The Thyroid hormone Receptor Interacting Protein 12 (TRIP12) protein belongs to the 28-member Homologous to the E6-AP C-Terminus (HECT) E3 ubiquitin ligase family. First described as an interactor of the thyroid hormone receptor, TRIP12’s biolo...
Clark–Baraitser syndrome is a rare autosomal dominant intellectual disability syndrome caused by pathogenic variants in the TRIP12 (Thyroid Hormone Receptor Interactor 12) gene. TRIP12 encodes an E3 ligase in the ubiquitin pathway. The ubiquiti...
Background: Pathogenic variants in the TRIP12 gene are associated with Clark-Baraitser syndrome, a condition characterized by neurodevelopmental disorders, including intellectual disability, autism spectrum disorder (ASD), and speech delay. Phenotypi...
The Ku heterodimer, composed of subunits Ku70 and Ku80, is known for its essential role in repairing double-stranded DNA breaks via non-homologous end joining (NHEJ). We previously identified Ku70 S155 as a novel phosphorylation site within the von W...
Suburban tourist railway is an emerging transportation mode for tourism. Knowing the travel demand and trip distribution patterns of tourists is an important prerequisite to the planning and construction of suburban tourist railways. However, this is...
Recently, local governments have been using transportation card data to monitor the use of public transport and improve the service. However, local governments that are applying a single-fare scheme are experiencing difficulties in using data for acc...
Increasing private car ownership and car dependency has led to a low share of walking as an active mode as well as congestion, air pollution, and health problems in developing countries. This paper aims to identify and compare the impacts of a select...
A reliable estimation of public bicycle trip characteristics, especially trip distribution and duration, can help decision-makers plan for the relevant transport infrastructures and assist operators in addressing issues related to bicycle imbalance....
Walking has been recognized as an important mode of transportation in recent years, and recent research has improved travel demand models for walk trips. One important added stage is the distribution of walk trips, which can be evaluated using destin...
Trip generation modeling is essential in transportation planning activities. Previous modeling methods that depend on traditional data collection methods are inefficient and expensive. This paper proposed a novel data-driven trip generation modeling...
Personalized travel recommendations propose locations of interest (LOIs) for users. The LOI sequence suggestion is more complicated than a single LOI recommendation. Only a few studies have considered LOI sequence recommendations. Creating a reliable...
Carsharing as a means to provide individuals with access to automobiles to complete a personal trip has grown significantly in recent years in China. However, there are few case studies based on operational data to show the role carsharing systems pl...
For various reasons, individuals sometimes cannot go on trips. These are known as unrealized trips. In this study, we focus on discretionary trips, such as those for shopping and leisure, and analyze the factors that lead to their lack of realization...
The tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b/PEX5R) is an interaction partner and auxiliary subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, which are key for rhythm generation in the brain a...
The bacterial genome contains numerous repeated sequences that greatly affect its genomic plasticity. The Escherichia coli K-12 genome contains three copies of the TRIP1 repeat sequence (TRIP1a, TRIP1b, and TRIP1c). However, the diversity, distributi...
Geoscience courses, such as geology and geomorphology, require not only classroom lessons and laboratory exercises, but field trips as well. However, the COVID-19 restrictions did not allow the execution of most planned field trips, and an alternativ...
14 November 2020
Tripping hazards on the sidewalk cause many falls annually, and the inspection and repair of these hazards cost cities millions of dollars. Currently, there is not an efficient and cost-effective method to monitor the sidewalk to identify any possibl...
With the quick evolution of mobile apps and trip guidance technologies, a trip recommender that recommends sequential points of interest (POIs) to travelers has emerged and recently received popularity. Compared to other outing recommenders, which su...
To adequately prepare students for engineering practices, it is imperative that institutions adopt innovative methods of teaching, learning, and assessment. One such approach is the use of real field trips (RFT) to construction sites, which can enhan...
Personalized trip recommendation attempts to recommend a sequence of Points of Interest (POIs) to a user. Compared with a single POI recommendation, the POIs sequence recommendation is challenging. There are only a couple of studies focusing on POIs...
Describing travel patterns and identifying significant locations is a crucial area of research in transportation geography and social dynamics. Our study aims to contribute to this field by analyzing taxi trip data from Chengdu and New York City. Spe...
Due to the phenomenon of deformation-induced phase transformation, the mechanical properties of TRIP steel, including the elastic modulus, undergo changes during the deformation process. This deviation from plastic theory in describing the deformatio...
Following an earthquake, abnormal travel demand causes traffic congestion and poses significant problems for relief efforts. Research on post-earthquake travel demand is essential for disaster management. An effective disaster management strategy ens...
A pumping-while-tripping method is proposed to mitigate pressure swabs during tripping out in wells with a narrow mud density window and extended reach. In the proposed tripping-out process, the fluid circulation is started by using a special pump fr...
The National Household Travel Survey (NHTS), conducted by the Federal Highway Administration, has historically been used for documenting personal mobility trends. Current techniques using surveys to collect this data are labor-intensive and difficult...
This paper presents a model to predict the number of refuelling trips by vehicles on any given day considering weather conditions and time of the year. The predicted refuelling trips were founded on count-based data, i.e., data that contain events th...
Teaching through field trips has been very effective in the architecture, engineering and construction (AEC) disciplines as it allows students to bridge the gap between theory and practice. However, it is not always feasible to take a large class on...
A power line is particularly vulnerable to wildfires in its vicinity, and various damage including line tripping can be caused by wildfires. Using remote sensing techniques, a novel model developed to assess the risk of line tripping caused by the wi...
The efficient operation of emergency medical services is critical for any society. Typically, optimisation and simulation models support decisions on emergency ambulance stations’ locations and ambulance management strategies. Essential inputs for su...
Background/Objectives: Gastric cancer (GC), a prevalent global malignancy and a leading cause of cancer-related mortality, has a poorly understood prognosis related to TRIP13 expression. TRIP13 has a recognized part in driving tumor progression acros...
In Korea, decisions for high-speed railway (HSR) construction are made based on long-term demand forecasting. A calibration process that simulates current trip patterns is an important step in long-term demand forecasting. However, a trial-and-error...
Drive-through establishments are becoming increasingly prominent in urban transport systems; however, their impacts on traffic generation, spatial form, and sustainability remain insufficiently understood. Conventional trip generation manuals often r...
Active safety systems for three-wheeled vehicles seem to be in premature development; in particular, delta types, also known as tuk-tuks or sidecars, are sold with minimal protection against accidents. Unfortunately, the risk of wheel lifting and lat...
Eukaryotic initiation factor subunit I (EIF3i), also called as p36 or TRIP-1, is a component of the translation initiation complex and acts as a modulator of TGF-β signaling. We demonstrated earlier that this intracellular protein is not only ex...
TRIP13 is a member of the large AAA+ ATPase protein superfamily that plays a crucial role in the precise segregation of chromosomes during mitosis. The abnormal function of TRIP13 has diverse functions, including mitotic processes, DNA repair pathway...
A trip generation manual and database are important for transportation planners and engineers to forecast new trip generation for any new development. Nowadays, many petrol stations have fast-food restaurant outlets. However, this land use category h...
Climate protection goals in transportation can only be achieved with a worldwide change in mobility behavior that is supported by technological progress and changes in vehicle concepts. One contribution to reducing greenhouse gas emissions may be usi...
In order to investigate the roll bonding of high-alloy transformation induced plasticity (TRIP) and twinning induced plasticity (TWIP) steel, roll-bonded sheets of the TRIP and TWIP steel were manufactured starting from hot rolling, followed by brush...
Trip faults are obviously increased by frequent lightning strikes, and increasing lightning trip-out seriously affects a system’s stability and power supply reliability. In this paper, the reasons for high lightning trip-out rates in electric p...
This study proposes a systematic design methodology for supporting field trips in software education. Various attempts have been made to enhance the educational effects of field trips, but it is difficult to continue them due to the limitations of ed...
Bicycle Sharing Systems (BSSs) are exponentially increasing in the urban mobility sector. They are traditionally conceived as a last-mile complement to the public transport system. In this paper, we demonstrate that BSSs can be seen as a public trans...
Thyroid hormone receptor-interacting protein 13 (TRIP13) participates in various regulatory steps related to the cell cycle, such as the mitotic spindle assembly checkpoint and meiotic recombination, possibly by interacting with members of the HORMA...
For effective transportation planning, land use, travel behavior, and infrastructure capacity should be optimized to support sustainable urban growth and reduce congestion. Every new site development generates traffic volume, which can affect the qua...
4 November 2024
Travelers’ perceptions of hotels and their aspects have been the focus of much research and are often studied by analyzing consumers’ online reviews. Yet, little attention has been given to the effect of the trip mode, i.e., whether the p...
This study used spatial interaction modeling to examine whether origin-specific and destination-specific factors, distance decay effects, and spatial structures explain the criminal trips of residential burglars. In total, 4041 criminal trips committ...
To address the decline in system inertia and the risk of frequency instability resulting from high penetration of renewable energy, and to overcome the limitations of centralized control—such as high computational burden and slow response&mdash...
Understanding and promoting guest satisfaction is central to the economic sustainability of the hospitality industry. Satisfaction influences consumers’ booking intentions, hotel choice, loyalty, and the reputation and performance of accommodat...
Leisure trips have become more important in an era where people are increasingly concerned with quality of life. Leisure trips are unique in that they are not as strict as mandatory trips, while, at the same time, they have wider characteristics beca...
A low-voltage circuit breaker thermal trip plays a role in power systems, including opening and closing, control, protection, and more. Their reliability directly affects the security and stability of the power distribution system. The Wiener process...
In this study, the resistance spot weldabilty of zinc galvanize-coated and uncoated TRIP800 steels was investigated in detail. Depending on the welding parameters such as welding current and welding time, the effects of zinc coating on the weld nugge...
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