Background/Objectives: The Structural Maintenance of Chromosomes (SMC) proteins form essential heterocomplexes for the preservation of DNA structure and its functions, and hence cell viability. The SMC5/6 dimer is assembled by direct interactions of...
The structural maintenance of chromosomes (SMC) protein complexes shape and regulate the structure and dynamics of chromatin, thereby controlling many chromosome-based processes such as cell cycle progression, differentiation, gene transcription and...
The genome replication process is challenged at many levels. Replication must proceed through different problematic sites and obstacles, some of which can pause or even reverse the replication fork (RF). In addition, replication of DNA within chromos...
The X-linked SMC1A gene encodes a core subunit of the cohesin complex that plays a pivotal role in genome organization and gene regulation. Pathogenic variants in SMC1A are often dominant-negative and cause Cornelia de Lange syndrome (CdLS) with grow...
SMC2 (structural maintenance of chromosomes 2) is the core subunit of condensins, which play a central role in chromosome organization and segregation. However, the functions of SMC2 in embryonic development remain poorly understood, due to the embry...
Hepatitis B virus (HBV), belonging to the genus Orthohepadnavirus, can cause chronic hepatitis and hepatocarcinoma in humans. HBV ensures optimal replication by encoding X, a multifunctional protein responsible for degrading the structural maintenanc...
The SMC-5/6 complex safeguards genome stability through the coordinated action of its core SMC proteins and associated NSE subunits. NSE-1 is a key component of the complex and is essential for DNA repair, yet it remains poorly characterized in Caeno...
Only six years ago, the first clear-cut example of a ferroelectric, lyotropic liquid crystal was discovered. Since then, ongoing investigations in this new research field provided numerous instances of the missing pieces to complete the formerly blan...
Structural maintenance of chromosomes protein 2 (SMC2) is a central component of the condensin complex involved in DNA supercoiling, an essential process for embryonic stem cell survival. SMC2 over-expression has been related with tumorigenesis and c...
Cultured meat is one of the meat substitutes produced through tissue engineering and other technologies. Large-scale cell culture is the key for cultured meat products to enter the market. Therefore, this study is aimed to explore the effect of long-...
Chromosome organization, dynamics and stability are required for successful passage through cellular generations and transmission of genetic information to offspring. The key components involved are Structural maintenance of chromosomes (SMC) complex...
Chromatin-based processes are essential for cellular functions. Structural maintenance of chromosomes (SMCs) are evolutionarily conserved molecular machines that organize chromosomes throughout the cell cycle, mediate chromosome compaction, promote D...
Structural Maintenance of Chromosomes (SMC) complexes are important for many aspects of the chromosomal organization. Unlike cohesin and condensin, the SMC5/6 complex contains a variant RING domain carried by its Nse1 subunit. RING domains are charac...
The multi-subunit structural maintenance of chromosomes (SMC) 5/6 complex includes SMC6 and non-SMC element (NSE)3. SMC5/6 is essential for homologous recombination DNA repair and functions as an antiviral factor during hepatitis B (HBV) and herpes s...
Cells have developed various mechanisms to counteract viral infections. In an evolutionary arms race, cells mobilize cellular restriction factors to fight off viruses, targeted by viral factors to facilitate their own replication. The hepatitis B vir...
It is widely accepted that DNA replication fork stalling is a common occurrence during cell proliferation, but there are robust mechanisms to alleviate this and ensure DNA replication is completed prior to chromosome segregation. The SMC5/6 complex h...
Hepatitis B X protein (HBx) plays an essential role in the hepatitis B virus (HBV) replication cycle, but the function of HBx has been elusive until recently. It was recently shown that transcription from the HBV genome (covalently-closed circular DN...
Dedifferentiated vascular smooth muscle cells (vSMCs) play an essential role in neointima formation, and we now aim to investigate the role of the bone morphogenetic protein (BMP) modulator BMPER (BMP endothelial cell precursor-derived regulator) in...
Previously, we isolated lactic acid bacteria from the slime of the garden snail Helix aspersa Müller and selected Weissella viridescens UCO-SMC3 because of its ability to inhibit in vitro the growth of the skin-associated pathogen Cutibacterium acnes...
Background/Objectives: Mosaic variegated aneuploidy (MVA) is a rare chromosomal instability disorder. Biallelic variants in SMC5, a core component of the DNA repair machinery, cause Atelis Syndrome, characterized by severe growth failure and multi-sy...
Dinoflagellates have some of the largest genomes, and their liquid-crystalline chromosomes (LCCs) have high degrees of non-nucleosomal superhelicity with cation-mediated DNA condensation. It is currently unknown if condensins, pentameric protein comp...
This paper presents an investigation of different cruciform specimen designs for the characterization of sheet molding compound (SMC) under biaxial loading. The considered material is a discontinuous glass fiber reinforced thermoset. We define variou...
Active suspension control technologies have become increasingly significant in improving suspension performance for driving stability and comfort. An RBF-based fractional-order SMC fault-tolerant controller is developed in this research to guarantee...
This study deals with the separation and detection methods for 12 synthetic musk compounds (SMCs), which are some of the emerging contaminants in fish samples, are widely present in environmental media, and can be considered serious risks due to thei...
Active Debris Removal (ADR) missions demand precise and rapid controllers that lower collision risks specifically in the capture phase of tumbling objects. Sliding Mode Control (SMC), in general, offers robustness against model uncertainties. However...
Fe-Si-Cr soft magnetic powder cores (SMCs), with high electrical resistivity, magnetic permeability, saturation magnetic induction, and good corrosion resistance, are widely applied to inductors, filters, choke coils, etc. However, with the developme...
This study investigates the application of soft magnetic composite (SMC) materials in alternator core manufacturing for bladeless wind turbines operating under the principle of vortex-induced vibration (VIV), employing additive manufacturing (AM) tec...
The control system is one of the important components of the hydrofoil craft. By adjusting the navigation attitude of the craft, the hydrofoil craft can navigate stably and safely in the turbulent environment. Aiming at the problem that existing cont...
In response to safety concerns pertaining to multi-UAV formation flights, a novel obstacle avoidance method based on an Improved Adaptive Artificial Potential field (IAAPF) is presented. This approach enhances UAV obstacle avoidance capabilities by u...
In multi-target tracking, the sequential Monte Carlo probability hypothesis density (SMC-PHD) filter is a practical algorithm. Influenced by outliers under unknown heavy-tailed measurement noise, the SMC-PHD filter suffers severe performance degradat...
To enable safe cooperative flight of multi-UAV formations in urban 3-D airspace with wind-field disturbances, we develop an integrated planning-control framework.The planning layer uses an APF-guided RRT* with continuous collision prediction and expl...
Germline mutations in the X-linked cohesin subunit gene SMC1A have been increasingly recognized as a cause of developmental and epileptic encephalopathy (DEE); however, the underlying basis of its marked phenotypic heterogeneity remains elusive. In o...
During the wireless charging of an automated guided vehicle (AGV), the output voltage is unstable due to changes in parameters such as coil mutual inductance and load resistance caused by external interferences and internal mismatches of the system....
Currently, artificial intelligence (AI) is emerging as a dominant force in various technologies, owing to its unparalleled efficiency. Among the plethora of AI techniques available, neural networks (NNs) have garnered significant attention due to the...
It has been recently shown that zero padding (ZP)-orthogonal frequency-division multiplexing (OFDM) is a promising candidate for 6G wireless systems requiring joint communication and sensing. In this paper, we consider a multiuser uplink scenario whe...
The actuator dead zone of free-form surface grinding robots (FFSGRs) is very common in the grinding process and has a great impact on the grinding quality of a workpiece. In this paper, an improved trajectory tracking algorithm for an FFSGR with an a...
We propose a sequential Monte Carlo-based cardinalized probability hypothesis density (SMC-CPHD) filter with adaptive survival probability for multiple frequency tracking to enhance the tracking performance. The survival probability of the particles...
In this study, a model-free
This study investigates an adaptive differential control system for 4WID (4-wheel-independent-drive) electric vehicles. The novel adaptive system will maneuver the independently operating hub motors without the help of any conventional steering mecha...
This contribution shortly introduces the anisotropic, micromechanical damage model for sheet molding compound (SMC) composites presented in the authors’ previous publication [1]. As the considered material is a thermoset matrix reinforced with long (...
As one of the main parasitic parameters in permanent magnet (PM) synchronous machines (PMSMs), cogging torque is the main component of the torque ripple, which has always been the handicap in the high-performance, low-speed drive systems. Over the la...
Background: The majority of small supernumerary marker chromosomes (sSMCs) are derived from one single chromosome. Complex sSMCs instead consist of two to three genomic segments, originating from different chromosomes. Additionally, discontinuous sSM...
This paper provides a comprehensive investigation of nonlinear robust control methodologies, with a specific emphasis on the development of sliding mode controllers (SMCs) for quadcopter unmanned aerial vehicles (UAVs). Quadcopters are highly interco...
This study presents a comprehensive performance analysis of four different control strategies, Proportional–Integral (PI), classical Sliding Mode Control (SMC), Super-Twisting SMC (ST-SMC), and Exponential Reaching Law SMC (ERL-SMC), applied to...
This paper investigates the optimal sliding mode control (SMC) of modular multilevel converters (MMCs) by considering control input constraints. Conventional SMC methods for MMCs typically overlook the system’s constraints. To address this, an...
Owing to the competitive advantages of fast response speed, large pushing force, high reliability, and high precision, the permanent magnet linear synchronous motor (PMLSM) has played an increasingly vital role in various high-speed and high-precisio...
This study examined the effects of phosphoric acid (H3PO4), polyimide (PI), and lubricants (MoS2, graphite) on the phase stability, microstructure, and magnetic performance of Fe-5.0 wt.%Si soft magnetic composites (SMCs). Warm compaction (≤550 &d...
The occurrence and development of Benggang is closely related to the decreased shear strength of collapsing walls. Plant roots can improve the soil shear resistance, and their soil reinforcing effect is restricted by soil moisture content (SMC). Howe...
Spent mushroom compost (SMC) substrates are commonly used as growth media for greenhouse crops and horticulture production. This study aimed to investigate the responses of physiochemical soil properties, enzyme activities, and microbial community co...
The electro-optical tracking system (ETS) on moving platforms is affected by the vibration of the moving carrier, the wind resistance torque in motion, the uncertainty of mechanisms and the nonlinear friction between frames and other disturbances, wh...
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