Search Results (141)

Overtourism has intensified socio-environmental pressures in popular destinations, raising concerns about ethical responsibility and sustainable behavior among tourism actors and visitors. In this study, we explored how environmental awareness and ethical values shape behavioral intentions under overtourism pressure by combining a systematic literature review with qualitative field data from Bali. Through a PRISMA-based review of 100 peer-reviewed journal articles published between 2015 and 2024, we synthesized evidence on environmental ethics, responsible tourism, and pro-environmental behavioral mechanisms. The review reveals that increasing scholarly attention is being paid to ethical norms, emotional engagement, and contextual constraints but shows that there is limited empirical understanding of how these factors are experienced in practice by local actors and domestic tourists. To address this gap, qualitative interviews were conducted with three key stakeholders, including accommodation and tourism service providers, and 10 domestic tourists. Thematic analysis identifies three interrelated mechanisms influencing behavioral intention: (a) recognition of environmental risk and destination vulnerability, (b) ethical reasoning and sense of collective responsibility, and (c) structural barriers shaped by convenience, economic pressures, and weak governance. While participants express strong environmental awareness and moral concern, behavioral intentions are often constrained by limited information, the perceived ineffectiveness of individual actions, and a lack of regulatory enforcement. This study contributes to the sociological literature on sustainable tourism by elucidating how ethics and awareness translate into intention under overtourism pressure. We report the practical implications for ethical communication, stakeholder collaboration, and participatory governance. Full article

Food insecurity (FI) may lead to lower academic achievement, yet college students with inadequate food underutilize campus food pantries. This research aimed to identify predictors of academic success among pantry shoppers (PSs) to inform outreach. Data from AY 2021–2022 (N = 847) and 2022–2023 (N = 951) were derived from swipes of student identification cards, merged with university student-provided data, and de-identified. Multiple regression, logistic regression, and Least Absolute Shrinkage and Selection Operator (LASSO) were employed to create and validate models using Machine Learning. Grade Point Averages (GPAs) were compared by two-sample t tests. The PSs demonstrated higher GPAs in the fall term than non-pantry shoppers (p = 0.04). Validation of the models indicated strong performance. Multiple regression yielded a low prediction error (0.05), and logistic regression achieved 71% accuracy (AUC = 0.776). LASSO identified positive predictors of academic success, including graduate and honors status, junior and senior classification, females, international residency, and frequency of pantry shopping. Negative predictors included part-time status, first-year status, Black or Hispanic ethnicity, and Pell Grant eligibility. Findings underscore the complex interplay between sociodemographic and academic factors that should be considered when planning pantry outreach programs and highlight the need for standardized measures of student pantry utilization, which may aid resource allocation and sustainability. Full article

Diabetes continues to impose significant global health and economic burdens, driving the demand for robust, enzyme-free glucose sensors capable of reliable operation under physiological conditions. Here, we report the development of a high-performance nonenzymatic glucose sensor based on laser-induced graphene (LIG) modified with zinc oxide (ZnO) and platinum (Pt) nanostructures. ZnO was electrodeposited onto LIG with modulation potential and deposition duration systematically optimized. The ZnO/LIG electrodes were characterized electrochemically using potassium ferricyanide and evaluated for glucose oxidation in phosphate-buffered solution. Subsequent electrodeposition of Pt under analogous optimized conditions yielded a ternary Pt/ZnO/LIG architecture with enhanced electrocatalytic activity. Sensor performance was assessed by cyclic voltammetry and chronoamperometry, with hydrodynamic conditions optimized for maximal response. The Pt/ZnO/LIG sensor demonstrated a high sensitivity of 37.125 µA mM⁻¹ cm⁻², a wide linear dynamic range (0.5–10 mM; 12–28 mM), and a low detection limit of 77.78 µM. The electrode exhibited excellent reproducibility, long-term stability over 7 weeks, and strong selectivity against common interfering species. Robust performance was also confirmed through real sample testing, highlighting its applicability in physiologically relevant matrices. These findings highlight the Pt/ZnO/LIG platform as a promising candidate for next-generation enzyme-free glucose monitoring systems for clinical and point-of-care diabetes management. Full article

Background: Early-onset colorectal cancer (EOCRC), defined as diagnosis before age 50, is increasing despite declining colorectal cancer (CRC) rates among older adults. Emerging evidence suggests widening racial and ethnic disparities. We aimed to characterize long-term EOCRC incidence and mortality trends across racial and ethnic groups in the United States with comparisons by tumor subtype. Methods: We conducted a population-based analysis using United States Cancer Statistics data (2001–2021) for EOCRC incidence and National Center for Health Statistics data (2000–2022) for mortality. Analyses were stratified by race/ethnicity and histology. Trends were quantified using average annual percent change (AAPC) with 95% confidence intervals (Cis). Results: Among 474,601 early-onset adenocarcinoma (EO-ADC) cases, incidence increased in all racial and ethnic groups except Non-Hispanic Black individuals, in whom incidence declined (AAPC = −0.35%, 95% CI −0.63 to −0.08; p = 0.01). The steepest incidence increases occurred among American Indian/Alaska Native (AIAN; AAPC = 3.39%, 95% CI 2.70–4.15), Hispanic (AAPC = 0.94%, 95% CI 0.61–1.30), and Asian/Pacific Islander populations (AAPC = 0.64%, 95% CI 0.37–0.95; all p < 0.001). EOCRC mortality increased among AIAN (AAPC = 2.67%, 95% CI 1.26–4.26; p = 0.001) and Hispanic populations (AAPC = 0.81%, 95% CI 0.39–1.27; p < 0.001), but declined among Black individuals (AAPC = −1.08%, 95% CI −1.29 to −0.77; p < 0.001). Neuroendocrine tumors increased more rapidly than adenocarcinomas across all groups. Conclusions: EOCRC incidence and mortality are rising most rapidly among AIAN and Hispanic populations. Distinct incidence trajectories of colorectal neuroendocrine tumors compared with adenocarcinomas highlight the importance of histology-specific analyses for accurate epidemiologic interpretation. Full article

Kennel-raised dogs are exposed to more stressors and fewer positive experiences than dogs raised in homes. We created a Dog Socialization and Training class to enrich the environment of university teaching dogs. Undergraduate students (103 total) were assigned a dog (64 total) to socialize and train for at least 36 30 min periods across 12 weeks. Each student used a Qualitative Behavior Assessments (QBA) tool to score 20 different behaviors on a scale of 0 to 125 for his/her dog at the beginning (PRE) and the end (POST) of each of the nine semesters. The PRE QBA scores were high for the ten positive valence behaviors including Relaxed (mean ± SE: 75 ± 6) and low for the ten negative valence behaviors including Distressed (31 ± 3). Following the interactive experiences, QBA scores for all 20 behaviors appeared to improve from 9% to 53% (p < 0.006). Principal Component Analysis identified four dimensions in the QBA scores that were responsible for most of the data variance. Providing kennel-housed dogs with regular, positive human interactions was perceived to increase the dogs’ positive valence towards humans and reduced negative responses. These benefits are expected to enhance the dogs’ teaching effectiveness with veterinary students, adoptability, and future adaptation to new forever homes. Full article

(1) Background: School-based mental health interventions represent a promising approach to address the substantial treatment gap affecting adolescents, with only 20% of youth with diagnosable mental health conditions receiving adequate care. (2) Methods: This meta-analysis synthesized evidence from 18 randomized controlled trials to examine the effectiveness of school-based mental health interventions and potential moderators of outcomes. (3) Results: Using Hedges’ g as the effect size index and a random-effects model, the analysis revealed a statistically significant overall effect size of 0.068 (95% CI [0.019, 0.117], p = 0.006), indicating small but reliable improvements in adolescent academic, social, emotional, behavioral, and mental health outcomes. Heterogeneity across studies was minimal (I² = 15%), suggesting consistent effects across diverse intervention types and contexts. Meta-regression analyses examining eight potential moderators including intervention focus, grade level, provider type, delivery format, duration, study design, geographic location, and theoretical foundation did not reveal statistically significant moderation effects, likely due to limited statistical power. However, descriptive patterns suggested that targeted interventions, small-group formats, and interventions delivered by mental health professionals may produce larger effects than universal programs, classroom-based approaches, and teacher-delivered interventions. (4) Conclusions: These findings support continued investment in school-based mental health programming while highlighting the need for specialized focus to optimize outcomes for all adolescents. Full article

Understanding how processes of magma genesis and magma differentiation control and modify the chemical composition of erupted lavas from the geochemical measurements of the latter is an under-constrained inverse problem, as there is only one known parameter—the measured composition of the erupted lava—but two unknown parameters—the chemical composition and lithology of the source before melting and how melting, crystallization, and melt–rock interactions act to alter the lava en route to the surface. In this invited contribution, we review nearly seven decades of scientific research that demonstrate the potential of U and Th decay series measurements for unraveling the complexities of oceanic magmatism. We review the underlying nuclear theory, geochemical principles, and application of the ²³⁸U, ²³⁵U, and ²³²Th decay series for (i) defining the timescales of magma genesis during decompression mantle melting, (ii) establishing the timescales of magma recharge and magma degassing, and (iii) determining the eruption ages of oceanic Quaternary volcanism. Full article

The REPRIEVE Trial recently reported high rates of sudden cardiac death (SCD) middle-aged people living with HIV-1 infection (PWH) using the WHO/NIH-recommended two nucleoside reverse transcriptase inhibitors (NRTIs)/one integrase strand inhibitor (INSTI) regimen to manage HIV-1 viremia. To date, clinically relevant animal models to delineate underlying causes for this remain limited. Here, we assessed if HIV-1-infected NOD.Cg-Prkdc^scidIl2rg^tm1Wjl/SzJ humanized mice (Hu-mice) treated with the WHO/NIH-recommended antiretroviral regimen, dolutegravir (DTG, INSTI)/tenofovir disoproxil fumarate (TDF, NRTIs)/emtricitabine (FTC, NRTIs), can recapitulate abnormalities in the ECG and subclinical structural heart disease that serve as harbingers of SCD in middle-aged PWH. HIV-1-infected and uninfected Hu-mice served as controls. After one month of infection (HIV-1_ADA), ECG intervals/segments were significantly altered. ECG changes progressively worsened as the duration of untreated infection increased. Treating HIV-1-infected animals with the DTG/TDF/FTC for eight weeks, starting four weeks after infection, prevented worsening, but did not restore ECG intervals/segments to those before infection. In hearts from DTG/TDF/FTC-treated animals, steady-state levels of the sarco-(endo) plasmic reticulum Ca²⁺ ATPase (SERCA2) were reduced by 35%. Steady-state levels of type 2 ryanodine receptor (RyR2) did not change, but its phosphorylation status at Ser2808 was 2-fold higher than that of uninfected controls, indicative of a gain-of-function. The density of perfused micro vessels and fibrosis in hearts of DTG/TDF/FTC-treated animals was not significantly different from that of HIV-1-infected and uninfected Hu-mice. These data show for the first time that HIV-1 infection is triggering abnormalities in the ECG of Hu-mice, and changes in ECG persisted with DTG/TDF/FTC treatment, independent of ischemia and/or fibrosis. They also indicate that chronic DTG/TDF/FTC treatment did not worsen ECG changes, including the QT interval. Since phosphorylation of RyR2 at Ser2808 occurs via β-adrenergic activation of protein kinase A, these new data also suggest that chronic hyperadrenergic activity may be increasing the risk of SCD via Ca²⁺ leak through RyR2. Full article

Background/Objectives: Osteoarthritis (OA) remains a global health problem, as it can cause permanent joint damage, leading to irreversible disability. Therefore, there is a need for accessible and non-invasive alternative examinations, such as USG, serum COMP, and 25-hydroxyvitamin D [25(OH)D] assessment. This study aims to analyze the correlation between serum COMP and 25(OH)D levels and the degree of articular cartilage degradation in patients with knee OA, based on findings from USG and MRI examinations. Methods: A cross-sectional analytical study was conducted at Mohammad Hoesin Hospital, Palembang, from December 2024 to August 2025. 31 patients diagnosed with knee OA based on the 1990 American College of Rheumatology (ACR) classification criteria were enrolled. Serum COMP and 25(OH)D levels were measured. All patients underwent standardized USG and MRI examinations of the knee. Spearman’s rank correlation coefficient was used for statistical analysis. Results: The majority of the study subjects were female, comprising 23 (74.2%). The mean age was 63.90 ± 7.77 years with a body mass index of 25.46 ± 5.51 kg/m². Most subjects were engaged in heavy physical activity 17 (54.8%). Laboratory examination showed serum COMP levels with a median of 869 ng/mL and a range of 136–3302 ng/mL. Meanwhile, the 25(OH)D level demonstrated a mean value of 24.84 ± 7.33 ng/mL. The analysis revealed a strong and statistically significant positive correlation between serum COMP levels and the degree of articular cartilage degradation in knee OA. This correlation was observed in both USG (r = 0.61; p < 0.001) and MRI assessments (r = 0.72; p < 0.001). In contrast, serum 25(OH)D levels showed no significant correlation with cartilage degradation. The correlation coefficient between 25(OH)D levels and USG-assessed cartilage degradation was r = −0.12 (p = 0.51), and for MRI assessment, it was r = 0.17 (p = 0.92). Conclusions: A strong and significant positive correlation exists between serum COMP levels and the degree of articular cartilage degradation based on USG (r = 0.61; p < 0.001) and MRI (r = 0.72; p < 0.001). In contrast, serum 25(OH)D levels showed no significant correlation with cartilage degradation, implying that 25(OH)D may not directly reflect the extent of structural cartilage damage in knee osteoarthritis. This finding proves that an increase in serum COMP levels is associated with an increase in the degree of articular cartilage degradation in knee OA as measured by both USG and MRI. Full article

Engine knock remains a critical limitation in spark-ignition engine design. Future hybrid powertrains employ downsized engines operating on Atkinson cycles, creating different knock conditions compared to modern naturally aspirated or turbocharged engines. At the same time, petroleum-based gasoline is increasingly being replaced by biofuels and electrofuels. This study evaluates knock behavior in projected hybrid engine architectures and examines the chemical composition of emerging fuel blends. The analysis shows that hybrid engines benefit from fuels with lower sensitivity, defined as the difference between the Research and Motor Octane Numbers. This is because the higher end-gas temperatures associated with the Atkinson cycle shift the value of K, which is an interpolation factor used to capture the relationship between fuel sensitivity and anti-knock performance. In conventional engines, K is negative, favoring fuels with higher sensitivity. In hybrid engines, the increased engine temperatures result in K becoming positive, favoring low-sensitivity fuels. Using low-sensitivity fuels allows hybrid engines to operate with higher geometric compression ratios and advanced thermodynamic cycles while reducing knock constraints. Biofuels and electrofuels can meet these requirements by producing paraffinic and naphthenic hydrocarbons with high octane quality and low sensitivity. These findings emphasize the need to align renewable fuel development with hybrid engine requirements to improve thermal efficiency, reduce emissions, and reduce reliance on energy-intensive refinery processes for octane enhancement. Full article

Soil amendments can enhance soil and plant health; however, limited research has addressed their effects on soil health and crop productivity in alkaline soil. This study investigated the effects of various soil amendments and biostimulants by the Haney Soil Health Test, plant sap analysis, and Cucurbita pepo cv. ‘Dunja’ yield and quality. Treatments included unamended soil (T1) and applications of Humisoil® (T2), Humisoil with biochar (T3), wood vinegar (T4), Ensoil algae^TM (T5), and Humisoil with biochar and basaltic rock dust (T6). Compared to T1, T6, T5, T2, and T3 increased yield by 107%, 87%, 86%, and 52%, respectively. Regarding total fruit number per plant, T2, T6, and T5 outperformed T1 by 42%, 37%, and 37%, respectively. Additionally, T6 decreased Na concentration by 59% in the sap of young leaves and 50% in old leaves compared to T1. Compared to T1, T2 also reduced Na concentration in the sap of old leaves by 63%. For Cl, decreases of 30%, 16%, and 24% in old leaves were observed in T2, T4, and T6 treatments, respectively. These findings highlight the potential of biostimulants and soil amendments to improve zucchini yield and quality while improving soil health in alkaline soils. Full article

The North Atlantic Ocean is vital to Earth’s climate system. Scientific investigations have identified the Atlantic Meridional Overturning Circulation (AMOC) as a significant factor influencing global climate change. This circulation involves ocean currents that carry relatively warm, salty water northward in the upper layers, while transporting colder, less salty water southward in the deeper layers. The AMOC relies on descending water at deep convection sites in the high-latitude North Atlantic (NA), where warmer water cools, becomes denser, and sinks. A concern regarding the AMOC is that the freshening of the sea surface at these convection sites can slow it by inhibiting deep convection. Researchers have used oceanographic observations and models of Earth’s climate and ocean circulation to investigate decadal shifts in the AMOC and NA. We examined these findings to provide insights into these models, observational analyses, and palaeoceanographic reconstructions, aiming to deepen our understanding of AMOC variability and offer potential predictions for future climate change in the North Atlantic. While the influence of high-latitude freshwater is crucial and may slow the AMOC, evidence also shows a complex feedback mechanism. In this mechanism, the negative feedback from wind stress can stabilize the AMOC, partially counteracting the positive feedback effects of freshwater at high latitudes. Although some models predict significant shifts in AMOC dynamics, suggesting imminent and possibly severe deceleration, recent observational research presents a more cautious view. These data analysis studies acknowledge changes, but highlight the robustness of the AMOC, particularly in its upper arm within the Gulf Stream system. While it cannot be entirely dismissed that the AMOC may reach its tipping point within this century, an analysis of data concerning the decadal variability in the AMOC’s upper arm indicates that a collapse is unlikely within this timeframe, although significant weakening remains quite possible. Furthermore, deceleration of the AMOC’s upper arm could lead to less stable and more vulnerable North Atlantic Ocean climate patterns over extended periods. Full article

This study found a strong link between interferon-gamma (IFN-γ) secretion from immune cells and changes in bone quality in pancreatic tumor-bearing humanized-BLT (hu-BLT) mice. Tumor presence in hu-BLT mice led to bone resorption and reduced IFN-γ production compared to healthy mice. Interestingly, oral supplementation with probiotic bacteria AJ2, either alone or combined with supercharged NK (sNK) cells, inhibited tumor growth and increased IFN-γ levels in tissue compartments and tumor sites. Enhanced IFN-γ secretion was observed in cell cultures from the pancreas, spleen, PBMCs, splenocyte-derived NK cells, and bone marrow of mice treated with sNK cells and AJ2 compared to untreated tumor-bearing mice. Higher IFN-γ levels were associated with improved bone integrity in hu-BLT mice. TRAP staining showed increased osteoclastic activity and bone resorption in untreated tumor mice, in contrast to those treated with sNK and AJ2. This research highlights the role of immune cell-derived IFN-γ in preventing tumor-induced bone loss and improving bone quality, suggesting that probiotics, alone or with immunotherapies, have potential as treatments for osteolytic cancers. Full article

Water scarcity poses a substantial challenge for turfgrass irrigation in the drought- and heat-stressed Desert Southwest region of the United States. Bermudagrass (Cynodon spp.), renowned for its exceptional drought resistance, is the predominant warm-season turfgrass in the region. Selecting and using drought-resistant bermudagrass cultivars remains a primary strategy for sustaining the turfgrass industry in the region. This study evaluated 48 hybrid bermudagrasses (Cynodon dactylon × C. transvaalensis Burtt-Davy), including two commercial cultivars (‘TifTuf’ and ‘Tifway’, as controls), under 80% × ETo (0.8ET), 60% × ETo (0.6ET) and 40% × ETo (0.4ET) reference evapotranspiration (ETo) replacement irrigation systems at Maricopa, AZ. The experiment was laid out in a split-plot design with two replications, where the 3 irrigation treatments were assigned to main plots and 48 genotypes were in sub-plots. Analysis of data from two years (2022 and 2023) revealed significant differences among bermudagrass hybrids, irrigation treatments, and their interaction effects. The hybrids exhibited substantial variation for spring green-up, density, turf color, and quality. With the largest deficit irrigation treatment 40% × ETo (0.4ET), OSU2104, OSU2106, and OSU2105 showed greater mean greenness and aesthetic quality scores than recorded for ‘TifTuf’ (6.5), a popular drought-tolerant cultivar. The results highlight the prevalence of genetic variation in germplasm with potential for development of improved varieties for drought tolerance. Full article

Protein Disulfide Isomerases (PDIs) are emerging targets in anticancer therapy, with several PDI inhibitors demonstrating anticancer efficacy in preclinical models. Research has largely focused on “canonical” PDIs, such as PDIA1, which contain CXXC active site motifs where C represents Cysteine. Canonical PDIs have well-studied, critical roles in forming, breaking, and exchanging/scrambling disulfide bonds during protein folding. In contrast, non-canonical PDIs, which harbor CXXS active site motifs, remain less well-studied despite their role as sensors or effectors of protein folding quality control during protein trafficking in the secretory pathway. Here, we provide a review of the literature relating to the non-canonical PDIs ERp44, AGR2, and AGR3, which have been identified as strong dependencies in specific cancer subtypes according to the DepMap database. The biological and biochemical functions of ERp44, AGR2, and AGR3 are discussed, highlighting the role of ERp44 in two mechanisms of protein folding quality control, AGR2 as a selective sensor of mucin protein misfolding, and a unique role for AGR3 in cilia. Finally, we discuss recent efforts to develop small molecule inhibitors of ERp44, AGR2, and AGR3 as tool compounds and experimental therapeutics. Full article