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22 pages, 539 KiB  
Protocol
A Conceptual Engineering Approach to Developing a Bio-Based Hair Mask
by Ana S. P. Pascoal, Maria J. Moura, Paula C. N. Ferreira, Mara L. C. Ramos, Mónica A. N. Salavessa and Belmiro P. M. Duarte
Cosmetics 2025, 12(2), 45; https://doi.org/10.3390/cosmetics12020045 - 4 Mar 2025
Cited by 1 | Viewed by 1277
Abstract
Developing innovative cosmetics products is essential for businesses in the beauty industry, influencing their ability to grow, remain competitive, and respond to rapidly shifting market trends. A structured, customer-oriented approach to product design and development is particularly crucial in cosmetics, where factors such [...] Read more.
Developing innovative cosmetics products is essential for businesses in the beauty industry, influencing their ability to grow, remain competitive, and respond to rapidly shifting market trends. A structured, customer-oriented approach to product design and development is particularly crucial in cosmetics, where factors such as product safety, regulatory compliance, and sustainability are paramount. In this context, Conceptual Engineering offers a valuable early-phase framework for cosmetics design, providing a foundation to define the structure, functionality, and feasibility of product concepts prior to detailed development. This study focuses on the application of Conceptual Engineering to the creation of a bio-based cosmetic product, specifically a hair mask. Here, we address unique challenges in cosmetics design, including strict health regulations, ingredient safety, environmental considerations, and cost management in generating and validating product concepts. To meet these demands, we propose an iterative concept development process tailored to cosmetics: a single concept is generated and iteratively refined through feasibility testing, physical validation, and further adaptation based on feedback. Each successful iteration brings the concept closer to market readiness, bridging the gap between sustainable product innovation and practical industrialization. This structured process, implemented in collaboration with an industry partner, underscores the potential of Conceptual Engineering to support sustainable cosmetics design. The case of the bio-based hair mask illustrates how aligning design innovation with environmental and regulatory requirements can enhance the responsiveness of cosmetics companies to consumer demand for eco-friendly products. Full article
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19 pages, 3197 KiB  
Article
Utility Assessment of Isolated Starch and Extract from Thai Yam (Dioscorea hispida Dennst.) for Cosmetic via In Vitro and In Vivo Studies
by Suthinee Sangkanu, Jiraporn Khanansuk, Sathianpong Phoopha, Wandee Udomuksorn, Thitiporn Phupan, Jirapa Puntarat, Sucharat Tungsukruthai and Sukanya Dej-adisai
Life 2025, 15(2), 151; https://doi.org/10.3390/life15020151 - 22 Jan 2025
Cited by 1 | Viewed by 1329
Abstract
In Thailand, wild yam, or Dioscorea hispida Dennst., is a starchy crop that is usually underutilized in industry. The purpose of this study was to isolate the starch and extract the phytochemical from D. hispida and use them in cosmetics. Starch was used [...] Read more.
In Thailand, wild yam, or Dioscorea hispida Dennst., is a starchy crop that is usually underutilized in industry. The purpose of this study was to isolate the starch and extract the phytochemical from D. hispida and use them in cosmetics. Starch was used instead of talcum, which can cause pulmonary talcosis in dusting powder formulas (DP 1-5). GC-MS was used to identify the bioactive components present in the ethanolic extract of D. hispida. The main compounds were identified as 9,12-octadecadienoic acid (Z,Z)- (6.51%), stigmasta-5,22-dien-3-ol, (3.beta.,22E)- (6.41%), linoleic acid ethyl ester (5.72%), (Z,Z)-9,12-octadeca-dienoic acid, 2,3-dihydroxy-propyl (3.89%), and campesterol (3.40%). Then, the extract was used as an ingredient in facial sleeping mask gel formulas (SM 1–SM 5). Stability tests, physical characteristics, enzyme inhibitions, and sensitization dermal toxicity tests were used to evaluate the DP and SM formulations. The results showed that the fresh tubers of D. hispida showed a 12.5% w/w starch content. The findings demonstrated that starch powder had a restricted size distribution, ranging from 2 to 4 μm, and a smooth surface that was polygonal. Following stability testing, the color, odor, size, and flowability of all DP formulations did not significantly differ. The SEM investigation revealed that DP particles were homogenous. For the sensitization dermal toxicity test, DP denoted no erythema or skin irritation in the guinea pigs. After stability testing, the colors of the SM formulas were deeper, and their viscosity slightly increased. The pH did not significantly change. After the stability test, SM formulas that contained Glycyrrhiza glabra and D. hispida extracts exhibited stable tyrosinase and elastase inhibitory activities, respectively. In the sensitization dermal toxicity test, guinea pigs showed skin irritation at level 2 (not severe) from SM, indicating that redness developed. All of these findings indicate that D. hispida is a plant that has potential for use in the cosmetics industry. Furthermore, D. hispida starch can be made into a beauty dusting powder, and more research should be conducted to develop an effective remedy for patients or those with skin problems. Full article
(This article belongs to the Special Issue Advances in the Biomedical Applications of Plants and Plant Extracts)
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24 pages, 11434 KiB  
Article
Multivariate Statistical Analysis of Cosmetics Due to Potentially Toxic/Heavy Metal(loid) Contamination: Source Identification for Sustainability and Human Health Risk Assessment
by Mahmood Ahmed, Muhammad Ahmad, Aamir Sohail, Mudassar Sanaullah, Ahmad Saeed, Shaista Qamar, Tanveer A. Wani, Seema Zargar, Hamad M. Alkahtani and Khuram Khalid
Sustainability 2024, 16(14), 6127; https://doi.org/10.3390/su16146127 - 18 Jul 2024
Cited by 7 | Viewed by 4416
Abstract
Cosmetics are a staple in daily beauty routines worldwide, embraced for their role in enhancing personal appearance and self-care. However, their direct application exposes the skin to a range of ingredients, including metal(loid)s, and these can have a hazardous impact on human health [...] Read more.
Cosmetics are a staple in daily beauty routines worldwide, embraced for their role in enhancing personal appearance and self-care. However, their direct application exposes the skin to a range of ingredients, including metal(loid)s, and these can have a hazardous impact on human health if they exceed the limits defined by regulatory agencies. As a result, it is important to evaluate metal(loid) levels to ensure the safety of these cosmetic products. This research aimed to analyze several cosmetic products (massage cream, cleaner, mud mask, skin polish, scrub, lipstick, foundation, lotion, face powder, and highlighter) for metalloids (Al, Cr, Mn, Fe, Co, Ni, Cu, Zn, Sr, As, Sb, Cd, Pb, Bi, and Hg) by using inductively coupled plasma-optical emission spectrometry (ICP-OES). Multivariate and bivariate statistical approaches were used to interpret the sources and association between the metal(loid)s. The concentration ranges of metals were found to be Al (1.18–4.15 mg/kg), Cr (0.13–2.19 mg/kg), Mn (1.89–28.77 mg/kg), Fe (4.09–126.02 mg/kg), Co (0.19–31.62 mg/kg), Ni (0.11–5.39 mg/kg), Cu (0.08–0.19 mg/kg), Zn (1.99–47.81 mg/kg), Sr (0.99–10.34 mg/kg), Cd (0.16–1.50 mg/kg), Pb (0.29–2.44 mg/kg), Bi (0.23–2.18 mg/kg), and Hg (0.012–0.42 mg/kg), whereas the concentration ranges of metalloids were found to be As (0.011–0.051 mg/kg) and Sb (0.042–1.66 mg/kg). Among the tested cosmetic products for the metal(loid) levels, the estimation of the margin of safety (MOS < 100), hazard quotient (HQ > 1), hazard index (HI > 1), and cumulative cancer risk (LCR ≤ 1 × 10−3) indicated non-carcinogenic and carcinogenic health risks associated with the use of few products. Most of the cosmetics products under investigation are safe with respect to non-carcinogenic and carcinogenic health risks. By highlighting the need to limit excessive use and adhering to sustainable safety practices, this study underscores the importance of monitoring and regulating metal(loid) content to ensure consumer safety and mitigate environmental impact. Full article
(This article belongs to the Section Hazards and Sustainability)
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18 pages, 722 KiB  
Review
Polyglutamate: Unleashing the Versatility of a Biopolymer for Cosmetic Industry Applications
by Mónica Serra, Eduardo Gudina, Cláudia Botelho, José António Teixeira and Ana Novo Barros
Cosmetics 2024, 11(3), 76; https://doi.org/10.3390/cosmetics11030076 - 8 May 2024
Cited by 2 | Viewed by 7029
Abstract
Polyglutamic acid (PGA), a biopolymer comprising repeating units of glutamic acid, has garnered significant attention owing to its versatile applications. In recent years, microbial production processes have emerged as promising methods for the large-scale synthesis of PGA, offering advantages such as sustainability, efficiency, [...] Read more.
Polyglutamic acid (PGA), a biopolymer comprising repeating units of glutamic acid, has garnered significant attention owing to its versatile applications. In recent years, microbial production processes have emerged as promising methods for the large-scale synthesis of PGA, offering advantages such as sustainability, efficiency, and tailored molecular properties. Beyond its industrial applications, PGA exhibits unique properties that render it an attractive candidate for use in the cosmetic industry. The biocompatibility, water solubility, and film-forming characteristics of PGA make it an ideal ingredient for cosmetic formulations. This article explores the extensive potential cosmetic applications of PGA, highlighting its multifaceted role in skincare, haircare, and various beauty products. From moisturizing formulations to depigmentating agents and sunscreen products, PGA offers a wide array of benefits. Its ability to deeply hydrate the skin and hair makes it an ideal ingredient for moisturizers, conditioners, and hydrating masks. Moreover, PGA’s depigmentating properties contribute to the reduction in hyperpigmentation and uneven skin tone, enhancing the overall complexion. As the demand for sustainable and bio-derived cosmetic ingredients escalates, comprehending the microbial production and cosmetic benefits of PGA becomes crucial for driving innovation in the cosmetic sector. Full article
(This article belongs to the Special Issue Natural Sources for Cosmetic Ingredients: Challenges and Innovations)
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12 pages, 1577 KiB  
Article
Physical Properties and Release Profiles of Chitosan Mixture Films Containing Salicin, Glycerin and Hyaluronic Acid
by Katarzyna Lewandowska, Alina Sionkowska and Marzanna Kurzawa
Molecules 2023, 28(23), 7827; https://doi.org/10.3390/molecules28237827 - 28 Nov 2023
Cited by 5 | Viewed by 1705
Abstract
Chitosan (CS) has gained considerable attention due to its distinctive properties and its broad spectrum of potential applications, spanning cosmetics, pharmaceuticals, and biomedical uses. In this study, we characterized thin films comprising chitosan mixtures containing salicin (SAL) and glycerin (GLY), both with and [...] Read more.
Chitosan (CS) has gained considerable attention due to its distinctive properties and its broad spectrum of potential applications, spanning cosmetics, pharmaceuticals, and biomedical uses. In this study, we characterized thin films comprising chitosan mixtures containing salicin (SAL) and glycerin (GLY), both with and without hyaluronic acid (HA) as active ingredients. Characterization was achieved through release studies of SAL, infrared spectroscopy, microscopy techniques (AFM and SEM), and thermogravimetric analysis (TGA). CS/GLY/SAL and CS/GLY/SAL/HA mixture films were fabricated using the solvent evaporation technique. We probed interactions between the components in the chitosan mixtures via infrared analysis. The concentration of released salicin was monitored at various time intervals in a phosphate buffer (PBS) at pH 5.5 using HPLC. The linear regression analysis for the calibration graph showed a good linear relationship (R2 = 0.9996) in the working concentration range of 5–205 mg/dm3. Notably, the release of SAL reached its peak after 20 min. Furthermore, the introduction of HA caused changes in the films’ morphology, but their roughness remained largely unchanged. The results obtained were compared, indicating that the release of SAL in the CS mixture films is sufficient for diverse applications, including wound-healing materials and cosmetic beauty masks. Full article
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14 pages, 5902 KiB  
Article
Chitosan-Based Films Containing Rutin for Potential Cosmetic Applications
by Alina Sionkowska, Katarzyna Lewandowska and Marzanna Kurzawa
Polymers 2023, 15(15), 3224; https://doi.org/10.3390/polym15153224 - 28 Jul 2023
Cited by 18 | Viewed by 3315
Abstract
Chitosan is a polysaccharide with film-forming properties. Such properties are widely used for the preparation of beauty masks and wound-healing materials. In this work, chitosan-based films containing hyaluronic acid and rutin have been researched for potential cosmetic applications. Rutin was added to a [...] Read more.
Chitosan is a polysaccharide with film-forming properties. Such properties are widely used for the preparation of beauty masks and wound-healing materials. In this work, chitosan-based films containing hyaluronic acid and rutin have been researched for potential cosmetic applications. Rutin was added to a chitosan solution in lactic acid, and then thin films were fabricated. The structure of the films was studied using FTIR spectroscopy. Surface properties were studied using an AFM microscope. The release of rutin from chitosan-based film was researched by the HPLC method. The properties of the skin, such as elasticity and moisturization, were studied using the Aramo TS 2 apparatus. It was found that the addition of rutin did not have an influence on the chitosan structure but affected its thermal stability. The roughness of the films was bigger after the addition of rutin to chitosan-based films. Skin elasticity and skin moisturization were somewhat improved after the topical application of the proposed chitosan–rutin mask. The maximum release of rutin was found after 20 min at pH 5.5, related to the pH of normal human skin. The average percentage of release from chitosan-based film containing hyaluronic acid was smaller than from chitosan-based films. Full article
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33 pages, 75637 KiB  
Article
LCA-GAN: Low-Complexity Attention-Generative Adversarial Network for Age Estimation with Mask-Occluded Facial Images
by Se Hyun Nam, Yu Hwan Kim, Jiho Choi, Chanhum Park and Kang Ryoung Park
Mathematics 2023, 11(8), 1926; https://doi.org/10.3390/math11081926 - 19 Apr 2023
Cited by 3 | Viewed by 2475
Abstract
Facial-image-based age estimation is being increasingly used in various fields. Examples include statistical marketing analysis based on age-specific product preferences, medical applications such as beauty products and telemedicine, and age-based suspect tracking in intelligent surveillance camera systems. Masks are increasingly worn for hygiene, [...] Read more.
Facial-image-based age estimation is being increasingly used in various fields. Examples include statistical marketing analysis based on age-specific product preferences, medical applications such as beauty products and telemedicine, and age-based suspect tracking in intelligent surveillance camera systems. Masks are increasingly worn for hygiene, personal privacy concerns, and fashion. In particular, the acquisition of mask-occluded facial images has become more frequent due to the COVID-19 pandemic. These images cause a loss of important features and information for age estimation, which reduces the accuracy of age estimation. Existing de-occlusion studies have investigated masquerade masks that do not completely occlude the eyes, nose, and mouth; however, no studies have investigated the de-occlusion of masks that completely occlude the nose and mouth and its use for age estimation, which is the goal of this study. Accordingly, this study proposes a novel low-complexity attention-generative adversarial network (LCA-GAN) for facial age estimation that combines an attention architecture and conditional generative adversarial network (conditional GAN) to de-occlude mask-occluded human facial images. The open databases MORPH and PAL were used to conduct experiments. According to the results, the mean absolution error (MAE) of age estimation with the de-occluded facial images reconstructed using the proposed LCA-GAN is 6.64 and 6.12 years, respectively. Thus, the proposed method yielded higher age estimation accuracy than when using occluded images or images reconstructed using the state-of-the-art method. Full article
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14 pages, 1908 KiB  
Article
Face Database Protection via Beautification with Chaotic Systems
by Tao Wang, Yushu Zhang and Ruoyu Zhao
Entropy 2023, 25(4), 566; https://doi.org/10.3390/e25040566 - 25 Mar 2023
Cited by 1 | Viewed by 2233
Abstract
The database of faces containing sensitive information is at risk of being targeted by unauthorized automatic recognition systems, which is a significant concern for privacy. Although there are existing methods that aim to conceal identifiable information by adding adversarial perturbations to faces, they [...] Read more.
The database of faces containing sensitive information is at risk of being targeted by unauthorized automatic recognition systems, which is a significant concern for privacy. Although there are existing methods that aim to conceal identifiable information by adding adversarial perturbations to faces, they suffer from noticeable distortions that significantly compromise visual perception, and therefore, offer limited protection to privacy. Furthermore, the increasing prevalence of appearance anxiety on social media has led to users preferring to beautify their faces before uploading images. In this paper, we design a novel face database protection scheme via beautification with chaotic systems. Specifically, we construct the adversarial face with better visual perception via beautification for each face in the database. In the training, the face matcher and the beautification discriminator are federated against the generator, prompting it to generate beauty-like perturbations on the face to confuse the face matcher. Namely, the pixel changes produced by face beautification mask the adversarial perturbations. Moreover, we use chaotic systems to disrupt the order of adversarial faces in the database, further mitigating the risk of privacy leakage. Our scheme has been extensively evaluated through experiments, which show that it effectively defends against unauthorized attacks while also yielding good visual results. Full article
(This article belongs to the Special Issue Image Encryption and Privacy Protection Based on Chaotic Systems)
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18 pages, 4554 KiB  
Article
The Integrated mRNA and miRNA Approach Reveals Potential Regulators of Flowering Time in Arundina graminifolia
by Sagheer Ahmad, Chuqiao Lu, Jie Gao, Yonglu Wei, Qi Xie, Jianpeng Jin, Genfa Zhu and Fengxi Yang
Int. J. Mol. Sci. 2023, 24(2), 1699; https://doi.org/10.3390/ijms24021699 - 15 Jan 2023
Cited by 7 | Viewed by 2996
Abstract
Orchids are among the most precious flowers in the world. Regulation of flowering time is one of the most important targets to enhance their ornamental value. The beauty of Arundina graminifolia is its year-round flowering, although the molecular mechanism of this flowering ability [...] Read more.
Orchids are among the most precious flowers in the world. Regulation of flowering time is one of the most important targets to enhance their ornamental value. The beauty of Arundina graminifolia is its year-round flowering, although the molecular mechanism of this flowering ability remains masked. Therefore, we performed a comprehensive assessment to integrate transcriptome and miRNA sequencing to disentangle the genetic regulation of flowering in this valuable species. Clustering analyses provided a set of molecular regulators of floral transition and floral morphogenesis. We mined candidate floral homeotic genes, including FCA, FPA, GI, FT, FLC, AP2, SOC1, SVP, GI, TCP, and CO, which were targeted by a variety of miRNAs. MiR11091 targeted the highest number of genes, including candidate regulators of phase transition and hormonal control. The conserved miR156-miR172 pathway of floral time regulation was evident in our data, and we found important targets of these miRNAs in the transcriptome. Moreover, endogenous hormone levels were determined to decipher the hormonal control of floral buds in A. graminifolia. The qRT-PCR analysis of floral and hormonal integrators validated the transcriptome expression. Therefore, miRNA-mediated mining of candidate genes with hormonal regulation forms the basis for comprehending the complex regulatory network of perpetual flowering in precious orchids. The findings of this study can do a great deal to broaden the breeding programs for flowering time manipulation of orchids. Full article
(This article belongs to the Special Issue Orchid Biochemistry)
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9 pages, 1949 KiB  
Review
Evolution of Bacterial Cellulose in Cosmetic Applications: An Updated Systematic Review
by Thais Jardim Oliveira, Talita Cristina Mena Segato, Gabriel Pereira Machado, Denise Grotto and Angela Faustino Jozala
Molecules 2022, 27(23), 8341; https://doi.org/10.3390/molecules27238341 - 30 Nov 2022
Cited by 14 | Viewed by 4860
Abstract
In recent decades, there has been an increase in environmental problems caused by cosmetic products derived from toxic substances. Based on this issue, researchers and developers of new beauty cosmetics are looking for new natural alternatives that work well for the consumer and [...] Read more.
In recent decades, there has been an increase in environmental problems caused by cosmetic products derived from toxic substances. Based on this issue, researchers and developers of new beauty cosmetics are looking for new natural alternatives that work well for the consumer and have biodegradable characteristics. This systematic review highlights the major publications of bacterial cellulose used strictly for cosmetics in the last 10 years. Bacterial cellulose is a natural product with great cosmetic properties and low cost that has shown excellent results. This study aimed at collecting rigorous information on bacterial cellulose in the cosmetic field in the last decade to produce a systematized review. A comprehensive search was conducted with selected descriptors involving the topic of “bacterial cellulose”, “cosmetics”, “clean beauty”, and “skin mask”. Seventy studies were found, which went through exclusion criteria that selected only those related to the topic that was searched. In the 12 remaining studies that met the criteria, bacterial cellulose showed conditions for use as a mask-forming product for facial care. The increase in the number of publications concerning bacterial cellulose in cosmetics in the last ten years is a strong indicator that this is a growing area for both research and the industry. Full article
(This article belongs to the Section Macromolecular Chemistry)
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12 pages, 38869 KiB  
Article
Virtual Hairstyle Service Using GANs & Segmentation Mask (Hairstyle Transfer System)
by Mohamed S. Abdallah and Young-Im Cho
Electronics 2022, 11(20), 3299; https://doi.org/10.3390/electronics11203299 - 13 Oct 2022
Cited by 2 | Viewed by 4986
Abstract
The virtual hair styling service, which now is necessary for cosmetics companies and beauty centers, requires significant improvement efforts. In the existing technologies, the result is unnatural as the hairstyle image is serviced in the form of a ‘composite’ on the face image, [...] Read more.
The virtual hair styling service, which now is necessary for cosmetics companies and beauty centers, requires significant improvement efforts. In the existing technologies, the result is unnatural as the hairstyle image is serviced in the form of a ‘composite’ on the face image, image, extracts and synthesizing simple hair images. Because of complicated interactions in illumination, geometrical, and occlusions, that generate pairing among distinct areas of an image, blending features from numerous photos is extremely difficult. To compensate for the shortcomings of the current state of the art, based on GAN-Style, we address and propose an approach to image blending, specifically for the issue of visual hairstyling to increase accuracy and reproducibility, increase user convenience, increase accessibility, and minimize unnaturalness. Based on the extracted real customer image, we provide a virtual hairstyling service (Live Try-On service) that presents a new approach for image blending with maintaining details and mixing spatial features, as well as a new embedding approach-based GAN that can gradually adjust images to fit a segmentation mask, thereby proposing optimal styling and differentiated beauty tech service to users. The visual features from many images, including precise details, can be extracted using our system representation, which also enables image blending and the creation of consistent images. The Flickr-Faces-HQ Dataset (FFHQ) and the CelebA-HQ datasets, which are highly diversified, high quality datasets of human faces images, are both used by our system. In terms of the image evaluation metrics FID, PSNR, and SSIM, our system significantly outperforms the existing state of the art. Full article
(This article belongs to the Special Issue AI and Smart City Technologies)
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18 pages, 3631 KiB  
Article
Biophysical and Biological Tools to Better Characterize the Stability, Safety and Efficacy of a Cosmeceutical for Acne-Prone Skin
by Sabrina Sommatis, Maria Chiara Capillo, Cristina Maccario, Elsa Liga, Giulia Grimaldi, Raffaele Rauso, Pier Luca Bencini, Stefania Guida, Nicola Zerbinati and Roberto Mocchi
Molecules 2022, 27(4), 1255; https://doi.org/10.3390/molecules27041255 - 13 Feb 2022
Cited by 5 | Viewed by 3838
Abstract
(1) Background: Acne is a widespread skin disease, especially among adolescents. Following the COVID-19 pandemic and the use of masks, the problem has been affecting a greater number of people, and the attention of the skin care beauty routine cosmetics has been focused [...] Read more.
(1) Background: Acne is a widespread skin disease, especially among adolescents. Following the COVID-19 pandemic and the use of masks, the problem has been affecting a greater number of people, and the attention of the skin care beauty routine cosmetics has been focused on the “Maskne”, caused by the sebum excretion rate (SER) that stimulates microbial proliferation. (2) Methods: the present study was focused on the rheological characterization and quality assurance of the preservative system of an anti-acne serum. The biological effectiveness (cytotoxicity—skin and eye irritation—antimicrobial, biofilm eradication and anti-inflammatory activity) was evaluated in a monolayer cell line of keratinocytes (HaCaT) and on 3D models (reconstructed human epidermis, RHE and human reconstructed corneal epithelium, HCE). The Cutibacterium acnes, as the most relevant acne-inducing bacterium, is chosen as a pro-inflammatory stimulus and to evaluate the antimicrobial activity of the serum. (3) Results and Conclusions: Rheology allows to simulate serum behavior at rest, extrusion and application, so the serum could be defined as having a solid-like behavior and being pseudoplastic. The preservative system is in compliance with the criteria of the reference standard. Biological effectiveness evaluation shows non-cytotoxic and irritant behavior with a good antimicrobial and anti-inflammatory activity of the formulation, supporting the effectiveness of the serum for acne-prone skin treatment. Full article
(This article belongs to the Special Issue New Trends in Skin Care: Topical Delivery of Cosmeceutical Molecules)
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13 pages, 1482 KiB  
Article
Innovative Eco-Friendly Hydrogel Film for Berberine Delivery in Skin Applications
by Stefania Cometa, Maria Addolorata Bonifacio, Caterina Licini, Annalisa Bellissimo, Loris Pinto, Federico Baruzzi, Monica Mattioli-Belmonte and Elvira De Giglio
Molecules 2021, 26(16), 4901; https://doi.org/10.3390/molecules26164901 - 13 Aug 2021
Cited by 18 | Viewed by 4909
Abstract
Hydrogel formulations (masks or patches, without tissue support) represent the new frontier for customizable skin beauty and health. The employment of these materials is becoming popular in wound dressing, to speed up the healing process while protecting the affected area, as well as [...] Read more.
Hydrogel formulations (masks or patches, without tissue support) represent the new frontier for customizable skin beauty and health. The employment of these materials is becoming popular in wound dressing, to speed up the healing process while protecting the affected area, as well as to provide a moisturizing reservoir, control the inflammatory process and the onset of bacterial development. Most of these hydrogels are acrylic-based at present, not biodegradable and potentially toxic, due to acrylic monomers residues. In this work, we selected a new class of cellulose-derived and biodegradable hydrogel films to incorporate and convey an active compound for dermatological issues. Films were obtained from a combination of different polysaccharides and clays, and berberine hydrochloride, a polyphenolic molecule showing anti-inflammatory, immunomodulatory, antibacterial and antioxidant properties, was chosen and then embedded in the hydrogel films. These innovative hydrogel-based systems were characterized in terms of water uptake profile, in vitro cytocompatibility and skin permeation kinetics by Franz diffusion cell. Berberine permeation fitted well to Korsmeyer–Peppas kinetic model and achieved a release higher than 100 µg/cm2 within 24 h. The latter study, exploiting a reliable skin model membrane, together with the biological assessment, gained insights into the most promising formulation for future investigations. Full article
(This article belongs to the Special Issue New Trends in Skin Care: Topical Delivery of Cosmeceutical Molecules)
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16 pages, 4578 KiB  
Article
Biobased and Eco-Compatible Beauty Films Coated with Chitin Nanofibrils, Nanolignin and Vitamin E
by Luca Panariello, Alessandro Vannozzi, Pierfrancesco Morganti, Maria-Beatrice Coltelli and Andrea Lazzeri
Cosmetics 2021, 8(2), 27; https://doi.org/10.3390/cosmetics8020027 - 29 Mar 2021
Cited by 19 | Viewed by 5512
Abstract
A stable water-based suspension containing chitin nanofibrils (CN), chitin nanofibrils complexed with nanolignin and the latter containing Vitamin E was prepared starting from CN nanosuspension and nanostructured powders. The water-based coating was deposited by a spray technique on three different renewable and biodegradable [...] Read more.
A stable water-based suspension containing chitin nanofibrils (CN), chitin nanofibrils complexed with nanolignin and the latter containing Vitamin E was prepared starting from CN nanosuspension and nanostructured powders. The water-based coating was deposited by a spray technique on three different renewable and biodegradable films consisting of biodegradable polyesters and starch to prepare possible beauty mask prototypes. After drying, the films were extracted with water to control their potential release on the wet skin and different amounts of released materials were obtained. The results were discussed considering the composition and morphology of the adopted substrates and their interactions with the coating. The eco-compatibility of these films is related to the absence of preservatives and their easy biodegradability in several environmental conditions, decreasing their burden on solid waste management with respect to fossil-based versions. Full article
(This article belongs to the Special Issue Chitin Nanofibrils and Nanolignin for Advanced Cosmeceuticals)
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19 pages, 5972 KiB  
Article
Preliminary Studies on an Innovative Bioactive Skin Soluble Beauty Mask Made by Combining Electrospinning and Dry Powder Impregnation
by Jorge Teno, María Pardo-Figuerez, Nancy Hummel, Vincent Bonin, Alessandra Fusco, Claudio Ricci, Giovanna Donnarumma, Maria-Beatrice Coltelli, Serena Danti and Jose María Lagaron
Cosmetics 2020, 7(4), 96; https://doi.org/10.3390/cosmetics7040096 - 11 Dec 2020
Cited by 30 | Viewed by 8280
Abstract
The world of cosmetics is now aiming at biobased materials which are skin-compatible and can be used to generate more sustainable beauty masks with enhanced bioactivity. This work presents, in this line of interest, the combination of two innovative technologies, namely electrospinning and [...] Read more.
The world of cosmetics is now aiming at biobased materials which are skin-compatible and can be used to generate more sustainable beauty masks with enhanced bioactivity. This work presents, in this line of interest, the combination of two innovative technologies, namely electrospinning and dry powder impregnation, to generate biobased skin soluble electrospun pullulan carriers dry impregnated with chitin nanofibrils-nanolignin-glycyrrethinic acid (CLA) complexes, as effective biobased and skin compatible beauty masks. The scalability of the pullulan electrospun carrier and bioactive complexes impregnation were optimized and the morphology evaluated. Subsequently, skin compatibility and mask effectiveness were investigated in vitro and in vivo. The results showed that cell viability was optimal for both impregnated and neat pullulan fibers. Additionally, the CLA impregnated pullulan fibers were able to upregulate the endogenous antimicrobial molecule HBD-2. Preliminary studies in vivo indicated that the beauty mask containing the CLA complexes significantly decreased area, length and depth of forehead and crow’s feet wrinkles, and significantly increased moisturizing levels in the skin. The developed beauty mask was also seen to increase skin firmness, while it did not show skin irritation after the test. The work demonstrates that the combination of these two technologies may open new alternatives to more sustainable bioactive cosmetic products for the skin. Full article
(This article belongs to the Special Issue Chitin Nanofibrils and Nanolignin for Advanced Cosmeceuticals)
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