Search Results (3,311)

A multicomponent Ni₅₄Cr₂₈Mo₈Nb₅Ta₅ nickel-based superalloy was produced by vacuum induction melting followed by homogenization, hot forging, solution treatment, and aging to investigate its microstructural and mechanical behavior. The X Ray Fluorescence (XRF) analysis confirmed excellent agreement between the nominal and experimental chemical compositions. The X Ray Diffraction(XRD) combined with Rietveld refinement revealed a microstructure dominated by three closely related to face-centered cubic (FCC) (A1) solid-solution regions with slightly different lattice parameters, indicating local compositional variations. The Scanning Electron Microscopy(SEM)/Energy Dispersive Spectroscopy (EDS) observations showed a generally homogeneous elemental distribution, while optical and electron microscopy identified a dendritic microstructure with elongated interdendritic constituents enriched in refractory elements. Mechanical characterization yielded an average hardness of 497 HV_0.5, a compressive strength of approximately 1950 MPa, and room-temperature yield and ultimate tensile strengths of 1050 MPa and 1320 MPa, respectively. Tensile strength gradually decreased with increasing temperature up to 900 °C, while ductility increased from 16% to 25% total elongation. The results indicate that the alloy develops a stable FCC matrix primarily strengthened by solid-solution hardening, with the measured mechanical performance suggesting an additional contribution from precipitation hardening. This study provides an experimental baseline for the development and optimization of conventionally processed Ni–Cr–Mo–Nb–Ta superalloys for high-temperature applications. Full article

This study evaluates the short-term effects of nine commercially available fire retardants (FRs) on water quality under controlled laboratory conditions. FRs were diluted to a 1:10 FR:water stock solution to approximate readily water-extractable fractions, and ion solubility was quantified together with key physicochemical parameters, including pH, electrical conductivity (EC), and dissolved oxygen (DO). Results revealed substantial heterogeneity among formulations in the concentrations of solubilized ions. Notably, FR4 (NP+) exhibited exceptionally high concentrations of NH₄⁺, NO₃⁻, NO₂⁻, PO₄³⁻, and Br⁻, as well as elevated Ca²⁺ and Na⁺. Other formulations also released considerable loads of common nutrients, particularly NO₃⁻ and PO₄³⁻, although at lower magnitudes. Despite the pronounced ionic enrichment, pH and DO remained relatively stable across most treatments. However, DO decreased in several cases at higher FR concentrations, suggesting increased oxygen demand associated with dissolved constituents. EC displayed strong, concentration-dependent increases across treatments, reflecting the rapid dissolution of ionic components in water. Cluster analysis identified three distinct groups of FRs based on their water-quality responses. The PCA biplot further revealed two main gradients structuring the formulations: mineralization and compositional diversity (PC1), and physicochemical solution conditions (PC2), which together distinguish the chemical and physicochemical signatures of the tested products. Overall, the results highlight substantial formulation-specific differences in nutrient and metal release, with potential short-term implications for aquatic chemistry and ecosystem functioning. Although derived from controlled laboratory conditions, these findings provide a first-order assessment of FR impacts on water quality and underscore the importance of considering formulation composition in watershed risk assessments and post-fire water quality management strategies. Full article

Active molecules derived from traditional Chinese medicine (TCM) represent a valuable source of lead compounds for modern drug discovery, demonstrating considerable potential in the prevention and treatment of chronic diseases, cancer therapy, and immune modulation. Nevertheless, their clinical translation is often impeded by intrinsic limitations such as poor aqueous solubility, low bioavailability, inadequate chemical stability, and significant gastrointestinal irritation. Cyclodextrins (CDs) and their derivatives, characterized by a hydrophobic internal cavity, are capable of forming inclusion complexes with TCM and their derived active constituents, thereby improving their physicochemical and pharmacokinetic profiles. Over the past five years, substantial progress has been made in this domain. CD-based inclusion strategies have been shown to markedly enhance the solubility and dissolution rate of poorly water-soluble TCM compounds, including flavonoids, alkaloids, and terpenoids. Moreover, this approach contributes to improved drug stability, effective taste masking, and the achievement of modified release profiles, such as sustained or targeted delivery, ultimately leading to enhanced therapeutic efficacy and reduced adverse effects. The development of novel CD derivatives and smart delivery systems has further broadened their application potential. This review summarizes recent advances in the CD-based encapsulation of TCM active molecules, highlighting key formulation strategies that address persistent challenges in the modernization of TCM. It also provides a foundation for future research and development in natural product-based therapeutics. Full article

Functional coatings based on natural bioactive compounds have attracted increasing interest in topical and biomedical applications. In this study, textile substrates were coated with formulations containing propolis and selected biopolymers to create biocompatible surfaces with enhanced physicochemical and biological properties. The coating preparation process was optimized to achieve uniform deposition and stable incorporation of bioactive constituents. The chemical composition and interactions between propolis, biopolymers, and textile fibers were investigated using Fourier-transform infrared spectroscopy (FTIR), while surface morphology and coating distribution were characterized by scanning electron microscopy (SEM). The presence and stability of key phenolic compounds in propolis were analyzed by high-performance liquid chromatography (HPLC). Optical properties and UV-shielding performance of the coated textiles were evaluated using UV–Vis spectroscopy. The coffee-ring effect was investigated during coating formulation, as this phenomenon significantly reveals coating homogeneity, surface microstructure, and the spatial distribution of active compounds. The influence of formulation parameters on deposit morphology and coating quality was systematically assessed. The biocompatibility of the developed coatings was evaluated through in vitro cytotoxicity testing, demonstrating their suitability for direct skin contact. The combined analytical results confirmed successful incorporation of propolis into the biopolymer matrix, indicating that propolis–biopolymer coatings represent a promising approach for the fabrication of functional textiles intended for topical applications, including wound care, skin protection, and antimicrobial textile products. Full article

Plastic waste presents a persistent environmental burden, yet its constituent polymers represent structurally valuable chemical feedstocks. Mechanical recycling remains limited due to polymer degradation, additive contamination, and material downcycling, underscoring the need for alternative strategies. Chemical upcycling offers pathways to convert post-consumer plastics into higher-value monomers, functional chemicals, and bioactive or pharmaceutical precursors by exploiting inherent structural motifs such as aromatic rings, ester linkages, and heteroatom-containing backbones. Approaches such as catalytic depolymerization, molecular functionalization, microbial and enzymatic transformation, and scaffold repurposing enable the recovery of polymer-derived building blocks with improved functional value. Case studies illustrating the conversion of discarded plastics into advanced materials and biologically relevant small molecules demonstrate the potential of these approaches to stimulate innovation and expand sustainable chemical practices. Collectively, such developments align with green chemistry principles, support emerging circular chemical economies, and contribute to global sustainability priorities reflected in the United Nations Sustainable Development Goals. This review aims to outline the guiding principles of chemical upcycling and highlight the challenges in chemical design, encouraging the modern chemistry community to tap into the hidden potential of waste plastics. Full article

Ethanol (EtOH)-induced gastric ulcer (GU) is a common model used to investigate mechanisms of mucosal injury and repair. Omeprazole (OMP) is a conventional anti-ulcer drug that effectively suppresses gastric acid secretion, but its efficacy may be enhanced by combining it with bioactive phytochemicals derived from a Glycyrrhiza glabra L. (licorice; LIQ) extract that possess potent antioxidant and anti-inflammatory properties. The aim of the present study was to evaluate the gastroprotective effects of OMP, LIQ extract, and their combined treatment against EtOH-induced GU in rats, focusing on modulation of TLR4/NF-κB/NLRP3 signaling and PI3K/AKT/mTOR gene expression. The ethanolic extract of LIQ was chemically characterized by LC-ESI-QTOF-MS/MS, and molecular docking was performed to evaluate the potential binding interactions of its major constituents with H⁺/K⁺-ATPase and COX-2. Thirty male Wistar rats were randomly allocated into control, ulcer (ULC), OMP-treated, LIQ-treated, and combined treatment groups. GU was induced by absolute EtOH. Subsequently, gastric pH, stomach coefficient, oxidative stress, inflammatory mediators, and PI3K, AKT, and mTOR gene expression were assessed. Histopathological and immunohistochemical analyses of mucosal architecture and the expression of TNF-α, caspase-3, and PCNA were performed. Coadministration of OMP and LIQ demonstrated the greatest gastroprotective activity, marked by a significant increase in gastric pH, restoration of antioxidant status, and substantial reduction in ROS, TLR4, NF-κB, and NLRP3 levels. The combined therapy significantly upregulated the expression of PI3K, AKT, and mTOR genes in comparison to ULC. Histopathological and immunohistochemical findings further demonstrated preservation of gastric mucosal integrity, reduced inflammatory cell infiltration, and decreased TNF-α, caspase-3, and PCNA immunoreactivity, indicating attenuation of mucosal injury. In conclusion, LIQ extract enhanced the gastroprotective effect of OMP against EtOH-induced GU, supporting its potential as an adjunct to OMP. Further studies are warranted to confirm the underlying molecular mechanisms. Full article

Orchid seeds are dust-like and lack endosperm, which limits their capacity to support germination using endogenous nutrient reserves. Successful germination therefore depends on the establishment of a compatible symbiotic association with germination-promoting orchid mycorrhizal fungi (OMF). In plant-root symbioses, host-derived small molecules, such as strigolactones and flavonoids, function as early chemical signals that recruit microbial partners and stimulate their growth. However, the chemical constituents that may facilitate fungal recognition, growth, or colonization during orchid seed germination remain poorly understood. In this report, we combined metabolomics, UPLC-Q-TOF-MS/MS, molecular networking, phytochemical isolation, and bioactivity assays to characterize bioactive metabolites from the seeds of the medicinal orchid Cremastra appendiculata. Metabolomic profiling revealed abundant primary metabolites, including lipids, amino acids, organic acids, saccharides, and nucleosides. And then, nineteen secondary metabolites were isolated and identified, including two new structures. Functional assays showed that selected organic acids, saccharides, and lignanamides promoted the growth of Coprinellus disseminatus, a fungus required for seed germination, whereas lignanamides inhibited the plant pathogen Fusarium oxysporum. These findings provide the first systematic chemical and functional characterization of metabolites from C. appendiculata seeds and offer new insight into the molecular basis of symbiosis between orchids and fungi. Full article

Despite their introduction two decades ago as cessation tools, vaping devices and electronic cigarettes (ECs) have surged dramatically among adolescents and adults worldwide. The widespread misconception that ECs are harmless has raised substantial concern about their potential contribution to chronic diseases associated with oxidative stress (OS) pathways. To map this rapidly growing field, we combined a bibliometric analysis of human research on vaping-associated OS over the past decade with a narrative review of EC component toxicology and regulatory updates. The bibliometric analysis of 189 human studies identified four keyword clusters reflecting clinico-epidemiological, biological/mechanistic, methodological, and acute-event research themes. The results of this bibliometric analysis structure the narrative synthesis, which evaluates the chemical constituents of ECs, including e-liquid constituents, device-derived contaminants, and their aerosol by-products, and links them to pathways associated with OS development. Oxidative stress was the most frequent bridging keyword, reflecting predominant academic trends as research shifted from acute-focused investigations toward mechanistic chronic disease research. No prior review has integrated EC component toxicology with bibliometric evidence to map this landscape. This combined approach provides researchers, clinicians, and policymakers with an integrated evidence base and identifies priority areas for future investigation, including long-term exposure thresholds, age- and sex-specific outcomes, and the urgent need for harmonized global regulation. Full article

Background/Objectives: Ambient fine particulate matter (PM_2.5) poses significant health risks to older adult populations, yet the specific contributions of its chemical constituents, particularly non-phthalate and non-organophosphate ester compounds, remain poorly understood. This study aimed to elucidate the mechanistic links between PM_2.5-bound ester exposures and metabolic pathway alterations in elderly individuals. Methods: A total of 258 elderly residents aged 60 years or older from Fuzhou, China, were recruited. Personal PM_2.5 exposure was monitored over 72 h using UPAS V2 samplers, with chemical components analyzed via gas chromatography–mass spectrometry (GC–MS). Plasma metabolomic profiling was conducted using liquid chromatography–mass spectrometry (LC–MS), and metabolic pathway enrichment was performed using MetaboAnalyst 5.0. Linear regression models adjusted for covariates (age, sex, BMI, lifestyle factors) assessed associations between ester exposures and metabolite abundance. Results: The mean PM_2.5 concentration was 38.06 μg/m³, with ester compounds dominating the chemical composition. Twenty high-concentration non-target esters were prioritized for analysis. PM_2.5 ester exposure was associated with alterations in key metabolic pathways, including steroid biosynthesis, glycolysis/gluconeogenesis, glycerophospholipid metabolism, and purine/pyrimidine metabolism. When interpreted alongside prior epidemiological evidence, these alterations represent putative links to increased risks of insulin resistance, cardiovascular dysfunction, and metabolic syndrome—relationships that require confirmation in prospective cohort studies and controlled toxicological experiments. Conclusions: Putatively annotated PM_2.5-bound ester compounds, particularly non-regulated subclasses, are associated with systemic metabolic alterations in older adults, coincident with perturbations in steroid and lipid metabolism. While these findings are exploratory and hypothesis-generating, they highlight the need to incorporate specific ester profiles into PM_2.5 risk assessments and develop targeted interventions for vulnerable aging populations. Full article

Cabbage (Brassica oleracea var. capitata) is considered a healthy vegetable due to its chemical composition and high nutritional value, owing to its main constituents of carbohydrates and dietary fiber and the fact that it is also a source of ascorbic acid. The resulting product, sauerkraut, is low-calorie and has a long shelf life. Lactic acid bacteria play the most important role in cabbage fermentation, and their activity is influenced by physical factors such as temperature and chemical factors such as salt concentration and the addition of spices, which may inhibit undesirable microflora, in addition to their flavoring effect. This study explores the impact of incorporating essential oils into sauerkraut production on the lactic acid bacteria that drive cabbage fermentation. It also analyzes how these oils affect the primary chemical components of sauerkraut, including total soluble solids, total phenolics, and antioxidant activity. Essential oils from thyme, dill, wild thyme, laurel, and basil are tested. Incorporating essential oils into cabbage before fermentation may partially inhibit or slow the growth of bacteria involved in the fermentation process while also contributing to the improved flavor profile of the final product. Full article

The melon fruit fly, Bactrocera zonata, and the pumpkin fruit fly, Bactrocera cucurbitae (Diptera: Tephritidae), are important agricultural pests that cause significant losses in a wide range of fruit and vegetable crops. Increasing concerns over pesticide resistance and environmental contamination have driven interest in plant-derived insecticide alternatives. This study investigated the insecticidal activity of Ricinus communis L. leaf extracts against both species. The crude leaf extract was fractionated using solvents of increasing polarity (n-hexane, methanol, and ethyl acetate). The resulting fractions were assessed for insecticidal activity, and the most active fraction was further purified using column chromatography. Chemical constituents were identified using gas chromatography–mass spectrometry (GC-MS) and Fourier transform infrared spectroscopy (FTIR). Bioassay results indicated that the methanol, n-hexane, and ethyl acetate fractions exhibited the highest insecticidal activity against both B. zonata and B. cucurbitae. GC-MS analysis revealed several bioactive constituents in the active fractions, including neophytadiene, fatty acid derivatives, and 11,14,17-eicosatrienoic acid, which was tentatively identified as a candidate constituent associated with the most active fractions. These findings suggest that R. communis leaf extracts contain bioactive constituents with insecticidal properties against tephritid fruit flies and may contribute to the development of plant-based pest management strategies. However, further work is required to isolate pure compounds and confirm their individual toxicological roles under field conditions. Full article

Taxilli Herba (Sangjisheng) is a hemi-parasitic medicinal plant whose quality is intrinsically linked to its host species. While previous reviews have extensively summarized its chemical constituents and pharmacological activities, a systematic understanding of how host trees dictate its quality and safety remains largely fragmented. This review bridges this gap by proposing a “host-governed quality paradigm.” By integrating historical records with modern scientific findings, we critically evaluate the molecular mechanisms underlying host–parasite interactions and their impact on medicinal quality. We highlight that host species influence Taxilli Herba across three critical dimensions: (i) chemical composition, comprising both intrinsic bioactive compounds and host-derived metabolites; (ii) toxicity profile, where even hosts lacking cardiac glycosides may pose potential safety hazards; and (iii) pharmacological activity, where host identity modulates therapeutic potency and traditional medicinal properties (e.g., “cold” vs. “warm” nature). Importantly, we highlight that the cardiac glycoside test specified in the current Chinese Pharmacopoeia is insufficient to ensure the safety of Sangjisheng derived from diverse hosts. To address these challenges, we propose a host-governed quality paradigm comprising four pillars: (1) mechanistic studies on host–parasite interactions; (2) revision of pharmacopeial standards to restrict approved sources; (3) promotion of standardized cultivation using safe host species (e.g., Morus alba); and (4) stringent quality control for edible and medicinal applications. This framework aims to ensure the safety, efficacy, and sustainable use of Sangjisheng in clinical practice. Full article

Essential oils are increasingly investigated for their potential use in plant protection because of their insecticidal, fumigant, repellent, behavioural, and antifungal activities. This narrative review with a structured literature search synthesizes evidence relevant to European plant protection, focusing primarily on stored-product pests, with additional consideration of pests and plant pathogens outside storage systems, stage-specific susceptibility, formulation, practical limitations, and the EU regulatory framework. EO efficacy was strongly influenced by chemical composition, concentration, formulation, exposure time, developmental stage, target species, and environmental conditions. The strongest evidence was identified for stored-product pests (Coleoptera), although stage-specific susceptibility varied among species. Under field conditions, the practical application of essential oils remains challenging due to their high volatility, short persistence, sensitivity to environmental conditions, potential phytotoxicity, formulation requirements, and limited field validation. Methodological differences among assay types also limit direct comparison across studies. In the EU, regulatory acceptance remains substance-specific, with whole essential oils assessed separately from their individual volatile constituents. Most available evidence is derived from laboratory studies, while greenhouse and field validation remains limited. No formal methodological quality or risk-of-bias assessment of individual studies was performed. Overall, essential oils should be regarded as complementary, application-specific tools whose contribution to more sustainable plant protection depends on improved standardization, formulation, field validation, safety, economic viability, and regulatory acceptance. Full article

Micromelum falcatum (Lour.) Tanaka is a medicinal plant widely utilized in traditional Chinese medicine. In this study, the essential oil (EO) was isolated by hydrodistillation using a Clevenger-type apparatus, and its chemical composition and biological activities were systematically investigated. A total of 63 constituents were identified by GC–MS and GC–FID, with bicyclogermacrene (20.52%), γ-palmitolactone (18.16%), humulene (10.55%), caryophyllene (10.09%), and spathulenol (4.50%) representing the major components. Antioxidant capacity was evaluated using DPPH (IC₅₀ = 15780 ± 1490 μg/mL), ABTS (IC₅₀ = 3440 ± 40 μg/mL), and FRAP assays (Trolox equivalent antioxidant concentration: 734.47 ± 6.82 μmol/g), in which the EO exhibited relatively moderate radical-scavenging and ferric-reducing activities. In addition, the EO demonstrated notable β-lactamase inhibitory activity (IC₅₀ = 25.59 ± 4.99 μg/mL). Molecular docking analysis further suggested that compounds such as isospathulenol, globulol, and spathulenol may interact with the enzyme’s active site via hydrogen bonds. These findings indicate that M. falcatum EO represents a promising natural source of bioactive compounds with antioxidant and enzyme-inhibitory potential, warranting further pharmacological investigation. Full article

Paraffin wax precipitation and deposition significantly hinder crude oil production and transportation by reducing flow efficiency, increasing operational downtime, and requiring costly remediation procedures. Conventional wax mitigation methods commonly rely on environmentally unfriendly chemicals and energy-intensive thermal or mechanical treatments. This study investigates the use of a natural polymer from Swietenia macrophylla (Mahogany), modified with metal nanoparticles (MNPs), namely silver oxide (Ag₂O), zinc oxide (ZnO), and silver-doped zinc oxide (Ag-ZnO), for petroleum wax inhibition. Material characterization was conducted using FTIR, TGA and GC-MS analyses, while performance evaluation employed rheological measurements, Cross-Polarized Microscopy (CPM), and pour point testing. GC-MS analysis revealed the presence of oxygenated fatty acid esters such as glycidyl oleate (59.61%) and glycidyl palmitate (16.86%). These compounds indicate the presence of hydrocarbon-compatible and surface-active constituents beneficial for wax crystal modification. FTIR spectra further confirmed carbonyl, aliphatic hydrocarbon, and ether functionalities associated with natural wax-mitigation compounds and effective MNP binding sites. The application of 2 wt% polymeric materials demonstrated significant wax inhibition performance. The unmodified polymer reduced the activation energy (Ea) for crude oil flow by 49.4 kJ·mol⁻¹ from the virgin crude oil value of 213.6 kJ·mol⁻¹. The polymer + ZnO formulation achieved the highest pour point reduction of 1.72 °C, while polymer + Ag-ZnO recorded the greatest viscosity reduction of 77.1% at 1 s⁻¹ and 91.6% at 200 s⁻¹. This study demonstrates, for the first time, the potential of Swietenia macrophylla-derived nanocomposite polymers as sustainable and effective wax mitigation agents for waxy crude oil systems. Full article