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16 pages, 2823 KiB  
Article
Electronic Properties of Molybdenum Disulfide Rings-Based Chains Associated with Length and Bias
by Yang Shu, Jie Li, Rukai Liu and Junnan Guo
Coatings 2025, 15(7), 827; https://doi.org/10.3390/coatings15070827 - 16 Jul 2025
Viewed by 224
Abstract
Molybdenum disulfide is more attractive and valuable at the molecular level due to its unique structure and exceptional properties. Here, new-type MoS2-ring chains are constructed and theoretically investigated for relevant electronic properties influenced by the length of the chain and the [...] Read more.
Molybdenum disulfide is more attractive and valuable at the molecular level due to its unique structure and exceptional properties. Here, new-type MoS2-ring chains are constructed and theoretically investigated for relevant electronic properties influenced by the length of the chain and the bias. Different from traditional wires, our findings demonstrate that the conductance of such a new-type chain presents unusually non-exponential decay with the length of the chain, with a particularly anomalous length of seven rings, which shows stronger equilibrium conductance than a shorter four-ring chain. Multi-peaks of electron transmission and delocalized electronic states contribute such uniqueness. Mo atoms play a vital role in electron transport. Essentially, a narrower “HOMO-LUMO” (the two closest energy levels to the Fermi level of MoS2-ring chain) gap compensates for the lower device density of states of new-type molybdenum disulfide-ring chains. The usual electronic structure of a seven-ring chain is derived from its slightly arched structure and mainly originates from interference, which is the resonance occurring between the electrodes. Noticeably, the bias could greatly enhance conductance, which could reach 1000 times more than the equilibrium conductance. At a certain bias, the conductance of a seven-ring chain even exceeds the shortest one- or two-ring chain. Furthermore, the threshold voltage (at which the maximum conductance appears) gradually decreases with the length of the chain and eventually remains at 0.7 V. The valuable negative differential resistance (NDR) effect could be found in such a molecular chain, which becomes more obvious as the length rises until the seven-ring chain reaches the peak. Our findings shed light on the relations between electronic properties and the length of a new-type molybdenum disulfide-ring chain, and provide support for such new-type chains in applications of innovative low-power and controllable electronics. Full article
(This article belongs to the Special Issue Research in Laser Welding and Surface Treatment Technology)
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15 pages, 3025 KiB  
Article
High-Power-Density Miniaturized VLF Antenna with Nanocrystalline Core for Enhanced Field Strength
by Wencheng Ai, Huaning Wu, Lin Zhao and Hui Xie
Nanomaterials 2025, 15(14), 1062; https://doi.org/10.3390/nano15141062 - 9 Jul 2025
Viewed by 303
Abstract
In order to break through the difficulties with a very-low-frequency (VLF) miniaturized antenna with small power capacity and low radiation efficiency, this paper proposes a high-radiation-field-strength magnetic loop antenna based on a nanocrystalline alloy magnetic core. A high-permeability nanocrystalline toroidal core (μ [...] Read more.
In order to break through the difficulties with a very-low-frequency (VLF) miniaturized antenna with small power capacity and low radiation efficiency, this paper proposes a high-radiation-field-strength magnetic loop antenna based on a nanocrystalline alloy magnetic core. A high-permeability nanocrystalline toroidal core (μr = 50,000, Bs = 1.2 T) is used to optimize the thickness-to-diameter ratio (t = 0.08) and increase the effective permeability to 11,000. The Leeds wires, characterized by their substantial carrying capacity, are manufactured through a toroidal winding process. This method results in a 68% reduction in leakage compared to traditional radial winding techniques and enhances magnetic induction strength by a factor of 1.5. Additionally, this approach effectively minimizes losses, thereby facilitating support for kilowatt-level power inputs. A cascaded LC resonant network (resonant capacitance 2.3 μF) and ferrite balun transformer (power capacity 3.37 kW) realize a 20-times amplification of the input current. A series connection of a high-voltage isolation capacitor blocks DC bias noise, guaranteeing the stable transmission of 1200 W power, which is 6 times higher than the power capacity of traditional ring antenna. At 7.8 kHz frequency, the magnetic field strength at 120 m reaches 47.32 dBμA/m, and, if 0.16 pT is used as the threshold, the communication distance can reach 1446 m, which is significantly better than the traditional solution. This design marks the first instance of achieving kilowatt-class VLF effective radiation in a compact 51 cm-diameter magnetic loop antenna, offering a highly efficient solution for applications such as mine communication and geological exploration. Full article
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26 pages, 1541 KiB  
Article
Projected Urban Air Pollution in Riyadh Using CMIP6 and Bayesian Modeling
by Khadeijah Yahya Faqeih, Mohamed Nejib El Melki, Somayah Moshrif Alamri, Afaf Rafi AlAmri, Maha Abdullah Aldubehi and Eman Rafi Alamery
Sustainability 2025, 17(14), 6288; https://doi.org/10.3390/su17146288 - 9 Jul 2025
Viewed by 516
Abstract
Rapid urbanization and climate change pose significant challenges to air quality in arid metropolitan areas, with critical implications for public health and sustainable development. This study projects the evolution of air pollution in Riyadh, Saudi Arabia, through 2070 using an integrated modeling approach [...] Read more.
Rapid urbanization and climate change pose significant challenges to air quality in arid metropolitan areas, with critical implications for public health and sustainable development. This study projects the evolution of air pollution in Riyadh, Saudi Arabia, through 2070 using an integrated modeling approach that combines CMIP6 climate projections with localized air quality data. We analyzed daily concentrations of major pollutants (SO2, NO2) across 15 strategically selected monitoring stations representing diverse urban environments, including traffic corridors, residential areas, healthcare facilities, and semi-natural zones. Climate data from two Earth System Models (CNRM-ESM2-1 and MPI-ESM1.2) were bias-corrected and integrated with historical pollution measurements (2000–2015) using hierarchical Bayesian statistical modeling under SSP2-4.5 and SSP5-8.5 emission scenarios. Our results revealed substantial deterioration in air quality, with projected increases of 80–130% for SO2 and 45–55% for NO2 concentrations by 2070 under high-emission scenarios. Spatial analysis demonstrated pronounced pollution gradients, with traffic corridors (Eastern Ring Road, Northern Ring Road, Southern Ring Road) and densely urbanized areas (King Fahad Road, Makkah Road) experiencing the most severe increases, exceeding WHO guidelines by factors of 2–3. Even semi-natural areas showed significant increases in pollution due to regional transport effects. The hierarchical Bayesian framework effectively quantified uncertainties while revealing consistent degradation trends across both climate models, with the MPI-ESM1.2 model showing a greater sensitivity to anthropogenic forcing. Future concentrations are projected to reach up to 70 μg m−3 for SO2 and exceed 100 μg m−3 for NO2 in heavily trafficked areas by 2070, representing 2–3 times the Traffic corridors showed concentration increases of 21–24% compared to historical baselines, with some stations (R5, R13, and R14) recording projected levels above 4.0 ppb for SO2 under the SSP5-8.5 scenario. These findings highlight the urgent need for comprehensive emission reduction strategies, accelerated renewable energy transition, and reformed urban planning approaches in rapidly developing arid cities. Full article
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24 pages, 5362 KiB  
Article
Critical Design and Characterization Methodology for a Homemade Three-Axis Fluxgate Magnetometer Measuring Ultra-Low Magnetic Fields
by Hava Can, Fatma Nur Çelik Kutlu, Peter Svec, Ivan Skorvanek, Hüseyin Sözeri, Çetin Doğan and Uğur Topal
Sensors 2025, 25(13), 3971; https://doi.org/10.3390/s25133971 - 26 Jun 2025
Viewed by 399
Abstract
This paper presents the design, fabrication, calibration, and comprehensive characterization of a homemade tri-axial fluxgate magnetometer. The magnetometer, utilizing a ring core configuration, was developed to measure ultra-low magnetic fields with high sensitivity and stability. Critical stages from material selection to sensor geometry [...] Read more.
This paper presents the design, fabrication, calibration, and comprehensive characterization of a homemade tri-axial fluxgate magnetometer. The magnetometer, utilizing a ring core configuration, was developed to measure ultra-low magnetic fields with high sensitivity and stability. Critical stages from material selection to sensor geometry optimization are discussed in detail. A series of critical characterization processes were conducted, including zero-field voltage determination, scale factor calculation, resolution measurement, noise analysis, bias assessment, cross-field effect evaluation, temperature dependency, and bandwidth determination. The sensor demonstrated a minimum detectable magnetic field resolution of 2.2 nT with a noise level of 1.1 nT/√Hz at 1 Hz. Temperature dependency tests revealed minimal impact on sensor output with a maximum shift of 120 nT in the range of 60 °C, which was effectively compensated through calibration to less than 5 nT. Additionally, the paper introduces a model function in matrix form to relate the magnetometer’s output voltage to the measured magnetic field, incorporating temperature dependency and cross-field effects. This work highlights the importance of meticulous calibration and optimization in developing fluxgate magnetometers suitable for various applications, from space exploration to biomedical diagnostics. Full article
(This article belongs to the Special Issue Advances and Applications of Magnetic Sensors: 2nd Edition)
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12 pages, 823 KiB  
Review
Do Non-Circular Chainrings Enhance Cycling Performance? A Systematic Review of Randomized Crossover Trials
by Filipe Maia, Henrique Sousa, Oscar Garcia-Garcia, Ricardo Pimenta, Paulo Santiago, Pedro Castro Vigário, Gonçalo Torres and Fábio Yuzo Nakamura
J. Funct. Morphol. Kinesiol. 2025, 10(3), 233; https://doi.org/10.3390/jfmk10030233 - 20 Jun 2025
Viewed by 968
Abstract
Background: Athletes commonly use innovative strategies that aim to enhance their cycling performance. Among them, the effectiveness of non-circular chainrings has been a frequent topic of discussion. This systematic review aims to analyze the physiological and performance effects of using non-circular chainrings [...] Read more.
Background: Athletes commonly use innovative strategies that aim to enhance their cycling performance. Among them, the effectiveness of non-circular chainrings has been a frequent topic of discussion. This systematic review aims to analyze the physiological and performance effects of using non-circular chainrings in cyclists. Methods: A literature search was conducted on populations ranging from recreational to elite-level athletes, following the PRISMA guidelines. The electronic databases searched were PubMed, Web of Science, Academic Search Complete, Scopus, and SportDiscus, using the search terms (“oval chainring*” OR “non-circular chainring*” OR “elliptical chainring*” OR “asymmetric chainring*” OR “Q-Ring*” OR “eccentric chainring*” OR “chainring*”) AND (cycl*), on 11 May 2025. The risk of bias was assessed using the Cochrane Risk of Bias tool with an extension for crossover studies, indicating some concerns regarding the included studies. Results: The initial search identified 291 research articles, which, after applying the screening criteria, resulted in the inclusion of 18 manuscripts. The results suggest that non-circular chainrings do not appear to improve cycling performance metrics or physiological variables during prolonged efforts; however, it is possible that they enhance the sprinting capacity. Conclusions: While the research remains inconclusive, future studies should further explore the effects of non-circular chainrings on sprinting performance. Full article
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15 pages, 2006 KiB  
Article
A CMOS-Based Terahertz Reconfigurable Reflectarray with Amplitude Control: Design and Validation
by You Wu, Yongli Ren, Fan Yang, Shenheng Xu and Maokun Li
Appl. Sci. 2025, 15(12), 6638; https://doi.org/10.3390/app15126638 - 12 Jun 2025
Viewed by 447
Abstract
Terahertz reconfigurable reflectarray antennas (RRAs) hold significant promise for next-generation wireless communication systems by enabling dynamic beam control to mitigate severe path loss at high frequencies. This work presents a Complementary Metal-Oxide-Semiconductor (CMOS)-based RRA for terahertz amplitude control using tunable split-ring resonators. First, [...] Read more.
Terahertz reconfigurable reflectarray antennas (RRAs) hold significant promise for next-generation wireless communication systems by enabling dynamic beam control to mitigate severe path loss at high frequencies. This work presents a Complementary Metal-Oxide-Semiconductor (CMOS)-based RRA for terahertz amplitude control using tunable split-ring resonators. First, a terahertz switch in standard 65 nm CMOS process is designed, tested, and calibrated on the chip to extract the equivalent impedance, enabling precise RRA element design. Next, a reconfigurable element architecture is presented through the co-design of a split-ring radiator, control line, and a single switch. Experimental characterization demonstrates that the fabricated RRA achieves 3 dB amplitude variation at 0.290 THz with <8.5 dB element loss under 0.8 V gate bias. The measured results validate that the proposed single-switch topology effectively balances reconfigurability and loss performance in the terahertz regime. The demonstrated CMOS-compatible RRA provides a scalable solution for real-time beamforming in terahertz communication systems. Full article
(This article belongs to the Special Issue Recent Advances in Reflectarray and Transmitarray Antennas)
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15 pages, 4087 KiB  
Article
A 0.4 V CMOS Current-Controlled Tunable Ring Oscillator for Low-Power IoT and Biomedical Applications
by Md Anas Abdullah, Mohamed B. Elamien and M. Jamal Deen
Electronics 2025, 14(11), 2209; https://doi.org/10.3390/electronics14112209 - 29 May 2025
Viewed by 888
Abstract
This work presents a current-controlled CMOS ring oscillator (CCRO) optimized for ultra-low-voltage applications in next-generation energy-constrained systems. Leveraging bulk voltage tuning in 22 nm FDSOI differential inverter stages, the topology enables frequency adjustment while operating MOSFETs in the subthreshold region—critical for minimizing power [...] Read more.
This work presents a current-controlled CMOS ring oscillator (CCRO) optimized for ultra-low-voltage applications in next-generation energy-constrained systems. Leveraging bulk voltage tuning in 22 nm FDSOI differential inverter stages, the topology enables frequency adjustment while operating MOSFETs in the subthreshold region—critical for minimizing power in sub-1 V environments. Simulations at 0.4 V supply demonstrate robust performance: a three-stage oscillator achieves a 537–800 MHz tuning range with bias current (IBIAS) modulation from 30–130 nA, while a four-stage configuration spans 388–587 MHz. At 70 nA IBIAS, the three-stage design delivers a nominal frequency of 666.8 MHz with just 10.23 µW power dissipation, underscoring its suitability for ultra-low-power IoT and biomedical applications. The oscillator’s linear frequency sensitivity (2.63 MHz/nA) allows precise, dynamic control over performance–power tradeoffs. To address diverse application needs, the design integrates three tunability mechanisms: programmable capacitor arrays for coarse frequency adjustments, configurable stage counts (three- or four-stage topologies), and supply voltage scaling. This multi-modal approach extends the operational range to 1 MHz–1 GHz, ensuring compatibility with low-speed sensor interfaces and high-speed edge-computing tasks. The CCRO’s subthreshold operation at 0.4 V—coupled with nanoampere-level current consumption—makes it uniquely suited for battery-less systems, wearable health monitors, and implantable medical devices where energy efficiency and adaptive clocking are paramount. By eliminating traditional voltage-controlled oscillators’ complexity, this topology offers a compact, scalable solution for emerging ultra-low-power technologies. Full article
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11 pages, 2795 KiB  
Article
Experiment and Analysis of Termination Robustness Design for 1200 V 4H-SiC MOSFET
by Mengyuan Yu, Yi Shen, Hongping Ma and Qingchun Zhang
Nanomaterials 2025, 15(11), 805; https://doi.org/10.3390/nano15110805 - 27 May 2025
Viewed by 541
Abstract
This study investigates the degradation mechanisms of 1200 V SiC MOSFETs during High-temperature Reverse Bias (HTRB) reliability testing, focusing on breakdown voltage (BV) reduction. Experimental results reveal that trapped charges at the SiC/SiO2 interface in the termination region alter electric field distribution, [...] Read more.
This study investigates the degradation mechanisms of 1200 V SiC MOSFETs during High-temperature Reverse Bias (HTRB) reliability testing, focusing on breakdown voltage (BV) reduction. Experimental results reveal that trapped charges at the SiC/SiO2 interface in the termination region alter electric field distribution, leading to premature breakdown. To address this issue, an optimized termination structure is proposed, incorporating reduced spacing between adjacent field rings and additional outer rings. TCAD simulations and experimental validation demonstrate that the improved design stabilizes BV within 2% deviation during 1000 h HTRB testing, which significantly enhances termination robustness. Full article
(This article belongs to the Section Nanoelectronics, Nanosensors and Devices)
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15 pages, 2171 KiB  
Article
First Application of a New Rapid Method of Age Determination in European Anchovy (Engraulis encrasicolus) by Fourier Transform Near-Infrared Spectroscopy
by Gualtiero Basilone, Miryam Fortuna, Gabriella Lo Cicero, Simona Genovese, Giovanni Giacalone, Ignazio Fontana, Angelo Bonanno, Salvatore Aronica and Rosalia Ferreri
J. Mar. Sci. Eng. 2025, 13(5), 961; https://doi.org/10.3390/jmse13050961 - 15 May 2025
Viewed by 421
Abstract
Age determination through reading annual rings in whole otoliths is a complicated, time-consuming task that can lead to errors in population age structure, negatively affecting marine fish management plans. Recently, Fourier transform near-infrared spectroscopy (FT-NIRS) has been successfully used to evaluate annual age, [...] Read more.
Age determination through reading annual rings in whole otoliths is a complicated, time-consuming task that can lead to errors in population age structure, negatively affecting marine fish management plans. Recently, Fourier transform near-infrared spectroscopy (FT-NIRS) has been successfully used to evaluate annual age, at least in several long-life fish species. European anchovy (Engraulis encrasicolus) is an important pelagic species for its ecological role and socioeconomic value. In the Mediterranean Sea, anchovy stocks are regularly monitored for assessment purposes, and fish age is calculated by traditional otolith reading. In the present study, anchovies, caught over a decade (2012 to 2023) during on-board surveys in four different areas (i.e., North Tyrrhenian, South Tyrrhenian, North of Sicily, and Strait of Sicily), provided an otolith collection used to acquire absorption spectra by FT-NIRS. These spectra were processed to optimize calibration models, and the best linear models obtained revealed a good predictability for anchovy annual age (coefficient of determination of 0.90, mean squared error 0.3 years, bias < 0.001 years). The calibration model developed for all regions combined proved more robust than the models for each area, demonstrating its efficacy for the entire study area. FT-NIRS analyses proved suitable for predicting age, when applied to E. encrasicolus individuals within the age range of 0 to 3, also when compared to traditional aging methods. Moreover, this methodology improved the standardization of age estimates. Finally, this preliminary study encourages the further application of FT-NIRS also to short-life pelagic species involved in stock assessment plans. Full article
(This article belongs to the Section Marine Biology)
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14 pages, 5389 KiB  
Article
Impact of the Guard Rings on Self-Induced Signal and Leakage Current in Trench-Isolated Low Gain Avalanche Diodes
by Gordana Lastovicka-Medin, Gregor Kramberger, Jiri Kroll and Mateusz Rebarz
Sensors 2025, 25(10), 3006; https://doi.org/10.3390/s25103006 - 10 May 2025
Viewed by 711
Abstract
In this contribution, we explored the interplay of guard ring (GR) configuration and isolation structures, as well as irradiation effects, which all together create a rich landscape of phenomena such as self-induced signals (“ghosts”) in trench-isolated Low-Gain Avalanche Diodes (TI-LGADs). The ghost effect [...] Read more.
In this contribution, we explored the interplay of guard ring (GR) configuration and isolation structures, as well as irradiation effects, which all together create a rich landscape of phenomena such as self-induced signals (“ghosts”) in trench-isolated Low-Gain Avalanche Diodes (TI-LGADs). The ghost effect is related to the increased surface current due to presence of SiO2 trenches (and defects) in studied diodes, but it is also affected by interplay between the guard ring(s) and the n+ bias ring, implanted in inter-pixel region of these devices. In double-trenched sensors, the n+ bias ring is inserted in between the two trenches. We present the investigation on the role of these structures on the self-induced signals in trench-isolated sensors from two different productions (RD50 and AIDAinnova). The sensors from the first production have multiple guard rings, whereas the second type of devices feature only one. Detailed examination of the ghost effect and leak current was performed when guard rings were left floating or connected to the pixels (brought to the same potential). The results show that guard ring configuration in trenched sensors can be critical for the leak current and the presence of a ghost signal. To our best knowledge, the latter problem has not been investigated yet. Full article
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21 pages, 4293 KiB  
Article
Temperature Compensation Method for MEMS Ring Gyroscope Based on PSO-TVFEMD-SE-TFPF and FTTA-LSTM
by Hongqiao Huang, Wen Ye, Li Liu, Wenjing Wang, Yan Wang and Huiliang Cao
Micromachines 2025, 16(5), 507; https://doi.org/10.3390/mi16050507 - 26 Apr 2025
Viewed by 478
Abstract
This study proposes a novel parallel denoising and temperature compensation fusion algorithm for MEMS ring gyroscopes. First, the particle swarm optimization (PSO) algorithm is used to optimize the time-varying filter-based empirical mode decomposition (TVFEMD), obtaining optimal decomposition parameters. Then, TVFEMD decomposes the gyroscope [...] Read more.
This study proposes a novel parallel denoising and temperature compensation fusion algorithm for MEMS ring gyroscopes. First, the particle swarm optimization (PSO) algorithm is used to optimize the time-varying filter-based empirical mode decomposition (TVFEMD), obtaining optimal decomposition parameters. Then, TVFEMD decomposes the gyroscope output signal into a series of product function (PF) signals and a residual signal. Next, sample entropy (SE) is employed to classify the decomposed signals into three categories: noise segment, mixed segment, and feature segment. According to the parallel model structure, the noise segment is directly discarded. Meanwhile, time–frequency peak filtering (TFPF) is applied to denoise the mixed segment, while the feature segment undergoes compensation. For compensation, the football team training algorithm (FTTA) is used to optimize the parameters of the long short-term memory (LSTM) neural network, forming a novel FTTA-LSTM architecture. Both simulations and experimental results validate the effectiveness of the proposed algorithm. After processing the MEMS gyroscope output signal using the PSO-TVFEMD-SE-TFPF denoising algorithm and the FTTA-LSTM temperature drift compensation model, the angular random walk (ARW) of the MEMS gyroscope is reduced to 0.02°/√h, while the bias instability (BI) decreases to 2.23°/h. Compared to the original signal, ARW and BI are reduced by 99.43% and 97.69%, respectively. The proposed fusion-based temperature compensation method significantly enhances the temperature stability and noise performance of the gyroscope. Full article
(This article belongs to the Section A:Physics)
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20 pages, 10457 KiB  
Article
Design of a Double-Matched Cross-Polar Single Antenna Harmonic Tag
by Alessandro DiCarlofelice, Antonio DiNatale, Emidio DiGiampaolo and Piero Tognolatti
Appl. Sci. 2025, 15(8), 4590; https://doi.org/10.3390/app15084590 - 21 Apr 2025
Viewed by 387
Abstract
Radio frequency identification (RFID) technology has gained significant attention in various industry sectors due to its potential for efficient inventory management, asset tracking, and object localization. Different RFID technologies are available; resorting to harmonic signals is currently less used but, recently, has gained [...] Read more.
Radio frequency identification (RFID) technology has gained significant attention in various industry sectors due to its potential for efficient inventory management, asset tracking, and object localization. Different RFID technologies are available; resorting to harmonic signals is currently less used but, recently, has gained interest in research activity. In this study, we present the design, prototype realization, and performance evaluation of a dual-band dual-polarized harmonic tag. The tag incorporates a dual-band matching circuit utilizing a zero-bias Schottky diode HSMS-2850 connected to a perturbed annular ring patch antenna. The antenna, in fact, is able to radiate in cross-polarization at the higher frequency. Through a comprehensive design methodology, including simulation optimization and prototype fabrication, we demonstrate the successful implementation of the tag. Measurements to validate the impedance matching properties, radiation patterns, and backscattering capability of the tag are also shown. Full article
(This article belongs to the Section Electrical, Electronics and Communications Engineering)
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21 pages, 1675 KiB  
Review
Biomarkers of Skeletal Muscle Atrophy Based on Atrogenes Evaluation: A Systematic Review and Meta-Analysis Study
by André Luiz Gouvêa de Souza, Anna Luisa Rosa Alves, Camila Guerra Martinez, Júlia Costa de Sousa and Eleonora Kurtenbach
Int. J. Mol. Sci. 2025, 26(8), 3516; https://doi.org/10.3390/ijms26083516 - 9 Apr 2025
Cited by 1 | Viewed by 893
Abstract
Muscle atrophy leads to decreased muscle mass, weakness, inactivity, and increased mortality. E3 ubiquitin ligases, key regulators of protein degradation via the ubiquitin–proteasome system, play a critical role in atrophic mechanisms. This meta-analysis followed Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) [...] Read more.
Muscle atrophy leads to decreased muscle mass, weakness, inactivity, and increased mortality. E3 ubiquitin ligases, key regulators of protein degradation via the ubiquitin–proteasome system, play a critical role in atrophic mechanisms. This meta-analysis followed Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, and its objective was to evaluate the association between E3 ligases Muscle Atrophy F-box (MAFbx)/Atrogin-1 (Fbxo32) and Muscle RING-finger protein 1 (MuRF-1) (TRIM63) E3 ligase mRNA levels, reductions in skeletal muscle CSA measures, and atrophy conditions. We examined papers published on PubMed®, Scopus, and Web of Science that studied E3 ligase gene expression signatures for Fbxo32 (MAFbx/Atrogin-1) and Trim63 (MuRF1) in different types of muscle atrophy and hypertrophy murine models. Twenty-nine studies selected by two independent raters were analyzed. Standardized mean differences (SMDs)/effect sizes (ESs) and 95% confidence intervals (CIs) were calculated for the outcomes using fixed-effects models. We found that 6- and 4.8-fold upregulation, respectively, of Fbxo32 and Trim63 was sufficient to reduce the ES to −3.89 (95% CI: −4.45 to −3.32) for the muscle fiber cross-sectional area and the development of skeletal muscle atrophy. I² and Q test statistics did not indicate heterogeneous data. There was a low probability of bias after both the funnel plot and Egger’s test analyses. These results were sustained independently of the atrophic model and muscle type. Therefore, the magnitude of the increase in muscle Fbxo32 and Trim63 mRNA is a feasible, reliable molecular marker for skeletal muscle atrophy in mice. The next step for the Ubiquitin-proteasome system (UPS) field involves elucidating the targets of E3 ligases, paving the way for diagnostic and treatment applications in humans. Full article
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22 pages, 4060 KiB  
Article
Quantitative Analysis of the Labeling Quality of Biological Images for Semantic Segmentation Based on Attribute Agreement Analysis
by Rong Xiang, Xinyu Yuan, Yi Zhang and Xiaomin Zhang
Agriculture 2025, 15(7), 680; https://doi.org/10.3390/agriculture15070680 - 22 Mar 2025
Viewed by 486
Abstract
Semantic segmentation in biological images is increasingly common, particularly in smart agriculture, where deep learning model precision is tied to image labeling quality. However, research has largely focused on improving models rather than analyzing image labeling quality. We proposed a method for quantitatively [...] Read more.
Semantic segmentation in biological images is increasingly common, particularly in smart agriculture, where deep learning model precision is tied to image labeling quality. However, research has largely focused on improving models rather than analyzing image labeling quality. We proposed a method for quantitatively assessing labeling quality in semantically segmented biological images using attribute agreement analysis. This method evaluates labeling variation, including internal, external, and overall labeling quality, and labeling bias between labeling results and standards through case studies of tomato stem and group-reared pig images, which vary in labeling complexity. The process involves the following three steps: confusion matrix calculation, Kappa value determination, and labeling quality assessment. Initially, two labeling workers were randomly selected to label ten images from each category twice, according to the requirements of the attribute agreement analysis method. Confusion matrices for each image’s dual labeling results were calculated, followed by Kappa value computation. Finally, labeling quality was evaluated by comparing Kappa values against quality criteria. We also introduced a contour ring method to enhance Kappa value differentiation in imbalanced sample scenarios. Three types of representative images were used to test the performance of the proposed method. The results show that attribute agreement analysis effectively quantifies image labeling quality, and the contour ring method improves Kappa value differentiation. The attribute agreement analysis method allows for quantitative analysis of labeling quality based on image labeling difficulty, and Kappa values can also be used as a metric of image labeling difficulty. Dynamic analysis of image labeling variations over time needs further research. Full article
(This article belongs to the Section Artificial Intelligence and Digital Agriculture)
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20 pages, 4344 KiB  
Article
Zero-Power, High-Frequency Floating Memristor Emulator Circuit and Its Applications
by Imen Barraj, Amel Neifar, Hassen Mestiri and Mohamed Masmoudi
Micromachines 2025, 16(3), 269; https://doi.org/10.3390/mi16030269 - 26 Feb 2025
Cited by 2 | Viewed by 895
Abstract
This paper presents a novel passive floating memristor emulator that operates without an external DC bias, leveraging the DTMOS technique. The design comprises only four MOSFETs and eliminates the need for external capacitors. The emulator achieves a high operating frequency of around 250 [...] Read more.
This paper presents a novel passive floating memristor emulator that operates without an external DC bias, leveraging the DTMOS technique. The design comprises only four MOSFETs and eliminates the need for external capacitors. The emulator achieves a high operating frequency of around 250 MHz and consumes zero static power. A comprehensive analysis and simulation, conducted using 180 nm CMOS technology, validates the circuit’s performance. The versatility and effectiveness of the proposed emulator are demonstrated through its application in various circuits, including logic gates, a ring oscillator, and analog filters, highlighting its potential for diverse low-power, high-frequency applications. The proposed emulator provides a compact, efficient, and integrable solution for nanoelectronic circuit designs. Full article
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