Maximum latewood density (MXD) chronologies have been widely used to reconstruct summer temperature variations. Precipitation signals inferred from MXD data are, however, rather scarce. In this study, we assess the potential of using MXD data derived...
Among the first discovered and most prominent cellular oncogenes is MYC, which encodes a bHLH-ZIP transcription factor (Myc) that both activates and suppresses numerous genes involved in proliferation, energy production, metabolism and translation. M...
Polyphenon E (Poly E) is a standardized, caffeine-free green tea extract with defined polyphenol content. Poly E is reported to confer chemoprotective activity against prostate cancer (PCa) progression in the TRAMP model of human PCa, and has shown l...
Obesity is closely linked to metabolic diseases, particularly non-alcoholic steatohepatitis (NASH) or non-alcoholic fatty liver disease (NAFLD), ultimately leading to hepatocellular carcinoma (HCC). However, the molecular mechanisms of NASH-associate...
We previously found that 1% minoxidil (MXD) nanoparticles prepared using a bead mill method led to an increase I n hair follicle delivery and hair growth in C57BL/6 mice. In the present study, we designed a nanoparticle formulation containing 5% MXD...
Moxidectin (MXD) is an antiparasitic drug used extensively in veterinary clinics. In this study, to develop a new formulation of MXD, a thermosensitive gel of MXD (MXD-TG) was prepared based on poloxamer 407/188. Furthermore, the gelation temperature...
Poly(m-xylylene adipamide) (MXD6) has good gas barrier properties and high mechanical strength. However, in nature, this resin has a low rate of crystallization. In order to overcome this obstacle in its applications, this study prepares a new, effic...
MYC family proteins play fundamental roles in stem and progenitor cell homeostasis, morphogenesis and cancer. As expected for proteins that profoundly affect the fate of cells, the activities of MYC are regulated at a multitude of levels. One mechani...
The Myc Network, comprising a small assemblage of bHLH-ZIP transcription factors, regulates many hundreds to thousands of genes involved in proliferation, energy metabolism, translation and other activities. A structurally and functionally related se...
Myc, a member of the “Myc Network” of bHLH-ZIP transcription factors, supervises proliferation, metabolism, and translation. It also engages in crosstalk with the related “Mlx Network” to co-regulate overlapping genes and func...
The debate on mixed states (MS) has been intense for decades. However, several points remain controversial from a nosographic, diagnostic, and therapeutic point of view. The different perspectives that have emerged over the years have turned into a l...
Maximum latewood density (MXD) measurements from long-lived Black pines (Pinus nigra spp. laricio) growing at the upper treeline in Corsica are one of the few archives to reconstruct southern European summer temperatures at annual resolution back int...
Current topical minoxidil (MXD) formulations involve an unpleasant organic solvent which causes patient incompliance in addition to side effects in some cases. Therefore, the objective of this work was to develop an MXD formulation providing enhanced...
Tree-ring density has been used for climate-response analysis and climate reconstruction for many species. However, our knowledge of wood density for the responses of different species to climate remains very limited and inconclusive. To determine th...
Mixed-use development (MXD) is crucial for urban planning and travel. The COVID-19 outbreak had a significant impact on travel behaviour and MXD projects worldwide, particularly in high-income countries. However, limited studies have explored the pre...
The maximum latewood density (MXD) of tree rings can reflect the temperature of the growing season, but the timing of the response differs among regions. We selected 152 maximum latewood density chronologies from the Northern Hemisphere that showed a...
Limnoperna fortunei, the golden mussel, is a bivalve mollusk considered an invader in South America. This species is responsible for ecological and economic damages due to its voluminous fouling capability. Chemical biocides such as MXD-100™ an...
Moderate Resolution Imaging Spectroradiometer (MODIS) Land Surface Temperature (LST) products are essential data sources for global and regional climate change research. Currently, several versions of the MODIS LST product have been released, yet the...
Radial tree growth at high-elevation and high-latitude sites is predominantly controlled by changes in summer temperature. This relationship is, however, expected to weaken under projected global warming, which questions the reliability of tree-ring...
Combining tree ring data with remote sensing data can help to gain a deeper understanding of the driving factors that influence vegetation change, identify climate events that lead to vegetation change, and improve the parameters of global vegetation...
Ongoing climate variability strongly affects high-elevation forests, influencing the wood formation process (e.g., xylogenesis). Furthermore, spatio-temporal studies to establish links of wood properties and tree performance are needed. Using linear...
Micro- and nanoemulsions are potential drug solubilizers and penetration enhancers through the high surfactant/co-surfactant content. This study aimed to evaluate the influence of minoxidil (MXD) solubilized in the microemulsions (MEs) on drug releas...
Sheep are the most bred species in the Central Italy Apennine using the natural pastures as a trophic resource and grazing activity is fundamental to maintain the grassland biodiversity: this goal can be reached only ensuring an economical sustainabi...
The accurate of i identificationntrinsically disordered proteins or protein regions is of great importance, as they are involved in critical biological process and related to various human diseases. In this paper, we develop a deep neural network tha...
Much research has been conducted to determine how hair regeneration is regulated, as this could provide therapeutic, cosmetic, and even psychological interventions for hair loss. The current study focused on the hair growth effect and effective utili...
Purpose: The aim of this research was to prepare adhesive nanoparticles for the topical application of Minoxidil (MXD). Methods: Thiolated β-CDs were prepared via conjugation of cysteamine with oxidized CDs. MXD was encapsulated within thiolated...
Global reservoir information can not only benefit local water management but can also improve our understanding of the hydrological cycle. This information includes water area, elevation, and storage; evaporation rate and volume values; and other cha...
The biological and psychological importance of hair is recognized worldwide. Molecules that can promote the activation of hair follicle stem cells and the initiation of the growth phase have been subjects of research. Clarifying how hair regeneration...
The Combined ASTER (Advanced Spaceborne Thermal Emission and Reflection Radiometer) MODIS (Moderate Resolution Imaging Spectroradiometer) Emissivity over Land (CAMEL) Version 2 (V002) has been available since March 2019 from the NASA LP DAAC (Land Pr...
RNA polymerase III (Pol III) subunit RPC7α, which is encoded by POLR3G in humans, has been linked to both tumor growth and metastasis. Accordantly, high POLR3G expression is a negative prognostic factor in multiple cancer subtypes. To date, the...
This study performs a systematic analysis of the recent and future changes of dry spells (DS) in Croatia. DS are defined as consecutive sequences of days with daily precipitation less than 5 mm of the precipitation-per-day threshold (DS5). Daily prec...
Fish stocks and their management are paramount for sustainable fisheries under the ongoing changes in atmosphere–sea interactions. The Aegean Sea, one of the composite seas influenced by different water masses, is characterized by a diverse eco...
MNT is a crucial modulator of MYC, controls several cellular functions, and is activated in most human cancers. It is the largest, most divergent, and most ubiquitously expressed protein of the MXD family. MNT was first described as a MYC antagonist...
Surface encrustation by minerals, which impedes cellular metabolism, is a potential hazard for microbes. The reduction of U(VI) to U(IV) by Shewanella oneidensis strain MR-1 leads to the precipitation of the mineral uraninite, as well as a non-crysta...
Ghrelin (GhRL) is an orexigenic hormone influenced by nutritional state. It plays a role in skin repair and diseases, though little information exists regarding its function in this organ. GhRL and its receptor were investigated in the skin of sheep...
The epidermis hosts populations of epithelial stem cells endowed with well-documented renewal and regenerative functions. This tissue thus constitutes a model for exploring the molecular characteristics of stem cells, which remain to date partially c...
The operational Moderate Resolution Imaging Spectroradiometer (MODIS) Aerosol Products (APs) have provided long-term and wide-spatial-coverage aerosol optical properties across the globe, such as aerosol optical depth (AOD). However, the performance...
Satellite-derived rugged land surface temperature (LST) is an important parameter indicating the status of the Earth’s surface energy budget and its seasonal/temporal dynamic change. However, existing LST products from rugged areas are more pro...
Prostate cancer (PCa) is a leading cause of cancer-related deaths among men worldwide, and novel therapies for advanced PCa are urgently needed. Cardiac glycosides represent an attractive group of candidates for anticancer repurposing, but the cardia...
Air pollution contributes significantly to morbidity and mortality globally. The Niger Delta Region of Nigeria flares the second largest amount of natural gas in the world, with residents of oil-producing communities bearing the burden of outdoor pol...