Skip Content
You are currently on the new version of our website. Access the old version .

67 Results Found

  • Review
  • Open Access
7 Citations
3,489 Views
22 Pages

Percutaneous Coronary Intervention for Chronic Total Occlusion—Contemporary Approach and Future Directions

  • Emil Julian Dąbrowski,
  • Michał Święczkowski,
  • Joanna Maria Dudzik,
  • Oliwia Grunwald,
  • Tomasz Januszko,
  • Paweł Muszyński,
  • Piotr Pogorzelski,
  • Justyna Tokarewicz,
  • Maciej Południewski and
  • Sławomir Dobrzycki
  • + 1 author

30 May 2023

In the aging society, the issue of coronary chronic total occlusion (CTO) has become a challenge for invasive cardiologists. Despite the lack of clear indications in European and American guidelines, the rates of percutaneous coronary interventions (...

  • Review
  • Open Access
3 Citations
120 Views
10 Pages

17 December 2014

Percutaneous coronary intervention (PCI) for chronic total occlusions (CTO) has been referred to as the “last frontier” in interventional cardiology. In recent years novel devices, refined imaging modalities and innovative techniques have increased s...

  • Feature Paper
  • Review
  • Open Access
2 Citations
4,296 Views
20 Pages

Recent Advances in Coronary Chronic Total Occlusions

  • Andreas Synetos,
  • Leonidas Koliastasis,
  • Nikolaos Ktenopoulos,
  • Odysseas Katsaros,
  • Konstantina Vlasopoulou,
  • Maria Drakopoulou,
  • Anastasios Apostolos,
  • Soritios Tsalamandris,
  • George Latsios and
  • Constantinos Tsioufis
  • + 2 authors

25 February 2025

Coronary chronic total occlusions (CTOs) have been a point of interest of the medical community for the last decade. The natural history of CTOs was for a long time unknown, as the presence of a single CTO was the most frequent cause for the exclusio...

  • Article
  • Open Access
8 Citations
2,069 Views
10 Pages

Safety and Efficiency of Rotational Atherectomy in Chronic Total Coronary Occlusion—One-Year Clinical Outcomes of an Observational Registry

  • Mohamed Ayoub,
  • Noé Corpataux,
  • Michael Behnes,
  • Tobias Schupp,
  • Jan Forner,
  • Ibrahim Akin,
  • Franz-Josef Neumann,
  • Dirk Westermann,
  • Volker Rudolph and
  • Kambis Mashayekhi

17 May 2023

The study sought to assess the procedural success of rotational atherectomy (RA) in coronary chronic total occlusion (CTO) and to investigate the in-hospital and one-year outcomes following RA. From 2015 to 2019, patients undergoing percutaneous coro...

  • Article
  • Open Access
7 Citations
2,859 Views
9 Pages

Left Main Coronary Artery Disease and Outcomes after Percutaneous Coronary Intervention for Chronic Total Occlusions

  • Max-Paul Winter,
  • Georg Goliasch,
  • Philipp Bartko,
  • Jolanta Siller-Matula,
  • Mohamed Ayoub,
  • Stefan Aschauer,
  • Klaus Distelmaier,
  • Catherine Gebhard,
  • Kambis Mashayekhi and
  • Aurel Toma
  • + 2 authors

30 March 2020

Background: Concomitant left main coronary artery (LMCA) disease in patients with chronic total occlusions (CTO) commonly results in referral for coronary artery bypass grafting, although the impact of LMCA in CTO patients remains largely unknown. Ne...

  • Article
  • Open Access
800 Views
11 Pages

Impact of the Presence of Chronic Total Occlusions on the Survival of Patients Treated with Coronary Artery Bypass Grafting

  • Albi Fagu,
  • Joseph Kletzer,
  • Franziska Marie Ernst,
  • Laurin Micek,
  • Stoyan Kondov,
  • Maximilian Kreibich,
  • Clarence Pingpoh,
  • Matthias Siepe,
  • Martin Czerny and
  • Tim Berger

Although chronic total occlusions (CTO) are a common finding in patients treated with coronary artery bypass grafting (CABG), it is still not clear how their presence impacts the long-term outcomes achieved with surgery. We aimed to investigate the i...

  • Article
  • Open Access
2 Citations
2,386 Views
10 Pages

Angiographic Characteristics and Outcomes of Percutaneous Coronary Intervention of Reattempted Chronic Total Occlusion: Potential Contributing Factors to Procedural Success

  • Mohsen Mohandes,
  • Cristina Moreno,
  • Mónica Fuertes,
  • Sergio Rojas,
  • Alberto Pernigotti,
  • Diego Zambrano,
  • Marta Guillén,
  • Jordi Guarinos and
  • Alfredo Bardají

30 November 2021

This study aimed to analyze angiographic characteristics of new attempted percutaneous coronary intervention (PCI) on chronic total occlusion (CTO) compared to first attempt group. The cohort of 527 CTO-PCIs was divided into first-attempt and re-atte...

  • Review
  • Open Access
1 Citations
1,540 Views
16 Pages

The Role of Intravascular Imaging in Coronary Chronic Total Occlusion PCI: Enhancing Procedural Success Through Real-Time Visualization

  • Hussein Sliman,
  • Rim Kasem Ali Sliman,
  • Paul Knaapen,
  • Alex Nap,
  • Grzegorz Sobieszek and
  • Maksymilian P. Opolski

15 July 2025

Coronary chronic total occlusions (CTOs) are diagnosed in a significant portion of patients undergoing coronary angiography and represent one of the most complex scenarios in contemporary percutaneous coronary interventions (PCI). This review systema...

  • Review
  • Open Access
7 Citations
3,347 Views
13 Pages

The Role of Coronary Imaging in Chronic Total Occlusions: Applications and Future Possibilities

  • Giuseppe Panuccio,
  • Youssef S. Abdelwahed,
  • Nicole Carabetta,
  • Ulf Landmesser,
  • Salvatore De Rosa and
  • Daniele Torella

Chronic total occlusions (CTOs) represent a challenging scenario in coronary artery disease (CAD). The prevalence of CTOS in patients undergoing coronary angiography underscores the need for effective diagnostic and therapeutic strategies. Coronary a...

  • Article
  • Open Access
5 Citations
2,085 Views
12 Pages

Background and Objectives: Chronic total occlusion (CTO) is a complex lesion of coronary artery disease (CAD) with a detection rate of approximately 25% on coronary angiography. CTO patients generally experience poor quality of life and prognosis. Th...

  • Systematic Review
  • Open Access
2 Citations
3,446 Views
26 Pages

Percutaneous Coronary Intervention versus Optimal Medical Therapy in Patients with Chronic Total Occlusion: A Meta-Analysis

  • Sascha Macherey-Meyer,
  • Khalid Salem,
  • Sebastian Heyne,
  • Max Maria Meertens,
  • Karl Finke,
  • Victor Mauri,
  • Stephan Baldus,
  • Christoph Adler and
  • Samuel Lee

15 May 2024

Background/Objectives: Chronic total occlusion (CTO) is a prevalent finding in patients with coronary artery disease and is associated with increased mortality. Prior reports on the efficacy of percutaneous coronary intervention (PCI) compared to opt...

  • Review
  • Open Access
23 Citations
3,706 Views
16 Pages

Prognostic Impact of Percutaneous Coronary Intervention of Chronic Total Occlusion in Acute and Periprocedural Myocardial Infarction

  • Seung-Hyun Kim,
  • Michael Behnes,
  • Kambis Mashayekhi,
  • Alexander Bufe,
  • Markus Meyer-Gessner,
  • Ibrahim El-Battrawy and
  • Ibrahim Akin

12 January 2021

Coronary chronic total occlusion (CTO) has gained increasing clinical attention as the most advanced form of coronary artery disease. Prior studies already indicated a clear association of CTO with adverse clinical outcomes, especially in patients wi...

  • Review
  • Open Access
11 Citations
5,384 Views
17 Pages

Patient Selection and Clinical Indication for Chronic Total Occlusion Revascularization—A Workflow Focusing on Non-Invasive Cardiac Imaging

  • Kevin Hamzaraj,
  • Andreas Kammerlander,
  • Mariann Gyöngyösi,
  • Bernhard Frey,
  • Klaus Distelmaier and
  • Senta Graf

20 December 2022

Percutaneous coronary intervention of chronic total occlusion (CTO PCI) is a challenging procedure with high complication rates and, as not yet fully understood long-term clinical benefits. Ischemic symptom relief in patients with high ischemic burde...

  • Article
  • Open Access
3 Citations
1,821 Views
14 Pages

Exosomal miRNAs Differentiate Chronic Total Occlusion from Acute Myocardial Infarction

  • Ji-Hye Son,
  • Jeong Kyu Park,
  • Ji-Hong Bang,
  • Dongeon Kim,
  • Inki Moon,
  • Min Gyu Kong,
  • Hyun-Woo Park,
  • Hyung-Oh Choi,
  • Hye-Sun Seo and
  • Jon Suh
  • + 2 authors

23 September 2024

Although coronary artery occlusion can have a negative effect on the myocardium, chronic total occlusion (CTO) exhibits different clinical features from those of acute myocardial infarction (AMI). In this study, we identify the differential associati...

  • Review
  • Open Access
1 Citations
3,927 Views
15 Pages

Coronary Chronic Total Occlusion Revascularization: When, Who and How?

  • Elisabetta Ricottini,
  • Federica Coletti,
  • Annunziata Nusca,
  • Nino Cocco,
  • Andrea Corlianò,
  • Alessandro Appetecchia,
  • Rosetta Melfi,
  • Fabio Mangiacapra,
  • Paolo Gallo and
  • Gian Paolo Ussia
  • + 2 authors

27 March 2024

Coronary chronic total occlusions (CTO) are an increasingly frequent entity in clinical practice and represent a challenging percutaneous coronary intervention (PCI) scenario. Despite data from randomized trials that have not yet demonstrated a clear...

  • Article
  • Open Access
1 Citations
2,311 Views
11 Pages

Bioresorbable Scaffold Use in Coronary Chronic Total Occlusions: A Long-Term, Single-Center Follow-Up Study

  • Dace Sondore,
  • Ieva Briede,
  • Matiss Linde,
  • Karlis Trusinskis,
  • Inga Narbute,
  • Sanda Jegere,
  • Aigars Lismanis,
  • Indulis Kumsars,
  • Karlis Grikis and
  • Andrejs Erglis
  • + 1 author

30 July 2024

Background and Objectives: Percutaneous coronary intervention (PCI) of chronic total occlusion (CTO) is often associated with longer total stent length. Our aim was to evaluate the long-term safety and effectiveness of bioresorbable scaffold (BRS) im...

  • Article
  • Open Access
2 Citations
2,837 Views
14 Pages

Differences between Lower Extremity Arterial Occlusion vs. Stenosis and Predictors of Successful Endovascular Interventions

  • Damianos G. Kokkinidis,
  • Dimitrios Schizas,
  • Sumant Pargaonkar,
  • Dimitrios Karamanis,
  • Konstantinos S. Mylonas,
  • Natasha Hasemaki,
  • Leonidas Palaiodimos,
  • Dimitrios Varrias,
  • Georgios Tzavellas and
  • Christos Bakoyiannis
  • + 5 authors

17 November 2023

Background and Objectives: In patients with peripheral artery disease, there is insufficient understanding of characteristics that predict successful revascularization of the lower extremity (LE) chronic total occlusions (CTOs) and baseline differenc...

  • Article
  • Open Access
1,170 Views
11 Pages

Indications, Management, and Short- and Medium-Term Outcomes of Patients with Chronic Coronary Occlusion Treated with Percutaneous Revascularization—A Single-Center Study

  • Lucia Barbieri,
  • Gabriele Tumminello,
  • Lorenzo Mafrici,
  • Guido Pasero,
  • Luca Mircoli,
  • Federico Colombo,
  • Cecilia Gobbi,
  • Alessandra S. Rizzuto and
  • Stefano Carugo

The diagnosis of chronic total occlusion (CTO), characterized by the complete obstruction of a coronary artery for at least three months, remains challenging and can be entirely asymptomatic. Since the indications for performing a recanalization proc...

  • Article
  • Open Access
4 Citations
1,560 Views
9 Pages

Prognostic Value of Different Levels of Uric Acid in Patients with Coronary Chronic Total Occlusion Undergoing Percutaneous Coronary Intervention

  • Mohamed Ayoub,
  • Kambis Mashayekhi,
  • Michael Behnes,
  • Tobias Schupp,
  • Muharrem Akin,
  • Jan Forner,
  • Ibrahim Akin,
  • Franz-Josef Neumann,
  • Dirk Westermann and
  • Aurel Toma
  • + 1 author

31 May 2023

Recent data suggest that uric acid (UA) might be an independent predictor of clinical outcomes following percutaneous coronary intervention (PCI). The predictive value of uric acid in patients undergoing PCI for chronic total occlusions (CTO) is unkn...

  • Article
  • Open Access
119 Views
6 Pages

Treatment of Patients with Chronically Occluded Coronary Arteries

  • Pascal Müller,
  • Barbara Sauter,
  • Sarah Noll,
  • Patrick Siegrist,
  • Jasmina Alibegovic,
  • Thomas F. Lüscher,
  • Alfredo R Galassi and
  • Oliver Gaemperlia

BACKGROUND: Chronic total occlusions (CTOs) are a common finding in patients with coronary artery disease; however, their best management is currently debated. OBJECTIVES: The aim of this study was to assess treatment strategies in patients with CTOs...

  • Article
  • Open Access
2 Citations
1,909 Views
11 Pages

Mid-Term Outcome of Ventricular Arrhythmias Catheter Ablation in Patients with Chronic Coronary Total Occlusion Compared to Ischemic and Non-Ischemic Patients

  • Maria Lucia Narducci,
  • Giampaolo Niccoli,
  • Francesco Flore,
  • Francesco Perna,
  • Gianluigi Bencardino,
  • Rocco Antonio Montone,
  • Gemma Pelargonio and
  • Filippo Crea

2 December 2022

Chronic coronary total occlusions (CTO) are considered an emerging predictor of ventricular arrhythmias (VAs), but currently there are few data on arrhythmic outcomes in patients affected by CTO undergoing radiofrequency catheter ablation of VAs. Thi...

  • Article
  • Open Access
1,708 Views
13 Pages

Revascularization of Chronic Total Occlusions vs. Planned Complex Percutaneous Coronary Intervention: Long-Term Outcomes and Mortality

  • Marcel Almendarez,
  • Alberto Alperi,
  • Isaac Pascual,
  • Rut Alvarez-Velasco,
  • Rebeca Lorca,
  • Daniel Hernández-Vaquero,
  • José Luis Betanzos,
  • Juan Francisco Ortiz de Zarate,
  • Raul Ptaszynski and
  • Pablo Avanzas
  • + 2 authors

24 January 2025

Introduction: The number of chronic total occlusion (CTO) revascularization procedures has continuously increased, obtaining better results in recent years. However, there are few data regarding long-term outcomes and no comparisons to planned comple...

  • Article
  • Open Access
5 Citations
2,677 Views
12 Pages

Association of Prolonged Fluoroscopy Time with Procedural Success of Percutaneous Coronary Intervention for Stable Coronary Artery Disease with and without Chronic Total Occlusion

  • Peter Tajti,
  • Mohamed Ayoub,
  • Thomas Nuehrenberg,
  • Miroslaw Ferenc,
  • Michael Behnes,
  • Heinz Joachim Buettner,
  • Franz-Josef Neumann and
  • Kambis Mashayekhi

3 April 2021

Background: In percutaneous coronary interventions (PCI), the impact of prolonged fluoroscopy time (FT) on procedural outcomes is poorly studied. Methods and Results: We analyzed the outcomes of 12,538 consecutive elective PCIs. The primary endpoint...

  • Systematic Review
  • Open Access
16 Citations
3,614 Views
11 Pages

Clinical and Procedural Outcomes of IVUS-Guided vs. Angiography-Guided CTO-PCI: A Systematic Review and Meta-Analysis

  • Giuseppe Panuccio,
  • Youssef S. Abdelwahed,
  • Nicole Carabetta,
  • Nadia Salerno,
  • David Manuel Leistner,
  • Ulf Landmesser,
  • Salvatore De Rosa,
  • Daniele Torella and
  • Gerald S. Werner

27 July 2023

Chronic total occlusions (CTO) in coronary angiographies present a significant challenge nowadays. Intravascular ultrasound (IVUS) is a valuable tool during CTO-PCI, aiding in planning and achieving procedural success. However, the impact of IVUS on...

  • Article
  • Open Access
1,610 Views
14 Pages

Technically Challenging Percutaneous Interventions of Chronic Total Occlusions Are Associated with Enhanced Platelet Activation

  • Ádám Illési,
  • Zsolt Fejes,
  • Marianna Pócsi,
  • Ildikó Beke Debreceni,
  • Katalin Hodosi,
  • Béla Nagy Jr.,
  • János Kappelmayer,
  • Zsolt Kőszegi,
  • Zoltán Csanádi and
  • Tibor Szük

29 October 2023

Percutaneous coronary intervention (PCI) is a frequently performed treatment option for recanalization in patients with chronic total occlusion (CTO). As CTO-PCIs are often complicated and challenging for interventionalists, the stressful and damagin...

  • Article
  • Open Access
5 Citations
2,416 Views
17 Pages

One-Stage Detection without Segmentation for Multi-Type Coronary Lesions in Angiography Images Using Deep Learning

  • Hui Wu,
  • Jing Zhao,
  • Jiehui Li,
  • Yan Zeng,
  • Weiwei Wu,
  • Zhuhuang Zhou,
  • Shuicai Wu,
  • Liang Xu,
  • Min Song and
  • Lin Chen
  • + 2 authors

21 September 2023

It is rare to use the one-stage model without segmentation for the automatic detection of coronary lesions. This study sequentially enrolled 200 patients with significant stenoses and occlusions of the right coronary and categorized their angiography...

  • Article
  • Open Access
14 Citations
5,663 Views
12 Pages

21 November 2018

Complete blockage of a coronary artery, called chronic total occlusion (CTO), frequently occurs due to atherosclerosis. To reopen the obstructed blood vessels with a stent, guidewire crossing is performed with the help of angiography that can provide...

  • Article
  • Open Access
12 Citations
2,910 Views
12 Pages

Machine Learning for Prediction of Technical Results of Percutaneous Coronary Intervention for Chronic Total Occlusion

  • Tatsuya Nakachi,
  • Masahisa Yamane,
  • Koichi Kishi,
  • Toshiya Muramatsu,
  • Hisayuki Okada,
  • Yuji Oikawa,
  • Ryohei Yoshikawa,
  • Tomohiro Kawasaki,
  • Hiroyuki Tanaka and
  • Osamu Katoh

9 May 2023

(1) Background: The probability of technical success in percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) represents essential information for specifying the priority of PCI for treatment selection in patients with CTO. Howev...

  • Article
  • Open Access
2 Citations
1,681 Views
12 Pages

Single versus Dual-Operator Approaches for Percutaneous Coronary Interventions within Chronic Total Occlusion—An Analysis of 27,788 Patients

  • Rafał Januszek,
  • Giuseppe De Luca,
  • Wojciech Siłka,
  • Leszek Bryniarski,
  • Krzysztof Piotr Malinowski,
  • Andrzej Surdacki,
  • Wojciech Wańha,
  • Stanisław Bartuś,
  • Aleksandra Piotrowska and
  • Zbigniew Siudak
  • + 2 authors

14 July 2023

(1) Background: Since the treatment of chronic total occlusion (CTO) with percutaneous coronary intervention (PCI) is associated with high procedural complexity, it has been suggested to use a multi-operator approach. This study was aimed at evaluati...

  • Systematic Review
  • Open Access
7 Citations
2,851 Views
15 Pages

Procedural Success Prediction Scoring Systems Used in Percutaneous Coronary Interventions for Chronic Total Occlusions: A Systematic Evaluation

  • Crischentian Brinza,
  • Iolanda Valentina Popa,
  • Alexandru Basarab,
  • Radu Crisan-Dabija and
  • Alexandru Burlacu

11 August 2021

(1) Background: Data suggest that patients with coronary chronic total occlusion (CTO) managed with percutaneous coronary intervention (PCI) could have better outcomes than those treated with optimal medical therapy alone. We aimed to systematically...

  • Article
  • Open Access
3 Citations
2,423 Views
15 Pages

Leveraging Machine Learning Techniques to Forecast Chronic Total Occlusion before Coronary Angiography

  • Yuchen Shi,
  • Ze Zheng,
  • Yanci Liu,
  • Yongxin Wu,
  • Ping Wang and
  • Jinghua Liu

26 November 2022

Background: Chronic total occlusion (CTO) remains the most challenging procedure in coronary artery disease (CAD) for interventional cardiology. Although some clinical risk factors for CAD have been identified, there is no personalized prognosis test...

  • Article
  • Open Access
789 Views
14 Pages

4 July 2025

Background/Objectives: Data on the prognostic value of frailty in patients undergoing percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) is limited. This study aimed to evaluate the association between frailty and in-hospital...

  • Article
  • Open Access
11 Citations
3,315 Views
10 Pages

16 August 2019

Background and objectives: Different scoring systems are used to stratify patients with chronic total coronary artery occlusions (CTO) according to disease complexity to predict the success of the percutaneous coronary intervention (PCI). Comparison...

  • Feature Paper
  • Article
  • Open Access
14 Citations
2,645 Views
11 Pages

Impact of Drug-Coated Balloon-Based Revascularization in Patients with Chronic Total Occlusions

  • Eun-Seok Shin,
  • Ae-Young Her,
  • Mi Hee Jang,
  • Bitna Kim,
  • Sunwon Kim and
  • Houng Bang Liew

9 June 2024

Background: Percutaneous coronary intervention (PCI) with a drug-eluting stent (DES) for chronic total coronary occlusions (CTOs) improves clinical symptoms and quality of life. However, data on drug-coated balloon (DCB)-based PCI in CTO lesions are...

  • Systematic Review
  • Open Access
867 Views
20 Pages

Hybrid Strategies for CTO PCI: A Systematic Review and Meta-Analysis of Antegrade and Retrograde Techniques

  • Andrei-Mihnea Rosu,
  • Maria-Daniela Tanasescu,
  • Theodor-Georgian Badea,
  • Emanuel-Stefan Radu,
  • Eduard-George Cismas,
  • Alexandru Minca,
  • Oana-Andreea Popa and
  • Luminita-Florentina Tomescu

12 November 2025

Background: Chronic total occlusion percutaneous coronary intervention (CTO PCI) is a complex revascularization procedure requiring advanced techniques to ensure procedural success and safety. Hybrid strategies combining antegrade dissection/re-entry...

  • Article
  • Open Access
1,269 Views
14 Pages

Effect of Coronary Collateral Supply on Left Ventricular Global Longitudinal Strain after Recanalization of Chronic Total Occlusion

  • Haci Ali Kurklu,
  • Nil Ozyuncu,
  • İrem Muge Akbulut Koyuncu,
  • Kerim Esenboga and
  • Turkan Seda Tan

11 September 2024

Percutaneous coronary intervention (PCI) to chronic total occlusion (CTO) is still a subject of debate. The primary goal of revascularization is to provide symptomatic relief and enhance left ventricular (LV) functions. Global longitudinal strain (GL...

  • Article
  • Open Access
1,140 Views
11 Pages

The Prevalence and Impact of Atrial Fibrillation on Patients with Chronic Total Occlusions: Insights from the National Inpatient Sample

  • Maximilian Will,
  • Konstantin Schwarz,
  • Eric Holroyd,
  • Josip A. Borovac,
  • Adnan I. Qureshi,
  • Gregory Y. H. Lip,
  • Julia Mascherbauer,
  • Gregor Leibundgut,
  • Thomas W. Weiss and
  • Chun Shing Kwok

The impact of atrial fibrillation (AF) on patients with chronic total occlusions (CTOs) at the national level remains unclear. In this study, we conducted a retrospective analysis of data from the National Inpatient Sample to assess the characteristi...

  • Article
  • Open Access
12 Citations
2,706 Views
9 Pages

Impact of Chronic Kidney Disease on Chronic Total Occlusion Revascularization Outcomes: A Meta-Analysis

  • Wei-Chieh Lee,
  • Po-Jui Wu,
  • Chih-Yuan Fang,
  • Huang-Chung Chen,
  • Chiung-Jen Wu and
  • Hsiu-Yu Fang

23 January 2021

Objectives: To examine the impact of revascularization and associated clinical outcomes of chronic kidney disease (CKD) chronic total occlusion (CTO) and non-CKD CTO groups. Background: The influence of CKD on clinical outcomes after percutaneous cor...

  • Article
  • Open Access
2 Citations
2,640 Views
13 Pages

Non-Invasive Evaluation of Patients Undergoing Percutaneous Coronary Intervention for Chronic Total Occlusion

  • Tatsuya Nakachi,
  • Shingo Kato,
  • Naka Saito,
  • Kazuki Fukui,
  • Tae Iwasawa,
  • Tsutomu Endo,
  • Masami Kosuge,
  • Daisuke Utsunomiya,
  • Kazuo Kimura and
  • Kouichi Tamura

14 October 2021

Background: As percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) gains wider acceptance as a therapeutic option for coronary artery disease, the importance of appropriate patient selection has increased. Although cardiovascul...

  • Article
  • Open Access
6 Citations
4,444 Views
17 Pages

Scoring System for Identification of “Survival Advantage” after Successful Percutaneous Coronary Intervention in Patients with Chronic Total Occlusion

  • Tatsuya Nakachi,
  • Shun Kohsaka,
  • Masahisa Yamane,
  • Toshiya Muramatsu,
  • Atsunori Okamura,
  • Yoshifumi Kashima,
  • Shunsuke Matsuno,
  • Masami Sakurada,
  • Yoshitane Seino and
  • Maoto Habara

Background: Percutaneous coronary intervention (PCI) is widely used in patients with chronic total occlusion (CTO), but its benefit in improving long-term outcomes is controversial. We aimed to develop a prediction score for grading “survival advanta...

  • Article
  • Open Access
271 Views
20 Pages

Percutaneous Coronary Intervention for Chronic Total Occlusions Modulates Cardiac Hypoxic and Inflammatory Stress

  • Luis Carlos Maestre-Luque,
  • Rafael Gonzalez-Manzanares,
  • Ignacio Gallo,
  • Francisco Hidalgo,
  • Javier Suárez de Lezo,
  • Miguel Romero,
  • Simona Espejo-Perez,
  • Carlos Perez-Sanchez,
  • Julio Manuel Martínez-Moreno and
  • Soledad Ojeda
  • + 2 authors

8 January 2026

Background/Objectives: The cardiac hypoxia- and inflammation-associated processes in patients with chronic coronary artery disease remain unknown. The coronary sinus (CS) can be used to explore changes in cardiac microenvironment. This study sought t...

  • Article
  • Open Access
341 Views
11 Pages

The Relationship Between Collateral Circulation and Electrocardiographic Frontal QRS-T Angle in Patients with Coronary Artery Chronic Total Occlusion

  • Muhammet Öztürk,
  • Nadir Emlek,
  • Ali Gökhan Özyıldız,
  • Elif Ergül,
  • Hüseyin Durak,
  • Afag Özyıldız and
  • Mustafa Çetin

24 December 2025

Background: Ischemic heart disease is the primary contributor to global mortality. The QRS-T angle at the anterior aspect of the heart serves as a significant biomarker of the heterogeneity in myocardial repolarization and the electrophysiological in...

  • Article
  • Open Access
6 Citations
2,283 Views
15 Pages

Circ-MBOAT2 Regulates Angiogenesis via the miR-495/NOTCH1 Axis and Associates with Myocardial Perfusion in Patients with Coronary Chronic Total Occlusion

  • Wei Gao,
  • Chenguang Li,
  • Jie Yuan,
  • Youming Zhang,
  • Guobing Liu,
  • Jianhui Zhang,
  • Hongcheng Shi,
  • Haibo Liu and
  • Junbo Ge

Revascularization of coronary chronic total occlusion (CTO) still remains controversial. The factors that impact collateral circulation and myocardial perfusion are of interest. Circular RNA (circRNA) has been shown to regulate the process of angioge...

  • Article
  • Open Access
4 Citations
2,126 Views
15 Pages

Causal Models for the Result of Percutaneous Coronary Intervention in Coronary Chronic Total Occlusions

  • Maria Ganopoulou,
  • Ioannis Kangelidis,
  • Georgios Sianos and
  • Lefteris Angelis

5 October 2021

Background: Patients undergoing coronary angiography very frequently exhibit coronary chronic total occlusions (CTOs). Over the last decade, there has been an increasing acceptance of the percutaneous coronary interventions (PCI) in CTOs due to, amon...

  • Article
  • Open Access
8 Citations
3,265 Views
11 Pages

Predictors for Target Vessel Failure after Recanalization of Chronic Total Occlusions in Patients Undergoing Surveillance Coronary Angiography

  • Martin Geyer,
  • Johannes Wild,
  • Marc Hirschmann,
  • Zisis Dimitriadis,
  • Thomas Münzel,
  • Tommaso Gori and
  • Philip Wenzel

9 January 2020

(1) Background: Knowledge about predictors for the long-time patency of recanalized chronic total coronary occlusions (CTOs) is limited. Evidence from invasive follow-up in the absence of acute coronary syndrome (routine surveillance coronary angiogr...

  • Article
  • Open Access
880 Views
14 Pages

Role of Femoral Artery Access Characteristics and Female Sex in In-Hospital Complications for Patients Undergoing Recanalization of Chronic Total Occlusions

  • Kevin Hamzaraj,
  • Caglayan Demirel,
  • Antonia Domanig,
  • Senta Graf,
  • Mariann Gyöngyösi,
  • Christian Hengstenberg,
  • Bernhard Frey and
  • Rayyan Hemetsberger

25 June 2025

Background: Percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) remains a complex procedure that requires advanced operator skills and dedicated devices. Despite increased success rates in experienced centers, the in-hospital c...

  • Article
  • Open Access
3 Citations
2,777 Views
13 Pages

Computed Tomography Angiography-Derived Scores for Prediction of Chronic Total Occlusion Percutaneous Coronary Intervention Using the Hybrid Algorithm

  • Antoni Zyśk,
  • Rafał Wolny,
  • Mariusz Kruk,
  • Jacek Kwieciński,
  • Artur Dębski,
  • Umberto Barbero,
  • Cezary Kępka,
  • Marcin Demkow,
  • Adam Witkowski and
  • Maksymilian P. Opolski

Whereas coronary computed tomography angiography (CCTA) exceeds invasive angiography for predicting the procedural outcome of chronic total occlusion (CTO) percutaneous coronary intervention (PCI), CCTA-derived scores have never been validated in the...

  • Article
  • Open Access
967 Views
14 Pages

Comparative Impact of Coronary Imaging Strategies in CTO-PCI: A Retrospective Single-Center Analysis

  • Giuseppe Panuccio,
  • Kambis Mashayekhi,
  • Gerald S. Werner,
  • Yasuhiro Ichibori,
  • Nicole Carabetta,
  • Carsten Skurk,
  • Ömer Göktekin,
  • Patrick T. Siegrist,
  • David M. Leistner and
  • Youssef S. Abdelwahed
  • + 3 authors

1 October 2025

Background: Coronary imaging is increasingly used in chronic total occlusion percutaneous coronary intervention (CTO-PCI), but the impact of different imaging strategies on procedural decisions and outcomes remains unclear. Methods: We retrospectivel...

  • Review
  • Open Access
1 Citations
3,132 Views
13 Pages

Chronic Total Occlusions: Current Approaches, Evidence and Outcomes

  • Remi Arnold,
  • Richard Gervasoni and
  • Florence Leclercq

2 July 2025

Chronic total occlusions (CTOs), defined as complete coronary artery blockages persisting for over three months, are frequently encountered in up to 25% of coronary angiograms. Although percutaneous coronary intervention (PCI) for CTO remains technic...

  • Article
  • Open Access
1 Citations
1,488 Views
10 Pages

Postprocedural Contrast-Associated Acute Kidney Injury and Prognosis of Patients Undergoing Recanalization of Chronic Total Occlusions

  • Kevin Hamzaraj,
  • Caglayan Demirel,
  • Mariann Gyöngyösi,
  • Philipp E. Bartko,
  • Christian Hengstenberg,
  • Bernhard Frey and
  • Rayyan Hemetsberger

16 December 2024

Introduction: Percutaneous coronary intervention (PCI) for chronic total occlusions (CTOs) requires advanced techniques and prolonged procedural efforts, often necessitating high contrast volumes, which may increase the risk of contrast-associated ac...

of 2