Search Results (182)

Four full-scale exterior beam-to-column connections comprising H-section beams and square hollow-section (SHS) columns were tested under low-cycle reversed loading to investigate two engineering-oriented T-stub section configurations and the effects of the presence or absence of triangular stiffeners. Failure modes, moment–rotation response, stiffness degradation, energy dissipation, and cumulative damage were evaluated, together with nonlinear finite element simulations and a modified Park–Ang damage assessment. All specimens progressed from bolt-hole slip through plastic deformation to localized fracture. In the unstiffened connections, damage concentrated near the T-stub flange-to-web junction; stiffeners redistributed critical demand toward the stiffener welds, adjacent T-stub webs, and SHS column walls. The maximum differences in initial rotational stiffness relative to J1A were 15.69% and 15.07% in the positive and negative loading directions, indicating that the elastic-stage response reflected the combined deformability of the T-stub, blind-bolt assembly, and column wall. The maximum increases in yield moment, peak-resistance moment, and ductility coefficient were 20.59%, 43.71%, and 45.91%, respectively. Complete-history energy dissipation varied non-monotonically across the tested configurations. The finite element model reproduced the global and local responses, while the damage-index results showed overall correspondence with the observed failure progression. The findings emphasize stiffness compatibility and rational distribution of plastic demand rather than maximum local stiffness. Full article

This study investigates the effects of introducing a manufacturer-operated online recycling channel (hereafter “online channel”) and adopting a residual-capacity-based differentiated-pricing strategy in spent power-battery recycling. We develop a manufacturer-led Stackelberg game involving a manufacturer, a retailer, and consumers. We solve and compare the equilibrium decisions under four modes: the offline-only identical-pricing (SI) mode, the dual-channel identical-pricing (DI) mode, the offline-only differentiated-pricing (SH) mode, and the dual-channel differentiated-pricing (DH) mode. The results show that under the baseline model, the total collection volume under the dual-channel recycling mode is greater than that under the offline-only recycling mode, while the retailer’s offline collection volume is lower. This indicates that introducing an online channel expands total collection but diverts part of the retailer’s offline collection. Compared with uniform pricing under the same channel structure, differentiated pricing yields the same total collection volume but performs better in collecting batteries with high residual capacity, suggesting that it reallocates incentives toward high-residual-capacity batteries rather than increasing total collection. For mode preference, the manufacturer earns the highest profit under the DH mode, whereas the retailer achieves the highest profit under the SH mode. These results are further examined in several extended studies. The contributions are threefold. First, the study distinguishes the market-expansion effect of online recycling from the value-recognition effect of differentiated pricing. Second, the consistency and applicability boundaries of baseline conclusions are examined and proposed under operational costs, residual-capacity measurement errors, consumer differentiation, and piecewise-linear demand. Third, a feasible profit-sharing mechanism is developed to coordinate the conflict between the manufacturer’s and retailer’s mode preferences. Full article

This study investigated the influence of a novel flow–through electro-Fenton (EF) reactor configuration on hydrodynamics and dye removal efficiency using Pt and boron-doped diamond (BDD) anodes coupled with a carbon–PTFE gas diffusion cathode. In this work, an innovative pre–pilot-scale reactor operating in recirculation mode was used to treat 100 mg L⁻¹ Calcon dye solutions in 0.05 mol L⁻¹ Na₂SO₄ at pH 3.0 under electrochemical oxidation (EO) with electrogenerated H₂O₂ (EO-H₂O₂), EF, and Photoelectro-Fenton (PEF) conditions. The effects of applied current density (30–90 mA cm⁻²) and Fe²⁺ concentration (0.25–0.75 mmol L⁻¹) were evaluated through color removal, TOC decay, and identification of oxidation intermediates. The hydrodynamic characterization results revealed flow conditions in a transitional region between laminar and turbulent flow (Re = 3.6 × 10³; Sh = 246). Comparing EF and EO-H₂O₂ processes, when Fe²⁺ was added to the solution, it significantly accelerated discoloration and, consequently, dye degradation in the former, while the absence of Fe²⁺ resulted in slower discoloration kinetics, reaching only 85.8% color removal after 180 min in the latter. The best performance was obtained with 0.50 mmol L⁻¹ Fe²⁺ in EF, achieving >98% discoloration. Among the investigated processes, PEF exhibited the highest mineralization efficiency. TOC removals using BDD as the anode efficiently reached high mineralization levels of 83.88%, 86.99%, and 93.38% for EO-H₂O₂, EF, and PEF, respectively, while Pt as the anode achieved 81.80%, 85.14%, and 91.63%. Overall, the BDD/PEF system showed the best degradation and mineralization performance. The proposed reactor was designed at the pre-pilot scale and incorporates vertical recirculation flow with hydrodynamic optimization, enabling efficient mass transfer and improved oxidant generation. The study provides practical insights into the reactor engineering aspects required for the future scale-up of EF technologies. Full article

To address the trade-off between stiffness and auxeticity in conventional star-shaped honeycombs (SH), this study introduces a novel star-ellipse honeycomb (SEH) design, incorporating elliptical stiffeners that enhance both load-bearing capacity and energy absorption. The mechanical performance of SEH was comprehensively evaluated using FE simulations, theoretical modeling, and quasi-static tests on 3D-printed multi-cell specimens. An equivalent Cauchy model using the Variational Asymptotic Method (VAM) was established and validated against experiment and finite element results, demonstrating high predictive accuracy in elastic behavior analysis while significantly reducing computational costs. Based on the collapse mechanism of a representative unit cell, a theoretical model was proposed to estimate the plateau stress. Comparative analyses show that the elliptical stiffener mitigates the classic stiffness–auxeticity trade-off by enabling cooperative deformation, which results in a simultaneous increase in elastic modulus and a stronger negative Poisson’s ratio compared to conventional star-shaped honeycombs. Additionally, the SEH exhibited a unique progressive folding mode under compression, delivering enhanced stiffness and energy dissipation, albeit with reduced ductility. The elliptical aspect ratio of 1.3, length ratio of 2.1, thickness ratio of 1.0, and star angle of 45–50° offer the best compromise between stiffness, energy dissipation, and auxetic performance, providing clear guidelines for tailoring SEH structures toward specific lightweight protective applications. Full article

This work presents an experimental and numerical investigation on the cyclic behaviour of square hollow section (SHS) beams made of 6060-T6 aluminium alloy subjected to non-uniform cyclic bending. Eight specimens with width-to-thickness ratios ranging from 18 to 48 were tested under a three-point cyclic bending protocol. The work provides relevant experimental findings, including moment-chord rotation curves, the number of cycles to local buckling onset, failure modes, and energy dissipation capacity. Additionally, a numerical model was created implementing a damage model to predict the progressive degradation and failure mechanism of the beams. Finally, the reliability of the Finite Element model was assessed by direct comparison of the results with the experimental data. Full article

To address the engineering issues of local plastic buckling of the chord wall and low ultimate capacity in unreinforced T-joints with square chord and circular brace (CHS-to-SHS) under brace axial compression, this paper proposes a doubler plate-reinforced CHS-to-SHS T-joint configuration. The mechanical behavior of the-reinforced joints is investigated based on a refined finite element (FE) model calibrated against experimental data. An extensive parametric analysis is conducted using FE method to investigate the key factors influencing the failure mode, ultimate capacity, and reinforcement efficiency of doubler plate-reinforced CHS-to-SHS T-joints, including the non-dimensional geometric parameters of the doubler plate (α₂, β₂, τ₂), and the ratio between the brace diameter and chord width (β). The results indicate that the doubler plate thickness has the most significant effect on capacity enhancement, while the width has a limited influence. The ultimate capacity exhibits an initial increase followed by a plateau with increasing doubler plate length, with the optimal length ratio α₂ equal to 1.2. A decreasing trend in the strength ratio is observed with an increase in β. The highest strength ratio of 3.29 is obtained at β = 0.445, and this value declines markedly to 1.4 when β increases to 0.795. However, β ≤ 0.445 tends to induce brace axial yielding, whereas β ≥ 0.795 is prone to cause chord bending failure—both cases constituting over-strengthening. Based on the systematic parametric results, a capacity calculation formula for doubler plate-reinforced CHS-to-SHS T-joints is established and demonstrated to show good agreement with the FE results, providing theoretical basis and design recommendations for the engineering design of doubler plate-reinforced CHS-to-SHS T-joints. Full article

In this study, a new series of (E)-4-((2-(2-(4-amino-3-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)acetyl)hydrazono)methyl)phenyl 4-halogenobenzenesulfonates (3a–3d), where 3a = F, 3b = Cl, 3c = Br, and 3d = I, were successfully synthesized via a straightforward synthetic route. The structures of the obtained compounds were fully characterized and confirmed by spectroscopic techniques, including FT-IR, ¹H NMR, and ¹³C NMR, as well as LC-MS/MS analysis. 1,2,4-triazole-based hydrazone derivatives (3a–3d) were investigated using IR and NMR spectroscopy and DFT calculations. Intermolecular interactions, HOMO-LUMO, dipole moment, polarization, first-order hyperpolarizability, and molecular electrostatic potential studies on the molecules were examined. The HOMO and LUMO energy gap study supports the charge transfer probability in the molecules. These were conducted to investigate the reactivity and stability of heterocyclic molecules in bioactivity analysis. Electron density mapping within the molecular electrostatic potential plot and electrostatic potential representation within the iso-surface plot evaluated the concept of charge distribution in the molecule as nucleophilic reactions and electrophilic regions. The predicted nonlinear optical (NLO) properties of the molecules are much greater than those of urea. The results obtained from these investigations collectively provide evidence that the molecules possess nonlinear optical applications. Novel triazole–hydrazone-functionalized aryl sulfonate derivatives (3a–3d) were evaluated for their anticancer potential against a panel of brain and non-brain cancer cell lines. Compound 3b exhibited the most favorable overall biological profile, displaying potent activity against SH-SY5Y neuroblastoma (GI = 7.59 μM) and U87MG glioblastoma cells (GI = 13.85 μM), together with the lowest toxicity toward normal FL fibroblasts (GI = 62.02 μM). Compounds 3c and 3d demonstrated remarkable potency against IDHmut-U87 glioma cells (GI = 3.87 and 3.27 μM, respectively), although their selectivity toward cancer cells was limited. DNA degradation studies revealed substantial fragmentation, particularly in C6 and SH-SY5Y cells, while migration assays indicated reduced cellular motility. Molecular docking studies identified compound 3b as the strongest PI3Kα binder, supporting a possible. In addition, the antimicrobial activities of compounds 3a–3d were evaluated against selected Gram-positive and Gram-negative bacteria as well as Candida species using the broth microdilution method. The compounds exhibited measurable antimicrobial effects with MIC values ranging from 156 to 625 µg/mL, showing moderate growth inhibition against the tested microorganisms. Although the observed activity was lower than that of the reference antimicrobial agents, the results indicate that these triazole–hydrazone derivatives possess a detectable level of antimicrobial activity and provide a basis for further structural optimization. Collectively, the results suggest that compound 3b represents the most promising lead structure due to its balanced combination of potency, selectivity, and predicted target engagement. Molecular docking was performed to evaluate the binding potential of newly synthesized triazole derivatives (3a–3d) against PI3Kα. The docking protocol was validated by re-docking alpelisib, yielding an RMSD of 0.64 Å. Among the tested compounds, 3b showed the most favorable binding energy (−9.94 kcal/mol) and estimated Ki value (52.13 nM), consistent with its superior in vitro activity. Its interactions with key PI3Kα residues, including Val851, Ser854, Met922, and Asp933, support a stable binding mode within the ATP-binding pocket. In silico ADME and toxicity analyses suggested acceptable drug-likeness characteristics, absence of major hepatotoxic, mutagenic, and carcinogenic liabilities, and moderate predicted acute toxicity profiles. These findings suggest that 3b is the most promising derivative for further validation. Full article

Magnetostrictive patch transducers (MPTs) are highly efficient for generating and detecting ultrasonic waves for non-destructive evaluation (NDE), though their use on cementitious media and fibre-reinforced concrete has not yet been investigated. In this study, a COMSOL simulation, validated with laser-Doppler vibrometry, was first used to quantify patch deformation for use in subsequent simulation of wave propagation in samples. The MPT system was then validated on thin glass plates, producing tunable A₀, S₀, and SH₀ modes through frequency-wavelength matching. In cementitious mortar plates, SH₀ and SH₁ modes were demonstrated experimentally for the first time using MPTs. The validated COMSOL model was then used to interpret complex signals in quasi-plate and half-space cementitious mortar prisms, showing that MPTs generate Rayleigh, bulk SH, and surface-skimming SH modes. In steel fibre-reinforced concrete, surface-skimming SH wave speed correlated with increases in breaking strength even in the presence of surface features such as notches. Notably, Rayleigh wave speeds could not be measured in the presence of surface features, and the Rayleigh velocities measured in the same sample, but not in the local tested area did not correlate with SH speed. This behaviour is likely due to the non-uniform distribution of material constituents, including fibre-reinforcement and coarse aggregate, combined with the different propagation paths and depth sensitivities of the reported wave modes. Overall, racetrack-coil MPTs enable multimodal inspection of cementitious media, providing information on the presence of geometric features and material properties. Full article

Background: Patients with prolonged mechanical ventilation (PMV) frequently require tracheostomy due to failure to wean, yet the pathway from ventilator dependence to successful decannulation remains complex and poorly standardised. Comprehensive respiratory rehabilitation is recognised as a core strategy for improving decannulation outcomes, but no unified, evidence-based guidelines currently exist for this population. This review addresses that gap by synthesising current evidence on respiratory rehabilitation and decannulation strategies for tracheostomized PMV patients. Methods: A narrative review was conducted through a systematic search of PubMed/MEDLINE covering publications indexed from May 2019 to February 2026, supplemented by targeted searches of Embase and the Cochrane Library. The search combined free-text keywords and Medical Subject Headings (MeSH) terms across eight search string combinations. Following title and abstract screening of 830 deduplicated records, 51 studies met eligibility criteria and were included in the final narrative synthesis. Results: Six core rehabilitation intervention domains were identified: respiratory muscle training, physical rehabilitation and nutritional optimisation, sedation and delirium management, speaking valve use, airway complication management, and ventilator mode optimisation. High-intensity inspiratory muscle training at no less than 50% of maximal inspiratory pressure is currently supported by the strongest available evidence among the interventions reviewed, although this threshold derives primarily from general ICU populations and has not been specifically validated in heterogeneous tracheostomized PMV cohorts. Decannulation readiness assessment may benefit from evaluating five core domains—neurological readiness, secretion management capacity (suctioning ≤ 4 times/24 h), cough efficacy (peak cough flow > 160 L/min), safe swallowing confirmed by instrumental assessment, and upper airway patency confirmed by fiberoptic bronchoscopy—using a structured multidisciplinary framework. Conclusions: Successful decannulation in tracheostomized PMV patients requires integration of evidence-based rehabilitation interventions, structured multidisciplinary assessment, and a patient-centred outcome framework that extends beyond physiological endpoints to encompass voice restoration, psychological well-being, and social reintegration. Significant evidence gaps remain—particularly for expiratory muscle training, population-specific decannulation protocols, and adapted rehabilitation models for resource-limited settings—representing priority areas for future research. Full article

Landslides are the most common geological hazards, and chemical reinforcement is an effective method for enhancing the stability of soil slopes. Based on the coupled Eulerian–Lagrangian method, finite element analyses were conducted to develop a simple design approach for soil slope reinforcement using the curing agent. First, the effects of internal friction angle, cohesion, soil unit weight, slope height and angle on the slope stability were systematically quantified through 93 numerical cases. On this basis, an empirical formula was established for the factor of safety (FOS) of soil slope, and a method for determining the failure mode was proposed using a dimensionless parameter and two critical values related to slope angle. Subsequently, the reinforcement performance of the SH curing agent was investigated by varying the reinforcement position and length. The results indicate that the reinforcement of Case I-II-III and Case I-II provide the best performance, and the optimum reinforcement length was determined for different slope conditions. For slope angles ranging from 25° to 65°, the FOS after reinforcement was found to increase by 12.1% to 18.8% compared with that before reinforcement. Based on the FE results, empirical formulae for predicting the FOS of reinforced slope were further developed. Finally, a simple design approach was proposed for soil slope reinforcement with curing agent. The proposed method provides a convenient and effective reference for engineering practice in soil slope reinforcement with curing agents. Full article

Neuroblastoma is characterized by noticeable resistance to chemotherapy, largely driven by the ability of tumour cells to reorganize stress-adaptive signalling networks rather than relying on single oncogenic drivers. We conducted a study to investigate the pharmacological mode of action of doxorubicin in modifying adaptive signalling pathways in SH-SY5Y neuroblastoma cells, and whether the capacity of plant metabolites can exploit emergent biochemical vulnerabilities. Transcriptomic profiling through RNA sequencing conducted 48 h post-doxorubicin exposure unveiled the organized disruption of pathways linked with amyloidogenic processes, oncogenic signalling pathways, oxidative stress, and DNA repair. The protein–protein interactions, coupled with Kyoto Encyclopedia of Genes and Genomes pathway evaluations, revealed five network-central-hubs: BRAF, GSK3β, PARP1, BACE1, and MAOB. Structural docking integrated with 200 ns molecular dynamics simulations illustrated binding stability across multiple targets driven by three metabolites, Lactol binding to BRAF (−54.13 kcal/mol) and MAOB (−39.08 kcal/mol), Amino(1H-indol-2-yl)acetic acid to BACE1 (−41.07 kcal/mol) and GSK3β (−47.38 kcal/mol), and Quercetin-3-(6″-malonyl-glucoside) binding to PARP1 (−46.03 kcal/mol). In vitro Cell Counting Kit-8 proliferation assays validated the significant anti-neuroblastoma efficacy, with the lowest IC₅₀ (0.2397 µM) being exhibited by Amino(1H-indol-2-yl)acetic acid, followed by Lactol (1.226 µM) and Quercetin-3-(6″-malonyl-glucoside) (1.301 µM), which mirrored the cytotoxic action of doxorubicin (1.306 µM). These results suggest that plant-derived metabolites may interact with stress-adaptive signalling pathways connected with neuroblastoma. However, direct experimental validation of target engagement and pathway modulation will be required to confirm these predicted interactions. Full article

By means of characterization techniques such as XRD, TEM, and in situ EBSD, the texture evolution, recrystallization behavior, and their modulation by the Al₃Zr phase in hot-rolled Al-Zn-Mg-Cu-Zr alloys with varied homogenization treatments were investigated. Results show that both the single-stage homogenized (SH) alloy and the double-stage homogenized (DH) alloy acquired a typical β-fiber texture after hot rolling, including brass, S, and copper orientations. The DH alloy experienced suppressed recrystallization (a recrystallization fraction of 6.05%) owing to its higher density of Al₃Zr precipitates. In contrast, the SH alloy exhibited more significant dissolution and agglomeration of Al₃Zr, leading to extensive recrystallization peaking at 78.1%. The primary recrystallization mode was identified as continuous recrystallization, characterized by the growth and coarsening of subgrains. Although dynamically recrystallized (DRx) grains formed during hot rolling could act as potential recrystallization nuclei, most of them exhibited weak growth capability, except the cube-oriented grains. During recrystallization, deformed grains with S orientation tended to transform into cube-oriented grains, while those with brass orientation prefer to convert into Goss-oriented grains. This can be attributed to the presence of highly mobile grain boundaries between these specific orientation pairs. In the DH alloy, subgrain growth and DRx grain consumption during annealing reduced orientation dispersion in deformed grains, promoting marked brass texture strengthening, with its volume fraction reaching 57.7%. Full article

Genetic factors are key determinants in the pathophysiology of obesity, regulating energy homeostasis. Monogenic non-syndromic obesity accounts for 2–3% of obesity in both children and adults and is most often attributable to mutations in genes encoding components of the leptin–melanocortin pathway. Genetic testing is indicated in children with severe obesity before age 5, hyperphagia, a family history of obesity, and neurodevelopmental delay or organ dysfunction. Mutations associated with monogenic obesity follow autosomal recessive (LEP, LEPR, POMC, and PCSK1) or autosomal dominant (MC4R, SH2B1, SIM1, GNAS) modes of inheritance. Other gene mutations in heterozygous states (MRAP2, MC3R, SRC1, KSR2) are associated with obesity and may exhibit autosomal dominant inheritance; however, the clinical phenotype depends on the degree of genetic penetrance and interactions with other genetic and/or environmental factors. No approved targeted pharmacotherapies are currently available for autosomal dominant monogenic obesity, and the frequent detection of variants of uncertain significance often hinders timely diagnostic confirmation. The review provides a comprehensive appraisal of autosomal dominant forms of monogenic non-syndromic obesity, analyzing genetic and molecular features, clinical presentations, and therapeutic strategies. Full article

The growth of e-commerce live streaming has expanded sales channel options for fresh agricultural suppliers. This study investigates a two-echelon supply chain consisting of a fresh agricultural supplier and downstream retailers. Using differential game theory, we examine the supplier’s preservation technology level and product greenness, analyzing and comparing equilibrium strategies under three different modes: e-commerce platform sales mode (SP), head streamer sales mode (SH) and ordinary streamer sales mode (SN). The results demonstrate that SP is the dominant strategy when retailers’ marginal profits are low. Conversely, under high marginal profit conditions, the optimal selection depends on streamer cooperation costs: SH is preferred with low head streamer costs; widening cost gaps introduce temporal considerations between SH and SN; further gap expansion makes SN optimal. Furthermore, product greenness is related to supplier’s marginal profit, while the preservation technology level is jointly determined by supplier’s marginal profit and retailers’ inspection costs. Finally, combinations of these modes are also investigated. Full article

This paper experimentally investigates the resonant behavior of the one-way Lamb and SH (shear horizontal) mixing method in composite laminates with inherent quadratic nonlinearity, delamination damage and impact damage. When the fundamental S₀-mode Lamb waves and SH₀ waves mix in the damage regions of composite laminates, experimental results demonstrate the generation of the resonant SH₀ waves with the resonance condition. Meanwhile, the damage localization method in composite laminates is experimentally verified by the time-domain signal of resonant waves. Furthermore, it is found that the one-way Lamb and SH mixing method is sensitive to inherent quadratic nonlinearity and impact damage but insensitive to delamination damage. Full article