Search Results (436)

While Lean methodologies have been widely adopted in large enterprises, their application in small and medium enterprises remains an area requiring further exploration. This study aims at a hybrid approach combining a systematic literature review based on the PEO framework and PRISMA methodology with comprehensive data analysis from 780 respondents to examine the direct relation between Lean and SMEs. Various statistical methods were used to identify different patterns and themes. The findings suggest that while resource constraints pose significant challenges for SMEs in adopting Lean, tailored approaches with a significant reliance on leadership commitment can considerably enhance operational efficiency, resilience, costs, and waste reduction. Insights from the analysis further revealed a preference for operational methods with limited adoption of complex and strategic methods of Lean across SMEs. The paper concludes with practical recommendations for SMEs and lays a foundation for future directions in terms of integration with ESG and sustainability. Full article

Images used in real-world applications such as image or video retrieval, outdoor surveillance, and autonomous driving suffer from poor weather conditions. When designing robust computer vision systems, removing adverse weather such as haze, rain, and snow is a significant problem. Recently, deep-learning methods offered a solution for a single type of degradation. Current state-of-the-art universal methods struggle with combinations of degradations, such as haze and rain streaks. Few algorithms have been developed that perform well when presented with images containing multiple adverse weather conditions. This work focuses on developing an efficient solution for multiple adverse weather removal, using a unified quaternion neural architecture called CMAWRNet. It is based on a novel texture–structure decomposition block, a novel lightweight encoder–decoder quaternion transformer architecture, and an attentive fusion block with low-light correction. We also introduce a quaternion similarity loss function to better preserve color information. The quantitative and qualitative evaluation of the current state-of-the-art benchmarking datasets and real-world images shows the performance advantages of the proposed CMAWRNet, compared to other state-of-the-art weather removal approaches dealing with multiple weather artifacts. Extensive computer simulations validate that CMAWRNet improves the performance of downstream applications, such as object detection. This is the first time the decomposition approach has been applied to the universal weather removal task. Full article

Although the clinical course and pathogenesis of lymphocystis disease virus (LCDV) infection have been extensively described in freshwater and seawater environments, lymphocystis disease has not been studied in the copperband butterflyfish (Chelmon rostratus) or described at the molecular level in orbicular batfish (Platax orbicularis). The present study aimed to identify LCDV in a copperband butterflyfish and an orbicular batfish using light and electron microscopy (morphological) and molecular methods, namely PCR followed by phylogenetic analysis. We present a case series of two representatives of two distinct fish species with stress-induced chronic LCDV infection, which presented with typical, recurring, macroscopically visible lymphocystis nodules on their pectoral, caudal, and dorsal fins. After collecting lymphocystis nodules from live animals using skin scraping, we processed the hypertrophic giant cells for qualitative analysis using light and electron microscopy. Through our qualitative morphological analysis, we also share intimate observations of putative viral replication and assembly in the intracytoplasmic inclusion bodies of lymphocystis nodules. We present LCDV infection in a novel species, the copperband butterflyfish, and our molecular analysis identified the virus from the orbicular batfish as a novel LCDV species. Full article

Background: Ageism is a growing concern in aging societies and can affect future professionals’ attitudes toward older adults. Objective: To analyze the association between attitudes toward old age, self-perceptions of aging, and contact with older adults in the community among students at a private university in Chile. Methods: A descriptive, cross-sectional study was conducted with 515 university students aged 18 to 42 years from 11 campuses of Santo Tomás University in Chile. Attitudes toward older adults were assessed using the Kogan’s Attitudes toward Older People Scale (KAOP), and additional data on self-perceptions of health and aging, and contact with grandparents or older adults, were collected through a self-designed questionnaire. Statistical analyses included chi-square tests, one-way ANOVA, and Bonferroni post hoc comparisons. Results: A majority of students (61.2%) exhibited low-level positive attitudes toward older adults. Female students and those aged 26–42 years had significantly more positive attitudes than male and younger students (p < 0.05). Students with a healthier self-perception of aging (p = 0.011) and those who maintained contact with grandparents or older adults (p = 0.006) showed significantly more favorable attitudes toward aging. Nationality was also associated with attitudes, with Chilean students scoring higher than their foreign counterparts. Conclusions: Positive attitudes toward older adults among university students were associated with gender, age, self-perception of aging, and intergenerational contact. These findings highlight the importance of integrating educational and intergenerational programs in higher education to reduce ageism and promote respectful and inclusive perceptions of aging. Full article

Inhalation of multi-walled carbon nanotubes (MWCNTs) poses potential health risks due to their structural similarity to asbestos and their ability to induce chronic lung inflammation, fibrosis, and lung cancer in animal models. This study investigated the pulmonary inflammatory and transcriptomic responses of two distinct MWCNTs—NM-401 (long, rigid) and NM-403 (short, thin)—in rats and mice using intratracheal instillation at matched dose levels at two post-exposure time points. Both MWCNTs induced acute neutrophilic inflammation and dose-dependent transcriptomic alterations in both species, with NM-403 eliciting a stronger response. Transcriptomic profiling revealed a substantial overlap in differentially expressed genes across materials and species, particularly at the early time point. Fibrosis-associated genes were upregulated in both species, with more persistent expression observed in rats. Acute phase response genes, including Orosomucoid 1 and Lipocalin 2 were commonly induced, while Serum Amyloid A3 and Orosomucoid 2 were selectively upregulated in mice. Functional enrichment analyses showed conserved activation of immune and inflammatory pathways. Our findings show that even short, non-fiber-like MWCNTs can provoke potent and persistent pulmonary effects, challenging assumptions based solely on MWCNT properties. Despite differences in long-term responses, the overall inflammatory and transcriptional profiles showed strong interspecies concordance, suggesting that both rats and mice are relevant models for assessing MWCNT-induced pulmonary toxicity. Full article

Calcium aluminate cement (CAC) offers rapid strength development, chemical durability in harsh environments, and high-temperature resistance, but its long-term performance may be compromised by the conversion of metastable hexagonal hydrates into stable cubic phases. Concurrently, recycling spent fluorescent lamp glass (SFLG) is limited because of its residual mercury content. This study investigates the use of manually (MAN) and mechanically (MEC) processed SFLG as partial CAC replacements (up to 50 wt.%). Both SFLG types had irregular morphologies with mean particle sizes of ~20 µm and mercury concentrations of 3140 ± 61 ppb (MAN) and 2133 ± 119 ppb (MEC). Moreover, the addition of SFLG reduced the initial and final setting times, whilst MEC waste notably extended the plastic state duration from 20 min (reference) to 69 min (50 wt.% MEC). Furthermore, strength development was accelerated, with SFLG/CAC mortars reaching peak strengths at 7–10 days versus 28 days as in the CAC reference. CAC and 15 wt.% SFLG mortars showed strength loss over time by reason of their phase conversion, whereas mortars with 25–50 wt.% SFLG experienced significant long-term strength gains, reaching ~60 MPa (25 wt.%) and ~45 MPa (35 wt.%), respectively, after 365 days, with strength activity indexes (SAI) near 90% and 70%, respectively. These improvements are attributed to the formation of strätlingite (C₂ASH₈), which stabilized hexagonal CAH₁₀ and mitigated conversion to cubic katoite (C₃AH₆). Mercury leaching remained below 0.01 mg/kg dry matter for all mixes and curing ages, classifying the mortars as non-hazardous and inert under Spanish Royal Decree 646/2020. The results suggest that SFLG can be safely reused as a sustainable admixture in CAC systems, enhancing long-term mechanical performance while minimizing environmental impact. Full article

Background/Objectives: Toxoplasma gondii is a major cause of zoonotic infections in both humans and animals, resulting in significant mortality in susceptible species, such as New World primates and marsupials. Toxoplasmosis is particularly concerning in zoos and wildlife reserves, where outbreaks threaten conservation efforts for endangered species. In the absence of a commercially available vaccine against toxoplasmosis for humans and captive wild animals, current prevention strategies are limited to restricting the access of cats to enclosures, controlling rodent populations, and maintaining strict food hygiene. Recent research has shown promising results with an intranasal vaccine (VXN-Toxo) composed of maltodextrin nanoparticles conjugated with a purified, inactivated T. gondii parasite. This experimental vaccine does not pose a risk of causing disease and offers advantages such as better stability compared with live pathogen-based vaccines. Methods: This study presents a large-scale evaluation of the effect of VXN-Toxo administered to captive wildlife across 20 zoos in Europe and the Americas between 2017 and 2025. Seven hundred and eighty-four animals, representing over 58 species (including primates, marsupials, rodents, and felids), were vaccinated without any adverse events reported. Results: Retrospective mortality data from 20 participating zoological institutions revealed an overall 96.7% reduction—and, in many cases, a complete elimination—of toxoplasmosis-associated deaths post vaccination. Conclusions: These results demonstrate, for the first time, consistent and broad-spectrum protection against T. gondii of different strains in a wide array of captive wildlife species. This universal vaccine represents a promising tool for toxoplasmosis prevention in zoological collections, with significant implications for animal health and conservation strategies. Full article

Optical coherence tomography (OCT) is a leading imaging technique for diagnosing retinal disorders such as age-related macular degeneration and diabetic retinopathy. Its ability to detect structural changes, especially in the optic nerve head, has made it vital for early diagnosis and monitoring. This paper surveys techniques for ocular disease prediction using OCT, focusing on both hand-crafted and deep learning-based feature extractors. While the field has seen rapid growth, a detailed comparative analysis of these methods has been lacking. We address this by reviewing research from the past 20 years, evaluating methods based on accuracy, sensitivity, specificity, and computational cost. Key diseases examined include glaucoma, diabetic retinopathy, cataracts, amblyopia, and macular degeneration. We also assess public OCT datasets widely used in model development. A unique contribution of this paper is the exploration of adversarial attacks targeting OCT-based diagnostic systems and the vulnerabilities of different feature extraction techniques. We propose a practical, robust defense strategy that integrates with existing models and outperforms current solutions. Our findings emphasize the value of combining classical and deep learning methods with strong defenses to enhance the security and reliability of OCT-based diagnostics, and we offer guidance for future research and clinical integration. Full article

Toxic shock syndrome (TSS) is a serious, often fatal disease, rarely occurring in dogs via infection with Staphylococcus and Streptococcus. The development of TSS is mainly dependent on the presence of bacterial toxins recognized to be potent superantigens causing the release of massive amounts of host inflammatory cytokines, notably TNF-α, progressing to high fever, hypotension, haemoconcentration, thrombosis and neutrophil and endothelial activation with multiple organ failure. Rarely, TSS is associated with erythematous and exfoliative dermatitis progressing to ulceration with extremely extensive dermo-epidermal detachment, which is often very painful. Like in humans, very little is known about the transmission and prevention of this condition. In our paper, a case of TSS-like caused by a mixed bacterial infection with Staphylococcus aureus, Streptococcus halichoeri and Dermatophilus spp. has been described in an 11 year-old, cross-breed male dog, most probably following injury due to biting and fighting. Lesions consisted of severe and diffuse ulceration on the dorsum, and bacterial culture/cytology led to the isolation and identification of Gram-positive staphylococci and streptococci associated with an intense neutrophil reaction. Dermatophilus spp. was presumed morphologically based on cytological preps, not by culture or molecular analysis. PCR demonstrated the presence of the nuc thermonucleaze gene (for S. aureus confirmation) together with the genes encoding enterotoxin H (seh), protein A (spa), toxic shock syndrome toxin TSST-1 (tst) and methicillin resistance (mecC); the exfoliative toxins (eta, etb) were detected. Clinical signs, cytology, bacterial culture and the response to systemic antibiotic therapy were compatible with a TSS-like diagnosis. The patient has completely recovered after 1 year of treatment. Full article

This article presents a new approach to the problem of transforming one quantum state into another. It is shown that an $r$-qubit superposition $|\mathit{x}⟩$ can be obtained from another $r$-qubit superposition $|\mathit{y}⟩$, by using only ${(2}^r-1)$ rotations, each presented by one controlled rotation gate. The quantum superpositions with real amplitudes are considered. The traditional two-stage approach $U_y^{-1}{U}_x:|\mathit{x}⟩\to |{0⟩}^{\oplus r}\to |\mathit{y}⟩$ requires twice as many rotations. Here, both transformations to the conventual basis state, $U_x: |\mathit{x}⟩\to |{0⟩}^{\oplus r}$ and $U_y: |\mathit{y}⟩\to |{0⟩}^{\oplus r}$, use ${(2}^r-1)$ rotations each on two binary planes, and many of these rotations require additional sets of CNOTs to be represented as 1- or 2-qubit-controlled gates. The proposed method is based on the concept of the discrete signal-induced heap transform (DsiHT) which is unitary and generated by a vector and a set of angular equations with given parameters. The quantum analog of this transform is described. The main characteristic of the DsiHT is the path of processing the data. It is shown that there exist such fast paths that allow for effective computing of the DsiHT, which leads to the simple quantum circuits for state preparation and transformation. Examples of such paths are given and quantum circuits for preparation and transformation of 2-, 3-, and 4-qubits are described in detail. CNOT gates are not used, but only controlled gates of elementary rotations around the $y$-axis. It is shown that the transformation and, in particular, only rotation gates with control qubits are required for initialization of 2-, 3-, and 4-qubits. The quantum circuits are simple and have a recursive form, which makes them easy to implement for arbitrary $r$-qubit superposition, with $r\ge 2.$ This approach significantly reduces the complexity of quantum state transformations, paving the way for more efficient quantum algorithms and practical implementations on near-term quantum devices. Full article

This study analyzes the impact of the COVID-19 pandemic on alcohol, cannabis, and tobacco use among adolescents aged 14–19 in Central Catalonia across three periods. Data were obtained from two waves of the DESKcohort project. The first wave (n = 4641) was pre-COVID-19 and the second wave was divided into two phases: post-COVID-19 with restrictions (n = 3478) and post-COVID-19 without restrictions (n = 2900). The prevalence of monthly binge drinking, cannabis use in the last 30 days, and daily tobacco use was calculated. Poisson regression models estimated adjusted prevalence ratios (aPR) comparing two post-pandemic phases to the pre-pandemic baseline. Binge drinking increased during the restrictions among girls [aPR = 1.5 (95%CI: 1.1–2.1)] and boys [aPR = 1.7 (95%CI: 1.3–2.3)]. Cannabis use decreased during restrictions and remained low post-pandemic, especially among girls [aPR = 0.6 (95%CI: 0.5–0.8)] and boys in the 4th Compulsory Secondary Education (CSE) [aPR = 0.4 (95%CI: 0.3–0.6)], and girls in the 2nd Post-Compulsory Secondary Education/Intermediate-Level Training Cycles (PCSE/ILTC) [aPR = 0.7 (95%CI: 0.6–0.9)]. Daily tobacco use also dropped among boys in the 4th year of CSE [aPR = 0.5 (95%CI: 0.3–0.7)] and girls in the 2nd year of PCSE/ILTC [aPR = 0.7 (95%CI: 0.6–0.9)]. The COVID-19 pandemic has created a unique opportunity to reassess patterns of adolescent substance use in a context of sudden social disruption. The findings highlight the need to denormalize alcohol and tobacco use and promote healthier adolescent behavior through education. Full article

Beneficial microorganisms are emerging as promising alternatives to conventional pesticides for the biological control of plant diseases. This study evaluated the efficacy of a consortium composed of Pseudomonas yamanorum and Trichoderma longibrachiatum and compost against three grapevine pathogens, Botrytis cinerea, Erysiphe necator, and Plasmopara viticola, in three cultivars: Victoria, Superior Seedless, and Early Sweet. The microbial consortium (P. yamanorum + T. longibrachiatum) combined with compost (treatment T4) significantly outperformed the individual treatments, reducing disease severity indices (DSIs) to 7.72, 5.35, and 3.37% in Victoria; 5.70, 6.95, and 3.32% in Superior Seedless; and 4.98, 2.35, and 2.84% in Early Sweet. The treatment also enhanced physiological traits, such as the chlorophyll content, and defense responses, including ascorbate peroxidase (APX), peroxidase (POX), and catalase (CAT) enzyme activities. Biochemical markers, including the total protein content, phenolic content, and reduced malondialdehyde (MDA) levels, indicated an improved oxidative stress tolerance. The soil analysis confirmed an increased pH, organic matter, nitrogen content, and microbial biomass. T4 further reduced the fruit disease incidence and improved quality attributes, including the sugar content and size, while lowering nitrate accumulation. These findings highlight the synergistic benefits of combining a microbial consortium with compost as a sustainable strategy to promote grapevine health, productivity, and soil resilience. Full article

Objectives: This study aimed to evaluate the effects of different titanium (Ti) anodized surfaces on soft tissue healing around dental implant abutments. Methods: Discs of machined (MC), pink anodized (PA) and yellow anodized (YA) surfaces were morphologically characterized and evaluated in vitro. Cell adhesion and collagen synthesis by human gingival fibroblasts (hGFs) were assessed to evaluate the regenerative potential of the surfaces under study. Their inflammatory potential was evaluated in THP-1 cell cultures by measuring cytokine secretion, and their proteomic adsorption patterns were characterized using nano-liquid chromatography mass spectrometry (nLC-MS/MS). Statistical significance was considered at 5%. In relation to proteomics, statistical differences were evaluated using the Student t-test with the Perseus application. Results: The anodization process resulted in a reduction in the surface roughness parameter (Ra) relative to the machined titanium (p < 0.05). No differences in hGF adhesion were found between the surfaces after one day. PA induced increased hGF collagen synthesis after 7 days (p < 0.05). The secretion of TNF-α was lower for anodized surfaces than for MC, and its concentration was lower for PA than for YA (p < 0.05). In turn, TGF-β was higher for PA and YA versus MC after one and three days of culture. A total of 176 distinct proteins were identified and 26 showed differences in adhesion between the anodized surfaces and MC. These differential proteins were related to coagulation, lipid metabolism, transport activity, plasminogen activation and a reduction in the immune response. Conclusions: Anodized Ti surfaces showed promising anti-inflammatory and regenerative potential for use in dental implant abutments. Anodization reduced surface roughness, increased collagen synthesis and lowered TNF-α secretion while increasing TGF-β levels compared to machined surfaces. Identified proteins related to coagulation and lipid metabolism supported these findings. Clinical relevance: Anodized surfaces could offer improved short-term peri-implant soft tissue healing over machined surfaces. The analysis of abutment surface, instead of implant surface, is a new approach that can provide valuable information. Full article