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Search Results (11,654)

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18 pages, 6413 KiB  
Article
A Recognition Method for Marigold Picking Points Based on the Lightweight SCS-YOLO-Seg Model
by Baojian Ma, Zhenghao Wu, Yun Ge, Bangbang Chen, He Zhang, Hao Xia and Dongyun Wang
Sensors 2025, 25(15), 4820; https://doi.org/10.3390/s25154820 (registering DOI) - 5 Aug 2025
Abstract
Accurate identification of picking points remains a critical challenge for automated marigold harvesting, primarily due to complex backgrounds and significant pose variations of the flowers. To overcome this challenge, this study proposes SCS-YOLO-Seg, a novel method based on a lightweight segmentation model. The [...] Read more.
Accurate identification of picking points remains a critical challenge for automated marigold harvesting, primarily due to complex backgrounds and significant pose variations of the flowers. To overcome this challenge, this study proposes SCS-YOLO-Seg, a novel method based on a lightweight segmentation model. The approach enhances the baseline YOLOv8n-seg architecture by replacing its backbone with StarNet and introducing C2f-Star, a novel lightweight feature extraction module. These modifications achieve substantial model compression, significantly reducing the model size, parameter count, and computational complexity (GFLOPs). Segmentation efficiency is further optimized through a dual-path collaborative architecture (Seg-Marigold head). Following mask extraction, picking points are determined by intersecting the optimized elliptical mask fitting results with the stem skeleton. Experimental results demonstrate that SCS-YOLO-Seg effectively balances model compression with segmentation performance. Compared to YOLOv8n-seg, it maintains high accuracy while significantly reducing resource requirements, achieving a picking point identification accuracy of 93.36% with an average inference time of 28.66 ms per image. This work provides a robust and efficient solution for vision systems in automated marigold harvesting. Full article
(This article belongs to the Section Smart Agriculture)
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10 pages, 335 KiB  
Article
On the Probability of the Astrometric Resolution of Spectroscopic Binaries into Components
by Dugasa Belay Zeleke, Alexey Yu. Sytov, Seblu Humne Negu, Arseniy M. Sachkov, Solomon Belay Tessema and Oleg Yu. Malkov
Galaxies 2025, 13(4), 87; https://doi.org/10.3390/galaxies13040087 (registering DOI) - 5 Aug 2025
Abstract
Resolved spectroscopic binaries (RSBs) are an extremely valuable class of objects, being the only (apart from trigonometric) supplier of dynamical stellar parallaxes. This circumstance, as well as the comparative paucity of studied RSBs, makes the problem of identifying binary systems potentially capable of [...] Read more.
Resolved spectroscopic binaries (RSBs) are an extremely valuable class of objects, being the only (apart from trigonometric) supplier of dynamical stellar parallaxes. This circumstance, as well as the comparative paucity of studied RSBs, makes the problem of identifying binary systems potentially capable of being added to the list of known RSBs extremely urgent. In this paper, we propose a methodology for estimating the probability of a spectroscopic binary system to be resolved into components, perform the first step of its application to the SB9 catalogue, and present preliminary results, in particular, a list of the most promising RSB candidates. Full article
(This article belongs to the Special Issue Stellar Spectroscopy, Molecular Astronomy and Atomic Astronomy)
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15 pages, 1507 KiB  
Article
Determination of Fumonisins B1 and B2 in Food Matrices: Optimisation of a Liquid Chromatographic Method with Fluorescence Detection
by Óscar Cebadero-Domínguez, Santiago Ruiz-Moyano, Alberto Martín and Elisabet Martín-Tornero
Toxins 2025, 17(8), 391; https://doi.org/10.3390/toxins17080391 - 5 Aug 2025
Abstract
Fumonisins, primarily produced by Fusarium spp. and Aspergillus section nigri, are common contaminants in maize, cereal grains, and other processed and derived products, representing a significant risk to food safety and public health. This study presents the development and optimisation of a [...] Read more.
Fumonisins, primarily produced by Fusarium spp. and Aspergillus section nigri, are common contaminants in maize, cereal grains, and other processed and derived products, representing a significant risk to food safety and public health. This study presents the development and optimisation of a high-performance liquid chromatography method with fluorescence detection (HPLC-FLD) for the quantification of fumonisin B1 (FB1) and B2 (FB2) in various food matrices. In contrast with conventional protocols employing potassium phosphate buffers as the mobile phase, the proposed method utilises formic acid, offering enhanced compatibility with liquid chromatography systems. An automated online precolumn derivatisation with o-phthaldialdehyde (OPA) was optimised through experimental design and response surface methodology, enabling baseline separation of FB1 and FB2 derivatives in less than 20 min. The method demonstrated high sensitivity, with limits of detection of 0.006 µg mL−1 for FB1 and 0.012 µg mL−1 for FB2, and excellent repeatability (intraday RSD values of 0.85% and 0.83%, respectively). Several solid-phase extraction (SPE) strategies were evaluated to enhance sample clean-up using a variety of food samples, including dried figs, raisins, dates, corn, cornmeal, wheat flour, and rice. FumoniStar Inmunoaffinity columns were the only clean-up method that provided optimal recoveries (70–120%) across all tested food matrices. However, the MultiSep™ 211 column yielded good recoveries for both fumonisins in dried figs and raisins. Additionally, the C18 cartridge achieved acceptable recoveries for both fumonisins in dried figs and wheat flour. Full article
(This article belongs to the Section Mycotoxins)
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18 pages, 1645 KiB  
Article
Assessing Zoonotic Risks of Blastocystis Infection in Singapore
by Thet Tun Aung, Charlotte Kai Qi How, Jean-Marc Chavatte, Nazmi Bin Nazir, Edgar Macabe Pena, Bryan Ogden, Grace Rou’en Lim, Yasmina Arditi Paramastri, Lois Anne Zitzow, Hanrong Chen, Niranjan Nagarajan, Kevin Shyong Wei Tan and Benoit Malleret
Pathogens 2025, 14(8), 773; https://doi.org/10.3390/pathogens14080773 (registering DOI) - 5 Aug 2025
Abstract
Blastocystis spp. is an enteric protist that is present worldwide. Despite being discovered a century ago, there is still much to be learned about its pathogenicity and transmission. Different subtypes (ST) of Blastocystis spp. have been identified in various hosts, including humans, birds, [...] Read more.
Blastocystis spp. is an enteric protist that is present worldwide. Despite being discovered a century ago, there is still much to be learned about its pathogenicity and transmission. Different subtypes (ST) of Blastocystis spp. have been identified in various hosts, including humans, birds, and insects, and there is potential for zoonotic transmission through contact between humans and animals. The prevalence of Blastocystis spp. in humans and macaques in Singapore was understudied, and the findings revealed a significant prevalence of the parasite, with rates of 90% and 100% observed in each respective Macaca fascicularis population 1 and 2, with main subtypes (ST1, ST2, ST3, and ST5). Using metagenomics, the different subtypes of Blastocystis spp. (comprising ST2, ST3, and ST17) were identified in a healthy Singaporean cohort. Additionally, seven incidental findings of Blastocystis spp. were discovered in human patients with other gut parasites, including two ST1, two ST2, two ST3, and one ST8. Several factors such as diet or reverse zoonotic transmission are suggested to play a role in Blastocystis sp. subtype distribution. Full article
(This article belongs to the Section Parasitic Pathogens)
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13 pages, 401 KiB  
Article
The Correlation Between Cracked Teeth and National Insurance Coverage of Dental Implants in South Korea: A Retrospective Cohort Analysis
by Se Hoon Kahm, YoungHa Shim and SungEun Yang
J. Clin. Med. 2025, 14(15), 5507; https://doi.org/10.3390/jcm14155507 - 5 Aug 2025
Abstract
Background/Objectives: The expansion of National Health Insurance (NHI) coverage for dental implants in South Korea has substantially increased implant placements among older adults. While implants offer functional and esthetic benefits, their lack of periodontal ligaments alters occlusal force distribution, potentially increasing biomechanical [...] Read more.
Background/Objectives: The expansion of National Health Insurance (NHI) coverage for dental implants in South Korea has substantially increased implant placements among older adults. While implants offer functional and esthetic benefits, their lack of periodontal ligaments alters occlusal force distribution, potentially increasing biomechanical stress on adjacent or opposing teeth. This study aimed to investigate the association between the increased number of dental implants and the incidence of cracked teeth following the introduction of implant insurance. Methods: A retrospective analysis was conducted using the Clinical Data Warehouse of Seoul St. Mary’s Dental Hospital. Patients who underwent molar crown restorations between 2014 and 2022 were included. The incidence and clinical features of cracked teeth were compared before (2014–2015) and after (2016–2022) the introduction of implant insurance. Statistical analyses assessed differences in symptom presentation, pulp status, and treatment outcomes. Results: Among 5044 molars restored with crowns, 1692 were diagnosed with cracks. The incidence of cracked teeth significantly increased after NHI coverage for implants (25.5% vs. 32.6%, p < 0.001). Cases after insurance implementation showed fewer signs and symptoms at initial presentation (67.4% vs. 50.0%, p < 0.001), reduced irreversible pulpitis (37.2% vs. 25.8%, p < 0.001), and increased preservation of pulp vitality (46.9% vs. 57.8%, p < 0.001). These shifts may reflect changes in occlusal adjustment practices and earlier clinical intervention. Conclusions: The findings suggest a temporal link between increased implant placement and the rising incidence of cracked teeth. Implant-induced occlusal changes may contribute to this trend. Careful occlusal evaluation and follow-up are essential after implant placement, and further prospective studies are warranted to confirm causality and refine prevention strategies. Full article
(This article belongs to the Special Issue Research Progress in Osseointegrated Oral Implants)
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22 pages, 6288 KiB  
Article
The Pontoon Design Optimization of a SWATH Vessel for Resistance Reduction
by Chun-Liang Tan, Chi-Min Wu, Chia-Hao Hsu and Shiu-Wu Chau
J. Mar. Sci. Eng. 2025, 13(8), 1504; https://doi.org/10.3390/jmse13081504 - 5 Aug 2025
Abstract
This study applies a deep neural network (DNN) to optimize the 22.5 m pontoon hull form of a small waterplane area twin hull (SWATH) vessel with fin stabilizers, aiming to reduce calm water resistance at a Froude number of 0.8 under even keel [...] Read more.
This study applies a deep neural network (DNN) to optimize the 22.5 m pontoon hull form of a small waterplane area twin hull (SWATH) vessel with fin stabilizers, aiming to reduce calm water resistance at a Froude number of 0.8 under even keel conditions. The vessel’s resistance is simplified into three components: pontoon, strut, and fin stabilizer. Four design parameters define the pontoon geometry: fore-body length, aft-body length, fore-body angle, and aft-body angle. Computational fluid dynamics (CFD) simulations using STAR-CCM+ 2302 provide 1400 resistance data points, including fin stabilizer lift and drag forces at varying angles of attack. These are used to train a DNN in MATLAB 2018a with five hidden layers containing six, eight, nine, eight, and seven neurons. K-fold cross-validation ensures model stability and aids in identifying optimal design parameters. The optimized hull has a 7.8 m fore-body, 6.8 m aft-body, 10° fore-body angle, and 35° aft-body angle. It achieves a 2.2% resistance reduction compared to the baseline. The improvement is mainly due to a reduced Munk moment, which lowers the angle of attack needed by the fin stabilizer, thereby reducing drag. The optimized design provides cost-efficient construction and enhanced payload capacity. This study demonstrates the effectiveness of combining CFD and deep learning for hull form optimization. Full article
(This article belongs to the Section Ocean Engineering)
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23 pages, 3121 KiB  
Article
Seasonal Changes in the Soil Microbiome on Chernozem Soil in Response to Tillage, Fertilization, and Cropping System
by Andrea Balla Kovács, Evelin Kármen Juhász, Áron Béni, Costa Gumisiriya, Magdolna Tállai, Anita Szabó, Ida Kincses, Tibor Novák, András Tamás and Rita Kremper
Agronomy 2025, 15(8), 1887; https://doi.org/10.3390/agronomy15081887 - 5 Aug 2025
Abstract
Soil microbial communities are crucial for ecosystem services, soil fertility, and the resilience of agroecosystems. This study investigated how long-term (31 years) agronomic practices—tillage, NPK fertilization, and cropping system—along with measured environmental variables influence the microbial biomass and its community composition in Chernozem [...] Read more.
Soil microbial communities are crucial for ecosystem services, soil fertility, and the resilience of agroecosystems. This study investigated how long-term (31 years) agronomic practices—tillage, NPK fertilization, and cropping system—along with measured environmental variables influence the microbial biomass and its community composition in Chernozem soil under corn cultivation. The polyfactorial field experiment included three tillage treatments ((moldboard (MT), ripped (RT), strip (ST)), two fertilization regimes (NPK (N: 160; P: 26; K: 74 kg/ha), and unfertilized control) and two cropping systems (corn monoculture and corn–wheat biculture). The soil samples (0–30 cm) were collected in June and September 2023. Microbial biomass and community structure were quantified using phospholipid fatty acid (PLFA) analysis, which allowed the estimation of total microbial biomass and community composition (arbuscular mycorrhizal (AM) fungi, fungi, Gram-negative (GN) and Gram-positive (GP) bacteria, actinomycetes). Our results showed that microbial biomass increased from June to September, rising by 270% in unfertilized plots and by 135% in NPK-fertilized plots, due to higher soil moisture. Reduced tillage, especially ST, promoted significantly higher microbial biomass, with biomass reaching 290% and 182% of that in MT plots in June and September, respectively. MT had a higher ratio of bacteria-to-fungi compared to RT and ST, indicating a greater sensitivity of fungi to disturbance. NPK fertilization lowered soil pH by about one unit (to 4.1–4.8) and reduced microbial biomass—by 2% in June and 48% in September—compared to the control, with the particular suppression of AM fungi. The cropping system had a smaller overall effect on microbial biomass. Full article
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4 pages, 1714 KiB  
Proceeding Paper
A Study on High-Precision Vehicle Navigation for Autonomous Driving on an Ultra-Long Underground Expressway
by Kyoung-Soo Choi, Yui-Hwan Sa, Min-Gyeong Choi, Sung-Jin Kim and Won-Woo Lee
Eng. Proc. 2025, 102(1), 10; https://doi.org/10.3390/engproc2025102010 - 5 Aug 2025
Abstract
GPSs typically have an accuracy ranging from a few meters to several tens of meters. However, when corrected using various methods, they can achieve an accuracy of several tens of centimeters. In autonomous driving, a positioning accuracy of less than 50 cm is [...] Read more.
GPSs typically have an accuracy ranging from a few meters to several tens of meters. However, when corrected using various methods, they can achieve an accuracy of several tens of centimeters. In autonomous driving, a positioning accuracy of less than 50 cm is required for lane-level positioning, route generation, and navigation. However, in environments where GPS signals are blocked, such as tunnels and underground roads, absolute positioning is impossible. Instead, relative positioning methods integrating IMU, IVN, and cameras are used. These methods are influenced by numerous variables, however, such as vehicle speed and road conditions, resulting in lower accuracy. In this study, we conducted experiments on current vehicle navigation technologies using an autonomous driving simulation vehicle in the Suri–Suam Tunnel of the Seoul Metropolitan Area 1st Ring Expressway. To recognize objects (lane markings/2D/3D) for position correction inside the tunnel, data on tunnel and underground road infrastructure in Seoul and Gyeonggi Province was collected, processed, refined, and trained. Additionally, a Loosely Coupled-based Kalman Filter was designed and applied for the fusion of GPSs, IMUs, and IVNs. As a result, an error of 113.62 cm was observed in certain sections. This suggests that while the technology is applicable for general vehicle lane-level navigation in ultra-long tunnels spanning several kilometers for public service, it falls short of meeting the precision required for autonomous driving systems, which demand lane-level accuracy. Therefore, it was concluded that infrastructure-based absolute positioning technology is necessary to enable precise navigation inside tunnels. Full article
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18 pages, 1160 KiB  
Article
The Importance of Hemostasis on Long-Term Cardiovascular Outcomes in STEMI Patients—A Prospective Pilot Study
by Aleksandra Karczmarska-Wódzka, Patrycja Wszelaki, Krzysztof Pstrągowski and Joanna Sikora
J. Clin. Med. 2025, 14(15), 5500; https://doi.org/10.3390/jcm14155500 - 5 Aug 2025
Abstract
Background/Objectives: Platelet activity contributes to myocardial infarction; inadequate inhibition is a risk factor for stent thrombosis and mortality. Inadequate platelet inhibition during treatment is an important risk factor for stent thrombosis and may be associated with increased mortality. This study assessed platelet and [...] Read more.
Background/Objectives: Platelet activity contributes to myocardial infarction; inadequate inhibition is a risk factor for stent thrombosis and mortality. Inadequate platelet inhibition during treatment is an important risk factor for stent thrombosis and may be associated with increased mortality. This study assessed platelet and coagulation activity in post-MI patients, identifying parameters associated with adverse ST-elevation myocardial infarction (STEMI) outcomes over 3 years, to identify patients needing intensive secondary prevention. Methods: From 57 admitted patients, 19 STEMI patients were analyzed. Thromboelastography (TEG) and Total Thrombus Formation Analysis System (T-TAS) were used to assess hemostasis and coagulation. Selected laboratory parameters were measured for correlations. Major adverse cardiovascular events (MACEs) were defined as ischemic stroke, myocardial infarction, ischemic heart disease, thrombosis, and death from cardiovascular causes. Results: The group with MACEs was characterized by a faster time to initial clot formation and greater reflection of clot strength. T-TAS parameters, such as area under the curve at 10 min (T-TAS AUC10), showed lower values in the same group of patients. A moderate positive correlation suggested that as white blood cell count increases, T-TAS AUC10 values also tend to increase. A strong negative correlation (rho = −1.000, p < 0.01) was observed between low-density lipoprotein and kinetics in the TEG using the kaolin test at baseline in patients with MACEs. Conclusions: Some of the parameters suggest they are associated with adverse outcomes of STEMI, indicate the existence of an inflammatory state, and may contribute to risk stratification of STEMI patients and identify who will require ongoing monitoring. Full article
(This article belongs to the Section Vascular Medicine)
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30 pages, 1235 KiB  
Article
Assessing Rainfall and Temperature Trends in Central Ethiopia: Implications for Agricultural Resilience and Future Climate Projections
by Teshome Girma Tesema, Nigussie Dechassa Robi, Kibebew Kibret Tsehai, Yibekal Alemayehu Abebe and Feyera Merga Liben
Sustainability 2025, 17(15), 7077; https://doi.org/10.3390/su17157077 - 5 Aug 2025
Abstract
In the past three decades, localized research has highlighted shifts in rainfall patterns and temperature trends in central Ethiopia, a region vital for agriculture and economic activities and heavily dependent on climate conditions to sustain livelihoods and ensure food security. However, comprehensive analyses [...] Read more.
In the past three decades, localized research has highlighted shifts in rainfall patterns and temperature trends in central Ethiopia, a region vital for agriculture and economic activities and heavily dependent on climate conditions to sustain livelihoods and ensure food security. However, comprehensive analyses of long-term climate data remain limited for this area. Understanding local climate trends is essential for enhancing agricultural resilience in the study area, a region heavily dependent on rainfall for crop production. This study analyzes historical rainfall and temperature patterns over the past 30 years and projects future climate conditions using downscaled CMIP6 models under SSP4.5 and SSP8.5 scenarios. Results indicate spatial variability in rainfall trends, with certain areas showing increasing rainfall while others experience declines. Temperature has shown a consistent upward trend across all seasons, with more pronounced warming during the short rainy season (Belg). Climate projections suggest continued warming and moderate increases in annual rainfall, particularly under SSP8.5 by the end of the 21st century. It is concluded that both temperature and rainfall are projected to increase in magnitude by 2080, with higher Sen’s slope values compared to earlier periods, indicating a continued upward trend. These findings highlight potential breaks in agricultural calendars, such as shifts in rainfall onset and cessation, shortened or extended growing seasons, and increased risk of temperature-induced stress. This study highlights the need for localized adaptation strategies to safeguard agriculture production and enhance resilience in the face of future climate variability. Full article
(This article belongs to the Section Air, Climate Change and Sustainability)
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18 pages, 1942 KiB  
Article
Surveillance and Characterization of Vancomycin-Resistant and Vancomycin-Variable Enterococci in a Hospital Setting
by Claudia Rotondo, Valentina Antonelli, Alberto Rossi, Silvia D’Arezzo, Marina Selleri, Michele Properzi, Silvia Turco, Giovanni Chillemi, Valentina Dimartino, Carolina Venditti, Sara Guerci, Paola Gallì, Carla Nisii, Alessia Arcangeli, Emanuela Caraffa, Stefania Cicalini and Carla Fontana
Antibiotics 2025, 14(8), 795; https://doi.org/10.3390/antibiotics14080795 (registering DOI) - 4 Aug 2025
Abstract
Background/Objectives: Enterococci, particularly Enterococcus faecalis and Enterococcus faecium, are Gram-positive cocci that can cause severe infections in hospitalized patients. The rise of vancomycin-resistant enterococci (VRE) and vancomycin-variable enterococci (VVE) poses significant challenges in healthcare settings due to their resistance to multiple [...] Read more.
Background/Objectives: Enterococci, particularly Enterococcus faecalis and Enterococcus faecium, are Gram-positive cocci that can cause severe infections in hospitalized patients. The rise of vancomycin-resistant enterococci (VRE) and vancomycin-variable enterococci (VVE) poses significant challenges in healthcare settings due to their resistance to multiple antibiotics. Methods: We conducted a point prevalence survey (PPS) to assess the prevalence of VRE and VVE colonization in hospitalized patients. Rectal swabs were collected from 160 patients and analyzed using molecular assays (MAs) and culture. Whole-genome sequencing (WGS) and core-genome multilocus sequence typing (cgMLST) were performed to identify the genetic diversity. Results: Of the 160 rectal swabs collected, 54 (33.7%) tested positive for the vanA and/or vanB genes. Culture-based methods identified 47 positive samples (29.3%); of these, 44 isolates were identified as E. faecium and 3 as E. faecalis. Based on the resistance profiles, 35 isolates (74.5%) were classified as VRE, while 12 (25.5%) were classified as VVE. WGS and cgMLST analyses identified seven clusters of E. faecium, with sequence type (ST) 80 being the most prevalent. Various resistance genes and virulence factors were identified, and this study also highlighted intra- and inter-ward transmission of VRE strains. Conclusions: Our findings underscore the potential for virulence and resistance of both the VRE and VVE strains, and they highlight the importance of effective infection control measures to prevent their spread. VVE in particular should be carefully monitored as they often escape detection. Integrating molecular data with clinical information will hopefully enhance our ability to predict and prevent future VRE infections. Full article
(This article belongs to the Special Issue Hospital-Associated Infectious Diseases and Antibiotic Therapy)
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17 pages, 2369 KiB  
Article
An Automatic Ear Temperature Monitoring Method for Group-Housed Pigs Adopting Infrared Thermography
by Changzhen Zhang, Xiaoping Wu, Deqin Xiao, Xude Zhang, Xiaopeng Lei and Sicong Lin
Animals 2025, 15(15), 2279; https://doi.org/10.3390/ani15152279 - 4 Aug 2025
Abstract
The goal of this study was to develop an automated monitoring system based on infrared thermography (IRT) for the detection of group-housed pig ears temperature. The aim in the first part of the study was to recognize pigs’ ears by using neural network [...] Read more.
The goal of this study was to develop an automated monitoring system based on infrared thermography (IRT) for the detection of group-housed pig ears temperature. The aim in the first part of the study was to recognize pigs’ ears by using neural network analysis (SwinStar-YOLO). In the second part of the study, the goal was to automatically extract the maximum and average values of the temperature in the ear region using morphological image processing and a temperature matrix. Our dataset (3600 pictures, 10,812 pig ears) was processed using 5-fold cross-validation before training the ear detection model. The model recognized pigs’ ears with a precision of 93.74% related to threshold intersection over union (IoU). Correlation analysis between manually extracted and algorithm-derived ear temperatures from 400 pig ear samples showed coefficients of determination (R2) of 0.97 for maximum and 0.88 for average values. This demonstrates that our proposed method is feasible and reliable for automatic pig ear temperature monitoring, serving as a powerful tool for early health warning. Full article
(This article belongs to the Special Issue Infrared Thermography in Animals)
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13 pages, 1787 KiB  
Article
A New Activity Cycle of V1413 Aql
by Anna Tatarnikova, Andrey Tatarnikov, Nataliia Maslennikova, Alexander Dodin, Marina Burlak, Natalia Ikonnikova, Alexander Belinski and Georgy Nikishev
Galaxies 2025, 13(4), 86; https://doi.org/10.3390/galaxies13040086 (registering DOI) - 4 Aug 2025
Abstract
V1413 Aql is an anomalous classical symbiotic star that has remained in an active state almost continuously. After failing to return to quiescence following the 2020 outburst, it underwent a new flare in 2025. We present an analysis of new photometric and spectroscopic [...] Read more.
V1413 Aql is an anomalous classical symbiotic star that has remained in an active state almost continuously. After failing to return to quiescence following the 2020 outburst, it underwent a new flare in 2025. We present an analysis of new photometric and spectroscopic observations, which provide estimates for the binary components at different stages of activity: Lcool=1700L, Rcool=130R; Lhot=800L, Rhot=28R during minimum; Lhot=7000L, Rhot=64R at the 2025 maximum. The significant increase in the luminosity of the hot component during the 2025 outburst deviates from the typical behavior observed in classical symbiotic stars, where outbursts are generally attributed to a redistribution of spectral energy rather than intrinsic changes in luminosity. Full article
(This article belongs to the Special Issue Stellar Spectroscopy, Molecular Astronomy and Atomic Astronomy)
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4 pages, 181 KiB  
Editorial
Epidemiology, Virulence Factors, and Antimicrobial Resistance in Staphylococcus aureus
by Maria de Lourdes Ribeiro de Souza da Cunha
Antibiotics 2025, 14(8), 792; https://doi.org/10.3390/antibiotics14080792 (registering DOI) - 4 Aug 2025
Abstract
Serious infections caused by bacteria that are resistant to commonly used antibiotics have become a global health problem in the 21st century [...] Full article
14 pages, 1588 KiB  
Case Report
Fatal Cytokine Collision: HLH–AIHA in Advanced AIDS—Case Report and Literature Review
by Xiaoyi Zhang, Maria Felix Torres Nolasco, Wing Fai Li, Toru Yoshino and Manasa Anipindi
Reports 2025, 8(3), 137; https://doi.org/10.3390/reports8030137 - 4 Aug 2025
Abstract
Background and Clinical Significance: Hemophagocytic lymphohistiocytosis (HLH) and autoimmune hemolytic anemia (AIHA) are both life-threatening hematologic syndromes that rarely present together outside of malignancy. Advanced acquired immunodeficiency syndrome (AIDS) creates a milieu of profound immune dysregulation and hyperinflammation, predisposing patients to atypical [...] Read more.
Background and Clinical Significance: Hemophagocytic lymphohistiocytosis (HLH) and autoimmune hemolytic anemia (AIHA) are both life-threatening hematologic syndromes that rarely present together outside of malignancy. Advanced acquired immunodeficiency syndrome (AIDS) creates a milieu of profound immune dysregulation and hyperinflammation, predisposing patients to atypical overlaps of these disorders. Case Presentation: A 30-year-old woman with poorly controlled AIDS presented with three weeks of jaundice, fever, and fatigue. Initial labs revealed pancytopenia, hyperbilirubinemia, and elevated ferritin level. Direct anti-globulin testing confirmed warm AIHA (IgG+/C3d+) with transient cold agglutinins. Despite intravenous immunoglobulin (IVIG), rituximab, and transfusions, she developed hepatosplenomegaly, extreme hyperferritinemia, and sIL-2R > 10,000 pg/mL, meeting HLH-2004 criteria. Bone marrow biopsy excluded malignancy; further work-up revealed Epstein–Barr virus (EBV) viremia and cytomegalovirus (CMV) reactivation. Dexamethasone plus reduced-dose etoposide transiently reduced soluble interleukin-2 receptor (sIL-2R) but precipitated profound pancytopenia, Acute respiratory distress syndrome (ARDS) from CMV/parainfluenza pneumonia, bilateral deep vein thrombosis (DVT), and an ST-elevation myocardial infarction (STEMI). She ultimately died of hemorrhagic shock after anticoagulation despite maximal supportive measures. Conclusions: This case underscores the diagnostic challenges of HLH-AIHA overlap in AIDS, where cytopenias and hyperferritinemia mask the underlying cytokine storm. Pathogenesis likely involved IL-6/IFN-γ overproduction, impaired cytotoxic T-cell function, and molecular mimicry. While etoposide remains a cornerstone of HLH therapy, its myelotoxicity proved catastrophic in this immunocompromised host, highlighting the urgent need for cytokine-targeted agents to mitigate treatment-related mortality. Full article
(This article belongs to the Section Allergy/Immunology)
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