contention window sizes and CCA thresholds, irrespective of the channel congestion status. To address this limitation, in this paper, we propose a channel measurement-based LBT (CM-LBT) scheme to enhance overall system throughput while ensuring fairness between LTE-LAA and WLAN systems. Our proposed CM-LBT scheme adaptively adjusts the contention window size and CCA threshold of LTE-LAA eNB in the LB-LBT scheme, according to the current channel access activities of LTE-LAA and WLAN systems. Through simulations, we evaluate the performance of our proposed CM-LBT scheme against existing LBT schemes by assessing the throughput of LTE-LAA and WLAN systems, as well as the fairness between them, using a reward function. Full article

Government plans are crucial for strengthening democratic regimes by defining clear policies and priorities, and by serving as essential channels of communication with voters and social groups within electoral systems. The political commitment to align these plans with the United Nations Sustainable Development Goals (SDGs) of the 2030 Agenda reflects an effort to integrate global priorities into local agendas. Such alignment is critical for fostering sustainable and inclusive progress. However, despite its importance, research on the intersection between government plans and the SDGs remains limited. In this study, we used natural language processing (NLP), artificial intelligence, and statistical analysis to examine the government plans of ten candidates in the 2022 gubernatorial election in the Brazilian state of São Paulo. Our analysis identified key policy topics, explored patterns and trends, and assessed alignment with the 17 SDGs across the social (SDGs 1, 2, 3, 4, 5, 10, and 16), environmental (SDGs 6, 13, 14, and 15), and economic (SDGs 7, 8, 9, 11, and 12) dimensions. The findings emphasize the need for government plans that are more closely aligned with sustainable development goals and that demonstrate a strong political commitment to addressing critical issues, particularly the impacts of climate change. This is especially urgent for the state of São Paulo, which faces significant challenges, including natural disasters, heat waves, flooding, water scarcity, and infrastructure deficiencies. Full article

Although the etiological relevance of the detection of microsporidia in human stool samples remains uncertain, the immunological status of patients has been posited as an important determinant of potential clinical impact of these parasites. To further assess the interplay between the epidemiology of microsporidia and immunological markers, we conducted a study utilizing real-time PCR targeting Enterocytozoon bieneusi, Encephalitozoon cuniculi, Encephalitozoon hellem, and Encephalitozoon intestinalis, combined in a single fluorescence channel. The study involved a cohort of 595 clinically and immunologically well-characterized Ghanaian HIV patients, alongside 82 HIV-negative control individuals from Ghana. While microsporidial DNA was absent in HIV-negative controls, among people living with HIV, its prevalence was inversely correlated with CD4+ lymphocyte counts: 6.0% in those with >500 cells/µL, 9.5% in those with 200–499 cells/µL, 13.8% in those with 50–199 cells/µL, and 27.5% in those with <50 cells/µL, respectively. Correspondingly, microsporidia were more frequently detected in HIV patients who were not receiving antiretroviral therapy. There were no associations with clinical symptoms including gastroenteritis with the exception of a non-significant trend towards weight loss. HLA-DR+CD38+ on CD4+ T lymphocytes, a marker of immune activation, as well as Ki67, a marker of cell proliferation, were increased on CD4+ T lymphocytes in HIV patients with microsporidia, suggesting an immune response may be triggered. In conclusion, our assessment indicates a higher prevalence of microsporidia in the stool of Ghanaian HIV patients, which varies with their immunological status. However, given the lack of clear associations with clinical symptoms, the detection of microsporidia in the stool of HIV patients needs to be cautiously interpreted in clinical settings. Full article

Improving productivity is an important channel for satisfying household food needs through food availability. Increasing the productivity of small-scale farmers is linked to a number of factors, including land access, labor, chemicals, fertilizers and so on. Most farmers resort to expanding their cultivated areas to increase production because of insufficient financial resources available for purchasing inputs during agricultural seasons. This situation, combined with increasing pressure on land, does not favor agricultural production and, by extension, food security. This study therefore assesses the impact of different modes of access to land on agricultural productivity. Regime-switching multinomial regression techniques were used to account for endogeneity bias due to observed and unobserved factors. The results of the study show that access through free loans, tenancy and sharecropping negatively affect agricultural yields. The counterfactual analysis reveals a positive gain estimated at 509.9 kg/ha from land access by landowners. If the lenders were landowners, their gain would be 396.6 kg/ha, whereas the farmers would gain 485.1 kg/ha if they were landowners, and similarly the sharecroppers would gain 389.8 kg/ha if they were landowners. It is clear from these results that improving agricultural yields depends on securing land and requires the establishment of an effective land ownership system. This research impacts land ownership policies, which need to be revised to address customary rights and reduce inequalities in access to secure land. It highlights the way land tenure security drives agricultural advancements and offers actionable recommendations for policy improvements on food security. Full article