Search Results (4,919)

This study was conducted in nine allotment garden complexes in Wrocław, West Poland (Central Europe). Soil samples were collected from each garden and analyzed for their total concentrations of Zn, Cu, Pb and Cd, alongside the percentage of organic carbon C. Contaminant levels varied widely between sites: Zn ranged from 101.1 to 3464.5 mg/kg, Cu from 24.93 to 322.45 mg/kg, Cd from 0.51 to 6.31 mg/kg, and Pb from 19.92 to 401.85 mg/kg. The highest metal contamination was found for the garden complex placed on the former impact of the Hutmen. The organic carbon content ranged from 2.12% to 7.64%, indicating substantial variability in organic matter levels across the studied sites. This variability may significantly influence the soils’ capacity to retain heavy metals. A significant positive correlation was observed between soil organic carbon and the total concentrations of Pb, Cu and Zn, suggesting that soils richer in organic matter may retain higher levels of heavy metals. These findings underscore the dual role of organic matter as both a beneficial soil component and a potential contributor to heavy metal retention in urban garden soils. Protecting and enhancing SOM in polluted soils is a beneficial strategy, remediating environmental damage while aligning with global sustainability goals. Full article

Fatigue in elite soccer is a multifaceted phenomenon involving physical, metabolic, psychological, and neuromuscular stressors that accumulate over training and competition. Traditional monitoring tools, while informative, are often invasive, impractical during play, or fail to provide real-time insights. This narrative review synthesizes sweat-based biomarkers linked to fatigue in elite soccer, with a focus on multi-modal domains (neuromuscular, metabolic, inflammatory, psychological). Using an integrative approach, we reviewed studies published across databases including PubMed, Scopus, and Web of Science that evaluate sweat biomarkers of different types of fatigue in soccer. We identified key candidates—lactate, sodium, cortisol, IL-6, and hypoxanthine—and evaluated their potential in non-invasive monitoring. Youth-specific and female populations remain underrepresented. We also assessed each biomarker’s technological maturity using a sweat-specific Technology Readiness Level (TRL) framework. Based on these findings, we propose a translational framework for practitioners and outline priorities for future research and validation in real-world sport settings. Full article

Background: This study presents a preliminary evaluation of a six-day outpatient psychotherapeutic training based on the Duc in Altum Therapy (DIAT) approach, examining its effectiveness in reducing symptoms of anxiety, depression, and stress among adults. Given the growing demand for brief, effective mental health interventions, this format aims to provide intensive support within a condensed timeframe. Methods: The intervention consisted of supportive and experiential group therapy delivered over six days and included 109 participants. Outcomes were assessed at three time points—pre-intervention, post-intervention, and three-month follow-up—using the Direct Behavior Rating Scale Items, the Brief Screen for Depression (BSD), and the Perceived Stress Scale (PSS-10). Results: Participants reported lower levels of anxiety (B = −1.435, p < 0.0001), depression (B = −0.717, p < 0.001), and stress (B = −1.882, p < 0.001) after training, reflecting statistically significant within-group changes. These improvements were maintained at the three-month follow-up. Conclusions: Although the absence of a control group limits causal inference, the findings provide preliminary support for the effectiveness of DIAT as a brief psychotherapeutic intervention. Participants reported lower levels of anxiety, depression, and stress after the training, reflecting statistically significant within-group changes. These improvements were maintained at the three-month follow-up. Full article

Background/Objectives: Colorectal cancer (CRC) frequently metastasizes to the peritoneum, significantly worsening patient prognosis. While serum tumor markers such as carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) are routinely measured, their diagnostic or prognostic role in peritoneal fluid remains unclear. This study aimed to assess the relationship between CEA and CA 19-9 levels in both serum and peritoneal fluid, and the clinical stage of CRC, particularly focusing on the presence of peritoneal metastases and positive cytology. Methods: We retrospectively analyzed data from 89 patients with histologically confirmed CRC who underwent surgery between 2020 and 2023. All patients had preoperative assessment of CEA and CA 19-9 levels in serum and peritoneal fluid, along with cytological examination of peritoneal fluid samples. Patients were categorized based on the presence or absence of macroscopic peritoneal metastases and cytology results. Results: Elevated levels of CEA and CA 19-9 in peritoneal fluid were significantly associated with the presence of peritoneal metastases. A positive cytological finding also correlated with higher marker concentrations. Conclusions: CEA and CA 19-9 levels in peritoneal fluid strongly correlate with peritoneal dissemination in CRC. These markers may serve as additional predictive factors, aiding in early detection of peritoneal spread and improved risk stratification. Their assessment may be useful in guiding intraoperative and postoperative decision-making. Full article

The jaw bones can manifest various cysts and tumors of different origins and etiologies. Any bone lesions lacking any potential odontogenic origin might require more accurate diagnostics, adequate investigation, and careful patient anamnesis. In cases of sharply demarcated radiolucency or mixed radiolucent–radiopaque radiological appearance lesions, they can sometimes extend between the displaced tooth roots or cause their resorption. The scope of cortical bone in radiographic studies might have a different status, and lesions can spread outside of the bone. If no odontogenic feature is present, an additional blood examination for bone markers and calcium–phosphate markers is useful to establish any endocrine-related pathologies. In the primary hyperparathyroidism (PHP), bone blood markers and bone scintigraphy are very useful to establish the possible occurrence of brown tumor. On the other hand, in central giant cell granuloma (CGCG), only a direct tumor lesion biopsy might confirm the diagnosis, where in microscopic evaluation, mostly fibroblasts and secondary cells have multinucleated giant cells along with some accessory cells like macrophages, dendrocytes, and other endothelial cells. Because both lesions can have similar clinical and radiological appearances and unclear borders, with different shapes, sizes, and symptoms, it is quite important to compare both clinical and radiological patient characteristics. The authors aim to present how radiological studies alone can easily lead to lesion misdiagnosis. They also aim to emphasize how local treatment methods without advanced microsurgical reconstruction can, in some cases, improve patient outcomes. Full article

Landslides are among the most frequent and dangerous natural hazards, posing serious threats to life and infrastructure. To mitigate their impacts, landslide susceptibility mapping (LSM) plays a crucial role by identifying areas prone to future landslide occurrences. This study aimed to assess how the choice of feature selection methods influences the performance of LSM models based on the eXtreme Gradient Boosting (XGBoost) algorithm when an extended set of input variables is used. Two study areas located in Southern Poland, called Biały Dunajec and Rożnów, were selected for analysis. These regions differ in terrain, elevation, and environmental characteristics and are situated approximately 65 km apart. Three widely used feature selection techniques were applied: the Pearson correlation coefficient (PCC), symmetrical uncertainty (SU), and analysis of variance (ANOVA). For each method, XGBoost models were trained and evaluated using multiple performance metrics, including the area under the curve (AUC), overall accuracy, precision, recall, and F1-score. The highest AUC values were achieved using the PCC method: 0.985 for Biały Dunajec and 0.983 for Rożnów. The best overall performance (accuracy of 0.93, recall of 0.94, and F1-score of 0.79) was obtained for the Rożnów case study using PCC features. These findings highlight that, when a comprehensive set of input variables is used, the exclusion of less informative features has little effect on model accuracy, as their information is largely preserved within the retained features. Full article

The main idea of this work is to implement organic nanomaterials, such as thiophosphoryl-PMMH dendrimers, for the potential detection and remediation of chemical, biological, radiological, and nuclear (CBRN) contamination. An IR–thermal technique for determining the material specific surface morphology and defects of a thiophosphoryl-PMMH dendrimers is presented. Optical (UV-Vis), thermal (DSC), and electrical (dielectric spectroscopy and thermal imaging) characterizations show that the generation and number of surface groups influence the properties of the investigated dendrimers. Finally, general guidelines and procedures of thiophosphoryl-PMMH dendrimers with various generations are proposed for both civilian and military users. Full article

Monk fruit extract (Siraitia grosvenorii, MFE) is a natural, non-caloric sweetener known for its intense sweetness, antioxidant properties, and potential metabolic health benefits. While certain aqueous monk fruit decoctions are recognised as non-novel foods in the UK and Ireland due to significant pre-1997 consumption, the European Union (EU) has adopted a more cautious approach under the Novel Food Regulation (EU) 2015/2283. As of October 2024, only one specific aqueous extract of monk fruit has been authorised in the EU under Regulation (EU) 2024/2345, permitting its use in several food categories. However, highly purified mogrosides and non-aqueous extracts remain unapproved due to gaps in toxicological data and the absence of industry-led applications. This review systematically analyses the EU’s regulatory barriers, comparing MFE’s legal status with other approved non-caloric sweeteners such as steviol glycosides and erythritol, and examining regulatory frameworks in the EU, United States, United Kingdom, and China. Findings indicate that although 18 non-caloric sweeteners are currently authorised in the EU, regulatory constraints continue to hinder the broader approval of MFE, limiting innovation and the availability of natural sweeteners for consumers. Harmonising regulations, leveraging international safety assessments, and promoting industry engagement are recommended to advance MFE’s authorisation and support sustainable food innovation in the EU. Addressing these challenges is crucial to ensure that European consumers and industry can benefit from safe, innovative, and health-promoting alternatives to sugar, aligning food policy with broader public health goals and sustainability commitments. Full article

Not all produced compost meets established quality standards, often resulting in environmental challenges. This study investigated the potential of using mature compost as a feedstock for biochar production, with a focus on evaluating the gas adsorption properties of the resulting biochars. Mature compost was utilized as a substrate, and the pyrolysis process involved heating samples within a temperature range of 400–650 °C, at 50 °C intervals, with heating rates of 10 °C·min⁻¹, 15 °C·min⁻¹, or 20 °C·min⁻¹ for a duration of 60 min. The resulting biochars were tested for their adsorption performance against a synthetic gas mixture simulating composting emissions (CO₂, CO, H₂S, NH₃, CH₄ in N₂). Our findings reveal a significant correlation between the pyrolysis temperature and the sorption characteristics of compost biochars. Specifically, biochars produced at temperatures of 550 °C, 600 °C, and 650 °C (with a heating rate of 10 °C·min⁻¹) demonstrated the highest efficacy in reducing emissions of CO₂, CH₄, and H₂S, achieving reductions of 69%, 69%, and 72%, respectively. However, these biochars exhibited lower adsorption capacity for CO and NH₃. Interestingly, biochars produced at 400 °C and 450 °C showed enhanced performance for CO adsorption. Compost biochar shows strong potential for gas adsorption, particularly for CO, CO₂, and H₂S. Due to its pronounced CH₄ sorption capacity, such biochar is better suited for mitigating emissions during composting rather than for biogas purification. Full article

The biocompatibility of orthodontic archwires is crucial for ensuring patient safety and the long-term success of orthodontic treatment. This study evaluated the biocompatibility of stainless steel (SS) and nickel–titanium (Ni-Ti) orthodontic archwires, as well as stainless steel metal brackets, before and after the application of a graphene coating. The assessment was based on the materials’ effects on a fibroblast cell line and on the development of a foetal chicken egg embryo. Fibroblasts that had been in temporary contact with steel and NiTi archwires after CW-CVD (cold wall chemical vapour deposition) treatment exhibited changes in morphology in the presence of the material. The materials exhibited moderate cytotoxicity. For metal brackets, the treated samples caused stronger cytotoxic changes in the culture. Unlike graphene-coated implants, where cells were found to directly adhere to the surface, the embryonic tissues did not treat the non-graphene-coated implants as an adhesive material. This study suggests that depositing carbon-based coatings, including graphene, on stainless steel archwires may reduce the cytotoxicity of orthodontic components. Using graphene increases adhesion of the implant surface to membrane-derived cells and the embryonic yolk and does not inhibit the further development of the chicken egg embryo. Full article

In this paper, I propose Yul2Vec, a novel method for representing Yul programs as distributed embeddings in continuous space. Yul serves as an intermediate language between Solidity and Ethereum Virtual Machine (EVM) bytecode, designed to enable more efficient optimization of smart contract execution compared to direct Solidity-to-bytecode compilation. The vectorization of a program is achieved by aggregating the embeddings of its constituent code elements from the bottom to the top of the program structure. The representation of the smallest construction units, known as opcodes (operation codes), along with their types and arguments, is generated using knowledge graph relationships to construct a seed vocabulary, which forms the foundation for this approach. This research is important for enabling future enhancements to the Solidity compiler, paving the way for advanced optimizations of Yul and, consequently, EVM code. Optimizing the EVM bytecode is essential not only for improving performance but also for minimizing the operational costs of smart contracts—a key concern for decentralized applications. By introducing Yul2Vec, this paper aims to provide a foundation for further research into compiler optimization techniques and cost-efficient smart contract execution on Ethereum. The proposed method is not only fast in learning embeddings but also efficient in calculating the final vector representation of Yul code, making it feasible to integrate this step into the future compilation process of Solidity-based smart contracts. Full article

Fruit and sour beers are popular due to their unique sensory characteristics. Owing to changes in physicochemical parameters, mixed culture fermentation is a promising research area. The aim of the study was to evaluate how ethanol and lactic acid fermentation, combined with the addition of berry fruits during the beer production process, influence the physicochemical and sensory characteristics of sour fruit beers. Three worts differing in hopping system were produced: one classic sweet wort and two lacto-fermented. Strawberries or raspberries were added to the young beer. This research showed that acidification of wort, fruit addition, and limiting of hopping time had a positive effect on both technological and sensory characteristics. Despite pH differences, alcohol content in beers was similar (2.52–3.21% v/v). Production method influenced mainly lactic acid (0–2.30 g/L), pH (3.53–4.79), and glycerol (0.83–1.62 g/L) contents. Non-acidified beers had the highest dextrin (17.64–23.13 g/L) and glycerol (1.36–1.62 g/L) levels. The addition of strawberries increased phenolics (205.21–237.03 mg GAE/L), FRAP (0.82–1.17 mmol TE/L), and refreshment sensation, while raspberries mainly enhanced sensory atributes (colour, foam, fruitiness, aroma). Lactic fermentation did not show a clear effect on polyphenol content or antioxidant activity. The research offers practical insights into functional beer development, with its novelty of using mixed fermentation and fruit addition to shape characteristics. Full article

Asthma is a multifactorial respiratory disease that naturally occurs in horses, humans, and cats, presenting common clinical signs and species-specific mechanisms. This review addresses the impact of asthma on the cardiovascular and neurological systems, with a primary focus on horses. It highlights the need for new biomarkers beyond the respiratory system due to diagnostic difficulties in animals. A comprehensive literature search was conducted using PubMed and Google Scholar, focusing on cardiovascular and neurological manifestations of asthma in humans, horses, cats, and experimental animal models. Studies were qualitatively compared, noting species-specific differences and mechanisms. Humans with asthma show an increased risk of cardiovascular disease and elevated cardiac biomarkers during exacerbations, while horses develop pulmonary hypertension and vascular remodeling. Cats exhibit significant pulmonary vascular changes. Heart rate variability analysis reveals altered autonomic function in humans and horses. Increased peripheral airway innervation and cough reflex sensitivity are noted across species. The renin–angiotensin–aldosterone system (RAAS) plays a crucial role in asthma pathophysiology in murine models. Asthma impacts the cardiovascular and nervous systems differently across species, emphasizing the importance of comparative medicine. Future research should integrate cardiovascular, autonomic, and inflammatory pathways to develop effective therapeutic approaches in human and veterinary medicine, leveraging insights from naturally occurring asthma models. Full article

Background/Objectives: The aim of this study was to investigate the acute effect of isometric and plyometric combined activation prior to the endurance performance assessed with the 30-15 Intermittent Fitness Test (30-15 IFT) and cardiovascular parameters. Methods: In this crossover study the data of 14 elite female soccer players aged 22.1 ± 2.9 years were assessed. The conditioning activity (CA) consisted of three sets of five seconds of maximal mid-thigh pull (IMPT), and peak force was measured, and four countermovement jumps were performed. Contact time, jump height, and reactive strength index (RSI) were assessed. Ninety seconds of rest between the sets was performed. Then, 7 min after the CA, the 30-15 IFT was performed. Results: One-way repeated measures (RM) ANOVA showed that performance during the CA did not decrease; what is more, it improved in RSI (p < 0.01). Further, paired samples t-test showed that the performance in the IFT did not change, whereas training impulse (TRIMP) was increased after CA (p = 0.039, ES = 0.61), thus the Bayesian paired test yielded only anecdotal evidence in favor of the alternative hypothesis (BF₁₀ = 1.92; error = 2%). Conclusions: The improvement in CA suggests potentiation rather than fatigue. However, the unchanged performance alongside a modest TRIMP increase should be interpreted with caution, as TRIMP alone provides a limited assessment of physiological cost. Therefore, while the applied protocol did not enhance endurance performance, further research using multiple physiological markers is needed to clarify its impact on internal load and overall efficacy. Full article

Urban road dust (URD) is a major source of particulate matter (PM) and pollutants, including trace elements and organic compounds, affecting human health and the environment. This study investigates the chemical composition, toxicity, and environmental transport mechanisms of URD from road and rail systems in two Polish cities. It compares trace element concentrations (e.g., Cu, Zn, Pb), chemical composition, toxicity of road vs. rail dust, and the impact of rainfall on contaminant dispersion. The oral pathway was identified as the main exposure route in both adults and children, followed by that of dermal contact. Railways pose additional challenges due to frequent maintenance and increased PM emissions. Results show that smaller cities like Rawicz may present higher health risks from URD due to local industry (e.g., metal processing) than larger cities like Wrocław. Rainfall mobilizes trace elements in urban dust, increasing pollutant runoff and exposure risks, highlighting the need for better runoff management. The highest road-related pollution was found in Rawicz (S5), with the highest railway-related pollution also found at the Rawicz station. Microtox showed no toxicity in Wrocław URD (except for short-term effect) but higher toxicity in Rawicz. Daphtoxkit showed the highest Daphnia magna mortality near roads (40.0%) in Rawicz. Ostracodtoxkit revealed strong growth inhibition in Wrocław (up to 94.29%). ECR confirmed a higher cancer risk in Rawicz, especially in children (Cr, As). Full article