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11 Results Found

  • Review
  • Open Access
27 Citations
4,992 Views
14 Pages

Genetic Polymorphism in Angiotensinogen and Its Association with Cardiometabolic Diseases

  • Momina Shahid,
  • Kanwal Rehman,
  • Muhammad Sajid Hamid Akash,
  • Shaleem Suhail,
  • Shagufta Kamal,
  • Muhammad Imran and
  • Mohammed A. Assiri

19 December 2022

Angiotensinogen (AGT) is one of the most significant enzymes of the renin-angiotensin-aldosterone system (RAAS) which is involved in the regulation and maintenance of blood pressure. AGT is involved in the production of angiotensin I which is then co...

  • Article
  • Open Access
6 Citations
2,063 Views
9 Pages

Polymorphism rs7079 in miR-31/-584 Binding Site in Angiotensinogen Gene Associates with Earlier Onset of Coronary Artery Disease in Central European Population

  • Jan Novák,
  • Soňa Maceková,
  • Renata Héžová,
  • Jan Máchal,
  • Filip Zlámal,
  • Ota Hlinomaz,
  • Michal Rezek,
  • Miroslav Souček,
  • Anna Vašků and
  • Julie Bienertová-Vašků
  • + 1 author

30 October 2022

Angiotensinogen (AGT) represents a key component of the renin–angiotensin–aldosterone system (RAAS). Polymorphisms in the 3′ untranslated region (3′UTR) of the AGT gene may alter miRNA binding and cause disbalance in the RAAS....

  • Article
  • Open Access
16 Citations
4,593 Views
11 Pages

Angiotensinogen Gene Missense Polymorphisms (rs699 and rs4762): The Association of End-Stage Renal Failure Risk with Type 2 Diabetes and Hypertension in Egyptians

  • Islam M. El-Garawani,
  • Eman M. Shaheen,
  • Hesham R. El-Seedi,
  • Shaden A. M. Khalifa,
  • Gaber A. M. Mersal,
  • Mahmoud M. Emara and
  • Zeinab A. Kasemy

25 February 2021

Type 2 diabetes mellitus (T2DM) and hypertension are common chronic diseases mainly associated with the development and progression of end-stage renal disease (ESRD) leading to morbidity and mortality. Gene polymorphisms linked to the renin–angiotens...

  • Article
  • Open Access
3 Citations
2,509 Views
10 Pages

The Association of M235T Genetic Polymorphism in Angiotensinogen Gene and Other Non-Genetic Factors with Essential Hypertension among Jordanian Patients

  • Hussein Alhawari,
  • Yazun Jarrar,
  • Malek Zihlif,
  • Ayman Wahbeh,
  • Sameeha Alshelleh,
  • Ruba Alhabahbeh and
  • Dalia Abdelrazaq

29 February 2024

Background: Hypertension, characterized by elevated pressure, poses a significant health risk. Recent studies in Jordan highlight high hypertension rates, emphasizing the need for genetic investigations to comprehend essential hypertension determinan...

  • Article
  • Open Access
5 Citations
3,407 Views
7 Pages

Renin-Angiotensin System Single Nucleotide Polymorphisms Are Associated with Bladder Cancer Risk

  • Maria Samara,
  • Maria Papathanassiou,
  • Ioanna Farmakioti,
  • Maria Anagnostou,
  • Maria Satra,
  • Lampros Mitrakas,
  • Dimitrios Anastasiou,
  • Georgios Chasiotis,
  • Agamemnon Christopoulos and
  • Panagiotis J. Vlachostergios
  • + 6 authors

15 November 2021

The renin-angiotensin system (RAS), besides being a major regulator of blood pressure, is also involved in tumor angiogenesis. Emerging evidence suggests a correlation between the use of pharmacologic RAS inhibitors and a delay in urothelial bladder...

  • Article
  • Open Access
1 Citations
2,657 Views
11 Pages

The Correlation Between Abnormal Uterine Artery Flow in the First Trimester and Genetic Thrombophilic Alteration: A Prospective Case-Controlled Pilot Study

  • Natalija Vedmedovska,
  • Diana Bokucava,
  • Anda Kivite-Urtane,
  • Vita Rovite,
  • Liene Zake-Nikitina,
  • Janis Klovins,
  • Violeta Fodina and
  • Gilbert G. G. Donders

Introduction. Evaluation of the first trimester uterine artery flow can predict the development of obstetrical complications. A genotype, making women prone to microthrombi. constitutes the main known susceptibility factor for anomalous development o...

  • Article
  • Open Access
1,632 Views
10 Pages

8 November 2024

Single nucleotide polymorphisms (SNPs) have been associated with the development of cardiovascular diseases (CVDs). This study correlated eight SNPs with the risk factors of CVD in a black elderly population. Genotyping was used to detect eight polym...

  • Article
  • Open Access
17 Citations
3,881 Views
10 Pages

Gene Polymorphisms of the Renin-Angiotensin-Aldosterone System as Risk Factors for the Development of In-Stent Restenosis in Patients with Stable Coronary Artery Disease

  • Madina Azova,
  • Kalima Timizheva,
  • Amira Ait Aissa,
  • Mikhail Blagonravov,
  • Olga Gigani,
  • Anna Aghajanyan and
  • Leyla Tskhovrebova

This study investigated the renin-angiotensin-aldosterone system (RAAS) gene polymorphisms as possible genetic risk factors for the restenosis development in patients with drug-eluting stents. 113 participants had coronary artery disease and underwen...

  • Article
  • Open Access
11 Citations
2,742 Views
11 Pages

The Genetic Variants in the Renin-Angiotensin System and the Risk of Heart Failure in Polish Patients

  • Iwona Gorący,
  • Anna Gorący,
  • Mariusz Kaczmarczyk,
  • Jakub Rosik,
  • Klaudyna Lewandowska and
  • Andrzej Ciechanowicz

15 July 2022

(1) Background: Heart failure (HF) is a complex disease and one of the major causes of morbidity and mortality in the world. The renin-angiotensin system (RAS) may contribute to the pathogenesis of HF. (2) Aim: To investigate the association of RAS k...

  • Article
  • Open Access
1,102 Views
9 Pages

12 June 2025

Background: The etiopathogenesis of atopic dermatitis is complicated, and it includes aspects such as dysfunction of the skin barrier, changes in immune responses, IgE-mediated hypersensitivity, and many characteristics of the environment. Regarding...

  • Systematic Review
  • Open Access
2,783 Views
24 Pages

15 September 2025

Background/Objectives: This systematic review aimed to gather the most recent evidence regarding the link between genetic polymorphisms and physical performance in team sports, with a focus on the practical utility of this information for athlete sel...