Search Results (60)

Medieval Islamic bustān gardens in the western Mediterranean played a crucial role in preserving and enriching rose diversity through the cultivation of species from the eastern Mediterranean and western Asia. These gardens, particularly in Al-Andalus, maintained distinctive rose varieties characterized by diverse flower morphology—ranging from white to deep crimson and near-black hues, including various yellow shades—and complex fragrance profiles with multiple olfactory nuances. The botanical heritage from these medieval Islamic gardens demonstrates remarkable persistence, with several of these cultivated rose species still found today in abandoned cortijos and aldeas throughout the mountains of eastern Spain. This study examines the transmission of rose culture through medieval Islamic bustān gardens, analyzing how these gardens served as repositories for ancient cultivars while introducing new varieties from eastern regions. Through examination of historical texts, iconographic evidence, and field documentation of surviving populations, we trace the continuity of medieval Islamic rose cultivation practices and their lasting impact on the rural landscape of eastern Spain. Flower scent is prominent as the leading factor determining preferences for medieval heritage rose cultivars, together with color and shape. The survival of these roses in abandoned settlements provides unique insight into the durability of medieval horticultural systems and the adaptation of cultivated species to semi-wild conditions over centuries. Full article

Psychiatric neurosurgery is undergoing a profound transformation, propelled by advances in neurotechnology, connectomics, and personalized medicine. Once controversial, surgical interventions are now guided by detailed functional brain mapping and precise neuromodulation techniques, such as deep brain stimulation (DBS), which offer therapeutic options for patients with severe, treatment-resistant psychiatric disorders. This manuscript reviews the current techniques, including lesion-based procedures and DBS, and explores their mechanisms of action, from synaptic plasticity to large-scale network modulation. It highlights recent progress in neuroimaging, connectomic targeting, and artificial intelligence applications for surgical planning and the prediction of treatment responses. Ethical considerations—including informed consent, identity, and long-term follow-up—are critically examined in light of these advances. Furthermore, the growing role of minimally invasive procedures and wearable integrated neurotechnologies is discussed as part of a shift toward dynamic and adaptive interventions. Although still investigational, psychiatric neurosurgery is emerging as a technologically sophisticated field that demands rigorous clinical evaluation, ethical accountability, and an individualized approach to restoring function and autonomy in some of the most disabling mental illnesses. Full article

Tongue-nibbling is a rare and previously undocumented affiliative behaviour in free-ranging killer whales (Orcinus orca), until now seen only in individuals under human care. This study presents the first recorded observation of tongue-nibbling between two wild killer whales in the Kvænangen fjords, Norway. The interaction, captured opportunistically by citizen scientists during a snorkelling expedition, lasted nearly two minutes and involved repeated episodes of gentle, face-to-face oral contact. This behaviour closely resembles sequences observed and described in detail in zoological settings, suggesting that it forms part of the species’ natural social repertoire. The observation also supports the interpretation of tongue-nibbling as a socially affiliative behaviour, likely involved in reinforcing social bonds, particularly among juveniles. The prolonged maintenance of this interaction in managed populations originating from geographically distinct Atlantic and Pacific lineages further indicates its behavioural conservation across contexts. This finding underscores the importance of underwater ethological observation in capturing cryptic social behaviours in cetaceans and illustrates the value of integrating citizen science into systematic behavioural documentation. The study also reinforces the relevance of managed populations in ethological research and highlights the ethical need for carefully regulated wildlife interaction protocols in marine tourism. Full article

The pituitary gland regulates essential physiological processes in mammals. Despite its importance, research on its anatomy and ultrastructure in dolphins remains scarce. Using non-invasive imaging technology (MRI) and a novel skull-opening and dissection protocol, this study characterizes the dolphin pituitary through immunohistochemistry (IHC) and transmission electron microscopy (TEM). A total of 47 pituitaries were collected from stranded common bottlenose dolphins (Tursiops truncatus). common dolphins (Delphinus delphis), and Atlantic spotted dolphins (Stenella frontalis). as well as from captive common bottlenose dolphins. MRI allowed visualization of the gland’s anatomy and its spatial relationship with the hypothalamus and surrounding structures. A modified skull-opening and pituitary extraction protocol ensured the preservation of the adenohypophysis and neurohypophysis for detailed analysis. Histological, immunohistochemical, and ultrastructural studies confirmed the gland’s structural organization, identifying eight distinct adenohypophyseal cell types: corticotrophs (ACTH), somatotrophs (GH), gonadotrophs (FSH and LH), lactotrophs (LTH), melanotrophs (MSH), thyrotrophs (TSH), follicular cells, and capsular cells. This study presents the first immunolabelling of thyrotrophs in cetacean adenohypophysis and the first detailed ultrastructural characterization of adenohypophyseal cells in cetaceans, providing baseline data for future research. By integrating multidisciplinary techniques, it advances the understanding of dolphin neuroendocrinology and highlights broader implications for cetacean health, welfare, and conservation. Full article

The SEA LIFE Trust Beluga Whale Sanctuary (BWS) has been in operation for over five years and serves as a unique case study to evaluate the effectiveness of marine sanctuaries for cetaceans. While cetacean sanctuaries are often regarded as a middle-ground solution between captivity and release, evidence from the BWS highlights complexities in adapting cetaceans to these environments. Despite initial assumptions that natural conditions would inherently improve welfare, the belugas at the BWS spent the majority of the operational period (92.6%) in a conventional indoor pool, due to health and welfare concerns. Repeated delays, challenges in acclimatization, and distress-related conditions observed during periods in the bay suggest that natural environments alone may not guarantee improved welfare. Additionally, the lack of publicly accessible data on health and welfare outcomes hinders comprehensive evaluation of the sanctuary’s success and raises questions about transparency and evidence-based practices. This review underscores the need for refined sanctuary models, improved infrastructure, and structured adaptation programs tailored to species and individual cetaceans. It highlights the importance of robust planning, ongoing research, and transparency to meet the ambitious goals of marine sanctuaries in the best interests of the well-being of cetaceans under human care. These considerations also raise concerns about the decision to relocate captive cetaceans to marine sanctuaries, as the available evidence suggests that such environments may not inherently guarantee better welfare outcomes. Full article

This study delves into the multifaceted realm of citrus fruits, exploring their significance and socioeconomic implications from their early introduction to Western Muslim and Renaissance gardens, tracing their journey throughout history. Employing a multidisciplinary approach, drawing from biological, archaeobotanical, iconographic, and textual sources, our study offers a comprehensive exploration of citrus symbolism and cultural significance, integrating historical, artistic, horticultural, and socioeconomic viewpoints. The genus Citrus (Rutaceae) comprises around thirty species and its natural habitat spans from the southern slopes of the Himalayas to China, Southeast Asia, nearby islands, and Queensland. Originating from only four of these species, humans have cultivated hundreds of hybrids and thousands of varieties, harnessing their culinary, medicinal, and ornamental potential worldwide. We delve into the symbolic value of citrus fruits, which have served as indicators of economic status and power. From their early presence in Mediterranean religious rituals to their depiction in opulent Roman art and mythical narratives like the Garden of the Hesperides, citrus fruits have epitomized luxury and desire. Christian lore intertwines them with the forbidden fruit of Eden, while Islamic and Sicilian gardens and Renaissance villas signify their prestige. We analyze diverse perspectives, from moralists to hedonists, and examine their role in shaping global agriculture, exemplified by rare varieties like aurantii foetiferi. Full article

Rainwater penetration into building facades results in multiple issues, including material and structural degradation, reduced energy efficiency, and health-related concerns among occupants. Currently, the watertightness performance of building facades is assessed based on standardized tests, which simulate generic water supplies and pressure differentials that do not reflect the specific exposure conditions of each facade. Consequently, practitioners’ decisions regarding facade design often rely on qualitative and imprecise criteria that do not align with the actual climatic loads. In this article, a comprehensive approach to facade design for preventing rainwater penetration is described, incorporating specific methodological refinements for reliable and practical implementation across various Spanish regions. In this approach, the parameters surpassed during any watertightness test (defined by the magnitude and duration of the water supplies and pressure differentials) are correlated with the recurrence of equivalent climatic exposures at the facade (determined by the climatic conditions of the site, facade height, and surrounding environment), thereby quantitatively characterizing the facade watertightness performance. The findings used to refine this method for implementation in Spain are illustrated and validated using selected case studies, and a comprehensive database is provided to enable its application at 360 locations distributed across various regions of the country. Full article

This study highlights the potential of aquariums as research platforms for bioacoustic research. Aquariums provide access to a wide variety of fish species, offering unique opportunities to characterize their acoustic features in controlled settings. In particular, we present a preliminary description of the acoustic characteristics of Myripristis jacobus, a soniferous species in the Holocentridae family, within a controlled environment at a zoological facility in the Canary Islands, Spain. Using two HydroMoth 1.0 hydrophones, we recorded vocalizations of the blackbar soldierfish in a glass tank, revealing a pulsed sound type with a peak frequency around 355 Hz (DS 64), offering a more precise characterization than previously available. The vocalizations exhibit two distinct patterns: short sequences with long pulse intervals and fast pulse trains with short inter-pulse intervals. Despite some limitations, this experimental setup highlights the efficacy of cost-effective methodologies in public aquariums for initial bioacoustic research. These findings contribute to the early stages of acoustic characterization of coastal fishes in the western central Atlantic, emphasizing the value of passive acoustic monitoring for ecological assessments and conservation efforts. Moreover, this study opens new avenues for considering the acoustic environment as a crucial factor in the welfare of captive fish, an aspect that has largely been overlooked in aquarium management. Full article

Antineoplastic therapies for prostate cancer (PCa) have traditionally centered around the androgen receptor (AR) pathway, which has demonstrated a significant role in oncogenesis. Nevertheless, it is becoming progressively apparent that therapeutic strategies must diversify their focus due to the emergence of resistance mechanisms that the tumor employs when subjected to monomolecular treatments. This review illustrates how the dysregulation of the lipid metabolic pathway constitutes a survival strategy adopted by tumors to evade eradication efforts. Integrating this aspect into oncological management could prove valuable in combating PCa. Full article

Risk-stratified pathways (RSPs) are recommended by the European Association of Uro-logy (EAU) to improve the early detection of clinically significant prostate cancer (csPCa). RSPs can reduce magnetic resonance imaging (MRI) demand, prostate biopsies, and the over-detection of insignificant PCa (iPCa). Our goal is to analyze the efficacy and cost-effectiveness of several RSPs by using sequential stratifications from the serum prostate-specific antigen level and digital rectal examination, the Barcelona risk calculators (BCN-RCs), MRI, and Proclarix™. In a cohort of 567 men with a serum PSA level above 3.0 ng/mL who underwent multiparametric MRI (mpMRI) and targeted and/or systematic biopsies, the risk of csPCa was retrospectively assessed using Proclarix™ and BCN-RCs 1 and 2. Six RSPs were compared with those recommended by the EAU that, stratifying men from MRI, avoided 16.7% of prostate biopsies with a prostate imaging–reporting and data system score of <3, with 2.6% of csPCa cases remaining undetected. The most effective RSP avoided mpMRI exams in men with a serum PSA level of >10 ng/mL and suspicious DRE, following stratifications from BCN-RC 1, mpMRI, and Proclarix™. The demand for mpMRI decreased by 19.9%, prostate biopsies by 19.8%, and over-detection of iPCa by 22.7%, while 2.6% of csPCa remained undetected as in the recommended RSP. Cost-effectiveness remained when the Proclarix™ price was assumed to be below EUR 200. Full article

The growing development of communication technologies has given rise to the Internet of Things, which has led to the emergence of new cities, smart grids, and smart buildings, and the development of energy generation using renewable sources, as well as the emergence of new electrical loads such as the electric car. These advances give rise to the need for new media devices with remote communication, and require a greater control and monitoring of the state of the electrical grid in order to verify its correct state, as well as the detection of faults or alterations that are occurring in it due to these new generation systems or new loads. These remote, unsupervised measurement devices require galvanic isolation to protect the measurement and communication system, so that even if there is a break in the isolation, the integrity of the measurement and communication system is maintained. In addition, as it is a device prepared for multipoint measurement, the cost of the probe must be contained. This article details the design, implementation, and validation of a low-cost remote isolated differential voltage probe. This probe is intended for monitoring at network supply points, as well as for the verification of the European standard EN 50160 as a means of detecting disturbances in network behaviour. Its characteristics as a differential and isolated probe provide it with the possibility of floating voltage averaging, guaranteeing the integrity of the electronics of the low-voltage probe, i.e., the digitalisation and communication system. The measurements collected are sent via an MQTT protocol, which makes the remote probe a device compatible with the Internet of Energy. For the validation of the probe, a full functional test is performed, including FFT spectral analysis to verify the compliance of the mains voltage with the aforementioned European standard EN 50160. Full article

Electronic fetal monitoring (EFM) is widely used in intrapartum care as the standard method for monitoring fetal well-being. Our objective was to employ machine learning algorithms to predict acidemia by analyzing specific features extracted from the fetal heart signal within a 30 min window, with a focus on the last deceleration occurring closest to delivery. To achieve this, we conducted a case–control study involving 502 infants born at Miguel Servet University Hospital in Spain, maintaining a 1:1 ratio between cases and controls. Neonatal acidemia was defined as a pH level below 7.10 in the umbilical arterial blood. We constructed logistic regression, classification trees, random forest, and neural network models by combining EFM features to predict acidemia. Model validation included assessments of discrimination, calibration, and clinical utility. Our findings revealed that the random forest model achieved the highest area under the receiver characteristic curve (AUC) of 0.971, but logistic regression had the best specificity, 0.879, for a sensitivity of 0.95. In terms of clinical utility, implementing a cutoff point of 31% in the logistic regression model would prevent unnecessary cesarean sections in 51% of cases while missing only 5% of acidotic cases. By combining the extracted variables from EFM recordings, we provide a practical tool to assist in avoiding unnecessary cesarean sections. Full article

Although linearly combining multiple variables can provide adequate diagnostic performance, certain algorithms have the limitation of being computationally demanding when the number of variables is sufficiently high. Liu et al. proposed the min–max approach that linearly combines the minimum and maximum values of biomarkers, which is computationally tractable and has been shown to be optimal in certain scenarios. We developed the Min–Max–Median/IQR algorithm under Youden index optimisation which, although more computationally intensive, is still approachable and includes more information. The aim of this work is to compare the performance of these algorithms with well-known Machine Learning algorithms, namely logistic regression and XGBoost, which have proven to be efficient in various fields of applications, particularly in the health sector. This comparison is performed on a wide range of different scenarios of simulated symmetric or asymmetric data, as well as on real clinical diagnosis data sets. The results provide useful information for binary classification problems of better algorithms in terms of performance depending on the scenario. Full article

Introduction: Penile cancer (PC) is a rare malignancy with an overall incidence in Europe of 1/100,000 males/year. In Europe, few studies report the epidemiology, risk factors, clinical presentation, and treatment of PC. The aim of this study is to present an updated outlook on the aforementioned factors of PC in Spain. Materials and Methods: A multicentric, retrospective, observational epidemiological study was designed, and patients with a new diagnosis of PC in 2015 were included. Patients were anonymously identified from the Register of Specialized Care Activity of the Ministry of Health of Spain. All Spanish hospitals recruiting patients in 2015 were invited to participate in the present study. We have followed a descriptive narration of the observed data. Continuous and categorical data were reported by median (p25th–p75th range) and absolute and relative frequencies, respectively. The incidence map shows differences between Spanish regions. Results: The incidence of PC in Spain in 2015 was 2.55/100,000 males per year. A total of 586 patients were identified, and 228 patients from 61 hospitals were included in the analysis. A total of 54/61 (88.5%) centers reported ≤ 5 new cases. The patients accessed the urologist for visually-assessed penile lesions (60.5%), mainly localized in the glans (63.6%). Local hygiene, smoking habits, sexual habits, HPV exposure, and history of penile lesions were reported in 48.2%, 59.6%, 25%, 13.2%, and 69.7%. HPV-positive lesions were 18.1% (28.6% HPV-16). The majority of PC was squamous carcinoma (95.2%). PC was ≥cT2 in 45.2% (103/228) cases. At final pathology, PC was ≥pT2 in 51% of patients and ≥pN1 in 17% of cases. The most common local treatment was partial penectomy (46.9% cases). A total of 47/55 (85.5%) inguinal lymphadenectomies were open. Patients with ≥pN1 disease were treated with chemotherapy in 12/39 (40.8%) of cases. Conclusions: PC incidence is relatively high in Spain compared to other European countries. The risk factors for PC are usually misreported. The diagnosis and management of PC are suboptimal, encouraging the identification of referral centers for PC management. Full article

A predictive model including age, PCa family history, biopsy status (initial vs repeat), DRE (normal vs abnormal), serum prostate-specific antigen (PSA), and DRE prostate volume ca-tegory was developed to stratify initial PCa suspicion in 1486 men with PSA > 3 ng/mL and/or abnormal DRE, in whom mpMRI followed; 2- to 4-core TRUS-guided biopsies where Prostate Imaging Report and Data System (PI-RADS) > 3 lesions and/or 12-core TRUS systematic biopsies were performed in one academic institution between 1 January 2016–31 December 2019. The csPCa detection rate, defined as International Society of Uro-Pathology grade group 2 or higher, was 36.9%. An external validation of designed BCN-RC 1 was carried out on 946 men from two other institutions in the same metropolitan area, using the same criteria of PCa suspicion and diagnostic approach, yielded a csPCa detection rate of 40.8%. The areas under the receiver operating characteristic curves of BCN-RC 1 were 0.823 (95% CI: 0.800–0.846) in the development cohort and 0.837 (95% CI: 0.811–0.863) in the validation cohort (p = 0.447). In both cohorts, BCN-RC 1 exhibited net benefit over performing mpMRI in all men from 8 and 12% risk thresholds, respectively. At 0.95 sensitivity of csPCa, the specificities of BCN-RC 1 were 0.24 (95% CI: 0.22–0.26) in the development cohort and 0.34 (95% CI: 0.31–0.37) in the validation cohort (p < 0.001). The percentages of avoided mpMRI scans were 17.2% in the development cohort and 22.3% in the validation cohort, missing between 1.8% and 2% of csPCa among men at risk of PCa. In summary, BCN-RC 1 can stratify initial PCa suspicion, reducing the demand of mpMRI, with an acceptable loss of csPCa. Full article