Search Results (277)

Background: Alcohol is associated with increased mortality and morbidity globally. Pulmonary infections with opportunistic pathogens can occur in healthy humans; however, binge alcohol intoxication (≥0.08% BAC) is a major risk factor. We have previously shown that a single dose of alcohol comparable to binge alcohol intoxication increases infection by reducing alveolar macrophage function in vivo. Sulforaphane (SFN), a phytonutrient, is a potent inducer of antioxidant production through the induction of nuclear factor erythroid 2-related factor 2 (Nrf2) and inhibition of the nuclear factor kappa-light-chain-enhancer (NF-kB) pathway. The aim of this study was to test the therapeutic potential of SFN given as a pretreatment to prevent alcohol-induced phagocytic dysfunction. Methods: Intracellular phagocytic killing was measured via colony-forming units (CFU) and cytokine expression via ELISA. G. mellonella survival was used to determine the therapeutic potential of SFN in vivo. Results: Dose–response curves indicated that SFN concentrations of less than 20 µM were not cytotoxic in either MH-S (murine) or THP-1 (human) cells. Live infection assay results showed that MH-S and THP-1 cells pretreated with SFN (5 µM) and challenged with 0.2% (v/v) alcohol for 3 or 8 h prior to live B. thailandensis or S. epidermidis infection improved intracellular pathogen killing between 12- and 20-fold compared to macrophages treated with alcohol alone. ELISA analysis indicated that SFN significantly reduced levels of Tumor necrosis factor-alpha (TNF-α) expression at 3 and 8 h compared to controls. Additionally, a Galleria mellonella larvae model demonstrated greater survivability in the prophylaxis group compared to larvae exposed to either Gram-positive or Gram-negative pathogens, as well as in groups that received alcohol prior to pathogen inoculation. Conclusions: Taken together, SFN-induced cytoprotection was extended beyond in vitro cell culture to include an in vivo G. mellonella model demonstrating protection against Gram-positive and negative opportunistic pathogens. These data demonstrate that SFN may be an effective pretreatment option to prevent alcohol-mediated innate immune dysfunction and restore macrophage phagocytic killing. Full article

Firefighters face elevated risks of alcohol misuse due to occupational stress, trauma exposure, and cultural norms within the fire service. This beta test study evaluated the feasibility, acceptability, and preliminary outcomes of From Bottle to Nozzle, a digitally delivered alcohol awareness and prevention intervention tailored for firefighters. Fifty fire service personnel were invited to participate; 46 consented and completed baseline questionnaires, and 22 completed the full program. The intervention consisted of five self-paced online modules incorporating multimedia content, quizzes, and self-assessments that addressed alcohol history, fire service culture, risk-reduction strategies, communication, and health effects. Pre- and post-intervention assessments measured changes in alcohol-related knowledge, alcohol use, motivation to reduce drinking, and usability. Reinforcement messages were delivered via text and email. Alcohol-related knowledge improved significantly post-intervention, particularly in the general and total knowledge domains. Moderate drinkers showed reductions in drinking days and AUDIT scores. Among heavy drinkers, overall consumption declined slightly, though binge-drinking episodes increased. Changes in motivation to reduce drinking were mixed. Usability ratings were high, with an 80% module completion rate and favorable feedback on program brevity and format, though navigation and video length were noted as challenges. From Bottle to Nozzle demonstrated strong feasibility and acceptability. While knowledge gains were robust, behavioral outcomes were mixed, highlighting the need for larger controlled studies with extended follow-up. Full article

Urbanization has significantly affected the availability and quality of urban green and blue spaces (UGBSs), which may affect mental health. In the United States, rates of anxiety and depression continue to rise, particularly in urban regions. This study examined the relationship between UGBS exposure and mental health, measured by Frequent Mental Distress (FMD), across major cities in the contiguous United States (CONUS) from 2015 to 2017. UGBS exposure was estimated using remote sensing and GIS, and its association with FMD was assessed using Ordinary Least Squares (OLS) regression and Geographically Weighted Regression (GWR). The analyses also included smoking, binge drinking, median income, and educational attainment as covariates. OLS results indicated statistically significant but spatially uniform associations, whereas GWR revealed considerable spatial variation in UGBS and covariate effects across cities. Median income and educational attainment consistently showed inverse relationships with FMD, while smoking showed direct relationships across all years. Binge drinking exhibited both direct and inverse relationships. Additionally, both green space and blue space showed different relationships with FMD depending on location and year. The beneficial effect of UGBS on FMD was not observed in every instance. These findings help clarify the relationship between environmental, behavioral, and socioeconomic factors and mental health in urban settings, providing information that may support informed urban planning and public health decisions. Full article

Background: Due to variability in patterns of consumption as well as well-known difficulties in obtaining valid self-report from heavy drinkers, quantifying the effects of heavy alcohol consumption on mortality is challenging. Using a DNA methylation biomarker of chronic heavy alcohol consumption (HAC) named the alcohol T-score (ATS), we previously showed that chronic HAC was a strong predictor of mortality. However, whether there is a similar effect when measures of shorter-term heavy alcohol use, i.e., recent “binge” drinking, were used to predict mortality was not examined. This is a critical issue because most biomarkers of HAC assess only short-term HAC. Methods: Therefore, we examined the prediction of all-cause mortality from a DNA methylation biomarker of smoking (cg05575921), the ATS and a short-term biomarker of recent heavy alcohol use (cg07375256) in 708 subjects from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial using Cox Proportional Hazards Regression Modeling. Models were compared using Akaike’s Information Criterion. Results: The ATS was the best single predictor among three-variable models that included controls for sex and age. Of the possible four variable models, the model consisting of age, sex, cg05575921 methylation and ATS best predicted mortality. The addition of cg07375256 methylation did not improve model performance. In sensitivity analyses using only participants who provided alcohol SR (n = 639), the importance of the ATS and cg05575921 was replicated. We also found that ATS values were higher among those who declined to provide self-report alcohol use, indicating that missing self-report data about alcohol intake are not missing at random, and sometimes reflects elevated alcohol consumption. Finally, cg05575921 methylation was strongly associated with ATS values but only weakly with alcohol SR and not at all with cg07375256 methylation. Conclusions: Accordingly, this study indicates a strong effect of chronic HAC, but not short-term HAC, on mortality, further highlights the limitations of self-reported alcohol use in the prediction of all-cause mortality and indicates the value of assessing HAC in addition to smoking. Full article

Background/Objectives: Since 1988, the IARC has classified alcohol as a type 1 carcinogen, causally linked to seven types of cancer (oral cavity, pharynx, larynx, esophagus, colorectum, liver and breast carcinomas). Several agencies, such as the WHO and the IARC, hold that there is a direct monotonic association between any gram of alcohol consumed and the risk of cancer, regardless of the drinking pattern. On the other hand, an expanding body of evidence indicates that drinking pattern may substantially modify the effect of alcohol consumption. The Mediterranean alcohol-drinking pattern (MADP) includes different aspects of alcohol consumption, such as preference for red wine, moderate alcohol consumption with meals, spreading consumption over the week and avoiding binge drinking. Conformity to this pattern has shown inverse associations with all-cause mortality, cardiovascular disease and diabetes. However, its relationship with cancer incidence has not been studied yet. Our objective was to assess how alcohol consumption patterns, with particular emphasis on the MADP, relate to the incidence of the seven alcohol-related cancers. This information is needed to support cancer prevention recommendations that may go beyond the amount of alcohol consumed to also include the drinking pattern. Methods: We prospectively followed 19,541 participants in the SUN (“Seguimiento Universidad de Navarra”) cohort for a median of 13.8 years. We classified participants into four groups, namely, abstainers and three further groups according to their adherence to the MADP score (low, moderate and high). Results: A substantial reduction in the risk of alcohol-related cancer incidence was observed only in men for high versus low adherence to the MADP, with an adjusted hazard ratio (HR) of 0.44 (95% confidence intervals (CIs) (0.21–0.92)). The category of moderate adherence to the MADP showed a lower risk of cancer incidence with a tendency towards statistical significance (HR = 0.56, 95% CI, 0.30–1.06). For women, no result reached statistical significance. Conclusions: Based on the available evidence, separate messages by sex should be delivered. In men, the association between alcohol and cancer goes beyond the amount of alcohol consumed, and a Mediterranean drinking pattern may be beneficial even for alcohol-related cancers. Men should, therefore, receive an additional message: among alcohol consumers, greater adherence to the MADP may help lower their risk of developing alcohol-related cancers. No benefit is supported for the MADP against alcohol-related cancers in women. Full article

Adolescence is a critical period during which alcohol is the most commonly used substance worldwide, and such use has detrimental effects on neurobiological, psychosocial, and physiological development. Despite substantial international evidence, little is known about the concurrent influence of drinking motives and internalizing symptoms on adolescent alcohol use, particularly in the Croatian context, where adolescent drinking rates remain high. A cross-sectional study using a survey questionnaire was conducted in 2024 in Split-Dalmatia County, Croatia. The final stratified cluster sample comprised 925 students (58.8% of the planned sample), with a mean age of 15.41 years. Using hierarchical regression analysis, the results showed that the final model, which included both drinking motives and mental health indicators, explained 39.6% of the variance in alcohol use, 37.2% of the variance in binge drinking, and 31.8% of the variance in alcohol intoxication. Male sex was consistently associated with all three outcomes, whereas age was positively associated with alcohol use and binge drinking. Drinking motives contributed the largest proportion of the explained variance. Furthermore, lower levels of loneliness and higher levels of anxiety were associated with more frequent alcohol use, while lower stress and higher anxiety were associated with more frequent intoxication. Drinking motives are stronger predictors of adolescent alcohol use and risky drinking patterns than internalizing symptoms whose predictive strength was generally small. Prevention programs should address aspects of drinking motives in addition to promoting mental health. Full article

Background: The use of electronic cigarettes (ECs) has become a significant public health problem, especially among young people. EC use has been associated with increased nicotine exposure and other toxic substances, increasing the risk of early addiction and health problems. Recently, attention has focused on understanding the interplay between psychosocial stressors, exposure to violence, psychological distress, and an increased propensity to experiment with nicotine. Hence, the aim of this study was to estimate the prevalence of EC use in the previous month and its associated factors. Methods: This is a cross-sectional study based on secondary data analysis of a nationwide survey conducted to monitor risk and protective factors for the health of school-aged adolescents (52.89% males; 55.97% aged up to 15 years old). Specifically, we analyzed data from adolescents aged 13–17 years who answered questions on EC use (n = 36,659). Results: The results show that the prevalence of EC use in this sample was 11.23% (IC95%: 11.23, 11.87). Logistic regression revealed several factors that increased the likelihood of EC use, such as alcohol use by friends, alcohol use in the past month, gender (male), intentional binge drinking, higher mental health symptoms, living in urban areas, experience of abuse at home, report of other drug use, and smoking friends, with the latter exerting a higher influence. Conclusion: Findings show the interplay of peers, family and environmental influences on youth risk behavior. Prevention strategies should therefore include school- and family-based interventions, trauma-informed approaches and anti-marketing campaigns to dispel misconceptions regarding EC. Full article

Chronic binge drinking is common among patients with alcohol-associated steatohepatitis. Therefore, we tested the hypothesis that chronic binge ethanol exposure disrupts mitophagic processing and stimulates release of mitochondrial damage-associated molecular patterns (mtDAMPs), thereby promoting hepatic inflammation and fibrosis after chronic binge ethanol (CBE) exposure in mice using the National Institute of Alcohol Abuse and Alcoholism model. After CBE, hepatic steatosis, liver injury, inflammation, and hepatic stellate cell (HSC) activation occurred. Alda-1, an aldehyde dehydrogenase-2 activator, attenuated these changes. After CBE, mitochondrial depolarization (mtDepo) occurred in ~85% hepatocytes, and mitophagy-associated proteins increased, which Alda-1 blunted. By contrast, transcription factor-EB (master regulator of lysosomal biogenesis) and lysosomal markers decreased, indicating disrupted lysosomal processing. After mitophagy, mitochondrial biogenesis (MB) restores mitochondrial mass and function. After CBE, peroxisome proliferator-activated receptor gamma coactivator-1 alpha (MB regulator), mitochondrial transcription factor-A, oxidative phosphorylation proteins, and fatty acid oxidation all decreased, which Alda-1 largely restored. After CBE, serum mtDAMPs (mitochondrial DNA and cytochrome c) increased 3- to 10-fold. In vitro, mitochondrial DNA stimulated macrophage and HSC activation, which was prevented by toll-like receptor-9 inhibition. In conclusion, CBE increases mtDepo in an acetaldehyde-dependent fashion, leading to mitophagic overburden, disruption of mitochondrial homeostasis, mtDAMP release, and ultimately development of liver inflammation and injury. Full article

Binge drinking is defined as consuming a large amount of alcohol in a short period of time, whereas hangover is a cluster of unpleasant mental symptoms and physical signs that typically manifest the next day after binge drinking. Binge drinking is a prevalent pattern of alcohol consumption, especially in adolescents, with dualistic effects on social behavior. While some studies demonstrate that a single episode of binge drinking enhances sociability and preference for social novelty, other studies indicate that repeating cycles of binge drinking and hangover can lead to persistent negative affect and consequently social withdawal. This is an integrative narrative review synthesizing human studies and animal models of binge drinking (also known as alcohol intoxication) and hangover (also known as alcohol withdrawal). The major databases consulted were PubMed, Scopus, and Web of Science. The search terms used were “binge drinking” or “hangover”and “social behavior” or “social brain” in combination with “rats”, “mice” or “humans”. Finding the missing link between structural and functional changes in the social brain in the context of binge drinking and hangover is crucial for developing novel therapeutic strategies for alcohol intoxication and withdrawal. This review focuses on changes in hypothalamic neurohormones and extrahypothalamic neurotransmitters in these states, and concludes with the statement that targeting neuropeptides such as corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) and their receptors, which are involved in both binge drinking and social behavior, may prevent repeated cycles of binge drinking and hangover from spiraling into alcohol addiction and, ultimately, social isolation. Full article

Binge drinking (BD) is defined as a pattern of alcohol consumption that results in a blood alcohol concentration of 0.08 g/dL or higher, typically achieved after consuming approximately 70 g of pure alcohol (about five drinks for men) or 56 g (about four drinks for women) within roughly two hours. It is highly prevalent among adolescents and young adults and has significant physical, psychological, and social consequences. Despite numerous interventions to reduce BD, there is limited systematic evidence on their effectiveness. This study presents a systematic review of randomized controlled trials (RCTs) evaluating interventions to reduce BD, focusing on their impact on frequency, intensity, and associated physical, psychological, or social outcomes. The review followed PRISMA 2020, and the protocol was registered with PROSPERO (CRD42024623481). A comprehensive search was conducted in multidisciplinary and specialized databases. Included studies were RCTs targeting BD in clinical or community populations of any age. Non-empirical and observational studies, or studies not specifically focused on BD were excluded. The risk of bias was assessed using RoB 2, and a total of 21 studies (N = 14,754 participants) were included, showing high variability in design, format, and theoretical basis. Brief, individual digital interventions predominated, although face-to-face group and multimodal interventions proved more effective. Eleven studies reported significant reductions in BD frequency or prevalence; fewer addressed intensity. Interventions based on motivational and cognitive behavioral approaches, especially in structured programmes with prolonged follow-up, were the most effective. Improvements were observed in psychosocial variables (e.g., negative consequences, self-efficacy, expectations, social norms, and intention to consume), but not in physical health or consumption of other substances. Most studies had a moderate risk of bias, and few demonstrated long-term effects. More robust, comparative, and longitudinal studies are needed. Full article

Cervical cancer is the fourth most common cancer among women worldwide and remains a significant cause of cancer-related mortality. Alcohol consumption is linked to an increased risk of several cancers and is a controversial risk factor for developing cervical cancer. This review updates existing information on the correlation between alcohol consumption and the risk of developing cervical cancer. Several comprehensive studies from different geographical regions have shown that moderate and heavy drinking is positively correlated with the development of cervical cancer. There is a synergistic relationship between human papillomavirus (HPV) viral load and alcohol use among drinkers with a high HPV viral load. Excessive alcohol consumption and exposure to second-hand smoke may elevate the risk of persistent HPV infection. Furthermore, high-risk behaviors associated with Human immunodeficiency virus (HIV)/HPV co-infection are more common among binge drinkers. However, several observations failed to establish a relationship between these factors. Despite some inconsistency in the literature, evidence suggests a modest association between alcohol consumption and increased risk of persistent HPV infection, causing cervical cancer. Full article

Short sleep duration (≤6 h) is a public health concern linked to cardiometabolic disease and premature mortality. However, persistent disparities across sociodemographic, psychosocial, and structural domains remain underexplored in recent nationally representative samples. We analyzed 2022 Behavioral Risk Factor Surveillance System (BRFSS) data, including 228,463 adults (weighted N ≈ 122 million). Sleep duration was dichotomized as short (≤6 h) versus adequate (≥7 h). Complex samples logistic regression estimated associations between sociodemographic, psychosocial, behavioral, and structural determinants and short sleep, accounting for survey design. The weighted prevalence of short sleep was 33.2%. Non-Hispanic Black (AOR = 1.56, 95% CI: 1.46–1.65) and American Indian/Alaska Native adults (AOR = 1.46, 95% CI: 1.29–1.65) were disproportionately affected compared with non-Hispanic White adults. Psychosocial factors contributed strongly: life dissatisfaction, limited emotional support, and low social connectedness increased odds, whereas high connectedness was protective. Food insecurity and smoking were significant structural and behavioral risks, while binge drinking and urbanicity were not. One-third of U.S. adults report short sleep, with marked disparities across demographic, socioeconomic status, psychosocial stressors, and structural barriers. Findings highlight the multifactorial nature of sleep health inequities and the need for multilevel interventions addressing both individual behaviors and upstream determinants. Full article

Alcohol, tobacco, and drug misuse continue to rise globally, with adolescents at particular risk. In response, school-based prevention programs have been widely implemented, yet their efficacy and long-term impact remain under-discussed. This scoping review synthesised evidence on the effectiveness of three commonly used programs (Preventure, Unplugged, and IPSYcare) in Europe. A search of four databases (PubMed, Embase, PsycInfo, and Web of Science) identified 21 peer-reviewed articles published between 2008 and 2023, spanning 12 European countries. Unplugged was most frequently evaluated (10 studies), followed by Preventure (6 studies) and IPSYcare (5 studies). Findings showed that Preventure yielded mixed outcomes, delaying binge drinking and reducing substance use among high-risk groups but with limited generalisability. Unplugged was associated with reductions in cannabis use and heavy drinking at 15 months post-intervention. IPSYcare demonstrated longer-term benefits, including improved school connectedness and reductions in alcohol and tobacco use. Results suggest that while standardised programs such as Unplugged enable scalability, contextual adaptations may enhance effectiveness, and tailored approaches are valuable for high-risk populations. Overall, the programs show potential, but variability indicate the need for further longitudinal and qualitative research in order to improve program delivery and sustain long-term impacts. Full article

Background/Objectives: University students frequently engage in risky alcohol consumption, making them a priority population for targeted interventions. Motivational interventions (MIs) have been widely implemented to address this issue, but evidence of their effectiveness remains heterogeneous. This study aimed to evaluate the efficacy of MIs in reducing alcohol consumption and related harm among university students through a systematic review and meta-analysis. Methods: A systematic search was conducted in PubMed, Scopus, and BVS Library, including randomized controlled trials (RCTs) published up to April 2025. The PRISMA and RoB-2 tools guided reporting and risk of bias assessment. Random-effects models were applied to pool effect sizes for changes in alcohol consumption patterns and related consequences. Results: Fifteen RCTs were included. MIs significantly reduced daily alcohol intake (−0.55 drinks/day; 95% CI: −0.78 to −0.32), with additional reductions in weekly consumption and binge drinking episodes, though these were not statistically significant. Positive effects were also observed in reducing alcohol-related consequences and blood alcohol concentration levels. Short, single-session formats (45–90 min) showed consistent efficacy across studies, with effects sustained at 2–3 months and, in some cases, up to one year post-intervention. Conclusions: MIs are effective, brief, and adaptable strategies for reducing harmful alcohol use and associated negative outcomes among university students. Their simplicity, feasibility, and sustained effects make them valuable tools for university health programs. Future research should focus on optimizing intervention components and evaluating their effectiveness in diverse cultural and socioeconomic contexts. Full article

Background/Objectives: Alcohol use is a significant public health concern for adolescents, not only for its direct health impacts but also for its association with other health risk behaviors. In particular, alcohol use has been linked to sexual behaviors that may increase the risk of HIV transmission. This systematic review aims to provide a deeper understanding of the relationships between various alcohol- and HIV-related risk behaviors among adolescents by synthesizing existing literature that exclusively uses Youth Risk Behavior Survey (YRBS) data. Methods: This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A search was conducted in PubMed, Web of Science, and PsycINFO. Eligible studies were peer-reviewed, published in English, and analyzed associations between alcohol use (age at first drink, alcohol use, binge drinking) and HIV risk behaviors (number of sexual partners, condom use, HIV testing) using YRBS data from the 2005–2021 collection years. Two authors independently screened 1133 records for eligibility, with 17 studies included in the final review. Results: The included studies consistently found a significant positive association between the frequency of alcohol use and binge drinking and a greater number of sexual partners. However, the evidence for an association between alcohol use and condom non-use was mixed. Limited evidence suggests that age of first alcohol use is not correlated with condom non-use. A key finding was the wide variation in study methodology, including the use of lifetime versus recent and dichotomized versus ordinal measures. Additionally, few studies were guided by a theoretical framework. Conclusions: The findings support a consistent link between alcohol use and having a greater number of sexual partners but highlight mixed evidence regarding condom use and little evidence for an association with HIV testing. This review demonstrates a need for more nuanced, theory-driven analyses that better utilize the multidimensional data available in the YRBS to capture the complex nature of risk behaviors. Full article