Search Results (28)

The Modular Multilevel Converter (MMC) has gained significant popularity over the past decade due to its versatility. The MMC features have been leveraged in numerous fields, including high-voltage DC transmission, electric vehicle power trains, motor drives, and wind energy conversion. In controlling the MMC, the circulating current (i.e., the current flowing through both the upper and lower converter arms without delivering power to the load) has consistently been the most critical variable. In early applications, it was perceived as a source of losses, but more recently, it has become evident that injecting a specific current could reduce voltage and energy ripples. This paper presents a theoretical framework, based on time-scale analysis, useful for modeling and controlling MMCs. The new approach is adopted for generating the circulating current reference, which is expressed as a linear combination of orthogonal functions. The goals are to decouple the control of the voltages of the upper and lower converter arms and manage additional harmonic components of the circulating current for voltage ripple reduction on module capacitors. The simulations and experimental results demonstrate the effectiveness of the proposed control strategy. Full article

Under overmodulation conditions, the capacitor voltages of half-bridge and full-bridge submodules in hybrid modular multilevel converters (MMCs) may become unbalanced. This imbalance not only gives rise to overvoltage stress on submodule capacitors, jeopardizing equipment safety, but also degrades power quality and may even trigger operational instability. To address this issue, this paper proposes a minimum second harmonic circulating current injection method based on Bayesian Adaptive Direct Search (BADS) within the overall framework of model predictive control for MMCs. The method efficiently solves complex objective functions by alternately performing local Bayesian optimization and global grid search. Optimal second harmonic injection values under different modulation indices are obtained through offline computation and curve fitting. This approach achieves dynamic capacitor voltage balancing across a wide modulation range while minimizing operational losses caused by harmonic currents. Full article

Modular multilevel converter (MMC)-based power electronic transformers (PETs) present a promising solution for connecting AC/DC microgrids to facilitate renewable energy access. However, the capacitor ripple voltage in MMC-based PET submodules hinders volume optimization and power density enhancement, significantly limiting their application in distribution networks. To address this issue, this study introduces an optimized method for suppressing the submodule capacitor ripple voltage in MMC-based PET systems under normal and grid fault conditions. First, an MMC–PET topology featuring upper and lower arm coupling is proposed. Subsequently, a double-frequency circulating current injection strategy is incorporated on the MMC side to eliminate the double-frequency ripple voltage of the submodule capacitor. Furthermore, a phase-shifting control strategy is applied in the isolation stage of the dual-active bridge (DAB) to transfer the submodule capacitor selective ripple voltages to the isolation stage coupling link, effectively eliminating the fundamental frequency ripple voltage. The optimized approach successfully suppresses capacitor ripples without increasing current stress on the isolated-stage DAB switches, even under grid fault conditions, which are not addressed by existing ripple suppression methods, thereby reducing device size and cost while ensuring reliable operation. Specifically, the peak-to-peak submodule capacitor ripple voltage is reduced from 232 V to 10 V, and the peak current of the isolation-stage secondary-side switch is limited to ±90 A. The second harmonic ripple voltage on the LVDC bus can be decreased from ±5 V to ±1 V with the proposed method under the asymmetric grid voltage condition. Subsequently, a system simulation model is developed in MATLAB/Simulink. The simulation results validated the accuracy of the theoretical analysis and demonstrated the effectiveness of the proposed method. Full article

Wide bandgap (WBG) power semiconductor devices are increasingly replacing silicon IGBTs in high-power and high-voltage power electronics applications. However, there is a significant gap in the literature regarding efficient testing methodologies for high-power and high-voltage converters under constrained laboratory resources. This paper addresses this gap by presenting comprehensive, hardware-focused testing methodologies for high-power and high-voltage WBG power semiconductor-based converter bring-up before the control validation phase steps in. The proposed methods enable thorough evaluation and validation of converter hardware, including device switching characteristics, driving circuit functionality, thermal management performance, insulation integrity, and sustained operation at full power. We utilized the double pulse test (DPT) to characterize switching performance in a two-level phase leg configuration, extract circuit parasitics, and validate magnetic components. The DPT was further applied to optimize gate driving circuits, validate overcurrent protection mechanisms, and measure device on-resistance. Additionally, a multicycle test was introduced to rapidly assess steady-state converter performance and estimate efficiency. Recognizing the critical role of thermal management in high-power converters, our methodologies extend to the experimental extraction of key thermal parameters—such as junction-to-ambient thermal resistance and thermal capacitance—via a heat loss injection method. A correlation method between temperature sensor measurements and junction temperature is presented to enhance the accuracy of device temperature monitoring during tests. To ensure reliability and safety, dielectric withstand tests and partial discharge measurements were conducted at both component and converter levels under conventional 60 Hz sinusoidal and high-frequency PWM waveforms. Finally, we highlight the importance of testing converters under full voltage, current, and thermal conditions through power circulating tests with minimal power consumption, applicable to both non-isolated and isolated high-power converters. Practical examples are provided to demonstrate the effectiveness and applicability of these hardware testing methodologies. Full article

Grid voltage imbalance conditions often occur. Modular multilevel rectifiers (MMCs) have high DC-link voltage fluctuation under an unbalanced grid, which affects the normal operation of DC-side equipment. To suppress voltage fluctuation under an unbalanced grid, a coupling injection strategy composed of third zero-sequence common-mode voltage (TZCV) and secondary circulating current (SCC) was designed in this paper. In this paper, we calculated the coupling time-domain expression of the TZCV and SCC under an unbalanced grid voltage. Then, the influence of an SCC and TZCV coupling injection on DC-link voltage fluctuation was analyzed. The converter power flow of different system control objectives under an unbalanced grid was calculated, and the overall control method of the converter based on the arm current was proposed. The advantage of the method proposed in this paper is that it can realize online control under different grid voltages and input power conditions in real time and effectively suppress DC-link voltage fluctuation. The simulation was carried out on the MATLAB/Simulink platform, and a hardware-in-the-loop experimental platform was built; the results verify the effectiveness of the proposed strategy. Full article

SARS-CoV-2 infection was shown to induce proprotein convertase subtilisin/kexin type 9 (PCSK9) plasma levels in sepsis. Here, we investigate the association between serum PCSK9 levels and disease severity. PCSK9 was measured in serum of 55 controls, 40 patients with moderate and 60 patients with severe COVID-19 disease. Serum PCSK9 was elevated in moderate COVID-19 compared to controls and further increased in severe cases. PCSK9 levels were not associated with C-reactive protein, bacterial superinfections, interventions, or survival in patients with severe COVID-19. PCSK9 regulates circulating cholesterol levels, and 15 cholesteryl ester (CE) species and free cholesterol (FC) were quantified by direct flow injection analysis using a high-resolution hybrid quadrupole-Orbitrap mass spectrometer. Most CE species with shorter fatty acid chains were decreased in severe compared to moderate COVID-19, and none of the CE species were correlated with PCSK9 in patients with severe COVID-19. Levels of all CE species negatively correlated with C-reactive protein in severe COVID-19 patients. Notably, FC was induced in severe compared to moderate COVID-19. The FC/CE ratio correlated positively with inflammatory markers and was associated with non-survival. The current study suggests that the imbalance between CE and FC levels is associated with disease severity and mortality in patients with COVID-19. Full article

This study proposes an adaptive high-frequency injection method (AHFI) aimed at mitigating common-mode voltage (CMV) on the AC side and alleviating current stress on power semiconductor devices within each arm of a medium-voltage motor propulsion system designed for modular multilevel converters. By adjusting the quantity of high-frequency components injected into each arm according to the fluctuation coefficient, the amplitude of injected high-frequency CMV and circulating currents can be reduced across medium to rated motor speeds. This approach enhances the start-up performance of medium-voltage motor drives while diminishing CMV effects on the motor side, resulting in decreased total harmonic distortion (THD) in the three-phase output waveforms. Furthermore, the effectiveness of the proposed AHFI method in SM voltage regulation and circulating current control under low-frequency operation is thoroughly analyzed. The validity of this method is established through comprehensive mathematical scrutiny and time–domain simulations performed using MATLAB/SIMULINK software (MATLAB version R2021b), along with real-time simulations conducted employing the real-time simulator OPAL/RT via hardware-in-the-loop simulation (HILS). Full article

Circulation of salty and fresh water through the electrodes of a deionization cell produces a voltage between the electrodes caused by the Capacitive Donnan Potential (CDP). The voltage so generated is very low (100 mV), but this work demonstrates that it is possible to develop a power converter suitable to inject this energy into the grid or into energy storage systems; this is a relevant aspect of this paper, for most works in the literature simply dissipate this energy over a resistor. To increase the input voltage, a stack of electrodes is connected in series. A bridgeless rectifier that uses a dual buck–boost converter to operate with both the positive and negative cycles is used to extract the energy from the cell. The topology chosen, which is operated as a current source, can work at extremely low voltage levels and provide power factor correction. After this stage, an H-bridge inverter can be included to inject the energy into the AC grid. The whole system implements a hysteresis control system using the current through the inductor of the power converter as control variable. This paper investigates the influence of such current on the efficiency of the total system. Full article

Wet age-related macular degeneration (AMD) is an end-stage event in a complex pathogenesis of macular degeneration, involving the abnormal growth of blood vessels at the retinal pigment epithelium driven by vascular endothelial growth factor (VEGF). Current therapies seek to interrupt VEGF signaling to halt the progress of neovascularization, but a significant patient population is not responsive. New treatment modalities such as integrin-binding peptides (risuteganib/Luminate/ALG-1001) are being explored to address this clinical need but these treatments necessitate the use of intravitreal injections (IVT), which carries risks of complications and restricts its availability in less-developed countries. Successful systemic delivery of peptide-based therapeutics must overcome obstacles such as degradation by proteinases in circulation and off-target binding. In this work, we present a novel dendrimer-integrin-binding peptide (D-ALG) synthesized with a noncleavable, “clickable” linker. In vitro, D-ALG protected the peptide payload from enzymatic degradation for up to 1.5 h (~90% of the compound remained intact) in a high concentration of proteinase (2 mg/mL) whereas ~90% of free ALG-1001 was degraded in the same period. Further, dendrimer conjugation preserved the antiangiogenic activity of ALG-1001 in vitro with significant reductions in endothelial vessel network formation compared to untreated controls. In vivo, direct intravitreal injections of ALG-1001 and D-ALG produced reductions in the CNV lesion area but in systemically dosed animals, only D-ALG produced significant reductions of CNV lesion area at 14 days. Imaging data suggested that the difference in efficacy may be due to more D-ALG remaining in the target area than ALG-1001 after administration. The results presented here offer a clinically relevant route for peptide therapeutics by addressing the major obstacles that these therapies face in delivery. Full article

Nowadays, high-speed permanent magnet synchronous machines (HSPMSMs) are widely used in high-speed direct-drive applications. Moreover, modular multilevel converters (MMCs) have attracted a lot of attention. In this paper, the mathematical model of the MMC for the HSPMSM was built on high- and low-speed regions, respectively, and the control of each model is completely decoupled. Moreover, energy balance control schemes based on the common mode current injection of the MMC with HSPMSM drive applications have been proposed for high- and low-speed cases, respectively. Based on this model, the controller is proposed for high- and low-speed cases, respectively. Simulation and experiment results indicate that the proposed energy balance control method for an MMC in the high-speed PMSM drive application exhibits significant performance, which can ensure the energy balance of the MMC and eliminate the circulating current of the MMC directly. Full article

Conventional circulating current (CC) control schemes of the modular multilevel converters (MMC) typically suppress the CC to zero to reduce the system loss. However, the non-zero CC can also bring additional benefits. In this paper, a peak arm current minimization method of the MMC using multiple circulating current injection control (MCCIC) is studied. Specifically, the second-order CC (SOCC) and the fourth-order CC (FOCC) are used to achieve this purpose. Firstly, the amplitude and phase angle of the SOCC are determined to shape the arm current into a saddle wave. Next, the amplitude and the phase angle of the FOCC are studied to further cut flat the crest of the saddle wave to minimize the peak arm current. The feasibility boundary for the proposed strategy is discussed quantitatively. Moreover, a decoupling circulating current control strategy is developed for precise control of the SOCC and FOCC. In the end, the proposed techniques are verified via both PSCAD/EMTDC simulation and RTLAB&RTU-BOX hardware-in-the-loop experiment. The results show that the peak arm current of the MMC operating with high power factors can be reduced by about 23% and its power handling capacity can be increased by about 30%. Full article

This paper proposes a decoupled control of a dc-dc modular multilevel converter (MMC) based on a double-T topology intended for multi-terminal high voltage direct current (MT-HVdc) transmission systems or emerging distribution systems operating in medium voltage direct current (MVdc). The aim of the proposed control strategy is to obtain an input current with reduced harmonic content and to eliminate the output ac common-mode voltage, which is not allowed in MT-HVdc systems. The control strategy consists of injecting two circulating ac currents and two dc currents that allow the energy balance between the arms of the converter and the general energy balance of the topology. The dc and ac currents are decoupled and allow control over load variations and reference changes in the dc-links. The proposed topology is mathematically modeled and the control method is then derived. Simulation results are presented to validate the proposed system. Full article

Modular multilevel converter (MMC) is a key device of high-voltage-direct circuit (HVDC) transmission system, the sub-module detection technology of which will directly influence the damage severity, and even the reliability of the whole system. In this paper, the open-circuit fault characteristics of an insulated gate bipolar transistor (IGBT) in a sub-module are analyzed, and a fault-tolerant optimal control strategy is proposed for the redundant hot-reserved MMC based on nearest-level modulation (NLM). A fault sub-module diagnosis and location strategy based on the deviation distance of the capacitor voltages is presented. After the faulty sub-module is removed, due to the asymmetric operation of the MMC, odd-order circulating currents are introduced in the faulty phase, in which the fundamental-frequency circulating current is the major component; the fundamental-frequency voltage related to the redundancy rate is injected into the faulty phase, which effectively suppresses the fundamental-frequency circulating current and harmonics in the faulty phase. The proposed method combines fault detection and fault ride-through steps, so it has the features of high reliability and high compatibility. Based on the Matlab/Simulink simulation model, the effectiveness of the proposed strategy is verified. Full article

Breast cancer is the most diagnosed type of cancer, with 2.26 million cases and 685,000 deaths recorded in 2020. If left untreated, this deadly disease can metastasize to distant organs, which is the reason behind its incurability and related deaths. Currently, conventional therapies are used to treat breast cancer, but they have numerous shortcomings such as low bioavailability, short circulation time, and off-target toxicity. To address these challenges, nanomedicines are preferred and are being extensively investigated for breast cancer treatment. Nanomedicines are novel drug delivery systems that can improve drug stability, aqueous solubility, blood circulation time, controlled release, and targeted delivery at the tumoral site and enhance therapeutic safety and effectiveness. Nanoparticles (NPs) can be administered through different routes. Although the injectable route is less preferred than the oral route for drug administration, it has its advantages: it helps tailor drugs with targeted moiety, boosts payload, avoids first-pass metabolism, and improves the pharmacokinetic parameters of the active pharmaceutical ingredients. Targeted delivery of nanomedicine, closer to organelles such as the mitochondria and nuclei in breast cancer, reduces the dosage requirements and the toxic effects of chemotherapeutics. This review aims to provide the current status of the recent advances in various injectable nanomedicines for targeted treatment of breast cancer. Full article

Periprosthetic joint infection (PJI) is a major adverse event of primary total knee arthroplasty (TKA) from the patient’s perspective, and it is also costly for health care systems. In 2010, the reported incidence of PJI in the first 2 years after TKA was 1.55%, with an incidence of 0.46% between the second and tenth year. In 2022, it has been published that 1.41% of individuals require revision TKA for PJI. The following risk factors have been related to an increased risk of PJI: male sex, younger age, type II diabetes, obesity class II, hypertension, hypoalbuminemia, preoperative nutritional status as indicated by prognostic nutritional index (PNI) and body mass index, rheumatoid arthritis, post-traumatic osteoarthritis, intra-articular injections prior to TKA, previous multi-ligament knee surgery, previous steroid therapy, current tobacco use, procedure type (bilateral), length of stay over 35 days, patellar resurfacing, prolonged operative time, use of blood transfusions, higher glucose variability in the postoperative phase, and discharge to convalescent care. Other reported independent risk factors for PJI (in diminishing order of importance) are congestive heart failure, chronic pulmonary illness, preoperative anemia, depression, renal illness, pulmonary circulation disorders, psychoses, metastatic tumor, peripheral vascular illness, and valvular illness. Preoperative intravenous tranexamic acid has been reported to diminish the risk of delayed PJI. Knowing the risk factors for PJI after TKA, especially those that are avoidable or controllable, is critical to minimizing (ideally preventing) this complication. These risk factors are outlined in this article. Full article