Organic Supramolecular Chemistry of Natural Products
A special issue of Organics (ISSN 2673-401X).
Deadline for manuscript submissions: 31 December 2025 | Viewed by 46
Special Issue Editor
Interests: organic chemistry and green organic synthesis; supramolecular chemistry; sustainable natural products and biomolecular chemistry; biosensors and bioimaging; biomaterials and nanomedicine
Special Issue Information
Dear Colleagues,
Natural product molecules and their synthetic derivatives have attracted a great variety of attention for their structural and functional diversity and specific bioactivity. It is essential to speed up their biomedical translation by improving their solubility, stability, controllability, and bioavailability and reducing off-target effects. Thus, it is of high demand to develop innovative molecular and supramolecular strategies to design and synthesise natural product-based (drug/lipid/peptide) conjugates with biostimuli-responsive release features; achieve the controllable self-assembly of natural product conjugate-based supramolecular aggregates (micelles, vesicles, fibres, gels) for targeted delivery or bioimaging; and develop natural product conjugate–polymer/inorganic hybrid systems for antimicrobial, anticancer, or tissue engineering applications. The topics of interest for this Special Issue include the following:
- Organic synthesis/catalysis methods of natural product conjugates.
- Stimuli-responsive (pH, redox, photo, enzymes) natural product conjugates.
- Degradation kinetics and drug release models of natural product conjugates.
- Natural product-containing macrocyclic chemistry and supramolecular chemistry (synthesis and self-assembly).
- Self-assembly techniques to prepare natural product conjugate-based supramolecular systems or nanoaggregates.
- Biochemistry and cell biology of synthesized natural product conjugates.
- Natural product conjugate–fluorescent labelling systems (fluorophores, quantum dots, metal complexes, or organic–inorganic hybrids) for advanced supramolecular theranostics or nanotheranostics.
- AI-based design or machine learning-guided synthesis of natural product conjugates.
This Special Issue of Organics aims to further accelerate the intercommunication at the intersection of organic chemistry, bioorganic chemistry and chemical biology, bioactive molecules and biomacromolecules, supramolecular chemistry and self-assembly, biomaterials and nanobiotechnology, and biochemical pharmacology to enhance drug delivery efficiency for advanced biomedicine. Therefore, we sincerely invite researchers from all over the world to contribute to this Special Issue.
Dr. Ruilong Sheng
Guest Editor
Manuscript Submission Information
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Keywords
- natural product conjugates
- supramolecular
- drug and gene delivery
- stimuli-responsive
- self-assembled
- synthesis methodology
- macrocyclic therapeutics
- AI-guided design and synthesis
- theoretical calculations
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