Search Results (10)

Iron monosulfides and neoformed pyrite below the sulfate–methane transition zone (SMTZ) of rapidly accumulating turbiditic sediments from the Gaoping submarine canyon off southwestern Taiwan were examined by SEM-EDS-EBSD, HRTEM, and HAADF STEM to investigate their microstructural characteristics and processes of formation and transformation. Within a few meters below the SMTZ, mackinawite (Mkw) is largely replaced by interlayered greigite-pyrrhotite (Grg-Po) with {111}_Grg//{001}_Po and ⟨110⟩_Grg//⟨110⟩_Po, followed by pyrite neoformation in clusters of disseminated matrix grains consisting of coalescing pyrite microcrystals, arrays of polycrystalline interlayer pyrite grains between the cleavage planes of layer silicates, with each grain’s core having inclusions of interlayered Grg-Po locally containing relict Mkw, and amassed pyrite microcrystals on the surface of porous interlayered Grg-Po micronodules. In the deeper sediments, neoformed pyrite is absent and Mkw is largely preserved, with partial replacement by interlayered Grg-Po having an overall topotactic relationship of ⟨110⟩_Grg//⟨110 ⟩_Po//⟨100⟩_Mkw and {111}_Grg//(001)_Po//~{011}_Mkw and a sharp reaction front without transitional profiles. The mineral grain boundaries and structural discontinuities with Mkw resulting from extensive interlayering between Grg {111} cubic close-packed segments and Po {001} hexagonal close-packed layers could serve as conduits for fluid flow and mass transport to drive the replacement reaction. The conversion of Mkw to metastable interlayered Grg-Po is inferred to occur through interface-coupled dissolution–reprecipitation processes associated with partial oxidation while the partial replacement of interlayered Grg-Po ± minor relict Mkw by pyrite microcrystals with irregular grain boundaries and orientations probably occurred via a dissolution–precipitation mechanism. Mkw could be initially formed by sulfate reduction driven by anaerobic oxidation of methane in reactive iron-rich sediments in paleo-SMTZs and subsequently transformed into interlayered Grg-Po followed by pyrite neoformation in the sulfidization front below the SMTZ or recent SMTZs in the Gaoping submarine canyon sediments. Full article

There are four shelf-incising submarine canyons off SW Taiwan. They are distributed along the active continental margin, which is periodically flushed by gravity flows. Shelf-incising canyons, such as Kaoping Canyon, may not only be affected by oceanographic conditions but also by extreme climate change due to the direct input of river sediment. In the canyons along the SW margin of Taiwan, strong sedimentary flows are reflected in highly abundant nutrient input and physical disturbances. The Kaoping Canyon possesses habitats that promote biodiversity but that are sensitive to environmental change. The aims of this study are to review the canyons along the SW margin of Taiwan and to present their geomorphological features and associated ecosystems. Full article

Colorectal cancer is the second most common cancer and the third cancer-associated death in Taiwan. Currently used serum markers for detecting colorectal cancer lack excellent diagnostic accuracy, which results in colorectal cancer being often recognized too late for successful therapy. Mitophagy is the selective autophagic degradation of damaged or excessive mitochondria. DJ-1 is an antioxidant protein that attenuates oxidative stress and maintains mitochondrial quality through activating mitophagy. Mitophagy activation contributes to anti-cancer drug resistance. However, the role of DJ-1-induced mitophagy in colorectal cancer progression remains unclear. In the present study, we collected matched tumor and adjacent normal tissues and serum from patients and cancer cells to demonstrate the clinical value and physiological function of DJ-1 in colorectal cancer. We found that DJ-1 increased in tumor tissues and serum; it was positively correlated with TNM (tumor-node-metastasis) stages of colorectal cancer patients. Through stable knockdown DJ-1 expression in metastatic colorectal adenocarcinoma cells SW620, DJ-1 knockdown inhibited cancer cell survival, migration, and colony formation. In SW620 cells, DJ-1 knockdown induced an incomplete autophagic response that did not affect ATP production; DJ-1 knockdown enhanced intracellular reactive oxygen species generation and damaged mitochondrial accumulation and mitophagy inhibition. It suggests that DJ-1 knockdown inhibits mitophagy that causes metastatic colorectal adenocarcinoma cells to be unable to remove damaged mitochondria and further enhance cancer cell apoptosis. Our data indicate that DJ-1 might be clinically valuable as serum and tissue biomarkers for predicting the TNM stage in colorectal cancer patients. Since DJ-1-induced mitophagy promotes tumor progression, DJ-1 inhibition is a potential therapeutic strategy for colorectal cancer treatment. Full article

The aim of the present study is to apply the three-dimensional Princeton Ocean Model to study the wind effects on Kuroshio-induced island wake in the lee of Green Island, Taiwan. Numerical results indicate that the effect of NE winds squeezes the Kuroshio-induced island vortex street close to the coast and the SW winds tend to push the island vortex street farther away from the coast. The simulated vortex streets are analyzed by the dimensionless spatial lengths to quantify the prescribed feature. By comparing the three-dimensional results with different wind conditions, the Ekman transports are observed and the influence depths of wind effects are studied. Additionally, some cold eddies are found in temperature fields resulting from numerical simulations. These results are in qualitative agreement with field measurements and satellite images. Full article

In this study, the performances of Mei-yu (May–June) quantitative precipitation forecasts (QPFs) in Taiwan by three mesoscale models: the Cloud-Resolving Storm Simulator (CReSS), the Central Weather Bureau (CWB) Weather Research and Forecasting (WRF), and the CWB Non-hydrostatic Forecast System (NFS) are explored and compared using an newly-developed object-oriented verification method, with particular focus on the various properties or attributes of rainfall objects identified. Against a merged dataset from ~400 rain gauges in Taiwan and the Tropical Rainfall Measuring Mission (TRMM) data in the 2008 season, the object-based analysis is carried out to complement the subjective analysis in a parallel study. The Mei-yu QPF skill is seen to vary with different aspects of rainfall objects among the three models. The CReSS model has a total rainfall production closest to the observation but a large number of smaller objects, resulting in more frequent and concentrated rainfall. In contrast, both WRF and NFS tend to under-forecast the number of objects and total rainfall, but with a higher proportion of bigger objects. Location errors inferred from object centroid locations appear in all three models, as CReSS, NFS, and WRF exhibit a tendency to simulate objects slightly south, east, and northwest with respect to the observation. Most rainfall objects are aligned close to an E–W direction in CReSS, in best agreement with the observation, but many towards the NE–SW direction in both WRF and NFS. For each model, the objects are matched with the observed ones, and the results of the matched pairs are also discussed. Overall, though preliminarily, the CReSS model, with a finer grid size, emerges as best performing model for Mei-yu QPFs. Full article

(1) Background: The potential of old drugs in novel indications is being greatly valued. We propose a triple-model study involving population-based, cell, and animal studies to investigate the effects of risperidone, a type of second-generation antipsychotic (SGA) drug, on colorectal cancer. (2) Methods: We used data from Taiwan’s National Health Insurance Research Database between 1997 and 2013 to compare 101,989 patients with colorectal cancer and 101,989 controls. Conditional logistic regression analyses were used to explore the association between SGA exposure and the risk of colorectal cancer. The following bench studies were performed to evaluate the findings of the population-based study. (3) Results: We found that SGAs had been less commonly used in colorectal cancer patients than in controls. The colorectal cancer risk was reduced with an increase in the cumulative defined daily dose (cDDD) of SGAs. The adjusted odds ratio of antipsychotic use for cDDD days was 0.32 (95% CI: 0.25–0.42). Risperidone exhibited the most prominent tumor inhibition effect in a cell screen study. Bench data revealed that risperidone significantly induced apoptosis and elevated intracellular ROS in human SW480 cells and suppressed the proliferation of the xenografted SW480 tumor in nude mice. (4) Conclusion: This triple-model study demonstrates the association between risperidone usage and a lower risk of colorectal cancer. Full article

Besides the application of the photonic crystal for the photodetector in the visible range, the infrared devices proposed with subwavelength structure are numerically and experimentally investigated thoroughly for infrared radiation sensing in this research. Several complementary metal oxide semiconductor (CMOS) compatible thermopiles with subwavelength structure (SWS) are proposed and simulated by the FDTD method. The proposed thermopiles are fabricated by the 0.35 μm 2P4M CMOS-MEMS process in TSMC (Taiwan Semiconductor Manufacturing Company). The measurement and simulation results show that the response of these devices with SWS is higher than for those without SWS. The trend of the measurement results is consistent with that of the simulation results. Obviously, the absorption efficiency of the CMOS compatible thermopile can be enhanced when the subwavelength structure exists. Full article

Many studies were conducted to investigate arsenic mobilization in different alluvial plains worldwide. However, due to the unique endemic disease associated with arsenic (As) contamination in Taiwan, a recent research was re-initiated to understand the transport behavior of arsenic in a localized alluvial plain. A comprehensive approach towards arsenic mobility, binding, and chemical speciation was applied to correlate groundwater hydrogeochemistry with parameters of the sediments that affected the As fate and transport. The groundwater belongs to a Na-Ca-HCO₃ type with moderate reducing to oxidizing conditions (redox potential = −192 to 8 mV). Groundwater As concentration in the region ranged from 8.89 to 1131 μg/L with a mean of 343 ± 297 μg/L, while the As content in the core sediments varied from 0.80 to 22.8 mg/kg with a mean of 9.9 ± 6.2 mg/kg. A significant correlation was found between As and Fe, Mn, or organic matter, as well as other elements such as Ni, Cu, Zn, and Co in the core sediments. Sequential extraction analysis indicated that the organic matter and Fe/Mn oxyhydroxides were the major binding pools of As. Batch adsorption experiments showed that the sediments had slightly higher affinity for As(III) than for As(V) under near neutral pH conditions and the As adsorption capacity increased as the contents of Fe oxyhydroxides as well as the organic matter increased. Full article

Steep topographic reliefs and heavy vegetation severely limit visibility when examining geological structures and surface deformations in the field or when detecting these features with traditional approaches, such as aerial photography and satellite imagery. However, a light detection and ranging (LiDAR)-derived digital elevation model (DEM), which is directly related to the bare ground surface, is successfully employed to map topographic signatures with an appropriate scale and accuracy and facilitates measurements of fine topographic features. This study demonstrates the efficient use of 1-m-resolution LiDAR for tectonic geomorphology in forested areas and to identify a fault, a deep-seated landslide, and the regional cleavage attitude in southern Taiwan. Integrated approaches that use grayscale slope images, openness with a tint color slope visualization, the three-dimensional (3D) perspective of a red relief image map, and a field investigation are employed to identify the aforementioned features. In this study, the previously inferred Meilongshan Fault is confirmed as a NE–SW-trending, eastern dipping thrust with at least a 750 m-wide deformation zone. The site where future paleoseismological studies should be performed has been identified, and someone needs to work further on this site. Signatures of deep-seated landslides, such as double ridges, trenches, main escarpments, and extension cracks, are successfully differentiated in LiDAR DEM images through the use of different visualization techniques. Systematic parallel and continuous lineaments in the images are interpreted as the regional cleavage attitude of cleavage, and a field investigation confirms this interpretation. Full article

A naturally new cyclopeptide, clavatustide C, was produced as a stress metabolite in response to abiotic stress elicitation by one of the hydrothermal vent fluid components Zn in the cultured mycelia of Aspergillus clavatus C2WU, which were isolated from Xenograpsus testudinatus. X. testudinatus lives at extreme, toxic habitat around the sulphur-rich hydrothermal vents in Taiwan Kueishantao. The known compound clavatustide B was also isolated and purified. This is the first example of a new hydrothermal vent microbial secondary metabolite produced in response to abiotic Zn treatment. The structures were established by spectroscopic means. The regulation of G1-S transition in hepatocellular carcinoma cell lines by clavatustide B was observed in our previous study. The purpose of the present study was to verify these results in other types of cancer cell lines and elucidate the possible molecular mechanism for the anti-cancer activities of clavatustide B. In different human cancer cell lines, including pancreatic cancer (Panc-1), gastric cancer (MGC-803), colorectal cancer (SW-480), retinoblastoma (WERI-Rb-1) and prostate cancer (PC3), clavatustide B efficiently suppressed cell proliferations in a dose-dependent manner. Although different cancer cell lines presented variety in Max effect dose and IC₅₀ dose, all cancer cell lines showed a lower Max effect dose and IC₅₀ dose compared with human fibroblasts (hFB) (p < 0.05). Moreover, significant accumulations in G1 phases and a reduction in S phases (p < 0.05) were observed under clavatustide B treatment. The expression levels of 2622 genes including 39 cell cycle-associated genes in HepG2 cells were significantly altered by the treatment with 15 μg/mL clavatustide B after 48 h. CCNE2 (cyclin E2) was proved to be the key regulator of clavatustide B-induced G1-S transition blocking in several cancer cell lines by using real-time PCR. Full article