Search Results (37)

Background: Snoring and mild to moderate obstructive sleep apnoea (OSA) are common sleep-related breathing disorders with increasing demand for minimally invasive treatment options. This study aimed to systematically evaluate the efficacy and safety of erbium:yttrium–aluminium–garnet (Er:YAG) laser therapy for these conditions. Methods: A systematic review and meta-analysis were conducted in line with PRISMA guidelines. Studies published between 2015 and 2025 were retrieved from major biomedical databases based on predefined inclusion criteria. Data were extracted on treatment outcomes, laser parameters, patient characteristics, and adverse effects. Results: Fifty-six studies were included. Er:YAG laser treatment, particularly in non-ablative SMOOTH and long-pulse modes, significantly reduced snoring intensity and improved subjective sleep quality. High patient satisfaction (65–85%) and a favourable safety profile were observed, with adverse effects generally mild and transient. Therapeutic effects typically lasted 12–24 months, though 25–40% of patients required maintenance sessions. Treatment success was associated with BMI, oropharyngeal anatomy, smoking status, and baseline apnoea-hypopnoea index scores (AHI 5–30 events/hour). Conclusions: Er:YAG laser therapy appears to be a safe and effective short- to medium-term treatment for selected patients with snoring or mild to moderate OSA. Optimising patient selection and treatment protocols may enhance long-term outcomes. Based on moderate-quality evidence for the immediate effects and safety profile, but low to very low quality evidence for long-term outcomes, erbium:yttrium–aluminium–garnet laser treatment appears to be a potentially effective and well-tolerated option for achieving short- to medium-term improvement in carefully selected patients with primary snoring or mild to moderate obstructive sleep apnoea. The practical significance of these findings lies in the refinement of candidate selection criteria, laser parameter settings, and the development of optimal protocols for long-term snoring control. Full article

This study investigates a risk-based approach to evaluate the effectiveness of sprinklers in residential buildings to offset the risk premium imposed by combustible cladding (expanded polystyrene and aluminium composite panels) installed on such buildings in Victoria, Australia. This approach builds upon the Initial Fire Spread in Cladding Assessment Number (IF-SCAN), a concept pioneered by Cladding Safety Victoria as a triage tool in their rectification program. The analysis uses published data from real fires in buildings with and without sprinkler systems installed. It considers three criteria: death rates, injury rates, and construction cost. The construction cost was determined using an existing costing model currently employed in Victoria. The results of this study suggest a higher risk tolerance can be accepted for combustible cladding on buildings equipped with sprinkler systems over that set out in government policy. More specifically, it was found that a building fully protected by sprinklers can generally counterbalance the fire risk posed by combustible cladding spanning up to seven apartments, while a span of up to ten apartments could be considered for buildings without balconies or a private courtyard. Full article

Treated wastewater (TWW) is recognised as an alternative irrigation source to mitigate global water scarcity for irrigation purposes. However, one of the challenges of using TWW as an irrigation source is the accumulation of non-essential toxic elements in soil post-irrigation. Thus, this study determined whether indigenous microbes that are tolerant to toxic elements would remediate non-essential toxic elements in contaminated soil following irrigation with TWW. Soil from a fallowed field at the University of Limpopo Experimental Farm was irrigated with TWW in pots for 12 weeks. After that, an incubation study was established to assess the abilities of Escherichia coli, Staphylococcus aureus, Aspergillus flavus, and Pseudomonas aeruginosa to remediate the contaminated soil over 12 weeks. Both water and soil samples (non-contaminated, contaminated, and remediated) were analysed for toxic elements: Aluminium (Al), Arsenic (As), Chromium (Cr), Cadmium (Cd), and Lead (Pb). Data were analysed using GenStat 20th edition. The results revealed that irrigation with TWW increased the concentration of non-essential toxic elements in soil by 110%, 31%, 31%, 31%, and 54% for Al, As, Cr, Cd, and Pb, respectively. The inoculation of soil with indigenous microbes led to the decline in the concentration of non-essential toxic elements in soil. Furthermore, soils inoculated with S. aureus led to a reduction in Cr to levels below those observed prior to irrigation with TWW. Overall, the findings of the study effectively convey that these indigenous microbes can be used for bioremediation. Full article

Aluminum (Al) toxicity is a major constraint to crop productivity in acidic soils, frequently encountered in banana-growing regions. This study investigates physiological and biochemical responses to Al stress in two Cavendish banana genotypes, Baodao and Baxi (Musa acuminata L.), which exhibit contrasting levels of Al tolerance. Banana plantlets were grown hydroponically under three AlCl₃ concentrations (0, 100, and 500 μM) for 24, 48, and 72 h. Root elongation was progressively inhibited with increasing Al concentrations, with Baodao showing greater inhibition than Baxi. Al primarily accumulated in roots and displayed genotype-specific distribution patterns: Baodao concentrated more Al in root tips, suggesting lower exclusion efficiency. In contrast, Baxi, the Al-tolerant genotype, translocated Al from roots to shoots more effectively, indicating potential sequestration mechanisms in less sensitive tissues. Al stress influenced enzyme activities, with Baxi exhibiting higher phosphoenolpyruvate carboxylase and citrate synthase activities at 100 µM Al, while both genotypes showed similar reductions at 500 µM. Baodao experienced more pronounced reductions in H⁺-ATPase activity. At 100 µM Al, Baxi retained higher levels of key nutrients (P, Zn, Mg, Mn, Fe, K, and B) in essential tissues than Baodao. However, nutrient levels were reduced in both genotypes at 500 µM Al. These findings highlight Baxi’s superior resilience under Al stress, making it a suitable genotype for cultivation and breeding in acidic soils. Full article

The rhizosheath, the layer of soil tightly attached to the roots, protects plants against abiotic stress and other adverse conditions by providing a bridge from the plant root system to the soil. It reduces the formation of air gaps between the root and soil and facilitates the transportation of water at the root–soil interface. It also serves as a favourable niche for plant-growth-promoting rhizobacteria in the surrounding soil, which facilitate the absorption of soil water and nutrients. This review compares the difference between the rhizosheath and rhizosphere, and summarises the molecular and physiological mechanisms of rhizosheath formation, and identifying the causes of rhizosheath formation/non-formation in plants. We summarise the chemical and physical factors (root hair, soil-related factors, root exudates, and microorganisms) that determine rhizosheath formation, and focus on the important functions of the rhizosheath in plants under abiotic stress, especially in drought stress, phosphorus deficiency, aluminium stress, and salinity stress. Understanding the roles played by the rhizosheath and the mechanisms of its formation provides new perspectives for improving plant stress tolerance in the field, which will mitigate the increasing environmental stress conditions associated with on-going global climate change. Full article

Alfalfa (Medicago sativa L.) grown in acidic soils is often affected by phosphorus (P) deficiency, which results in reduced mineral nutrient content and forage quality. In this context, the effects of phosphorus (P) fertiliser remain unclear. In this study, we analysed the effects of P application on mineral nutrient content and forage quality in aluminium (Al)-sensitive (Longzhong) and Al-tolerant (Trifecta) alfalfa cultivars cultivated in two acidic soil environments. Mineral nutrient content and quality were affected by genotype, soil type, and P treatment concentration (p < 0.001). In limestone soil, for Longzhong and Trifecta, the optimal potassium (K), calcium (Ca), and magnesium (Mg) contents as well as crude protein content (CP) and ether extract (EE) values were observed at 20 mg P kg⁻¹, that of the P content was observed at 40 mg P kg⁻¹, and the minimum neutral detergent fibre (NDF) acid detergent lignin (ADL) values were observed at 40 mg P kg⁻¹. In yellow soil, the maximum K, Ca, Mg, and P contents in Longzhong and Trifecta were observed at 40 mg P kg⁻¹, whereas the maximum CP, EE, and ADL values were observed at 20 mg P kg⁻¹. Our study provides an empirically based framework for optimising alfalfa fertilisation programmes in acidic soils. Full article

Background: Type 1 diabetes (T1D) is an autoimmune disorder characterised by the destruction of insulin-producing beta cells in the pancreatic islets, resulting from a breakdown in immunological tolerance. Currently, T1D treatment primarily relies on insulin replacement or immunosuppressive therapies. However, these approaches often have significant drawbacks, including adverse effects, high costs, and limited long-term efficacy. Consequently, there is a pressing need for innovative immunotherapeutic strategies capable of inducing antigen-specific tolerance and protecting beta cells from autoimmune destruction. Among the various antigens, β-cell antigens like 65 kDa glutamic acid decarboxylase (GAD65) have been explored as vaccine candidates for T1D. Despite their potential, their effectiveness in humans remains modest, necessitating the use of appropriate adjuvants to enhance the vaccine’s protective effects. Methods: In this study, we evaluated the therapeutic potential of kynurenine (KYN), dexamethasone (DXMS), tacrolimus (FK506), and aluminium hydroxide (Alum) in combination with the GAD65 phage vaccine as adjuvants. Results: Our findings demonstrate that KYN, when used in conjunction with the GAD65 vaccine, significantly enhances the vaccine’s immunosuppressive effects. Compared to dexamethasone, FK506, and Alum adjuvants, KYN more effectively reduced the incidence and delayed the onset of T1D, preserved β-cell function, and promoted the induction of regulatory T cells and antigen-specific tolerance. These results suggest that KYN combined with vaccines could offer superior preventive and therapeutic benefits for T1D compared to existing treatments. Additionally, we investigated the dose-dependent effects of the GAD65 vaccine by including a low-dose group in our study. The results indicated that reducing the vaccine dose below 10¹⁰ plaque-forming units (pfu) did not confer any protective advantage or therapeutic benefit in combination with KYN. This finding underscores that 10¹⁰ pfu is the minimum effective dose for the GAD65 vaccine in achieving a protective response. In conclusion, KYN shows considerable promise as an adjuvant for the GAD65 vaccine in T1D therapy, potentially offering a more effective and durable treatment option than current immunosuppressive strategies. Full article

Lotus pedunculatus (lotus) and Lupinus polyphyllus (Russell lupin) persist in the upland grasslands of New Zealand, where soil acidity and associated aluminium (Al) toxicity impede conventional pasture legumes. This experiment investigated the response of lotus and Russell lupin to soil acidity and Al. The species were sown in 20 cm tall 1.2 L pots of acidic upland soil. A mass of 4.5 or 6.7 g lime (CaCO₃)/L was added to either the top or bottom or both soil horizons (0–9 cm and 9–18 cm), resulting in six treatments across six randomised blocks in a glasshouse. The soil pH was 4.4, 4.9, and 5.4; the exchangeable Al concentrations were 24, 2.5, and 1.5 mg/kg for 0, 4.5, and 6.7 g lime/L. At 16 weeks post-sowing, the plants were divided into shoots and roots at 0–9 cm and 9–18 cm. Root morphology, shoot and root dry matter (DM), shoot nitrogen (N), and nodulation were measured. The total plant DM and shoot-to-root DM ratio were higher, and the shoot %N was lower for the lotus plants than the Russell lupin plants for the various lime rates (13.2 vs. 2.9 g plant⁻¹, 5.6 vs. 1.6, and 2.4 vs. 3.3%, p < 0.05). No response to lime in terms of total DM or total root morphology parameters was exhibited in either species (p > 0.05). Root morphology adjustments in response to acidity between soil horizons were not observed. The results indicated that lotus and Russell lupin are tolerant to high soil acidity (pH 4.4–5.4) and exchangeable Al (1.5–24 mg kg⁻¹), highlighting their considerable adaptation to grasslands with acidic soils. Full article

Periphytic rotifer assemblages from lentic habitats are understudied. To improve knowledge on the principal environmental determinants of their structure and composition, we examined summer periphyton from 184 freshwater bodies from a taxonomic and multi-trait-based perspective. Only the latter allowed consideration of all bdelloids. Alpha diversity decreased with electrolyte and aluminium concentration but increased with macrophyte richness, pointing at salinization, metal toxicity and loss of structural niche heterogeneity as potential threats for rotifer diversity. Replacement was the prominent component of beta diversity, with acidified sites showing the highest local contributions. Variation partitioning indicated that local conditions explained variation in species composition best, but general setting (soil type, land cover, connectivity) and spatial context were also not insignificant. Redundancy analysis related species composition more particularly to gradients of pH and trophic status, whereas the representation of functional groups was structured mainly by phytoplankton productivity. Mirroring shifts observed in the plankton, high phytoplankton productivity associated with larger size and more detritibacterivory. Dominance of collectors constrained variation in guild ratios, underlining the need for more refined functional approaches. To aid the use of periphytic rotifers in regional water quality assessment, we identified indicators and community thresholds for pH and trophic variables and determined optima and tolerances for individual taxa. Full article

Aluminium toxicity and phosphorus deficiency in soils are the main interconnected problems of modern agriculture. The aluminium-activated malate transporters (ALMTs) comprise a membrane protein family that demonstrates various physiological functions in plants, such as tolerance to environmental Al³⁺ and the regulation of stomatal movement. Over the past few decades, the regulation of ALMT family proteins has been intensively studied. In this review, we summarise the current knowledge about this transporter family and assess their involvement in diverse physiological processes and comprehensive regulatory mechanisms. Furthermore, we have conducted a thorough bioinformatic analysis to decipher the functional importance of conserved residues, structural components, and domains. Our phylogenetic analysis has also provided new insights into the molecular evolution of ALMT family proteins, expanding their scope beyond the plant kingdom. Lastly, we have formulated several outstanding questions and research directions to further enhance our understanding of the fundamental role of ALMT proteins and to assess their physiological functions. Full article

Fibre Metal Laminates (FMLs) are very interesting materials due to their light weight coupled with their high stiffness, high fatigue resistance, and high damage tolerance. However, the presence of the polymeric matrix in the composite layers and of polymeric adhesive at the metal/composite interface can constitute an Achille’s heel for this class of materials, especially when exposed to a hot environment or water. Therefore, in the present article, aluminium/carbon fibre FML specimens were produced, aged by considering different hydrothermal conditions, and then, subjected to mechanical testing. The End-Notched Flexure (ENF) test was considered for this activity. It was found that the first ageing stage, consisting of submersion in saltwater, was very detrimental to the specimens, while the second stage, composed of high and low temperature cycles, showed an increase in the maximum load, probably due to a post-curing effect of the resin during the higher temperatures of the ageing cycles and to the dissolution of salt crystals during the subsequently ageing stages in distilled water. Full article

An experimental analysis of mechanical behaviour for aluminium-based fibre metal laminates under compression after impact was conducted. Damage initiation and propagation were evaluated for critical state and force thresholds. Parametrization of laminates was done to compare their damage tolerance. Relatively low-energy impact had a marginal effect on fibre metal laminates compressive strength. Aluminium–glass laminate was more damage-resistant than one reinforced with carbon fibres (6% vs. 17% of compressive strength loss); however, aluminium–carbon laminate presented greater energy dissipation ability (around 30%). Significant damage propagation before the critical load was found (up to 100 times the initial damaged area). Damage propagation for assumed load thresholds was minor in comparison to the initial damage size. Metal plastic strain and delaminations are dominant failure modes for compression after impact. Full article

Grinding is widely used as the last step of the manufacturing process when a good surface finish and precise dimensional tolerances are required. However, if the grinding wheels have cracks, they may lead to a hazardous working environment and produce poor tolerance in machined products. Therefore, grinding wheels should be inspected for cracks before being mounted onto the machine. In this study, a novel method of finding possible internal cracks in the aluminium oxide grinding wheel will be explored by examining the natural frequency and displacement of wheels using an impact hammer testing method. Grinding wheels were cracked into two segments using a three-point bend fixture and then bonded intentionally to simulate cracks. The impact hammer test indicated that cracks in the grinding wheels caused a drop in natural vibration frequency and an increase in the maximum displacement of the accelerometer sensors. Full article

A widely used coating system for corrosion mitigation of offshore steel structures is thermally sprayed aluminium (TSA). Even though these coatings have been used for decades, it is not always clear how they perform in service over long periods, particularly if damaged during installation or in service. To understand the corrosion behaviour of damaged TSA coatings in seawater and their tolerance to levels of damage, TSA coatings (1050 Al) were prepared on carbon steel substrates using wire arc spray and tested in synthetic seawater. Prior to testing, various levels of holidays or damage (~5%, 10%, 15% and 18%) reaching the steel substrate were drilled on the front surface of the coated specimens. Open circuit potential was measured and linear polarization resistance technique was used to calculate the corrosion rate. The work showed that the TSA coatings polarised steel to potentials below −800 mV (Ag/AgCl) at 25 °C, even in the presence of damage or holiday (up to ~18%). The SEM/EDX and XRD data confirmed the presence of brucite and aragonite in the damage region. The presence of damage impacted the short-term corrosion rate at the start, but did not significantly affect the overall corrosion performance of the TSA coatings in 420 days of testing. Full article

Harvesting impacts the costs of microalgae production and affects the characteristics of the final product. Therefore, this study evaluated Moringa oleifera seed powder (MP) as a bioflocculant compared to two chemicals (Aluminium Sulphate—AS and Iron Chloride—IC) to harvest a mixed microalgae culture (Chlorella vulgaris and Desmodesmus sp.) grown on digestate. MP was the most stable flocculant but resulted in the lowest harvesting efficiency of 75%, compared to 94% for AS and 100% for IC. Process parameters such as pH, duration of mixing, grinding method for obtaining the powder, and granulometry had no significant effect on the harvesting efficiency of MP, reinforcing that this is a robust flocculant. The use of a water extraction step increased the harvesting efficiency of MP to 91%, albeit with the need for a higher dosage of flocculant. The algae harvested with MP complied with maximum tolerable levels for swine, cattle, and poultry regarding most trace elements. Nevertheless, all algae samples had Fe and Al contents above the recommended levels, possibly due to the entrapment of metal-rich digestate particles. Therefore, more attention should be paid to the final composition of algae when proposing flocculation as a harvesting method for feed production. Full article