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27 pages, 12109 KB  
Article
Stability of Return-Type Cable Gravity Anchors Under Predominantly Horizontal Loading: Asymmetric Stress Evolution, Model Tests and Numerical Verification
by Yu Zhu, Keyuan Ding and Dejun Gao
Symmetry 2026, 18(5), 754; https://doi.org/10.3390/sym18050754 (registering DOI) - 27 Apr 2026
Abstract
Return-type cable suspension bridges transfer the main-cable force to the anchorage predominantly in the horizontal direction, which may induce coupled sliding–overturning instability of the anchorage–foundation system. This study examines the stability of return-type cable gravity anchorage using the composite anchorage of the Jixin [...] Read more.
Return-type cable suspension bridges transfer the main-cable force to the anchorage predominantly in the horizontal direction, which may induce coupled sliding–overturning instability of the anchorage–foundation system. This study examines the stability of return-type cable gravity anchorage using the composite anchorage of the Jixin Expressway Yellow River Three Gorges Bridge as the prototype. A 1:100 laboratory specimen was designed based on similarity theory and tested under incremental loading until failure. Four configurations were considered by combining two embedment ratios (1/4 and 1/2) with two base types (flat-base and shear-keyed). Horizontal displacement, overturning angle, interface contact stress, and foundation strain were monitored throughout loading. Because the return-type cable transmits a predominantly horizontal force, the anchorage–foundation contact stress exhibits pronounced asymmetry between the toe and heel regions, and this stress asymmetry governs the coupled sliding–overturning instability mode. The shallow flat-base case exhibited a distinct displacement and contact stress jump at high load levels, followed by rapid rotation, indicating slip–tilt coupled instability. Increasing embedment improved confinement and delayed the onset of nonlinear deformation, but the flat-base configuration still showed pronounced toe stress concentration. By contrast, the shear-keyed base mobilized cooperative bearing of the surrounding foundation, producing smoother stress–strain evolution and higher ultimate capacity. Moreover, the shear-keyed base mitigates the stress asymmetry at the anchorage–foundation interface, leading to a more symmetric distribution of contact pressure and improved overall stability. Three-dimensional finite-element simulations reproduced the measured trends in displacement, stress concentration near the toe, and strain development, providing independent verification. The results clarify the dominant instability mechanism of return-type cable gravity anchors and offer design implications for embedment depth and shear-keyed base detailing. Full article
(This article belongs to the Special Issue Symmetry and Finite Element Method in Civil Engineering)
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16 pages, 3904 KB  
Article
Study on Optimization of Key Parameters for High-Pressure Water Jet Reaming Equipment of Anchor Holes in Soft Rock Roadways
by Aolong Liu, Hua Nan and Yida Sun
Appl. Sci. 2026, 16(9), 4280; https://doi.org/10.3390/app16094280 (registering DOI) - 27 Apr 2026
Abstract
To solve the problems of easy fracture of reaming cutter arms and mechanical jamming leading to equipment damage when mechanical reaming equipment is used for anchor hole reaming in soft rock roadways, this study proposes the development of a high-efficiency reaming device with [...] Read more.
To solve the problems of easy fracture of reaming cutter arms and mechanical jamming leading to equipment damage when mechanical reaming equipment is used for anchor hole reaming in soft rock roadways, this study proposes the development of a high-efficiency reaming device with a simple structure. This study combines theoretical analysis, numerical simulation, and laboratory experiments to systematically investigate the key parameters of high-pressure water jet reaming equipment. The results show that under the same conditions, the maximum velocity of the high-pressure water jet decreases with an increase in the number of nozzles and the nozzle spacing. Although the correlation between the maximum jet velocity and nozzle angle is weak, the jet velocity acting on the anchor hole wall reaches its peak at a nozzle angle of 60°. Based on the simulation results, a 1:1 scale nozzle model was manufactured using 3D printing technology, and high-pressure water jet reaming experiments and bolt pull-out tests were carried out at a pressure of 20 MPa. The experimental results demonstrate that the optimal reaming effect is achieved with a nozzle configuration of 3 nozzles, 10 mm spacing, and a nozzle angle range of 45–60°. Specifically, after reaming with the nozzle at a 60° angle and 10 mm spacing, the bolt anchoring force reaches 51.99 kN, representing a 41.16% increase in anchoring strength compared with conventional anchoring. This research provides technical support for the engineering application of anchor hole reaming technology in soft rock roadways and is of great significance for improving the support effect of soft rock roadways. Full article
(This article belongs to the Section Civil Engineering)
23 pages, 1587 KB  
Article
Synergistic Photothermal Catalysis over an MOF-Derived Matrix Enabled by Alloy-Coordination Interactions for Sustainable Hydrogen Production from Formic Acid
by Shenghao Li, Siyu Song, Chunlin Ke, Zhengting Gu, Mingzheng Liao and Chao Wang
Catalysts 2026, 16(5), 385; https://doi.org/10.3390/catal16050385 (registering DOI) - 27 Apr 2026
Abstract
Formic acid (FA) has emerged as a promising liquid hydrogen storage material, yet efficient photothermal dehydrogenation catalysts with high activity and H2 selectivity remain challenging. Herein, a polymetallic synergistic PdCu/M-ZNC (where M represents the co-doped In, Sn and Mo species) is fabricated [...] Read more.
Formic acid (FA) has emerged as a promising liquid hydrogen storage material, yet efficient photothermal dehydrogenation catalysts with high activity and H2 selectivity remain challenging. Herein, a polymetallic synergistic PdCu/M-ZNC (where M represents the co-doped In, Sn and Mo species) is fabricated by molten-salt-assisted pyrolysis of ZIF-8 precursors followed by metal incorporation. The unique molten salt environment effectively preserves the porous architecture of ZIF-8, enabling the secure anchoring of PdCu alloy nanoparticles onto the carbonaceous matrix enriched with M-Nₓ coordination sites. Under light irradiation, the PdCu alloy sites kinetically accelerated the overall adsorption and activation of FA molecules. Based on empirical observations and corroborated by the established literature, this alloying effect was inferred to facilitate the C-H bond cleavage and HCOO* desorption processes. Concurrently, the M-Nₓ sites act as efficient electron transfer channels, facilitating the rapid coupling of photogenerated electrons with protons (H+) to evolve H2. Consequently, the optimal catalyst exhibits an enhancement in gaseous product yield (404.46 mmol/g/h) and H2 selectivity (67.49%) at 75 °C. This work offers a catalyst design that aligns with several principles of green chemistry: it maximizes the atom utilization of precious Pd, incorporates synergistic non-precious metals within MOF-derived frameworks to enhance stability, and leverages solar energy to drive hydrogen production under mild conditions, presenting a more sustainable pathway for hydrogen release from liquid carriers. Full article
(This article belongs to the Special Issue Catalysis for Solid Waste Upcycling: Challenges and Opportunities)
20 pages, 2376 KB  
Article
ESP32-Based Hardware Key for Software Application Protection
by Alexandru-Ion Popovici and Florin-Daniel Anton
Appl. Sci. 2026, 16(9), 4251; https://doi.org/10.3390/app16094251 (registering DOI) - 27 Apr 2026
Abstract
In the current context, classic software licensing and protection mechanisms based exclusively on host application checks can be circumvented by patching, emulation and replay attacks in user-controlled environments. This paper presents an adaptive hardware key implemented on the ESP32-S3 platform, which externalizes sensitive [...] Read more.
In the current context, classic software licensing and protection mechanisms based exclusively on host application checks can be circumvented by patching, emulation and replay attacks in user-controlled environments. This paper presents an adaptive hardware key implemented on the ESP32-S3 platform, which externalizes sensitive decisions and cryptographic operations from the host application to a dedicated device. The solution combines a device-anchored root of trust (secure boot and flash memory encryption), a PKI-verifiable identity (Public Key Infrastructure X.509 certificate and digital signatures as proof of ownership), hierarchical key derivation to avoid static secrets and the establishment of an authenticated encrypted session for all essential data exchanges. User access is conditioned by three-factor authentication (PIN—Personal Identification Number, TOTP—Time based One Time Password and USB physical presence) and a “code-in-dongle” mechanism, in which the important logic runs on the device and the application receives tokens with limited duration. Experimental validation demonstrates correct provisioning, secure session establishment, negative brute-force testing, as well as lifecycle support via signed OTA (Over-The-Air) with anti-rollback and encrypted backup/recovery. Build reports indicate a balanced flash distribution and available DIRAM (Data/Instruction RAM) margin, while IRAM (Instruction RAM) saturation (99.99%) reflects a normal architectural behavior of the ESP32-S3 unified memory model rather than a capacity constraint. Full article
(This article belongs to the Topic Addressing Security Issues Related to Modern Software)
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28 pages, 12735 KB  
Article
FMW-YOLO: A Frequency-Enhanced and Multi-Scale Context-Aware Framework for PCB Defect Detection
by Yuguo Li, Shuo Tian, Wenzheng Sun, Longfa Chen, Jian Li, Junkai Hu and Na Meng
Micromachines 2026, 17(5), 531; https://doi.org/10.3390/mi17050531 (registering DOI) - 27 Apr 2026
Abstract
A high-precision and efficient surface defect detection for printed circuit board (PCB) is critical to ensuring the reliability of electronic systems. However, the presence of complex circuit backgrounds and the small scale of defects often limit the precision and effectiveness of conventional inspection [...] Read more.
A high-precision and efficient surface defect detection for printed circuit board (PCB) is critical to ensuring the reliability of electronic systems. However, the presence of complex circuit backgrounds and the small scale of defects often limit the precision and effectiveness of conventional inspection approaches. To address these challenges, this paper proposes FMW-YOLO, a lightweight and accurate detection framework based on YOLO11n. Specifically, a Frequency-Enhanced Channel-Transposed and Local Feature backbone network is developed to improve feature extraction. By designing a Dual-Frequency and Channel Attention Aggregation module and a Lightweight Edge-Gaussian Block, the original C3k2 structure is refined to suppress noise interference while preserving high-frequency details, thereby enhancing feature representation. Furthermore, a neck network incorporating a Multi-Scale Context-Aware Enhancement mechanism is constructed, in which an Attention-Integrated Feature Pyramid is employed to facilitate more effective cross-scale feature interaction. In addition, a Dilated Reparam Residual Module is embedded into the C3k2 structure to expand the receptive field without significantly increasing computational burden. Finally, Wise-IoU is adopted to optimize bounding box regression by assigning greater importance to anchors of moderate quality. Extensive experiments conducted on the HRIPCB and DeepPCB datasets demonstrate that FMW-YOLO improves mAP50 by 2.1% and 0.3%, respectively, while reducing the number of parameters by 23%. These results indicate that the proposed method achieves improved detection accuracy and demonstrates strong potential for practical industrial applications. Full article
(This article belongs to the Topic AI Sensors and Transducers)
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23 pages, 3168 KB  
Article
Experimental Evaluation of Wedge-Type Anchorage Systems for Smooth-Surfaced NiTi SMA Bars
by Moustafa Basha, Anas Issa and Ahmed Bediwy
Buildings 2026, 16(9), 1708; https://doi.org/10.3390/buildings16091708 (registering DOI) - 26 Apr 2026
Abstract
SMA bars, particularly those based on NiTi, exhibit superelastic and self-centering properties, providing damage-resistant, self-centering structural systems. However, their natural smoothness and low machinability pose a significant challenge to adequate mechanical anchorage. This paper experimentally measures the efficiency of two feasible wedge-type anchorage [...] Read more.
SMA bars, particularly those based on NiTi, exhibit superelastic and self-centering properties, providing damage-resistant, self-centering structural systems. However, their natural smoothness and low machinability pose a significant challenge to adequate mechanical anchorage. This paper experimentally measures the efficiency of two feasible wedge-type anchorage systems, wedge-and-barrel (WB) and spring anchor (SA), which are typically used in post-tensioning systems, and assesses their applicability for anchoring smooth-surfaced NiTi SMA bars. A total of 24 testing configurations were examined in this study. A complete monotonic tensile test regime was performed at steady loads with desired strain levels. The findings validate that both wedge-type anchorage systems were able to effectively anchor the SMA bars, although some performance differences were observed. The WB anchorage system showed increased stress capacity, improved load transfer efficiency, and less scatter across repeated tests, which can be attributed to its greater mechanical confinement and frictional interlock, exhibiting an increase of approximately 27% in stress capacity compared to the SA anchorage system. On the other hand, the SA system exhibited good anchorage performance. It showed a slightly lower stress response and greater variation at higher levels of deformation due to the spring’s compression mechanism. The results demonstrate the feasibility of using wedge-type anchorage systems to anchor SMA rebars for seismic applications and provide guidance for future anchorage design. Full article
(This article belongs to the Topic Advanced Composite Materials)
33 pages, 2618 KB  
Article
Bridging Cross-Modal Semantic Gaps with Multi-Source Semantic Anchors in Knowledge-Based Visual Question Answering
by Junming Hu, Jinxiong Zhang, Feng Zhan and Yiran Huang
Electronics 2026, 15(9), 1837; https://doi.org/10.3390/electronics15091837 (registering DOI) - 26 Apr 2026
Abstract
Knowledge-based visual question answering (KB-VQA) requires leveraging external knowledge relevant to the image to assist reasoning. Existing methods typically convert images into a single textual description for knowledge retrieval or directly rely on the implicit knowledge within large language models to generate answers. [...] Read more.
Knowledge-based visual question answering (KB-VQA) requires leveraging external knowledge relevant to the image to assist reasoning. Existing methods typically convert images into a single textual description for knowledge retrieval or directly rely on the implicit knowledge within large language models to generate answers. However, a single textual description struggles to preserve fine-grained visual information such as object attributes and scene text, limiting retrieval quality. Meanwhile, naively fusing multi-source information tends to introduce modality noise, undermining reasoning accuracy. To address these issues, we propose a unified framework that constructs multi-source semantic anchors to bridge the cross-modal semantic gaps among vision, questions, and external knowledge. Specifically, we unify image captions, object tags, and optical character recognition (OCR) text as semantic anchors. These anchors serve as shared intermediaries to pre-align visual and textual features, avoiding direct interaction between heterogeneous modalities. During cross-modal fusion, a cross-residual gating mechanism adaptively suppresses modality noise by leveraging the semantic anchors as stable references. The framework further integrates contrastive learning to strengthen cross-modal alignment and employs a retrieve-then-read pipeline for open-domain answer reasoning. Experiments on the OK-VQA, FVQA, and A-OKVQA datasets demonstrate that the proposed framework outperforms state-of-the-art methods across multiple metrics, validating the effectiveness and robustness of the proposed framework. Full article
(This article belongs to the Topic Generative AI and Interdisciplinary Applications)
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17 pages, 6286 KB  
Article
Effect of Hierarchical ZnO/PAC Nanosheets on the Rheological Performance of SBS-Modified Asphalt
by Kunpeng Zhao, Yi Leng, Qinxi Dong, Yongling Ding, Huadong Sun, Chunbao Ding, Ping Song, Yanan Ni, Chunyu Wang and Hong Yin
Coatings 2026, 16(5), 520; https://doi.org/10.3390/coatings16050520 (registering DOI) - 26 Apr 2026
Abstract
To improve the rutting resistance and low-temperature cracking performance of polymer-modified asphalt under extreme conditions, hierarchically structured ZnO-loaded porous activated carbon (ZnO/PAC) nanosheets were introduced as a synergistic reinforcing agent for SBS-modified asphalt. The ZnO/PAC hybrids were synthesized via template-assisted carbonization followed by [...] Read more.
To improve the rutting resistance and low-temperature cracking performance of polymer-modified asphalt under extreme conditions, hierarchically structured ZnO-loaded porous activated carbon (ZnO/PAC) nanosheets were introduced as a synergistic reinforcing agent for SBS-modified asphalt. The ZnO/PAC hybrids were synthesized via template-assisted carbonization followed by hydrothermal growth, and their effects were evaluated by microscopic characterization and rheological tests, including temperature sweeps, multiple stress creep and recovery (MSCR), and bending beam rheometer (BBR) analyses. ZnO was successfully anchored onto the PAC, forming a three-dimensional flower-like nanostructure. Among the investigated samples, ZPS3 with 3 wt.% ZnO/PAC showed the best overall performance. At 64 °C, the rutting factor increased from 4.2 kPa for the SBS-modified asphalt to 6.8 kPa for ZPS3, representing a ~62% enhancement and indicating markedly improved high-temperature deformation resistance. MSCR results further confirmed the superior rutting resistance of ZPS3, which exhibited the highest recovery and the lowest non-recoverable creep compliance. In addition, BBR results showed that the low-temperature performance grade improved from −12 °C for conventional the SBS-modified asphalt to −18 °C for the ZnO/PAC-modified system. These results demonstrate that ZnO/PAC nanosheets can effectively enhance both the high-temperature rutting resistance and low-temperature cracking resistance of SBS-modified asphalt. Full article
(This article belongs to the Special Issue Advances in Pavement Materials and Civil Engineering)
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31 pages, 15106 KB  
Article
Pre-Heritagisation and the Cultural Sustainability of Classical Suzhou Gardens During China’s Modern Transformation: A Study of Periodical Discourse, 1870–1948
by Zhenzhen Guo, Zhengyi Tang, Jiamin Sun, Hongjun Zhou and Yijing Chen
Sustainability 2026, 18(9), 4282; https://doi.org/10.3390/su18094282 (registering DOI) - 25 Apr 2026
Abstract
The heritagisation of cultural landscapes is often understood as a state-led administrative process. At the same time, the discursive origins and adaptive mechanisms that precede formal designation remain underexplored, especially in relation to cultural sustainability. This study examines the pre-heritagisation of Suzhou’s classical [...] Read more.
The heritagisation of cultural landscapes is often understood as a state-led administrative process. At the same time, the discursive origins and adaptive mechanisms that precede formal designation remain underexplored, especially in relation to cultural sustainability. This study examines the pre-heritagisation of Suzhou’s classical gardens during China’s modern transformation by analysing periodical discourse published between 1870 and 1948. Using a mixed-methods approach that combines quantitative content analysis and Critical Discourse Analysis (CDA), it investigates 699 historical texts from the Index to Chinese Newspapers & Periodicals database. The findings reveal a dual discursive process. On the one hand, reports portrayed the gardens as accessible, multifunctional civic spaces through narratives of public use. On the other hand, literati discourse reinforced their classical value through historical memory and aesthetic preservation. Together, these tendencies show how the gardens were materially refunctioned and symbolically re-anchored under modern conditions. Rather than directly producing later heritage designation, this process helped create the socio-cultural conditions through which the gardens acquired broader public intelligibility, cultural legitimacy, and heritage-like meanings before formal institutional recognition. Full article
(This article belongs to the Section Tourism, Culture, and Heritage)
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42 pages, 16476 KB  
Article
PIMSEL: A Physically Guided Multi-Modal Semi-Supervised Learning Framework for Earthquake-Induced Landslide Reactivation Risk Assessment
by Bingxin Shi, Hongmei Guo, Zongheng He, Shi Chen, Jia Guo, Yunxi Dong, Bingyang Shi, Jingren Zhou, Yusen He and Huajin Li
Remote Sens. 2026, 18(9), 1320; https://doi.org/10.3390/rs18091320 - 25 Apr 2026
Abstract
Earthquake-induced landslide reactivation poses a sustained hazard for years following major seismic events, yet operational prediction remains constrained by heterogeneous multi-modal data, sparse supervision, and the absence of uncertainty-aware frameworks. This paper presents PIMSEL, a physically guided multi-modal semi-supervised framework for post-seismic landslide [...] Read more.
Earthquake-induced landslide reactivation poses a sustained hazard for years following major seismic events, yet operational prediction remains constrained by heterogeneous multi-modal data, sparse supervision, and the absence of uncertainty-aware frameworks. This paper presents PIMSEL, a physically guided multi-modal semi-supervised framework for post-seismic landslide reactivation risk assessment. PIMSEL integrates satellite-derived morphological features, precipitation time series, and seismic hazard attributes through four components: entropy-regularized optimal transport for cross-modal semantic alignment without paired supervision; causally constrained hierarchical fusion enforcing domain-consistent modal weighting; scenario-based prototype mutation for semi-supervised learning from sparse expert annotations; and prototype-anchored variational graph clustering that simultaneously stratifies landslides into HIGH, MEDIUM, and LOW risk tiers and produces decomposed aleatoric and epistemic uncertainty estimates for operational triage. The HIGH risk tier operationally corresponds to predicted reactivation, validated against 598 documented reactivation events across 7482 co-seismic landslides from three Sichuan Province earthquake sequences: the 2013 Lushan (Mw 7.0), 2017 Jiuzhaigou (Mw 7.0), and 2022 Luding (Mw 6.8) events. PIMSEL achieves 82.5% reactivation recall and 66.4% precision, outperforming twelve baselines across clustering quality, classification, and uncertainty calibration metrics. Ablation studies confirm that optimal transport alignment contributes the largest individual performance gain. Current limitations include quarterly assessment frequency and dependence on optical imagery under cloud cover, which future integration of real-time meteorological triggers and SAR data should address. Full article
20 pages, 976 KB  
Article
Decoupling Fairness Perception from Grading Validity in Digitally Mediated Peer Assessment: A Two-Stage fsQCA Study
by Duen-Huang Huang and Yu-Cheng Wang
Information 2026, 17(5), 411; https://doi.org/10.3390/info17050411 (registering DOI) - 25 Apr 2026
Abstract
Artificial intelligence (AI) has become increasingly embedded in technology-enhanced learning environments, where peer assessment now serves both instructional and analytic purposes. Beyond allocating feedback and grades, it also produces data that is later interpreted through learning analytics systems. In practice, visible indicators such [...] Read more.
Artificial intelligence (AI) has become increasingly embedded in technology-enhanced learning environments, where peer assessment now serves both instructional and analytic purposes. Beyond allocating feedback and grades, it also produces data that is later interpreted through learning analytics systems. In practice, visible indicators such as students’ fairness perceptions and the degree of agreement among peer raters are often treated as signs that the assessment process is functioning effectively. However, these indicators do not necessarily correspond to grading validity. Students may regard a peer assessment process as fair even when peer-generated ratings remain weakly aligned with expert judgement. This study, therefore, examines whether the socio-technical configurations associated with high perceived fairness in a digitally mediated peer assessment environment also correspond to criterion-referenced grading validity. Data were collected from 215 undergraduate students enrolled in an Artificial Intelligence Foundations course over two consecutive semesters at a university in Taiwan, with instructor ratings serving as an external expert reference within the course context, rather than as a universal ground truth. Because anonymity conditions and semester were fully confounded in the study design, differences linked to anonymity should not be interpreted as isolated causal effects. A two-stage fuzzy-set Qualitative Comparative Analysis (fsQCA) was used. In the first stage, three equifinal configurations associated with high perceived fairness were identified. In the second stage, these configurations were examined against four grading objectivity outcomes: peer–instructor alignment, peer convergence, familiarity bias, and leniency bias. The findings show that fairness perception and grading validity are only partially aligned. Configurations anchored in explicit criterion transparency consistently supported both experiential legitimacy and evaluative accuracy. By contrast, one configuration was associated with high peer convergence while remaining weakly aligned with instructor standards, a pattern described here as false objectivity; this context-dependent configurational finding warrants further investigation across other settings. The study contributes to research on digitally enhanced assessment and learning analytics by showing that fairness perception, peer convergence, and grading validity should be treated as analytically distinct dimensions of assessment quality. Full article
(This article belongs to the Special Issue AI Technology-Enhanced Learning and Teaching)
24 pages, 2896 KB  
Review
Biomaterial Engineering for Spatiotemporal Regulation of Exosome Functions: From Design Principles to Key Applications in Regenerative Medicine
by Shan Long, Bo Wang, Shaodong Tian, Honglan Tang, Hanbing Wu, Xiaofeng Yang and Chuyue Zhang
Pharmaceuticals 2026, 19(5), 672; https://doi.org/10.3390/ph19050672 (registering DOI) - 25 Apr 2026
Abstract
As natural nanoscale intercellular messengers, exosomes exhibit considerable potential in modulating inflammation, angiogenesis, immunoregulation, and tissue remodeling, making them attractive candidates for regenerative medicine. However, their clinical translation remains limited by rapid systemic clearance, nonspecific biodistribution, insufficient lesion retention, and functional attenuation in [...] Read more.
As natural nanoscale intercellular messengers, exosomes exhibit considerable potential in modulating inflammation, angiogenesis, immunoregulation, and tissue remodeling, making them attractive candidates for regenerative medicine. However, their clinical translation remains limited by rapid systemic clearance, nonspecific biodistribution, insufficient lesion retention, and functional attenuation in hostile pathological microenvironments. In this review, we propose that biomaterial engineering should evolve from providing passive exosome carriers to constructing active regulatory platforms capable of precise spatiotemporal control. We summarize engineering strategies along two complementary dimensions. In the temporal dimension, biomaterials can enable sustained, sequential, or microenvironment-responsive release to match the dynamic phases of tissue repair. In the spatial dimension, biomaterials can improve local retention, tissue anchoring, structural guidance, endogenous cell recruitment, and lesion-specific delivery. Using cutaneous wound healing, osteochondral regeneration, myocardial repair, and neural regeneration as representative examples, we further analyze these strategies through a “clinical challenge–engineering strategy–biological mechanism” framework, with particular attention to how engineered systems influence key signaling pathways such as PI3K/Akt, Wnt/β-catenin, NF-κB, and PTEN/PI3K/Akt/mTOR. We also discuss translational barriers, including exosome heterogeneity, safety concerns inherited from parental cells, large-scale GMP-compliant manufacturing, product standardization, storage stability, and regulatory classification of exosome–biomaterial hybrids. Finally, we highlight emerging directions, including multi-mechanism combinational systems, closed-loop responsive platforms, and artificial intelligence-assisted design for personalized exosome therapeutics. This review provides a design-oriented framework to accelerate the bench-to-bedside development of biomaterial-enabled precision exosome therapy. Full article
25 pages, 1110 KB  
Review
Rediscovering the Gut–Mito–Ear Axis: A Systems-Biology Framework for Ototoxic Vulnerability and Microbiome-Targeted Prevention
by Chae Dong Yim, Hayeong Kwon, Jung Je Park, Seung-Jun Lee, Ji Hyun Seo, Young-Sool Hah and Seong-Ki Ahn
Cells 2026, 15(9), 769; https://doi.org/10.3390/cells15090769 - 24 Apr 2026
Viewed by 72
Abstract
Ototoxicity is traditionally viewed as a local cochlear adverse effect of indispensable therapies such as cisplatin and aminoglycosides. However, emerging evidence suggests that cochlear vulnerability is shaped by systemic physiology, including inflammatory tone, vascular barrier integrity, and metabolic state. In this Review, we [...] Read more.
Ototoxicity is traditionally viewed as a local cochlear adverse effect of indispensable therapies such as cisplatin and aminoglycosides. However, emerging evidence suggests that cochlear vulnerability is shaped by systemic physiology, including inflammatory tone, vascular barrier integrity, and metabolic state. In this Review, we propose a Gut–Mito–Ear axis in which gut ecosystem function influences circulating mediator modules that converge on two cochlear mediator nodes: blood–labyrinth barrier (BLB) gating and mitochondrial stress tolerance. We synthesize evidence showing that gut perturbation can alter cochlear outcomes in vivo, that at least one microbiota-derived metabolite signal can directly protect hearing in experimental settings, and that BLB dysfunction and inflammatory trafficking are mechanistically relevant to cisplatin- and aminoglycoside-induced injury. We further organize the literature using an evidence-weighted framework that distinguishes direct cochlear causality from mechanistic plausibility and explicitly retains negative studies as boundary-setting evidence. Finally, we outline a translational roadmap in which microbiome-targeted prevention is pursued through mediator-anchored, non-interference-aware strategies and evaluated across linked state variables spanning exposure context, gut function, defined mediator modules, BLB gating, mitochondrial stress tolerance, and auditory phenotype. The Gut–Mito–Ear axis is not considered an established mechanism. We present it as a falsifiable systems-biology model that organizes the current evidence. Within this model, we define the minimum and ideal standards for A-tier causal evidence, explicit criteria for interpreting boundary-setting negative (A−) studies, and a set of testable predictions for causal validation. Full article
(This article belongs to the Section Tissues and Organs)
38 pages, 7181 KB  
Article
Object-Oriented Geometric Figures with Operations and Transformations for Relational Modeling
by Steven D. P. Moore
Symmetry 2026, 18(5), 725; https://doi.org/10.3390/sym18050725 - 24 Apr 2026
Viewed by 68
Abstract
This article introduces novel methodologies, coordinate systems, and procedures in computational geometry that further develop a Euclidean-based relationalistic framework. The objective is to describe tools using object-oriented relational elements with symmetry, anchored to a fixed point in a relational model, that generate structured [...] Read more.
This article introduces novel methodologies, coordinate systems, and procedures in computational geometry that further develop a Euclidean-based relationalistic framework. The objective is to describe tools using object-oriented relational elements with symmetry, anchored to a fixed point in a relational model, that generate structured point sets serving as blueprints for geometric figures and physical structures representing their source objects. Geometric operations and transformations construct ratio figures and ordered proportional structures. Using discrete N-Euclidean geometry, two relational coordinate systems are introduced—polar-vertex coordinates and radial coordinates—both formed through discrete geometric operations. A relational unit circle of fixed magnitude is defined by a 4::1 proportional equivalence between radius and angular ratios, independent of real-number or arc-length geometry. Euclid’s theory of proportion is extended from static abstract magnitudes to symmetry-driven geometric construction, and a square-pyramid geometric blueprint is produced from an Earth ratio figure with accurate dimensional magnitudes. The findings reveal a novel commensurability between the radius of a circle and the side length of a square using a shared fixed point coupled via a 3:4:5 Pythagorean-triple triangle, introducing the concept of ordered proportions. Full article
14 pages, 1820 KB  
Article
Radiation Attenuation Performance of Highly Filled Tungsten/TPU Composites via Anchor–Chain Dispersant-Based Interfacial Design
by Seon-Chil Kim
Polymers 2026, 18(9), 1037; https://doi.org/10.3390/polym18091037 - 24 Apr 2026
Viewed by 146
Abstract
Environmentally friendly radiation shielding materials for medical institutions require lightweight characteristics and high flexibility as key performance indicators. One promising approach is the incorporation of lead-free materials that combine high-density shielding fillers with polymer matrices. High filler loading is necessary to maintain shielding [...] Read more.
Environmentally friendly radiation shielding materials for medical institutions require lightweight characteristics and high flexibility as key performance indicators. One promising approach is the incorporation of lead-free materials that combine high-density shielding fillers with polymer matrices. High filler loading is necessary to maintain shielding performance while preserving the inherent flexibility of the polymer. However, during the mixing of shielding materials with polymers, microvoids may form. Therefore, strategies are required to enhance structural densification of the composite by reducing microvoid formation. This study aims to investigate the effects of interfacial design using an anchor–chain dispersant (APTES: 3-aminopropyltriethoxysilane) on micropore formation, effective density, and X-ray shielding performance in highly filled tungsten/thermoplastic polyurethane (TPU) composites. TPU-based composite shielding sheets containing 75–90 wt% tungsten were fabricated. The dispersant (APTES) can adsorb onto the surface of metal particles and form a stabilization layer. In this study, the observed reduction in particle agglomeration and porosity upon addition of the dispersant suggests that interfacial stabilization was induced. As a result, in the 85 wt% composite sheet, the porosity decreased from 5.89% without the dispersant to 0.56% with the dispersant, leading to an improvement in the densification level and effective density of the sheet. Under the same thickness condition (0.25 mm), the dispersant-containing sheet exhibited a shielding efficiency that was 3–4% p higher than that of the sheet without dispersant in the 100–120 kVp range. Meanwhile, as the tungsten content increased, the overall density and shielding efficiency of the sheets also increased. At 90 wt% tungsten loading, the composite demonstrated shielding performance approaching that of conventional lead shielding even at a reduced thickness. These results indicate that interfacial design using an anchor–chain dispersant is an effective processing strategy for improving density uniformity and radiation shielding performance in highly filled tungsten/TPU composite shielding materials by controlling microvoid formation. Full article
(This article belongs to the Section Polymer Applications)
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