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810 Results Found

  • Article
  • Open Access
14 Citations
4,992 Views
12 Pages

Bubble-Proof Algorithm for Wave Union TDCs

  • Paweł Kwiatkowski,
  • Dominik Sondej and
  • Ryszard Szplet

Nowadays state-of-the-art time-to-digital converters (TDCs) are commonly implemented in field-programmable gate array (FPGA) devices using different variations of the wave union method. To take full advantage of this method many design challenges nee...

  • Article
  • Open Access
1,573 Views
21 Pages

Resting-State Activity Changes Induced by tDCS in MS Patients and Healthy Controls: A Simultaneous tDCS rs-fMRI Study

  • Marco Muccio,
  • Giuseppina Pilloni,
  • Lillian Walton Masters,
  • Peidong He,
  • Lauren Krupp,
  • Abhishek Datta,
  • Marom Bikson,
  • Leigh Charvet and
  • Yulin Ge

Transcranial direct current stimulation (tDCS) is a safe, well-tolerated method of non-invasively eliciting cortical neuromodulation. It has gained recent interest, especially for its positive clinical outcomes in neurodegenerative diseases such as m...

  • Article
  • Open Access
14 Citations
4,294 Views
22 Pages

Optimizing the Effect of tDCS on Motor Sequence Learning in the Elderly

  • Ensiyeh Ghasemian-Shirvan,
  • Ruxandra Ungureanu,
  • Lorena Melo,
  • Kim van Dun,
  • Min-Fang Kuo,
  • Michael A. Nitsche and
  • Raf L. J. Meesen

12 January 2023

One of the most visible effects of aging, even in healthy, normal aging, is a decline in motor performance. The range of strategies applicable to counteract this deterioration has increased. Transcranial direct current stimulation (tDCS), a non-invas...

  • Article
  • Open Access
1 Citations
2,047 Views
11 Pages

A Retrospective Study on tDCS Treatment in Patients with Drug-Resistant Chronic Pain

  • Yolanda A. Pérez-Borrego,
  • Vanesa Soto-León,
  • Ángela Brocalero-Camacho,
  • Antonio Oliviero and
  • Carmen Carrasco-López

Background. Transcranial direct current stimulation (tDCS) of the primary motor cortex (M1) has an analgesic effect superior to a placebo in chronic pain. Some years ago, tDCS was implemented at the Hospital Nacional of Paraplegics (Toledo, Spain) to...

  • Article
  • Open Access
4 Citations
3,175 Views
16 Pages

Effectiveness of Anodal otDCS Following with Anodal tDCS Rather than tDCS Alone for Increasing of Relative Power of Intrinsic Matched EEG Bands in Rat Brains

  • Nafe M. Al-Tawarah,
  • Zulal Kaptan,
  • Hashem A. Abu-Harirah,
  • Mohammad Nofal,
  • Belal Almajali,
  • Sultan Jarrar,
  • Zubeyir Bayraktaroğlu,
  • Haitham Qaralleh,
  • Khaled M. Khleifat and
  • Sacit Karamursel
  • + 3 authors

30 December 2022

Background: This study sought to determine whether (1) evidence is available of interactions between anodal tDCS and oscillated tDCS stimulation patterns to increase the power of endogenous brain oscillations and (2) the frequency matching the applie...

  • Systematic Review
  • Open Access
1 Citations
2,596 Views
20 Pages

The Effects of Transcranial Direct Current Stimulation (tDCS) in HIV Patients—A Review

  • James Chmiel,
  • Donata Kurpas,
  • Filip Rybakowski and
  • Jerzy Leszek

3 June 2024

Introduction: HIV is a severe and incurable disease that has a devastating impact worldwide. It affects the immune system and negatively affects the nervous system, leading to various cognitive and behavioral problems. Scientists are actively explori...

  • Article
  • Open Access
38 Citations
6,699 Views
14 Pages

Reliability and Variability of tDCS Induced Changes in the Lower Limb Motor Cortex

  • Sangeetha Madhavan,
  • Aishwarya Sriraman and
  • Sally Freels

Background: Transcranial direct current stimulation (tDCS) is emerging as a promising adjuvant to enhance motor function. However, there has been increasing reservations about the reliability and variability of the neuromodulatory effects evoked by t...

  • Article
  • Open Access
12 Citations
3,565 Views
14 Pages

Repetitive Anodal TDCS to the Frontal Cortex Increases the P300 during Working Memory Processing

  • Angela Voegtle,
  • Christoph Reichert,
  • Hermann Hinrichs and
  • Catherine M. Sweeney-Reed

14 November 2022

Transcranial direct current stimulation (TDCS) is a technique with which neuronal activity, and therefore potentially behavior, is modulated by applying weak electrical currents to the scalp. Application of TDCS to enhance working memory (WM) has sho...

  • Article
  • Open Access
5 Citations
3,047 Views
11 Pages

18 May 2022

Triple differential cross section (TDCS) results are reported for the electron impact ionization of nitrogen molecules. The TDCSs have been calculated in distorted wave Born formalism using orientation averaged molecular orbital (OAMO) approximation....

  • Review
  • Open Access
7 Citations
4,072 Views
18 Pages

20 October 2023

(1) Introduction: Anorexia nervosa (AN) is a severe, debilitating disease with high incidence and high mortality. The methods of treatment used so far are moderately effective. Evidence from neuroimaging studies helps to design modern methods of ther...

  • Review
  • Open Access
20 Citations
5,567 Views
17 Pages

Imaging Transcranial Direct Current Stimulation (tDCS) with Positron Emission Tomography (PET)

  • Thorsten Rudroff,
  • Craig D. Workman,
  • Alexandra C. Fietsam and
  • Laura L. Boles Ponto

Transcranial direct current stimulation (tDCS) is a form of non-invasive neuromodulation that is increasingly being utilized to examine and modify several cognitive and motor functions. Although tDCS holds great potential, it is difficult to determin...

  • Article
  • Open Access
29 Citations
7,224 Views
18 Pages

Transcranial direct current stimulation (tDCS) over the left inferior frontal gyrus (IFG) was found to improve oral and written naming in post-stroke and primary progressive aphasia (PPA), speech fluency in stuttering, a developmental speech-motor di...

  • Article
  • Open Access
3 Citations
3,420 Views
14 Pages

How Much of Me Do I See in Other Minds? Modulating Egocentricity in Emotion Judgments by tDCS

  • Anne Weigand,
  • Irene Trilla,
  • Lioba Enk,
  • Garret O’Connell,
  • Kristin Prehn,
  • Timothy R. Brick and
  • Isabel Dziobek

When inferring the mental states of others, individuals’ judgments are influenced by their own state of mind, an effect often referred to as egocentricity. Self–other differentiation is key for an accurate interpretation of other’s mental states, esp...

  • Article
  • Open Access
1,692 Views
16 Pages

Anatomical Characteristics Predict Response to Transcranial Direct Current Stimulation (tDCS): Development of a Computational Pipeline for Optimizing tDCS Protocols

  • Giulia Caiani,
  • Emma Chiaramello,
  • Marta Parazzini,
  • Eleonora Arrigoni,
  • Leonor J. Romero Lauro,
  • Alberto Pisoni and
  • Serena Fiocchi

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique promisingly used to treat neurological and psychological disorders. Nevertheless, the inter-subject heterogeneity in its after-effects frequently limits its...

  • Article
  • Open Access
1,200 Views
21 Pages

The Modulatory Effect of tDCS Onset Timing in Alleviating Vigilance Decrement

  • Zelin Pan,
  • Yang Chen,
  • Shanghong Wu and
  • Tiansheng Xia

8 October 2025

Vigilance refers to a sustained attentional state enabling the detection of specific but unpredictable changes in the external environment. This state typically declines rapidly over time. A deterioration in vigilance can lead to serious errors or ac...

  • Article
  • Open Access
24 Citations
5,045 Views
11 Pages

18 August 2022

Transcranial direct current stimulation (tDCS) is increasingly used for therapeutic purposes in attention-deficit hyperactivity disorder (ADHD). The dorsolateral prefrontal cortex (DLPFC) is the most targeted region of tDCS studies in ADHD. There is...

  • Article
  • Open Access
32 Citations
8,777 Views
13 Pages

The Role of Transcranial Direct Current Stimulation (tDCS) in Tourette Syndrome: A Review and Preliminary Findings

  • Valsamma Eapen,
  • Richard Baker,
  • Amelia Walter,
  • Veena Raghupathy,
  • Jordan J. Wehrman and
  • Paul F. Sowman

8 December 2017

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that is being investigated for a variety of neurological and psychiatric conditions. Preliminary evidence suggests that tDCS may be useful in the treatment o...

  • Article
  • Open Access
5 Citations
2,916 Views
13 Pages

Personality Traits Modulate the Effect of tDCS on Reading Speed of Social Sentences

  • Cristian Reyes,
  • Iván Padrón,
  • Sara Nila Yagual and
  • Hipólito Marrero

5 November 2021

In this case, 62 university students participated in the study, in which a between-subjects design was adopted. Participants were also given the behavioral approach system (BAS) and behavioral inhibition system (BIS) scales. Participants had to read...

  • Article
  • Open Access
2,512 Views
12 Pages

Does tDCS Enhance Complex Motor Skill Acquisition? Evidence from a Golf-Putting Task

  • Virginia Lopez-Alonso,
  • Gabriel López-Bermúdez,
  • Jeffrey Cayaban Pagaduan and
  • Jose Andrés Sánchez-Molina

10 July 2025

Transcranial direct current stimulation (tDCS) modulates cortical excitability, thus inducing improvements in motor learning of simple tasks. In this study, we aimed to evaluate the effect of different tDCS conditions—anodal stimulation over th...

  • Review
  • Open Access
2 Citations
3,903 Views
19 Pages

13 October 2023

Cocaine addiction is a significant problem worldwide. The development of addiction involves a reward system, which consists of certain brain regions like the ventral tegmental area, nucleus accumbens, and prefrontal cortex. Currently, there are no ap...

  • Article
  • Open Access
311 Views
13 Pages

25 January 2026

Background: Transcranial Direct Current Stimulation (tDCS) in conjunction with behavioural language therapy in PPA has previously been modified for variation at the group level, but not at the individual level. This pilot study used individualised tD...

  • Article
  • Open Access
503 Views
15 Pages

Neuroprotective Effects of Anodal tDCS on Oxidative Stress and Neuroinflammation in Temporal Lobe Epilepsy

  • Ali Osman Arslan,
  • Sevdenur Akcay,
  • Guven Akcay,
  • Dana Zaqzouq and
  • Aydın Him

Background: Epilepsy affects over 50 million people worldwide, and about 30% remain drug-resistant—underscoring the urgent need for new therapies. This study evaluated the neuroprotective effects of anodal transcranial direct current stimulatio...

  • Article
  • Open Access
6 Citations
3,684 Views
12 Pages

Contributions of the Right Prefrontal and Parietal Cortices to the Attentional Blink: A tDCS Study

  • Anna Pecchinenda,
  • Francesca De Luca,
  • Bianca Monachesi,
  • Manuel Petrucci,
  • Mariella Pazzaglia,
  • Fabrizio Doricchi and
  • Michal Lavidor

6 July 2021

The AB refers to the performance impairment that occurs when visual selective attention is overloaded through the very rapid succession of two targets (T1 and T2) among distractors by using the rapid serial visual presentation task (RSVP). Under thes...

  • Article
  • Open Access
17 Citations
4,471 Views
16 Pages

31 December 2021

Transcranial direct current stimulation (tDCS) has become a valuable tool in cognitive neuroscience research as it enables causal inferences about neural underpinnings of cognition. However, studies using tDCS to modulate cognitive functions often yi...

  • Review
  • Open Access
1 Citations
2,580 Views
14 Pages

Transcranial Direct Current Stimulation (tDCS) for Borderline Personality Disorder (BPD): Why and How?

  • Lionel Cailhol,
  • Kamilia Soltani,
  • Cécilia Neige,
  • Marine Mondino,
  • Jérôme Brunelin and
  • Martin Blay

Background: Borderline Personality Disorder (BPD) is a severe psychiatric condition characterized by pervasive emotional dysregulation, impulsivity, and unstable interpersonal relationships. Affecting over 1% of the general population, BPD carries si...

  • Article
  • Open Access
23 Citations
6,504 Views
14 Pages

Effects of tDCS on Real-Time BCI Detection of Pedaling Motor Imagery

  • Maria De la Soledad Rodriguez-Ugarte,
  • Eduardo Iáñez,
  • Mario Ortiz-Garcia and
  • José M. Azorín

8 April 2018

The purpose of this work is to strengthen the cortical excitability over the primary motor cortex (M1) and the cerebro-cerebellar pathway by means of a new transcranial direct current stimulation (tDCS) configuration to detect lower limb motor imager...

  • Article
  • Open Access
14 Citations
8,579 Views
23 Pages

Background: Transcranial Direct Current Stimulation (tDCS) of the primary motor cortex (M1) can modulate neuronal activity, and improve performance of basic motor tasks. The possibility that tDCS could assist in rehabilitation (e.g., for paresis post...

  • Review
  • Open Access
9 Citations
6,198 Views
16 Pages

25 January 2024

Introduction: Depression is the most prevalent comorbid neuropsychiatric condition in individuals with Parkinson’s disease (PD), and its underlying mechanisms are not yet fully understood. Current treatment methods are characterised by moderate...

  • Article
  • Open Access
13 Citations
5,503 Views
9 Pages

Ten Sessions of 30 Min tDCS over 5 Days to Achieve Remission in Depression: A Randomized Pilot Study

  • Rémi Moirand,
  • Laetitia Imbert,
  • Frédéric Haesebaert,
  • Gabrielle Chesnoy,
  • Benoit Bediou,
  • Emmanuel Poulet and
  • Jérôme Brunelin

31 January 2022

Although transcranial Direct Current stimulation (tDCS) shows promise in the treatment of major depressive episodes, the optimal parameters and population to target remain unclear. We investigated the clinical interest of a 10 session tDCS regimen in...

  • Article
  • Open Access
4 Citations
3,197 Views
15 Pages

12 November 2020

Brain plasticity in the somatosensory cortex and tactile performance can be facilitated by brain stimulation. Here, we investigated the effects of transcranial direct current stimulation (tDCS) on tactile perception in musicians and non-musicians to...

  • Article
  • Open Access
4 Citations
3,825 Views
21 Pages

26 March 2022

Schizophrenia is a psychotic disease that develops progressively over years with a transition from prodromal to psychotic state associated with a disruption in brain activity. Transcranial Direct Current Stimulation (tDCS), known to alleviate pharmac...

  • Article
  • Open Access
2 Citations
4,100 Views
18 Pages

Aims: This pilot study assessed the potential psychosocial and therapeutic impacts of augmenting transcranial direct current stimulation (tDCS) with cognitive behavioral therapy (CBT) in treatment-naïve patients diagnosed with major depressive d...

  • Review
  • Open Access
14 Citations
6,112 Views
10 Pages

14 August 2018

Major depression is the most frequent morbidity in pregnancy. The first-line therapies, psychopharmacologic treatment and psychotherapy, are either insufficient or may cause severe or teratogenic adverse events. As a result of its local limitation to...

  • Review
  • Open Access
119 Citations
9,243 Views
28 Pages

Due to its safety, portability, and cheapness, transcranial direct current stimulation (tDCS) use largely increased in research and clinical settings. Despite tDCS’s wide application, previous works pointed out inconsistent and low replicable r...

  • Article
  • Open Access
11 Citations
6,191 Views
16 Pages

Safety and Tolerability of tDCS across Different Ages, Sexes, Diagnoses, and Amperages: A Randomized Double-Blind Controlled Study

  • Derrick M. Buchanan,
  • Sarah Amare,
  • Genevieve Gaumond,
  • Amedeo D’Angiulli and
  • Philippe Robaey

28 June 2023

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique with substantial evidence for its safety and tolerability in adults. However, less than 5% of published tDCS research is in pediatrics. Our primary objective...

  • Article
  • Open Access
6 Citations
2,449 Views
11 Pages

A Single Session of Bifrontal tDCS Can Improve Facial Emotion Recognition in Major Depressive Disorder: An Exploratory Pilot Study

  • Laetitia Imbert,
  • Rémi Moirand,
  • Benoit Bediou,
  • Olivier Koenig,
  • Gabrielle Chesnoy,
  • Eric Fakra and
  • Jérôme Brunelin

26 September 2022

Emotional processing deficits are key features in major depressive disorder (MDD). Neuroimaging studies indicate that the dorsolateral prefrontal cortex (DLPFC) plays a pivotal role in both depressive symptoms and emotional processing. Recently, tran...

  • Review
  • Open Access
3 Citations
4,868 Views
41 Pages

10 July 2025

Introduction: Substance use disorders (SUDs) pose a significant public health challenge, with current treatments often exhibiting limited effectiveness and high relapse rates. Transcranial direct current stimulation (tDCS), a noninvasive neuromodulat...

  • Review
  • Open Access
6 Citations
4,351 Views
21 Pages

17 May 2024

Introduction: Binge eating disorder (BED) is the most common eating disorder among those contributing to the development of obesity, and thus acts as a significant burden on the lives and health of patients. It is characterized by complex neurobiolog...

  • Review
  • Open Access
1 Citations
2,032 Views
26 Pages

20 December 2024

Introduction: Neuropsychiatric symptoms such as depression and anxiety are a significant burden on patients with multiple sclerosis (MS). Their pathophysiology is complex and yet to be fully understood. There is an urgent need for non-invasive treatm...

  • Review
  • Open Access
1,545 Views
40 Pages

9 November 2025

Transcranial direct current stimulation (tDCS) is being explored as an adjunct for diabetes-related symptoms grounded in diabetes-associated alterations in brain networks. We reviewed clinical trials of tDCS conducted in people with diabetes and summ...

  • Article
  • Open Access
7 Citations
2,605 Views
12 Pages

Effect of Single Session of Anodal M1 Transcranial Direct Current Stimulation—TDCS—On Cortical Hemodynamic Activity: A Pilot Study in Fibromyalgia

  • Marianna La Rocca,
  • Livio Clemente,
  • Eleonora Gentile,
  • Katia Ricci,
  • Marianna Delussi and
  • Marina de Tommaso

18 November 2022

Transcranial direct current stimulation (TDCS) on the primary motor cortex (M1) has been reported to be effective in fibromyalgia (FM). Our previous works have shown hypometabolism of motor networks in FM using Functional Near Infrared Spectroscopy (...

  • Brief Report
  • Open Access
1 Citations
3,699 Views
10 Pages

27 November 2023

Stress impacts prefrontal cortex (PFC) activity and modulates working memory performance. In a recent study, stimulating the dorsolateral PFC (dlPFC) using transcranial direct current stimulation (tDCS) interacted with social stress in modulating par...

  • Brief Report
  • Open Access
1,532 Views
13 Pages

Cognitive Training Combined with Multifocal tDCS over the Reading Network Improves Reading Performance: A Case of Severe Dyslexia

  • Gloria Di Filippo,
  • Marika Bonuomo,
  • Martina Ravizza,
  • Andrea Velardi and
  • Rinaldo Livio Perri

11 August 2025

Background: Developmental dyslexia (DD) is the most common form of specific learning disorders (SLDs). From a neurocognitive point of view, dyslexic reading is associated with atypical neurofunctional patterns in the left hemisphere, mainly in the po...

  • Article
  • Open Access
7,334 Views
24 Pages

Transcranial Direct Current Stimulation (tDCS) in the Treatment of Youth Depression: Integrating Literature Review Insights in a Pilot Clinical Trial

  • Heidi Ka Ying Lo,
  • Suet Ying Yuen,
  • Iris Wai Tung Tsui,
  • Wing Fai Yeung,
  • Jia Yin Ruan,
  • Corine Sau Man Wong,
  • Joyce Xu Hao Jin,
  • Chit Tat Lee and
  • Ka Fai Chung

Background: Youth (ages 16–25) is a key window for mental health interventions, as depression rates significantly increase during this developmental stage. However, transcranial direct current stimulation (tDCS) application in youth depression...

  • Article
  • Open Access
2,417 Views
14 Pages

Neurostimulation and Sense of Agency: Three tDCS Experiments on the Modulation of Intentional Binding

  • Marika Bonuomo,
  • Davide Perrotta,
  • Gloria Di Filippo and
  • Rinaldo Livio Perri

11 February 2025

Objectives: This research investigated the impact of transcranial Direct Current Stimulation (tDCS) on sense of agency (SoA) when focusing on cortical regions like the cerebellum, the dorsolateral prefrontal cortex (DLPFC), and the angular gyrus (AG)...

  • Review
  • Open Access
7 Citations
5,179 Views
35 Pages

25 July 2025

Transcranial direct current stimulation (tDCS) can modulate cortical excitability in a polarity-specific manner, yet identical protocols often produce inconsistent outcomes across sessions or individuals. This narrative review proposes that much of t...

  • Systematic Review
  • Open Access
10 Citations
4,011 Views
35 Pages

Review of tDCS Configurations for Stimulation of the Lower-Limb Area of Motor Cortex and Cerebellum

  • Vicente Quiles,
  • Laura Ferrero,
  • Eduardo Iáñez,
  • Mario Ortiz and
  • José M. Azorín

11 February 2022

This article presents an exhaustive analysis of the works present in the literature pertaining to transcranial direct current stimulation(tDCS) applications. The aim of this work is to analyze the specific characteristics of lower-limb stimulation, i...

  • Article
  • Open Access
69 Citations
8,622 Views
18 Pages

28 August 2020

Noninvasive brain stimulation techniques, such as transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS), paired with behavioral language therapy, have demonstrated the capacity to enhance language abilities in pri...

  • Case Report
  • Open Access
3 Citations
2,989 Views
16 Pages

Alterations in Leg Muscle Glucose Uptake and Inter-Limb Asymmetry after a Single Session of tDCS in Four People with Multiple Sclerosis

  • Alexandra C. Fietsam,
  • Justin R. Deters,
  • Craig D. Workman,
  • Laura L. Boles Ponto and
  • Thorsten Rudroff

16 October 2021

Asymmetrical lower limb weakness is an early symptom and significant contributor to the progressive worsening of walking ability in people with multiple sclerosis (PwMS). Transcranial direct current stimulation (tDCS) may effectively increase neural...

  • Article
  • Open Access
1 Citations
1,510 Views
15 Pages

Background: Transcranial direct current stimulation (tDCS) has exhibited potential in augmenting motor functions, neuroplasticity, and cognitive abilities within neurological rehabilitation contexts. Despite these promising outcomes, the utilization...

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