Search Results (15)

The advancement of automated driving technologies offers potential safety and efficiency gains, yet safety remains the primary barrier to higher-level deployment. Failures in automated driving systems rarely result from a single technical malfunction. Instead, they emerge from coupled organizational, technical, human, and environmental factors, particularly in partial and conditional automation where human supervision and intervention remain critical. This study systematically identifies safety failures in automated driving systems and analyzes how they propagate across system layers and human–machine interactions. A qualitative case-based analytical approach is adopted by integrating the Swiss Cheese model and the SHELL model. The Swiss Cheese model is used to represent multilayer defensive structures, including governance and policy, perception, planning and decision-making, control and actuation, and human–machine interfaces. The SHELL model structures interaction failures between liveware and software, hardware, environment, and other liveware. The results reveal recurrent cross-layer failure pathways in which interface-level mismatches, such as low-salience alerts, sensor miscalibration, adverse environmental conditions, and inadequate handover communication, align with latent system weaknesses to produce unsafe outcomes. These findings demonstrate that autonomous driving safety failures are predominantly socio-technical in nature rather than purely technological. The proposed hybrid framework provides actionable insights for system designers, operators, and regulators by identifying critical intervention points for improving interface design, operational procedures, and policy-level safeguards in autonomous driving systems. Full article

Airport airspace safety is increasingly threatened by small, unmanned aircraft systems and wildlife that traditional radar cannot detect. While earlier reviews addressed general counter-UAS techniques, individual sensors, or the detection of single objects such as birds or drones, none has systematically reviewed airport-based, multi-sensor surveillance strategies through a safety-theoretical lens. A systematic review, performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement, synthesized recent research on fixed, ground-based aerial detection capabilities for small aerial hazards, specifically unmanned aircraft systems (sUAS) and avian targets, within operational airport environments. Searches targeted English-language, peer-reviewed articles from 2016 through 2025 in Web of Science and Scopus. Due to methodological heterogeneity across sensor technologies, a narrative synthesis was executed. The review of thirty-six studies, analyzed through Reason’s Swiss Cheese Model and Endsley’s Situational Awareness framework, found that only layered multi-sensor fusion architectures effectively address detection gaps for Low-Slow-Small (LSS) threats. Based on these findings, the review proposes seamless integration with Air Traffic Management (ATM) and UAS Traffic Management (UTM) systems through standardized data-exchange interfaces, complemented by theoretically grounded risk-based deployment strategies aligning surveillance technology tiers with operational risk profiles, from basic Remote ID receivers in low-risk rural environments to comprehensive multi-sensor fusion at high-density hubs, major airports, and urban vertiports. Full article

This review summarizes the current knowledge on the probiotic characteristics of dairy propionibacteria, represented by Propionibacterium freudenreichii and some Acidipropionibacterium species commonly consumed through raw milk cheese. For example, in Swiss-type cheeses, P. freudenreichii is added as a starter culture. Some strains of P. freudenreichii have been included in mixed probiotic commercial preparations or used to produce tablets from fermented culture media containing bioactive substances such as short-chain fatty acids (SCFAs), bifidogenic molecules, and vitamins. Acidipropionibacterium acidipropionici and A. jensenii strains have mainly been evaluated as health and productivity promoters in farm animals. For P. freudenreichii, the molecular mechanisms behind its probiotic action have been well elucidated, and recently, novel potential applications have been demonstrated in animal models. P. freudenreichii strains have been shown to mitigate inflammatory bowel diseases (IBDs) and mucositis and prevent necrotizing enterocolitis (NEC) in newborns. Their immunomodulation capacity has alleviated symptoms of food allergies, obesity, diabetes, colorectal cancer (CRC), and infections. Moreover, P. freudenreichii inhibited osteoclastogenesis in a rheumatoid arthritis model. Most observed effects are mediated by proteins on the cell surface or contained in extracellular vesicles (EVs) such as the surface layer (S-layer) protein SlpB, DlaT, and GroEL. No safety issues have been reported for these bacteria. However, investigations into transferable antibiotic resistance traits are still needed, and clinical trials are required to evaluate their effectiveness as probiotics for humans. Full article

Risk analysis is critical for preventing catastrophic failures in complex systems, as exemplified by the Deepwater Horizon disaster, a stark reminder of systemic vulnerabilities in offshore drilling operations, where inadequate appraisal of overlapping failures led to severe environmental and human losses. This study addresses the absence of a predictive framework capable of capturing cumulative risk interactions across both time stages and defensive layers. To fill this gap, and by drawing on prior frameworks such as the Swiss Cheese Model (SCM) and the Risk Matrix (RM), as well as critiques of their limitations, we introduce the Synergy and Accumulation Model for Analysis (SAMA). This model defines project life-cycle stages and risk recipients, characterizes each risk by four parameters (the focus of impact, suddenness, frequency, and effectiveness), and calculates horizontal (RF_h) and vertical (RF_v) risk factors. We applied SAMA to fifteen identified failure modes of the Macondo well, categorizing them across two time stages (operational and construction) and four defensive layers. Horizontal analysis revealed that the regulatory-laws layer accumulated the highest risk factors, RFh_1laws = 129.25 during the operational stage and RFh_2laws = 95.98 during the construction stage. Vertical analysis showed that the safety objective experienced the greatest systemic vulnerability, with RF_vsafety = 135.8 across ten overlapping risks, followed by the quality objective at RF_vquality = 128.39. These findings demonstrate SAMA’s enhanced capability to identify critical collapse paths often overlooked by conventional models. For researchers, SAMA offers a transparent, parameter-driven methodology applicable across engineering and construction domains. For industry stakeholders, regulators, project managers, and safety engineers, this model provides actionable insights to prioritize resource allocation and strengthen specific defensive layers, thereby enhancing both preventive planning and resilience against future disasters. Full article

Cognitive bias is widespread, hidden, and difficult to deal with. It impacts each and every aspect of the justice and legal systems, from the initial engagement of police officers attending the crime scene, through the forensic examination, and all the way to the final outcome of the jurors’ verdict and the judges’ sentencing. It impacts not only the subjective elements in the justice and legal systems but also the more objective scientific elements, such as forensic fingerprinting and DNA. The impact of bias on each of these elements has mainly been researched and considered in silo, neglecting the biasing interactions and how bias cascades and snowballs throughout the justice and legal systems. These should happen rarely, as the Swiss cheese model shows that such errors in the final outcome rarely occur because they require that the shortcomings in each element be coordinated and aligned with the other elements. However, in the justice and legal systems, the different elements are not independent; they are coordinated and mutually support and bias each other, creating and enabling hidden bias cascade and bias snowball effects. Hence, minimizing bias requires not only taking measures to reduce bias in each of the elements but also a wider perspective that addresses bias cascade and bias snowball effects. Full article

Per- and polyfluoroalkyl substances (PFASs) are found everywhere, including food, cosmetics, and pharmaceuticals. This review introduces PFASs comprehensively, discussing their nature and identifying their interconnection with microplastics and their impacts on public health and the environment. The human cost of decades of delay, cover-ups, and mismanagement of PFASs and plastic waste is outlined and briefly explained. Following that, PFASs and long-term health effects are critically assessed. Risk assessment is then critically reviewed, mentioning different tools and models. Scientific research and health impacts in the United States of America are critically analyzed, taking into consideration the Center for Disease Control (CDC)’s PFAS Medical Studies and Guidelines. PFAS impact and activities studies around the world have focused on PFAS levels in food products and dietary intake in different countries such as China, European countries, USA and Australia. Moreover, PFASs in drinking water and food are outlined with regard to risks, mitigation, and regulatory needs, taking into account chemical contaminants in food and their impact on health and safety. Finally, PFAS impact and activities briefings specific to regions around the world are discussed, referring to Australia, Vietnam, Canada, Europe, the United States of America (USA), South America, and Africa. The PFAS crisis is a multifaceted issue, exacerbated by mismanagement, and it is discussed in the context of applying the following problem-solving analytical tools: the Domino Effect Model of accident causation, the Swiss Cheese Theory Model, and the Ishikawa Fish Bone Root Cause Analysis. Last but not least, PFASs’ impacts on the Sustainable Development Goals (SDGs) of 2030 are rigorously discussed. Full article

Loopholes involve misalignments between rules about what should be done and what is actually done in practice. The focus of this paper is loopholes in interactions between human organizations’ implementations of task-specific artificial intelligence and individual people. The importance of identifying and addressing loopholes is recognized in safety science and in applications of AI. Here, an examination is provided of loophole sources in interactions between human organizations and individual people. Then, it is explained how the introduction of task-specific AI applications can introduce new sources of loopholes. Next, an analytical framework, which is well-established in safety science, is applied to analyses of loopholes in interactions between human organizations, artificial intelligence, and individual people. The example used in the analysis is human–artificial intelligence systems in gig economy delivery driving work. Full article

Background and objectives: In Switzerland, conventional dairy and fish products are major sources of iodine, along with iodized salt. However, the growing popularity of plant-based alternatives may impact the iodine supply of the population. This study aimed to comprehensively assess the iodine content in plant-based dairy (milk, yogurt, and cheese) and fish alternatives available in the Swiss retail market and compare them with conventional dairy and fish products. Methods: In 2022, a market survey was conducted in Zurich, Switzerland, to identify the plant-based dairy and fish alternatives available in major retail outlets, online grocery stores, and health food stores. Product information from a total of 477 plant- based alternative products was recorded. Iodine content in unfortified alternatives was factorially calculated using the nutritional composition of plant ingredients listed in the Swiss Food Composition Database. To further comprehend the impact of plant-based alternatives on iodine consumption, we modelled dietary scenarios by substituting the intake of dairy and fish items with plant-based alternatives, based on the recommendations of the Swiss Food Pyramid. Results: Out of the 477 products identified, 58% were organic products. Only 4 out of 170 milk alternatives were iodine fortified (mean iodine concentration: 22.5 μg/100 mL), and there were no yogurt, cheese, or fish alternatives that were iodine fortified. The median iodine concentration in unfortified plant-based alternatives was negligible compared to conventional dairy and fish products (milk: 0.21 vs. 9.5 μg/100 mL; yogurt 0.36 vs. 6.1 μg/100 g; cheese: 0.10 vs. 20 μg/100 g; fish 0.50 vs. 44 μg/100 g). Three portions of dairy per day as recommended by the Swiss Food Pyramid provide 25% of the RDA (150 μg/day), whereas substituting three portions of dairy per day with unfortified alternatives provides only 0.7% of the RDA for iodine. Discussion: Only 4 out of 170 plant-based milk alternatives are iodine-fortified in the Swiss market, while no fortified yogurt, cheese, or fish alternatives are available. Thus, the risk of the consumers to miss out on the ca. 25% of the RDA for iodine by consuming plant-based alternatives is high, placing them at a risk for inadequate iodine intake. Full article

If baryosynthesis is strongly nonhomogeneous, macroscopic regions with antibaryon excess can be created in the same process from which the baryonic matter is originated. This exotic possibility can become real, if the hints to the existence of antihelium component in cosmic rays are confirmed in the AMS02 experiment, indicating the existence of primordial antimatter objects in our Galaxy. Possible forms of such objects depend on the parameters of models of baryosynthesis and evolution of antimatter domains. We elaborate the formalism of analysis of evolution of antibaryon domain with the account for baryon-antibaryon annihilation at the domain borders and possible “Swiss cheese” structure of the domain structure. We pay special attention to evolution of various forms of high, very high and ultrahigh density antibaryon domains and deduce equations of their evolution in the expanding Universe. The proposed formalism will provide the creation of evolutionary scenarios, linking the possible forms and properties of antimatter bodies in our Galaxy to the mechanisms of nonhomogeneous baryosynthesis. Full article

With climate change, urban resilience is becoming a critical concept for helping cities withstand disasters and accidents. However, current research often focuses on concept identification, leaving a gap between concept and implementation. This study aims to investigate the lack of urban resilience in the face of sudden weather disasters, with a focus on the inadequate capacity of urban systems to effectively govern such events. The Zhengzhou subway flooding accident on 20 July 2021, serves as a case study for this research, and the accident causation theories, such as the Swiss cheese model, Surry’s accident model, and trajectory intersection theory are used to conduct a comprehensive analysis of the accident’s causes. Through this analysis, the paper identifies vulnerabilities in the natural, technical, and man-made systems of the urban system, and reveals deficiencies in four aspects of urban resilience: natural, technological, institutional, and organizational. Based on this analysis, the study proposes a resilient city governance framework that integrates the “Natural-Technical-Man-made” systems, offers relevant recommendations for urban resilience governance, and discusses potential challenges to urban resilience implementation. Full article

Patatin-like phospholipase domain-containing protein 6 (PNPLA6), originally called Neuropathy Target Esterase (NTE), belongs to a family of hydrolases with at least eight members in mammals. PNPLA6/NTE was first identified as a key factor in Organophosphate-induced delayed neuropathy, a degenerative syndrome that occurs after exposure to organophosphates found in pesticides and nerve agents. More recently, mutations in PNPLA6/NTE have been linked with a number of inherited diseases with diverse clinical symptoms that include spastic paraplegia, ataxia, and chorioretinal dystrophy. A conditional knockout of PNPLA6/NTE in the mouse brain results in age-related neurodegeneration, whereas a complete knockout causes lethality during embryogenesis due to defects in the development of the placenta. PNPLA6/NTE is an evolutionarily conserved protein that in Drosophila is called Swiss-Cheese (SWS). Loss of SWS in the fly also leads to locomotory defects and neuronal degeneration that progressively worsen with age. This review will describe the identification of PNPLA6/NTE, its expression pattern, and normal role in lipid homeostasis, as well as the consequences of altered NPLA6/NTE function in both model systems and patients. Full article

A recent work proposed that the recent cosmic passage to a cosmic acceleration era is the result of the existence of small anti-gravity sources in each galaxy and clusters of galaxies. In particular, a Swiss-cheese cosmology model, which relativistically integrates the contribution of all these anti-gravity sources on a galactic scale has been constructed assuming the presence of an infrared fixed point for a scale dependent cosmological constant. The derived cosmological expansion provides an explanation for both the fine tuning and the coincidence problem. The present work relaxes the previous assumption on the running of the cosmological constant and allows for a generic scaling around the infrared fixed point. Our analysis reveals that, in order to produce a cosmic evolution consistent with the best $\Lambda$CDM model, the IR-running of the cosmological constant is consistent with the presence of an IR-fixed point. Full article

This study aimed to infer the genetic parameters of five enteric methane emissions (EME) predicted from milk infrared spectra (13 models). The reference values were estimated from milk fatty acid profiles (chromatography), individual model-cheese, and daily milk yield of 1158 Brown Swiss cows (85 farms). Genetic parameters were estimated, under a Bayesian framework, for EME reference traits and their infrared predictions. Heritability of predicted EME traits were similar to EME reference values for methane yield (CH₄/DM: 0.232–0.317) and methane intensity per kg of corrected milk (CH₄/CM: 0.177–0.279), smaller per kg cheese solids (CH₄/SO: 0.093–0.165), but greater per kg fresh cheese (CH₄/CU: 0.203–0.267) and for methane production (dCH₄: 0.195–0.232). We found good additive genetic correlations between infrared-predicted methane intensities and the reference values (0.73 to 0.93), less favorable values for CH₄/DM (0.45–0.60), and very variable for dCH₄ according to the prediction method (0.22 to 0.98). Easy-to-measure milk infrared-predicted EME traits, particularly CH₄/CM, CH₄/CU and dCH₄, could be considered in breeding programs aimed at the improvement of milk ecological footprint. Full article

The present study compares the bioavailability of vitamin B₁₂ (B₁₂) of dairy products or synthetic B₁₂, using the pig as an experimental model for humans. Eleven pigs were used in a cross-over design to assess the net portal drained viscera (PDV) flux of blood plasma B₁₂ after ingestion of tofu (TF; devoid of B₁₂), Swiss cheese (SC), Cheddar cheese (CC), yogurt (YG), and synthetic B₁₂ (TB₁₂; TF supplemented with cyanocobalamin), providing a total of 25 µg of B₁₂ each. PDV blood plasma flow for SC and CC were higher than for TF and TB₁₂ (p ≤ 0.04) whereas YG was higher than TF (p = 0.05). Porto-arterial difference of blood plasma B₁₂ concentrations were higher for CC and TB₁₂ than for TF and YG (p ≤ 0.04) but not different from SC (p ≥ 0.15). Net PDV flux of B₁₂ was only different from zero for CC. However, the net PDV flux of B₁₂ for CC was not different from SC or TB₁₂. Cumulative net PDV flux of B₁₂ for SC, TB₁₂, and CC were 2.9, 4.4, and 8.3 µg 23 h post-meal, corresponding to a bioavailability of 11.6%, 17.5%, and 33.0%, respectively. In conclusion, CC had the best bioavailability of B₁₂ among the tested dairy products or compared to synthetic B₁₂. Full article

The Tazhong area of the Tarim Basin contains abundant oil and gas resources in Ordovician carbonate rocks, especially in the karst pores and caves of the Yingshan Formation. Research has indicated that the Yingshan Formation underwent a 7–11 Ma exposure during the middle Caledonian Period, resulting in large-scale karst pores and caves. However, the continental freshwater karst model cannot adequately explain the origin and distribution of karst pores and caves. In order to develop a more accurate karst model to guide petroleum exploration in the region, we analyzed the karst morphology, cave development statistics, and paleokarst environments. Karst reservoir characteristics were analyzed on the basis of the following analysis: (1) Karst morphological analyses based on core description and formation micro-imager (FMI) log analyses. The results showed that alveolar-like and Swiss cheese-like solution pores, spongy dissolution zones, pit cenotes, and small continuous karst caves developed in the Yingshan Formation. (2) The statistical analysis of pore and cave characteristics indicated that most of the karst pores and caves developed within 50 m below the unconformity where the average height of these features ranged from 0.1 to 3.0 m and their widths ranged up to 100 m. These pores and caves were commonly filled with gravel, clay, and calcite. Horizontal well and seismic attribute analysis indicated that these pores and caves were distributed over a large area. In plain view, the karst pore-cave system is comprised of cross-linked anastomosing networks of horizontal cave passages. And (3) Cathode luminescence and electron microprobe analyses suggested that clay filling within karst caves was freshwater related, while calcite filling was of seawater origin. Cements within solution pores showed three phases of luminescence, suggesting an alternating freshwater and seawater environment. Based on these characteristics, the karsts of the Yingshan Formation in the Tazhong area are interpreted to be similar to the eogenetic karsts in the Yucatan Peninsula of modern Mexico. Accordingly, this study indicates that the pore-caves of the Yingshan Formation can be subdivided into three sections. Further, the development and filling of these pore-cave sections are interpreted to have formed by eogenetic mixed-water karstification during three phases of relatively stable sea level in a coastal margin environment. Full article