Search Results (37)

Introduction: The anatomy of the distal tibiofibular joint (DTFJ) has been demonstrated to influence the radiological outcome of reduction with syndesmotic screw fixation in the course of ankle fracture treatment. The objective of this study was to describe the anatomy of the DTFJ and to analyze the effect of incisura anatomy on syndesmotic stabilization with suture button systems (SBS), also in the context of their flexible nature of fixation. Materials and Methods: Forty-four (21 females, 23 males) consecutive postoperative bilateral computed tomography scans after stabilization of the DTFJ by SBS in the course of operative treatment of unstable ankle fractures were retrospectively analyzed. The anatomy of the DTFJ was evaluated by examining the following parameters: depth of the tibial incisura (DI), rotation of the incisura (ROI), Nault talar dome angle (NTDA), Leporjärvi clear space (LCS), anterior tibiofibular distance (antTFD), and fibula engagement (FE). The side-to-side (Δ) of LCS, NTDA, and antTFD, which analyzed the reduction result, were correlated with DI, FE, ROI, and NTDA, as well as the transverse offset (TO), reflecting the flexible nature of fixation. Results: Patients with slight overtightening (ΔLCS > −1 mm) showed a fibula that protruded less into the incisura on the native side (smaller FE) compared to symmetrical reduced patients and to patients with slight diastasis (p < 0.05). There was no relationship between the parameters describing the anatomy of the incisura and parameters assessing the parameter of the “flexible nature of fixation” (rs < 0.300). Regarding the anatomical parameters, it was observed that there were inter-individual differences of more than 4 mm (p > 0.05). Conclusions: The considerable inter-individual anatomical variability of the DTFJ was confirmed. The morphological configuration of the incisura has no impact on the immediate radiological reduction result after SBS stabilization of the DTFG, as determined by CT. The extent of the flexible nature of fixation is also not affected by the morphology of the incisura. Stabilization of the DTFJ can be performed regardless of the anatomical configuration. Full article

Knowledge about determinants of addiction in people taking addictive substances is poor and needs to be supplemented. The novelty of this paper consists in the analysis of innovative aspects of current research about relationships between determinants of addiction in Polish patients taking addictive substances and rare available data regarding the relationships between these factors from studies from recent years from other environments, mainly in Europe, and on the development of genetic determinants of physiological responses. We try to explain the role of the microelements Mn, Fe, Cu, Co, Zn, Cr, Ni, Tl, Se, Al, B, Mo, V, Sn, Sb, Ag, Sr, and Ba, the toxic metals Cd, Hg, As, and Pb, and the rare earth elements Sc, La, Ce, Pr, Eu, Gd, and Nd as factors that may shape the development of addiction to addictive substances or drugs. The interactions between factors (gene polymorphism, especially ANKK1 (TaqI A), ANKK1 (Taq1 A-CT), DRD2 (TaqI B, DRD2 Taq1 B-GA, DRD2 Taq1 B-AA, DRD2-141C Ins/Del), and OPRM1 (A118G)) in patients addicted to addictive substances and consumption of vegetables, consumption of dairy products, exposure to harmful factors, and their relationships with physiological responses, which confirm the importance of internal factors as determinants of addiction, are analyzed, taking into account gender and region. The innovation of this review is to show that the homozygous TT mutant of the ANKK1 TaqI A polymorphism rs 1800497 may be a factor in increased risk of opioid dependence. We identify a variation in the functioning of the immune system in addicted patients from different environments as a result of the interaction of polymorphisms. Full article

In this study, to develop the composition ceramics for the application of an ultrasonic transducer device for alleviating temporomandibular joint disorder pain, Pb_0.88 (La_0.6 Sm_0.4)_0.08(Mn_1/3 Sb_2/3)_0.02Ti_0.98 O₃ ceramics were manufactured using CuO as sintering aids, and their piezoelectric and resonant properties were investigated. For the specimen sintered at 1200 °C, excellent values of piezoelectric properties appeared: the dielectric constant (εr) of 202, piezoelectric constant (d₃₃) of 56 pC/N, first and third overtone electromechanical coupling factors k_t of 0.548 and k_t3 of 0.219, and first and third overtone mechanical quality factors Q_mt1 of 345 and Q_mt3 of 292, respectively, made the device suitable for application as an ultrasonic transducer. When the length of the piezoelectric device was 7.7 mm, the first and third overtone electromechanical coupling factors k_t1 of 0.555 and k_t3 of 0.196, first and third overtone mechanical quality factors Q_mt1 of 381 and Q_mt3 of 393, and first and third overtone dynamic ratios (D.Rs) of 63.7 (dB) and 37.7 (dB) were suitable for device applications as an ultrasonic transducer and facial skin massage, respectively. Full article

Despite significant progress in modern medicine and pharmacology, damage to the nervous system with various etiologies still poses a challenge to doctors and scientists. Injuries lead to neuroimmunological changes in the central nervous system (CNS), which may result in both secondary damage and the development of tactile and thermal hypersensitivity. In our review, based on the analysis of many experimental and clinical studies, we indicate that the mechanisms occurring both at the level of the brain after direct damage and at the level of the spinal cord after peripheral nerve damage have a common immunological basis. This suggests that there are opportunities for similar pharmacological therapeutic interventions in the damage of various etiologies. Experimental data indicate that after CNS/PNS damage, the levels of 16 among the 28 CC-family chemokines, i.e., CCL1, CCL2, CCL3, CCL4, CCL5, CCL6, CCL7, CCL8, CCL9, CCL11, CCL12, CCL17, CCL19, CCL20, CCL21, and CCL22, increase in the brain and/or spinal cord and have strong proinflammatory and/or pronociceptive effects. According to the available literature data, further investigation is still needed for understanding the role of the remaining chemokines, especially six of them which were found in humans but not in mice/rats, i.e., CCL13, CCL14, CCL15, CCL16, CCL18, and CCL23. Over the past several years, the results of studies in which available pharmacological tools were used indicated that blocking individual receptors, e.g., CCR1 (J113863 and BX513), CCR2 (RS504393, CCX872, INCB3344, and AZ889), CCR3 (SB328437), CCR4 (C021 and AZD-2098), and CCR5 (maraviroc, AZD-5672, and TAK-220), has beneficial effects after damage to both the CNS and PNS. Recently, experimental data have proved that blockades exerted by double antagonists CCR1/3 (UCB 35625) and CCR2/5 (cenicriviroc) have very good anti-inflammatory and antinociceptive effects. In addition, both single (J113863, RS504393, SB328437, C021, and maraviroc) and dual (cenicriviroc) chemokine receptor antagonists enhanced the analgesic effect of opioid drugs. This review will display the evidence that a multidirectional strategy based on the modulation of neuronal–glial–immune interactions can significantly improve the health of patients after CNS and PNS damage by changing the activity of chemokines belonging to the CC family. Moreover, in the case of pain, the combined administration of such antagonists with opioid drugs could reduce therapeutic doses and minimize the risk of complications. Full article

With the tremendous development of the logistics industry, the global market of automated warehousing has been growing rapidly. Meanwhile, the warehousing industry shows drawbacks, such as low storage capacity and poor efficiency. By comparing and analyzing the shuttle-based storage and retrieval system (SBS/RS), miniload automated storage and retrieval system (AS/RS), and KIVA system, a novel efficient parts-to-picker approach in flexible warehousing systems is proposed. Among them, buffer racks and access racks, associated with the access of automated mobile robots (AMRs) and stackers are used. The results show that compared with other parts-to-picker systems (such as the KIVA system), this system provides a significant increase in storage capacity (more than three times), and the picking efficiency is also very high at various layout scales, where the picking efficiency is no less than the KIVA system when the number of AMRs reaches the max. The novel system is suitable for small-, medium-, and large-scale warehouses in terms of showing high capacity and producing excellent space utilization. More importantly, this system can easily compete with its traditional counterparts by using a layout of high density without much increase in cost. This sustainable improvement realizes the efficient utilization of spatial resources and provides important support for the construction of green supply chains. Full article

The amygdala is a core region in the limbic system that is highly sensitive to stress. Astrocytes are key players in stress disorders such as anxiety and depression. However, the effects of stress on the morphology and function of amygdala astrocytes and its potential mechanisms remain largely unknown. Hence, we performed in vivo and in vitro experiments using a restraint stress (RS) rat model and stress-induced astrocyte culture, respectively. Our data show that norepinephrine (NE) content increased, cytotoxic edema occurred, and aquaporin-4 (AQP4) expression was up-regulated in the basolateral amygdala (BLA) obtained from RS rats. Additionally, the p38 mitogen-activated protein kinase (MAPK) pathway was also observed to be significantly activated in the BLA of rats subjected to RS. The administration of NE to in vitro astrocytes increased the AQP4 level and induced cell edema. Furthermore, p38 MAPK signaling was activated. The NE inhibitor alpha-methyl-p-tyrosine (AMPT) alleviated cytotoxic edema in astrocytes, inhibited AQP4 expression, and inactivated the p38 MAPK pathway in RS rats. Meanwhile, in the in vitro experiment, the p38 MAPK signaling inhibitor SB203580 reversed NE-induced cytotoxic edema and down-regulated the expression of AQP4 in astrocytes. Briefly, NE-induced activation of the p38 MAPK pathway mediated cytotoxic edema in BLA astrocytes from RS rats. Thus, our data provide novel evidence that NE-induced p38 MAPK pathway activation may be one of the mechanisms leading to cytotoxic edema in BLA under stress conditions, which also could enable the development of an effective therapeutic strategy against cytotoxic edema in BLA under stress and provide new ideas for the treatment of neuropsychiatric diseases. Full article

Cellular vehicle-to-everything (C-V2X) facilitates direct communication between vehicles and other user equipment (UE) to improve the efficiency of the Internet of vehicles communication through sidelink. In addition, in the new radio vehicle-to-everything (NR-V2X) Mode 2, users can automatically select resources using the conventional sensing-based semi-persistent scheduling (SB-SPS) resource selection algorithm. This mechanism allows users to generate a list of available resources after a sensing window, after which the users can randomly select resources, and the resource can be used continuously over multiple periods before reselection. However, during the sensing window, neighbors may generate a similar list of available resources, and random selection may lead to resource conflicts. This phenomenon may lead to deteriorated communication performance and increased latency due to incorrect reception. Therefore, this paper proposes a reuse distance-aided resource selection (RD-RS) method which integrates resource reuse distance judgement with SB-SPS to mitigate resource conflicts and interference caused by random selection. Moreover, the reuse distance judgement is performed before the final resource selection, and whether the user will select the current resource depends on the reuse distance between that user and other occupiers. Furthermore, the performance of the proposed scheme is compared with other algorithms. Simulation results show that the proposed RD-RS not only achieves a higher packet reception ratio (PRR) but also effectively reduces the inter-packet gap (IPG). Moreover, in specific scenarios, the proposed method outperforms conventional schemes by 9% in terms of PRR and 70% in terms of Range. Full article

Hippophae rhamnoides L. has been widely used in research and application for almost two decades. While significant progress was achieved in the examination of its fruits and seeds, the exploration and utilization of its by-products have received relatively less attention. This study aims to address this research gap by investigating the effects and underlying mechanisms of sea buckthorn seed residues both in vitro and in vivo. The primary objective of this study is to assess the potential of the hydroalcoholic extract from sea buckthorn seed residues (HYD-SBSR) to prevent cell apoptosis and mitigate oxidative stress damage. To achieve this, an H₂O₂-induced B16F10 cell model and a D-galactose-induced mouse model were used. The H₂O₂-induced oxidative stress model using B16F10 cells was utilized to evaluate the cellular protective and reparative effects of HYD-SBSR. The results demonstrated the cytoprotective effects of HYD-SBSR, as evidenced by reduced apoptosis rates and enhanced resistance to oxidative stress alongside moderate cell repair properties. Furthermore, this study investigated the impact of HYD-SBSR on antioxidant enzymes and peroxides in mice to elucidate its reparative potential in vivo. The findings revealed that HYD-SBSR exhibited remarkable antioxidant performance, particularly at low concentrations, significantly enhancing antioxidant capacity under oxidative stress conditions. To delve into the mechanisms underlying HYD-SBSR, a comprehensive proteomics analysis was conducted to identify differentially expressed proteins (DEPs). Additionally, a Gene Ontology (GO) analysis and an Encyclopedia of Genes and Genomes (KEGG) pathway cluster analysis were performed to elucidate the functional roles of these DEPs. The outcomes highlighted crucial mechanistic pathways associated with HYD-SBSR, including the PPAR signaling pathway, fat digestion and absorption, glycerophospholipid metabolism, and cholesterol metabolism. The research findings indicated that HYD-SBSR, as a health food supplement, exhibits favorable effects by promoting healthy lipid metabolism, contributing to the sustainable and environmentally friendly production of sea buckthorn and paving the way for future investigations and applications in the field of nutraceutical and pharmaceutical research. Full article

Neuropathic pain is a debilitating condition that affects millions of people worldwide. Numerous studies indicate that this type of pain is a chronic condition with a complex mechanism that tends to worsen over time, leading to a significant deterioration in patients’ quality of life and issues like depression, disability, and disturbed sleep. Presently used analgesics are not effective enough in neuropathy treatment and may cause many side effects due to the high doses needed. In recent years, many researchers have pointed to the important role of chemokines not only in the development and maintenance of neuropathy but also in the effectiveness of analgesic drugs. Currently, approximately 50 chemokines are known to act through 20 different seven-transmembrane G-protein-coupled receptors located on the surface of neuronal, glial, and immune cells. Data from recent years clearly indicate that more chemokines than initially thought (CCL1/2/3/5/7/8/9/11, CXCL3/9/10/12/13/14/17; XCL1, CX3CL1) have pronociceptive properties; therefore, blocking their action by using neutralizing antibodies, inhibiting their synthesis, or blocking their receptors brings neuropathic pain relief. Several of them (CCL1/2/3/7/9/XCL1) have been shown to be able to reduce opioid drug effectiveness in neuropathy, and neutralizing antibodies against them can restore morphine and/or buprenorphine analgesia. The latest research provides irrefutable evidence that chemokine receptors are promising targets for pharmacotherapy; chemokine receptor antagonists can relieve pain of different etiologies, and most of them are able to enhance opioid analgesia, for example, the blockade of CCR1 (J113863), CCR2 (RS504393), CCR3 (SB328437), CCR4 (C021), CCR5 (maraviroc/AZD5672/TAK-220), CXCR2 (NVPCXCR220/SB225002), CXCR3 (NBI-74330/AMG487), CXCR4 (AMD3100/AMD3465), and XCR1 (vMIP-II). Recent research has shown that multitarget antagonists of chemokine receptors, such as CCR2/5 (cenicriviroc), CXCR1/2 (reparixin), and CCR2/CCR5/CCR8 (RAP-103), are also very effective painkillers. A multidirectional strategy based on the modulation of neuronal–glial–immune interactions by changing the activity of the chemokine family can significantly improve the quality of life of patients suffering from neuropathic pain. However, members of the chemokine family are still underestimated pharmacological targets for pain treatment. In this article, we review the literature and provide new insights into the role of chemokines and their receptors in neuropathic pain. Full article

The clutter becomes non-stationary for a space-based surveillance radar (SBSR), which is harmful for the moving targets detection due to the earth’s rotation. The non-stationarity will degrade the accuracy of clutter covariance matrix (CCM) estimation and increase the clutter degree of freedom (DOF), thereby degrading the performance of clutter suppression. To solve this problem, this paper proposes a novel non-stationary clutter suppression method using an elevation oblique subspace projection method. After analyzing the range ambiguity and non-stationarity of the clutter, the proposed method utilized the oblique projection matrix to project the signal onto the subspace spanned by the near-range and far-range clutter components along the subspace spanned by the main lobe clutter component. Then, the projected signal was used to estimate the elevation covariance matrix and calculate the optimal weight vector for the elevation adaptive filter. The proposed method can suppress the non-stationary clutter effectively with a higher improvement factor (IF) and a narrower main lobe width. Finally, the simulation results were given to verify the correctness and effectiveness of the proposed method. Full article

The subtype 6 of the serotoninergic receptors (5-HT6Rs) is highly expressed in the hippocampus, and evidence indicates the beneficial effects of 5-HT6Rs blockade on short- and long-term memory in rodents. Nevertheless, the underlying functional mechanisms still need to be established. To this end, we performed electrophysiological extracellular recordings to assess the effects of the 5-HT6Rs antagonist SB-271046 on the synaptic activity and functional plasticity at the CA3/CA1 hippocampal connections of male and female mice slices. We found that basal excitatory synaptic transmission and isolated N-methyl-D-aspartate receptors (NMDARs) activation were significantly increased by SB-271046. The NMDARs-related improvement was prevented by the GABAAR antagonist bicuculline in male but not in female mice. Regarding synaptic plasticity, neither paired-pulse facilitation (PPF) nor NMDARs-dependent long-term potentiation (LTP) (induced either by high-frequency or theta-burst stimulation) was affected by the 5-HT6Rs blockade. Taken together, our results indicate a sex-dependent 5-HT6Rs effect on synaptic activity at the CA3/CA1 hippocampal connections through changes in the excitation/inhibition balance. Full article

Underwater light reduction is presumably becoming more frequent and intensified due to eutrophication and algal blooms, which may significantly affect submerged macrophytes’ growth. However, a comprehensive understanding of how light reduction influences growth-related traits and responses is currently lacking. Here, we compiled data from 333 records of 62 published works that used controlled experiments to explore the responses of functional traits associated with growth to light reduction. Our results indicated that light reduction significantly decreased the relative growth rate (RGR), ramet number (RM), shoot biomass (SB), root biomass (RB), soluble carbohydrates (SC), and leaf number (LN) by 38.2%, 60.0%, 59.2%, 55.4%, 30.0%, and 56.1%, respectively, but elevated the chlorophyll content (Chl) by 25.8%. Meanwhile, the responses of RGR to light reduction increased significantly with the responses of RM, SB, RB, and root-to-shoot ratio (R/S). Considering the relationships among the growth-related traits, we further found that the responses of RGR to light reduction were mainly driven by the RM rather than leaf photosynthetic capability, indicating the importance of tiller ability under low light stress. We also identified a tipping point of the response of RGR to light reduction, which might be incorporated into hydrophyte dynamic models to improve precision. Our results highlight the importance of growth-related traits, andthese traits may need to be incorporated into models to improve the prediction of distribution and area for submerged species or to provide guidance for the restoration and sustainable development of aquatic ecosystems. Full article

Research into session-based recommendation systems (SBSR) has attracted a lot of attention, but each study focuses on a specific class of methods. This work examines and evaluates a large range of methods, from simpler statistical co-occurrence methods to embeddings and SotA deep learning methods. This paper analyzes theoretical and practical issues in developing and evaluating methods for SBSR in e-commerce applications, where user profiles and purchase data do not exist. The major tasks of SBRS are reviewed and studied, namely: prediction of next-item, next-basket and purchase intent. For physical retail shopping where no information about the current session exists, we treat the previous baskets purchased by the user as previous sessions drawn from a loyalty system. Mobile application scenarios such as push notifications and calling tune recommendations are also presented. Recommender models using graphs, embeddings and deep learning methods are studied and evaluated in all SBRS tasks using different datasets. Our work contributes a number of very interesting findings. Among all tested models, LSTMs consistently outperform other methods of SBRS in all tasks. They can be applied directly because they do not need significant fine-tuning. Additionally, they naturally model the dynamic browsing that happens in e-commerce web applications. On the other hand, another important finding of our work is that graph-based methods can be a good compromise between effectiveness and efficiency. Another important conclusion is that a “temporal locality principle” holds, implying that more recent behavior is better suited for prediction. In order to evaluate these systems further in realistic environments, several session-based recommender methods were integrated into an e-shop and an A/B testing method was applied. The results of this A/B testing are in line with the experimental results, which represents another important contribution of this paper. Finally, important parameters such as efficiency, application of business rules, re-ranking issues, and the utilization of hybrid methods are also considered and tested, providing comprehensive useful insights into SBRS and facilitating the transferability of this research work to other domains and recommendation scenarios. Full article

This paper studies performance comparison of two shuttle-based storage and retrieval system (SBS/RS) configurations developed on flexible or non-flexible travel policies of shuttles in the system. In the non-flexible SBS/RS, a shuttle is dedicated to a tier so that it cannot travel out of its dedicated aisle and tier. A lifting mechanism is installed in each aisle to provide vertical travel for loads. In flexible SBS/RS, shuttles can travel between tiers by a separate lifting mechanism installed on the other edge point of each aisle. The advantage of that flexible design is that there might be decreased number of shuttles settling in the system compared to the non-flexible design. We simulate the two system configurations and conduct an experimental design for the comparison purpose. Based on the three-performance metrics: total investment cost, throughput rate and energy consumption per transaction, the results show that mainly the flexible system provides better results which might be considered as future system investment for SBS/RS. Full article

While the e-commerce logistics industry is developing rapidly, its sustainable development has received certain attention. The ultimate goal of sustainable development is to achieve common, coordinated, fair, efficient, and multi-dimensional development. To promote the sustainable development of logistics, the automation technology of warehousing is undoubtedly an excellent breakthrough, since the automation technology can not only make the warehousing system efficient and with a low-error rate, but also affect the energy consumption of the warehousing system. This paper studies the Shuttle-Based Storage and Retrieval System (SBS/RS) in automated warehousing. Moreover, the paper classifies the existing literature into three categories: Physical design (including depth, configuration, and number of tiers); control strategy (including scheduling rules, storage strategies, scheduling command, and interference); and performance evaluation (including throughput, time, and energy). These categories are all factors that warehouse designers must consider when designing a system. Finally, this paper proposes future research directions for SBS/RS: Adding speed metrics, limiting buffer size, targeting space constraints, applying four-way shuttles, and increasing the carrying capacity of a single machine. Full article