Search Results (201)

Anemia affects nearly half of all pregnant and lactating women in India. Suboptimal compliance is often due to lack of awareness on effective management of perceived side effects, issues in ensuring regular last mile availability for distribution to beneficiaries owing to challenges in timely and adequate procurement supply chain management issues, family and household dynamics, lack of support for maternal nutrition. Implementation research was conducted in two states of India to deliver a package of interventions with the objective of preventing and managing anemia and improving health by increasing compliance with IFA and calcium supplements among pregnant and lactating women. Method: A quasi-experimental approach with a non-equivalent control group was adopted to assess the effectiveness of the model in a pragmatic setup across two blocks in each of the two states, divided into intervention and control arms (2007 pregnant and 2117 lactating women). Both arms continued with the standard government programs. Health systems interventions like supply chain strengthening, capacity building, behavior change were designed and delivered to ensure availability, accessibility and utilization of IFA and calcium by the beneficiaries in the intervention arm. The primary outcome was compliance with IFA among pregnant women. Secondary outcomes were compliance with calcium among pregnant women and IFA and calcium among lactating women. Difference-in-difference (DID) analysis was conducted, and logistic regression identified contributing factors. Results: The intervention package resulted in 26% improved compliance (DID: 8.1% vs. 1.5%) with IFA among pregnant women in the intervention arm compared to baseline. Similarly, compliance with IFA in lactating women increased by 49.2%. The attributable fraction was greatest (24.4%) for ‘proper instructions’ given. Compliance with calcium increased by 59% among pregnant women in one state, where the baseline parameters were lagging and interventions were initiated early within the stipulated time. Standardized ANC services and provision of proper instructions were consistently found to be associated with improved compliance. Interventions led to improved supply chain management, distribution of IFA and calcium in adequate quantities, increased awareness in the community, and better access to services. Conclusions: The intervention model was found to be effective in improving compliance with IFA in pregnant and lactating women. It is concluded that provision of proper instructions while distributing supplements seemed to have the greatest impact in improving compliance. State-specific variations highlight the need for tailored approaches. Scaling up such models, with emphasis on systemic and behavioral enablers, could strengthen India’s anemia control efforts. Full article

This paper proposes a high-sensitivity and sensitivity-tunable vibration sensing system based on a switchable loop length optoelectronic oscillator (OEO). Carrier-sideband separation is realized by using an acousto-optic modulator (AOM), and the resonant cavity length is designed to be independent of the sensing fiber arm. Compared with a conventional 10 GHz OEO under the same total loop delay condition, the proposed architecture provides a theoretical sensitivity enhancement of approximately $1.93\times {10}^4$, without requiring a high RF oscillation frequency. Meanwhile, the system oscillates at only 80 MHz, which greatly reduces the implementation difficulty of the frequency detection circuit. The proposed scheme further introduces a mechanical optical switch (MOS) to select intra-loop fibers of different lengths, thereby reconfiguring the equivalent loop delay and the free spectral range of the OEO. Experimental results show that stable single-mode oscillation is achieved at 80.42 MHz with a side-mode suppression ratio of 51 dB. By selecting loop fiber lengths of 1200 m, 500 m and 0 m, frequency-to-displacement sensitivities of 0.892 GHz/cm, 1.93 GHz/cm and 9.27 GHz/cm are obtained respectively, with excellent linearity. A 600 Hz vibration signal is successfully demodulated with a signal-to-noise ratio of 72.1 dB. The proposed method provides a simple and reconfigurable solution for high-precision vibration measurement under different operating conditions. Full article

This study presents finite element investigations on the use of polyethylene terephthalate (PET) bottles as void formers in reinforced concrete columns subjected to pure axial compression. The incorporation of PET bottles in reinforced concrete structures reduces concrete consumption while also providing a sustainable disposal solution for used PET bottles. In addition, for the same amount of concrete used in equivalent solid and voided columns, the voided column can exhibit greater flexural capacity due to the increased moment arm of the longitudinal reinforcement. In this study, a finite element-based parametric study is conducted on reinforced concrete columns containing voids within the core. The model was validated using the results of an experimental testing program consisting of 16 scaled reinforced concrete columns, of which 8 specimens had solid cross-sections and 8 specimens had hollow cross-sections. The numerical study considered variations in the longitudinal reinforcement ratio, tie spacing, concrete compressive strength and shape of cross-section. The finite element analyses were conducted using ABAQUS with consideration of material nonlinearity, and the results showed good agreement with the experimental findings. Furthermore, a parametric study was performed to quantify the effects of concrete compressive strength, longitudinal and transverse reinforcement ratios, void diameter, and column cross-sectional dimensions on the load-carrying capacity, ductility, stiffness, and residual strength of the columns. The findings of the study demonstrated that introducing voids formed by tightly stacked PET bottles within the core of reinforced concrete tied columns does not adversely affect their structural behavior under axial compressive loading, as the response of the voided columns was found to be comparable to that of their solid counterparts. The parametric study demonstrated that concrete compressive strength and longitudinal reinforcement ratio significantly influenced the load-carrying capacity and stiffness of voided columns, whereas tie spacing and void diameter had comparatively moderate effects, and changing the column shape while maintaining the same cross-sectional area as the equivalent solid section had negligible influence on the overall structural performance. Full article

Existing buckling stiffness tests usually load the ski boot in a manner that changes with the buckling angle of the boot cuff. As a result, the direction of the applied force changes as the cuff bends, which can cause a deviation between the measured force and the actual acting force and can influence the test result. In this study, a new buckling stiffness test device was designed and constructed. By introducing a translational-rod loading structure, the device keeps the loading force perpendicular to the prosthetic-foot loading rod throughout the test. Tests were conducted at a room temperature of 15 °C, with a fixed force-arm length of L = 0.31 m and a standard binding tension of F = 40 N, thereby improving the consistency of load-angle measurement. A binding-force adjustment unit was also designed through computer-aided design, and the standard binding force was determined through subjective comfort tests involving 20 skiers, enabling consistent control of the tightness state of the ski boot. Theoretically, the expression for ski-boot buckling stiffness was established using an equivalent torsional-spring model. Under small-angle and quasi-static conditions, the equivalent buckling stiffness was represented as a linear relationship between the applied load and the normalized deflection angle. The experimental results show that, within the loading range of 60–260 N, the relationship between load and deformation exhibited good linearity, with coefficients of determination of 0.986–0.996. Repeatability tests showed that the coefficients of variation of load and deflection-angle measurements were controlled within 0.40–1.48% and 6.92–8.26%, respectively, and the relative expanded uncertainty of equivalent buckling stiffness was 7.33–11.93%. These results indicate that the device has good stability. Although the fitted curves showed slight nonzero intercepts, these mainly originated from clamping error, contact effects, and sensor zero drift, and did not affect stiffness identification. Overall, the device can provide stable and reliable buckling stiffness measurement and offers an effective method for evaluating ski-boot performance. Full article

Floating liquefied natural gas (FLNG) facilities integrate natural gas liquefaction, storage, and offloading into a single vessel. During ship-to-ship (STS) side-by-side offloading, an LNG carrier (LNGC) moors alongside the FLNG to transfer liquefied cargo through a loading-arm system. The hydrodynamic interactions between the two vessels, combined with environmental loads, can lead to excessive relative motions that pose a risk of collision or damage to the loading arms and fenders. Accurate short-term prediction of vessel motions would provide operators with advance warning of potentially dangerous conditions, allowing preventive actions to be taken. This study presents a data-driven approach to short-term motion prediction using experimental data obtained from comprehensive basin model tests of an FLNG system. The model tests covered 15 environmental conditions, including survival conditions (100-year return period) and operating conditions (1-year return period), under both single-vessel and side-by-side configurations. Three prediction methods were evaluated: an autoregressive linear model, a single-degree-of-freedom multi-layer perceptron, and a multi-head attention cross-coupling network (MAC-Net) that leverages temporal attention, cross-DOF graph message passing, and multi-task learning with uncertainty-weighted loss. The results show that surge, sway, and yaw can be predicted with high skill scores at model-scale horizons of up to 4 s (32 s full-scale equivalent), while heave and pitch exhibit limited predictability beyond 2 s model scale. The MAC-Net model demonstrates particular advantages for roll prediction, achieving a skill score of 0.88 at a 4 s model-scale horizon compared to 0.76 for the conventional method, attributable to the physical coupling between roll and the horizontal-plane motions through the mooring system. These findings support a practical early warning concept in which horizontal-plane motions provide advance collision alerts and heave/pitch are treated as short-horizon monitoring quantities. Full article

Background/Objectives: Ankylosing Spinal Disorders (ASDs) encompass a heterogeneous group of rheumatic diseases characterized by progressive ankylosis of the axial skeleton, including Ankylosing Spondylitis (AS), Diffuse Idiopathic Skeletal Hyperostosis (DISH), and Non-Radiographic Axial Spondyloarthritis (nr-AxSpA). Spinal ankylosis profoundly alters the biomechanical properties of the vertebral column, transforming it into a rigid long-bone equivalent and dramatically increasing fracture risk even after low-energy trauma. Once a fracture occurs, the long lever arm created by the ankylosed segments generates enormous mechanical stress at the fracture site, making surgical stabilization mandatory in the vast majority of cases. Long posterior instrumentation is the treatment of choice; however, no consensus exists regarding the optimal number of instrumented levels. The aim of this study is to clinically and radiologically evaluate long posterior instrumentation in the 3 + 3 (3 proximal and 3 caudal screws), 3 + 2 (3 proximal and 2 caudal screws), or 2 + 2 (2 proximal and 2 caudal screws) configuration for the treatment of traumatic ASD thoracolumbar vertebral fractures, in terms of implant failure, infection rate, and mortality. Methods: Between 2018 and 2023, 65 consecutive patients with ASD-related thoracolumbar vertebral fractures were treated at our institution. After applying pre-defined inclusion and exclusion criteria, 37 patients were enrolled. Patients were retrospectively divided into three groups according to the posterior arthrodesis configuration (notation indicates number of instrumented vertebral levels proximal + distal to the fracture: 3 + 3, 3 + 2, or 2 + 2). Radiological outcomes were assessed for loosening, screw cut-out, and implant breakage. Infection and mortality rates within 3 months from surgery were evaluated as secondary endpoints. Statistical analysis was performed using the Fisher exact test (significance set at p < 0.05). Results: Thirty-seven patients (28 males and 9 females; mean age 77 ± 7.3 years) were included, with a mean follow-up of 30 ± 5.3 months. Instrumentation configurations were as follows: 23 (3 + 3), 5 (3 + 2), and 9 (2 + 2). Three implant failures (8.1%) and four infections (10.8%) were recorded. Eleven patients died within 3 months of surgery. A statistically significant difference was found between instrumentation length and mechanical complications (p = 0.0468), while no significant difference was observed for infection (p = 1) or mortality rate (p = 0.137). Conclusions: In this exploratory retrospective cohort, the 3 + 3 configuration was associated with the lowest observed rate of implant failure in ASD thoracolumbar fractures, suggesting a potential mechanical advantage over shorter constructs that warrants confirmation in larger prospective studies. No significant correlation was found between instrumentation length and infection rate or early mortality. Prospective, multicentre studies with larger cohorts are warranted to establish definitive guidelines for instrumentation length in this challenging patient population. Full article

Background: Stress urinary incontinence (SUI) is defined as involuntary urine loss during activities that increase intra-abdominal pressure. It is highly prevalent among women and significantly affects physical, emotional, and social well-being. Pelvic floor muscle training (PFMT) is the gold-standard conservative therapy. Second-generation radiofrequency (RF) therapy has shown promise as an alternative. It stimulates collagen synthesis and promotes tissue remodeling. This study will compare the effects of PFMT, RF, and their combination on pelvic floor function, urethral stability, and health-related quality of life (HRQoL) in women with SUI due to urethral hypermobility. Methods/Design: This will be a single-blinded, three-arm, randomized controlled trial conducted at Clínica Traña (San José, Costa Rica). Women aged ≥18 years with clinically confirmed SUI and a retrovesical (β) angle ≥ 140° during the Valsalva maneuver on functional transperineal ultrasound will be randomized (1:1:1) to PFMT (16 weeks, twice-weekly supervised sessions), RF (5 weekly sessions using Capenergy^® C500 Urogyne), or combined RF + PFMT (39 per arm; total N = 117 accounting for 30% attrition). The primary outcome is the change from baseline in pelvic floor muscle strength at 12 months post-intervention, measured by the modified Oxford scale and vaginal manometry. Secondary outcomes will include urethral stability (retrovesical β angle and bladder neck descent on ultrasound), incontinence severity (Sandvik Severity Index), and HRQoL (ICIQ-UI SF and King’s Health Questionnaire). All outcomes will be assessed at baseline, immediately post-intervention, 15 days, 3 months, 6 months, and 12 months follow-up. Assessments will be performed by blinded evaluators. Analysis will follow intention-to-treat principles using repeated-measures ANOVA or non-parametric equivalents (SPSS v.29; p < 0.05). The trial was prospectively registered on ClinicalTrials.gov (NCT07095283, registered on 24 July 2025), prior to the recruitment of the first participant. Expected outcomes: This study will provide comparative effectiveness data on whether the addition of RF to PFMT offers additional benefits over PFMT alone in the management of SUI. Full article

In hybrid-series-converter-based LCC-HVDC systems, controllable capacitor modules can provide additional voltage–time area during commutation, thereby improving inverter-side fault tolerance under AC faults. However, their switching behavior makes the commutation path impedance state-dependent, while most existing commutation-failure prediction methods still rely on fixed-reactance assumptions. To address this problem, this paper proposes a reactance-corrected predictive control and coordinated switching method. First, a capacitor switching coefficient is introduced to describe the insertion state of the controllable capacitor modules, and an equivalent commutation reactance of the HSC valve arm is derived. Then, the corrected reactance is incorporated into an extinction-angle margin index and an energy-margin index to quantify the influence of reactance variation on commutation capability. A segmented firing-angle controller with smooth compensation is further designed, and energy-margin feedback is coordinated with capacitor insertion control. PSCAD/EMTDC simulations verify that the proposed method reduces prediction error, provides a prediction lead time of 0.7–4.5 ms, and improves fault ride-through capability. Full article

Existing ground-slotted coplanar waveguide (CPW) spoof surface plasmon polariton (SSPP) low-pass filters (LPFs) remain constrained by the difficulty of achieving a wide stopband while maintaining a compact size, as well as by undesired radiation leakage arising from their open-aperture slot configuration. To address these issues, a grounded coplanar waveguide spoof surface plasmon polariton (GCPW-SSPP) low-pass filter based on a multi-arm star-shaped slot (MASS) loading topology is proposed. An equivalent-circuit interpretation and full-wave dispersion analysis show that the multi-arm slots introduce enhanced distributed reactive loading, thereby lowering the asymptotic frequency and enabling compact SSPP implementations. The near-field characteristics further demonstrate tighter electromagnetic confinement, as reflected by an approximately 48% reduction in the electric-field confinement width along the z-direction. To alleviate the trade-off between miniaturization and wide-stopband performance in cascaded SSPP LPFs, the single-cell S-parameters of the proposed topology are investigated. A single MASS unit exhibits a sharp cutoff and a deep transmission notch, allowing a wide stopband to be obtained with fewer cascaded cells. Radiation characteristics are subsequently quantified by a loss-decomposition method, and the MASS topology is found to suppress the radiation leakage of open-aperture ground-slotted structures, yielding a maximum radiation-loss reduction of approximately 75%. To validate the design methodology, a MASS-loaded GCPW-SSPP LPF is designed, fabricated, and measured. The measured results are in good agreement with the simulated ones, confirming the effectiveness of the proposed scheme. By simultaneously achieving a wide stopband, compact size, and suppressed radiation leakage, the proposed filter offers a promising low-interference filtering solution for highly integrated microwave and RF front-end systems. Full article

Background/Objectives: Chronic low back pain (CLBP) affects approximately 20% of the global population and is a leading cause of years lived with disability. Long-term, real-world evidence for inhaled cannabis in patients refractory to conventional multimodal therapy remains scarce. We assessed the five-year efficacy and safety of inhaled cannabis in CLBP patients who had documented failure of ≥1 year of opioid analgesics, anticonvulsants, antidepressants, NSAIDs, and physiotherapy, with each patient serving as their own historical control. Methods: We analyzed prospectively collected clinical data from 241 consecutive adults with treatment-refractory CLBP (mean age 49.3 ± 14.9 years; 37.8% female; mean pain duration 15.1 years) initiated on inhaled medical cannabis (predominantly smoking, THC 4–22%, CBD 2–22%) in a single-center tertiary orthopedic clinic between 2020 and 2025 (Hasharon Hospital, Rabin Medical Center, Israel; IRB protocols 0807-21-RMC and 0634-25-RMC). Year-0 outcomes during conventional therapy were compared with outcomes at Years 1–5 on cannabis. Primary outcomes were the Numeric Rating Scale (NRS), Oswestry Disability Index (ODI), and Brief Pain Inventory severity/interference (BPI-S/BPI-I). Concomitant-medication trajectories were a secondary outcome. The primary analysis was a mixed model for repeated measures (MMRM) with random intercept and slope, REML estimation, and time as a categorical fixed effect. Multiple imputation (MAR, m = 20, Rubin’s rules) was the primary missing-data approach; complete-case and tipping-point pattern-mixture sensitivity analyses were used. A multivariate Hotelling T² provided a joint test across the four correlated PROMs. Concomitant-medication discontinuation was modeled with GEE logistic regression and exact McNemar tests. Time to discontinuation was estimated by Kaplan–Meier and Cox regression. The Bonferroni-adjusted significance threshold for the four primary outcomes was α = 0.0125. BioWell gas-discharge-visualization (GDV) parameters were exploratory only. Results: Of 241 patients, 238 (98.8%) provided Year-5 data and 224 (92.9%) remained on cannabis at Year 5; only five patients (2.1%) discontinued for adverse events or inefficacy. All four primary PROMs improved markedly and durably. MMRM-estimated Year-5 minus Year-0 changes were: NRS −5.36 (95% CI −5.65, −5.07), ODI −17.68 (95% CI −19.73, −15.63), BPI-S −6.73 (95% CI −6.99, −6.47), and BPI-I −3.41 (95% CI −3.65, −3.16); all four contrasts had |z| ≥ 16.9 and p < 10⁻²⁰. MI-pooled estimates were within 0.05 of MMRM (FMI < 0.03 for all outcomes). Hotelling T² was F(4, 232) = 872.8, p < 10⁻²⁰. At Year 5, 89.2% achieved ≥30% NRS reduction, 77.2% ≥ 50%, and 93.4% met the NRS minimum clinically important difference (MCID); ODI MCID 65.6%, BPI-S MCID (≥1 pt) 98.3%, BPI-I MCID (≥1 pt) 91.3%. Concomitant opioid use fell from 100% at baseline to 4.6% at Year 5 (within-patient absolute risk reduction 95.4%, McNemar exact p = 1.16 × 10⁻⁶⁹), NSAID from 100% to 7.1%, SSRI/SNRI from 80.5% to 5.4%, and gabapentinoid from 38.6% to 2.5%. The ARR-derived NNT for opioid discontinuation was 1.05; this NNT is referenced to each patient’s own documented maximal-conventional-therapy state and is not equivalent to a between-arm randomized-trial NNT. Cannabis dose × time interaction was consistent with no pharmacological tolerance (β = −0.0044 per gram-month per year, p = 0.074). Across 1205 patient-years of cannabis exposure (calculated as 241 patients × 5 follow-up years from Year 1 through Year 5; baseline Year 0 represents pre-cannabis state and is not included in person-time on cannabis), 1338 organ-system AE events were recorded at 1.110/patient-year (Poisson 95% CI 1.05–1.17); 99.8% of graded events were mild (grade 1), with ocular (476 events, 0.40/PY), cognitive (460, 0.38/PY), and gastrointestinal (368, 0.31/PY) reactions predominating. The Year-3 retention dip reflected a documented telemedicine-clinic phenomenon during 2022–2024, with patients returning to in-person follow-up by Year 4–5. BioWell GDV discriminated NRS ≥ 4 only at chance level (BWS AUC 0.574, 95% CI 0.54–0.60; BWV AUC 0.51). Conclusions: In a treatment-refractory CLBP cohort with five-year longitudinal follow-up, inhaled cannabis was associated with large, sustained, and statistically robust improvements in pain, disability, and pain interference, accompanied by near-total displacement of opioids, NSAIDs, antidepressants, and gabapentinoids. These observational associations, although mechanically less susceptible to bias for the binary medication-discontinuation outcomes than for self-reported PROMs, cannot be interpreted causally in the absence of a concurrent randomized control arm and may reflect a combination of pharmacological effect, regression to the mean from a high pre-treatment baseline, expectancy and self-selection effects intrinsic to an actively chosen open-label therapy, and secular trends in pain reporting. The within-patient benefit-risk profile—ARR-derived NNT ≈ 1 for opioid sparing against a predominantly mild adverse-event burden—supports consideration of cannabis as a potentially clinically meaningful, opioid-sparing option in patients who have failed multimodal conventional therapy, pending confirmation in randomized comparative trials. Full article

Background: Retinol has consistently demonstrated efficacy in improving signs of skin aging. However, recent European Union regulations have limited its cosmetic concentration to 0.3%, creating the need for new formulations to be capable of maintaining high efficacy, safety, and tolerance. Material and Methods: This clinical study aimed to evaluate and compare the rejuvenating effects and tolerance of a 0.5% retinol serum with a new equivalent technology, Retinduo^®, which previously showed promising preclinical results. A single-center, prospective, randomized, controlled, double-blind, two-arm parallel study was conducted in 40 Caucasian women aged 38–60 years with moderate photoaging (Glogau II). A total of 20 participants applied Retinduo^® serum and 20 applied retinol 0.5%, following a progressive application protocol. Clinical and instrumental assessments measured hydration, firmness, elasticity, tone homogeneity, melanin levels, skin roughness, wrinkle parameters, and stratum corneum thickness. Results and Discussion: Both formulations significantly improved hydration, firmness, and elasticity from day 28 onward. Retinduo^® showed a significant increase in viscoelasticity (R8) from day 56, while retinol 0.5% did not demonstrate significant changes in this parameter. Melanin reduction was observed with Retinduo^® at days 28 and 56 and with retinol 0.5% just at day 28. Although a reduction in melanin was observed with both ingredients, the reduction was more significant with Retinduo^® at 56 days. Both treatments reduced the thickness of the stratum corneum; however, with Retinduo^®, a significant and more pronounced reduction was achieved after 3 months of treatment (30% (p = 0.0001) vs. 12% (p = 0.033). Retinduo^® demonstrated significant wrinkle depth reduction at day 28 and in wrinkle amplitude (width and length of wrinkles) at the end of treatment, while 0.5% retinol showed a positive trend in this parameter. Both products exhibited excellent tolerance. Conclusions: Overall, Retinduo^® achieved comparable or slightly superior anti-aging effects while aligning with current European regulatory limits. Full article

This study presents a symmetry-guided, mechanism-informed, and constraint-aware staged evolutionary framework for the structural optimization of a heavy-duty industrial robot with dominant joint flexibility. Unlike conventional sizing strategies that treat transmission compliance as a secondary verification issue, the proposed method incorporates joint-flexibility-induced low-frequency vibration directly into the optimization formulation and organizes the design problem through a symmetric joint-space/Cartesian-space evaluation framework. An equivalent linearized flexible-joint dynamic model is established for the dominant load-bearing joints under the heavy-load operating condition of interest, and three coordinated performance indices are constructed to characterize vibration robustness, end-effector static stiffness, and global velocity-transmission quality under explicit workspace-retention constraints. To improve engineering interpretability, a staged NSGA-II strategy is adopted, in which global link-length variables and local sectional variables are optimized sequentially. The results indicate that the proposed framework increases the minimum first-order vibration frequency, reduces end-effector deformation, and preserves acceptable workspace coverage. More importantly, the optimization process reveals an interpretable asymmetry in structural sensitivity: sectional redistribution, especially in the forearm, contributes more effectively to vibration suppression than direct reduction in the global arm span. The study therefore provides a reusable symmetry-oriented structural redesign methodology for heavy-duty serial manipulators whose low-frequency dynamics are governed primarily by compliant drive chains. Full article

The abdominal pressure–volume (P–V) relationship during laparoscopic insufflation is curvilinear and subject to substantial inter-individual variability, yet clinical practice relies on universal pressure targets derived from population-level guidelines. The Smart Inline Compliance Module (SICM) is a novel inline retrofit device that acquires intra-abdominal pressure and insufflation gas flow through physically separated sensing circuits, reconstructs insufflated volume by numerical integration of the flow signal, and derives the abdominal P–V curve and its biomechanical parameters in real time. This study reports the first two-arm pilot technical evaluation of the SICM system. Arm A comprised an exploratory biomechanical phantom with three defined stiffness levels (Soft, Medium, Rigid) tested under Continuous and Stepwise insufflation protocols (30 curves). Arm B comprised three female feline cadavers assessed under the same dual-protocol design (18 curves). This study should be interpreted as an early-stage technical evaluation rather than as a definitive validation benchmark. Signal quality was consistently high across both arms (Curve Quality Index: 1.0000 in the phantom arm; 0.9974 ± 0.0009 in the cadaveric arm). Volume integration accuracy was confirmed against an independent offline reference (mean absolute percentage difference: 0.07%). The system extracted reproducible biomechanical parameters under the Continuous protocol: in the cadaveric arm, maximum compliance (Cmax) ranged from 116.8 to 191.4 mL/mmHg across subjects, with intra-session coefficients of variation below 16%; Knee Pressure (Pknee), defined as a working operational index of the compliance transition, was 3.33–4.17 mmHg with CV below 8%. The Rigid phantom and cadaveric datasets showed partial numerical overlap in selected shape-derived parameters, which was interpreted only as an internal consistency check and not as evidence of biomechanical equivalence. The Stepwise protocol exposed the current methodological limits of the parameter-extraction workflow and identified specific targets for the next development iteration. These results are interpreted exclusively within the scope of technical feasibility and preliminary biomechanical characterisation; clinical applicability and optimal pressure guidance require adequately powered in vivo studies. Full article

Cascaded multilevel inverters constitute a promising system concept for battery electric powertrains due to their high efficiency, low harmonic distortion, and advanced battery management capabilities. This study presents a novel electro-thermal simulation framework for the symmetrical Parallel Enhanced Commutation Integrated Nested (PECIN) multilevel inverter. The proposed model employs a control-oriented approach that enables the development and evaluation of advanced inverter and battery control algorithms, which exploit the extensive series-parallel reconfiguration capabilities of the PECIN topology. The framework is based on electrical and thermal equivalent circuit models to capture physical behavior and cross-domain interactions. Electrical network analysis employs algorithms that iterate over each phase-arm network, replacing high-dimensional matrix inversions and thereby enhancing computational efficiency. The overall model is readily adaptable to various system configurations, including different AC and DC charging modes, and scalable with respect to the number of submodules and phases. Simulation results for a 31-level multilevel inverter in a three-phase AC charging configuration demonstrate the model’s operational capabilities. Execution time analysis shows that the current distribution calculation is the key contributor to computational effort as the number of submodules increases, resulting in a quadratic growth of the overall computational time. Full article

Many System-on-Chip (SoC) studies rely solely on simulation and tool-based results, encountering unexpected failures during post-silicon validation. In particular, silicon-level demonstrations of Hardware/Software (HW/SW) functional equivalence, which confirms that an FPGA-validated design operates identically on an ASIC with the same firmware, remain extremely rare. This work proposes a reproducible FPGA-to-silicon verification methodology that establishes HW/SW functional equivalence at the silicon level by applying an identical firmware source code, device driver, and memory map to both platforms. The methodology is validated on an Arm Cortex-M0-based SoC platform fabricated in Samsung 28 nm Low Power Plus (LPP) CMOS technology with a dual Inter-Integrated Circuit (I2C) interface. The fabricated chip integrates two 64KB on-chip memories within a core area of 653 $\mathsf{\mu }$m × 769 $\mathsf{\mu }$m, operates at 125 MHz, and consumes 17.5 mW at the optimal operating point of 1.0 V. The primary contributions are: (1) a reproducible FPGA-to-silicon HW/SW functional equivalence verification methodology based on shared firmware source code, device driver, and memory map across both platforms, (2) silicon-measurement-based performance characterization with verified experimental data, (3) a reproducible design methodology documenting the complete flow from FPGA verification through ASIC fabrication, including static timing closure, place-and-route, and physical verification, and (4) an extensible SoC platform architecture enabling researchers to integrate and validate their own Intellectual Property (IP) via Advanced High-performance Bus (AHB) and I2C interfaces. Full article