Search Results (27)

Background: Chronic diseases are leading causes of morbidity and mortality worldwide and their prevalence is increasing due to aging and lifestyle factors. A central element in their pathophysiology is chronic low-grade inflammation, linking metabolic, cardiovascular, neurodegenerative, and proliferative disorders. In this context, Opuntia dillenii, a cactus species traditionally used in folk medicine, has attracted considerable scientific interest due to its promising nutraceutical potential. Methods: This systematic review was conducted through a PRISMA-guided literature search using PubMed, Scopus, and Web of Science, identifying 45 studies that analyze the phytochemical composition and biological activity of O. dillenii. Results: The compounds highlighted include betalains, polyphenols, flavonoids, and polysaccharides that exhibit potent anti-inflammatory and analgesic effects by modulating key inflammatory mediators. In addition, O. dillenii demonstrates antiproliferative activity, inducing apoptosis and inhibiting tumor growth in various in vivo models, suggesting a potential role in cancer prevention and as a complementary therapy. The cactus also exhibits antiatherogenic and hypotensive effects, as well as hypolipidemic and antidiabetic properties by improving lipid profiles, reducing serum cholesterol and triglycerides, and enhancing insulin sensitivity. Furthermore, its protective actions against tissue damage extend its therapeutic potential. Antimicrobial properties have also been reported, reinforcing its value as a functional food. Conclusions: Taken together, the evidence supports the use of O. dillenii as a versatile nutraceutical resource with a low toxicity profile, capable of contributing to the prevention and treatment of various chronic inflammatory and metabolic diseases. Nevertheless, human clinical trials are needed to validate these findings and explore their full therapeutic utility. Full article

Fermentation represents a sustainable biotechnological approach for enhancing bioactive properties of plant-based foods, yet its anticancer effects remain underexplored. We evaluated the antiproliferative activity of fermented (with commercial probiotic lactic acid bacteria consortium) and unfermented plant-based beverages derived from tiger nut, carob, and rice using an in vitro model. Following INFOGEST 2.0 gastrointestinal digestion, bioaccessible fractions were applied to Caco-2 colorectal adenocarcinoma cells at 1:15 v/v dilution for 24 h. Analyses included cell viability, apoptosis detection, cell cycle distribution, reactive oxygen species production, glutathione content, mitochondrial membrane potential, and intracellular calcium levels. Fermented tiger nut achieved superior (p < 0.05) cytotoxicity compared to unfermented counterpart (39.6% vs. 77.4% cell viability) through dual mechanisms: depleting cellular antioxidant defenses (glutathione reduced to 55.9%) while inducing oxidative stress (180.3% ROS overproduction). This evoked irreversible apoptosis (76.9% early apoptosis) and extensive DNA fragmentation (84.8% SubG₁ population) via calcium-independent pathways. Fermented carob operated through cytostatic mechanisms, inducing G₀/G₁ cell cycle arrest (74.7% vs. 44.2% in blank digestion cells) without oxidative stress. Fermentation reduced (p < 0.05) rice beverage antiproliferative activity (90.2% vs. 71.9% unfermented beverage cell viability). These findings establish lactic acid fermentation as effective for developing plant-based beverages with anticancer mechanisms, offering dietary strategies for colorectal cancer prevention. Full article

Opuntia dillenii has gained considerable scientific attention as a potential natural source of antioxidants. This systematic review compiles and evaluates current evidence regarding its antioxidant activity. A PRISMA-guided literature search was conducted using PubMed, Scopus, and Web of Science, identifying 37 eligible studies. These studies employed two main methodological approaches: chemical-based assays and biological models. Chemical assays, including radical scavenging and reducing power assays, demonstrated a broad range of antioxidant activity influenced by factors such as the extraction method, plant part, plant maturity, and geographic origin. Polysaccharides, betalains, and polyphenols were consistently identified as primary contributors to these effects. Biological models further supported the antioxidant properties of O. dillenii extracts. In animal studies, administration of the extracts significantly improved oxidative stress biomarkers, increasing glutathione levels, reducing malondialdehyde concentrations, and enhancing the activity of antioxidant enzymes, particularly in the liver and other digestive tissues like the colon, stomach, and pancreas. Cellular studies using hepatocyte, macrophage, enterocyte, and neuronal cell lines produced comparable results, confirming the antioxidant effects. In conclusion, O. dillenii exhibits promising antioxidant potential across various experimental models. However, the absence of human clinical trials highlights the need for further research to establish its efficacy and safety as a nutraceutical product. Full article

Understanding aeolian sediment transport and wind erosion enhances our knowledge of desert dune formation and sand migration. The Makran region of southern Sistan and Baluchistan is prone to wind-driven erosion alongside frequent sand and dust storms (SDSs). Hourly wind data from two meteorological stations spanning 1994–2020 were analyzed to study erosive winds and sand transport. Wind energy analysis using drift potential (DP) indicated low energy (DP < 200 in vector unit) and minimal spatial variation across the Makran dune fields. The effective winds transporting sand particles were towards the east from November to May, and in the northwestern direction from June to October. The DP showed a gradual decline in the study area from 1990 to 2022, with no significant temporal trends. The sand dune morphology analysis indicates that bimodal wind regimes primarily form linear dunes and sand sheets, while crescentic, transverse, and topographic dunes are also present. Full article

Pakistan’s marine fishing industry is crucial to the country’s economy, generating employment opportunities and foreign revenue. It produces 80% of the country’s total fish production. Otolithes ruber is a commercially important fish on the Makran coast of Pakistan, contributing significantly to the region’s croaker fisheries. This study is the first to apply three length-based approaches for assessing the stock status of O. ruber in the Makran coast: (1) TropFishR to estimate the mortality, growth parameters, and current exploitation status, reference points based on the yield per recruitment model, (2) the length-based Bayesian biomass method (LBB) to calculate stock biomass, and (3) the length-based spawning potential ratio (LBSPR) to estimate the spawning potential ratio. The length–weight relationship of Otolithes ruber was a positive allometric pattern (b = 3.28; R² = 0.94). Growth parameters for Otolithes ruber were L_∞ = 55.47 cm, K = 0.50 year⁻¹. The calculated total mortality rate (Z), natural mortality (M), and fishing mortality (F) were 2.27 year⁻¹, 0.67 year⁻¹, and 1.6 year⁻¹, respectively. The exploitation rate (E) was 0.70, indicating severe overexploitation. The current length at first capture (Lc₅₀) = 27.37 cm was lower than that at first maturity (Lm₅₀) = 30.75 cm, indicating growth overfishing. The current spawning potential ratio (8%) was lower than the optimal value (40%), indicating recruitment overfishing. The current biomass, concerning virgin biomass B/B_o, was also 8%, resulting in a 92% stock decline. We recommend reducing the exploitation pressure by limiting the commercial catch to an optimum length range of 34.5–42.2 cm and reducing fishing pressure by 40% to ensure sustainable fishery management. Full article

The Makran Subduction Zone (MSZ) is a tectonic plate boundary where the Arabian Plate is subducting beneath the Eurasian Plate. This study investigated the dynamic response in the Gwadar region, located in the eastern part of the MSZ. A suite of seismic records compatible with the Building Code of Pakistan (BCP:2021) rock design spectrum was used as the input ground motions at the bedrock. The amplification characteristics were assessed through a series of one-dimensional (1D) site response analyses utilizing a non-linear (NL) approach. The results revealed significant de-amplification in soft soils at short spectral periods. A general depth-wise decrease in the shear stress ratio and peak ground acceleration values was observed, influenced by shear-strain-induced effects and shear wave velocity reversals within the site profiles. The code spectra, compared to the proposed design spectra, underestimated the site amplification for stiff soils (i.e., Site Class D) for periods of less than 0.32 s and overestimated it for soft soils (i.e., Site Class E) across all periods. These findings underscore the necessity for site-specific ground response analyses, particularly within the framework of the China–Pakistan Economic Corridor (CPEC). Full article

A Bottom Simulating Reflector (BSR) is a seismic feature closely related to marine gas hydrate as it is usually regarded as the seismic response of the base of the gas hydrate stability zone in seismic profiles. BSRs are widely distributed in the Makran accretionary wedge, and double BSRs are observed at some locations. Double BSRs usually appear on seismic profiles as two layers of BSRs located at distinct depths but with large lateral seismic amplitude variations. Based on the multi-channel seismic reflection data acquired over the Makran accretionary wedge, this work studies the origin of the double BSR in the Makran accretionary wedge and its association with fluid escape events. Our modeling suggests that double BSRs correspond to both the paleo-seafloor and modern seafloor caused by late sedimentary activities. Also, the residual paleo-BSR migrates upward due to the increase in local geothermal gradient caused by diapirs and gas chimney thermal fluids. Full article

Tsunamis are destructive oceanic hazards caused by underwater disturbances, mainly earthquakes. A deterministic tsunami hazard assessment for the United Arab Emirates (UAE), due to the Makran Subduction Zone (MSZ), was conducted based on the history of earthquakes in the region and considering the rapid development and urbanization of the east coast of the UAE. A variety of earthquake source scenarios was modeled, involving moment magnitudes of 8.2, 8.8, and 9.2. Tsunami travel time (TTT), run-up, flow depth, and inundation maps were generated to pinpoint the areas susceptible to tsunami hazards for the eastern coastal cities of Kalba, Al Fujairah, Khor Fakkan, and Dibba. The results show that the worst-case M_w 9.2 earthquake in a full MSZ rupture scenario resulted in an average TTT of 37 min, a maximum run-up height of 2.55 m, a maximum flow depth of 2.2 m, and a maximum inundation distance of 253 m on the east coast of the UAE. The M_w 8.2 western MSZ earthquake and the M_w 8.8 eastern MSZ earthquake scenarios were of less significant impact. These findings provide new insights into tsunami hazard assessment and are expected to play a vital role in advancing sustainable development in the region by providing key information for stakeholders and authorities as they highlight the need for enhanced tsunami mitigation and preparedness measures to reduce the potential impact of future tsunamis on the UAE. Full article

This review synthesizes existing research to elucidate the factors driving the distinct tectonic behaviors in the western and eastern Makran subduction zone, focusing on seismic activity, uplift rate, convergence rate, coupling, and subduction angle. The literature identifies the asymmetry in pressure and the variation in subduction angles between the western and eastern parts of the Makran as key factors in defining the region’s tectonic patterns. The western region has a steeper subduction angle, resulting in lower pressure, reduced coupling, and decreased seismic activity. This disparity arises from different interactions between the subducted and overriding plates. This article offers an overview of the Makran subduction zone, identifies some knowledge gaps, and suggests directions for future research to improve our understanding of this complex geological region. The review highlights the need for more comprehensive GPS stations and targeted studies on subduction dip angles to better understand the region’s tectonic dynamics. Full article

Plant sterols (PSs) have reported benefits in alleviating colitis in mice, but the mechanisms involved require further investigation. This study aimed to evaluate the effect of a dietary supplement containing PSs (PS-DS) on inflammation biomarkers in a mice model of chronic ulcerative colitis induced by dextran sulfate sodium (DSS). C57BL/6J mice (n = 34) were exposed to 1.5% DSS in drinking water for three 5-day periods, with 10-day rest intervals in between. The mice received daily PS-DS (35 mg PS/kg) or placebo by oral gavage, either simultaneously (treatment) or 30 days prior (pre-treatment) to DSS exposition. After euthanasia, myeloperoxidase (MPO) activity and the levels of pro- (TNF-α and IL-6) and anti-inflammatory cytokines (IL-10) in the colonic tissue were analyzed. PS-DS treatment reduced (vs. DSS + placebo) myeloperoxidase (MPO) activity (2.6 ± 0.2 vs. 2.1 ± 0.1-fold change) and levels of TNF-α (85 ± 11 vs. 39 ± 7 pg/mg protein) and IL-6 (214 ± 26 vs. 128 ± 18 pg/mg protein), increasing the levels of IL-10 (46 ± 5 vs. 136 ± 16 pg/mg protein). PS-DS pre-treatment provided a greater inhibition (vs. treatment) of MPO activity (2.1 ± 0.3 vs. 1.3 ± 0.1-fold change) and a greater increase in IL-10 levels (50 ± 9 vs. 178 ± 30 pg/mg protein). These findings suggest that PS-DS has the potential to alleviate colitis in mice by modulating the inflammatory response and reducing oxidative stress. However, studies in humans are required to validate and fully understand its anti-inflammatory effect. Full article

This study proposes an artificial intelligence approach to assess watershed morphometry in the Makran subduction zones of South Iran and Pakistan. The approach integrates machine learning algorithms, including artificial neural networks (ANN), support vector regression (SVR), and multivariate linear regression (MLR), on a single platform. The study area was analyzed by extracting watersheds from a Digital Elevation Model (DEM) and calculating eight morphometric indices. The morphometric parameters were normalized using fuzzy membership functions to improve accuracy. The performance of the machine learning algorithms is evaluated by mean squared error (MSE), mean absolute error (MAE), and correlation coefficient (R²) between the output of the method and the actual dataset. The ANN model demonstrated high accuracy with an R² value of 0.974, MSE of 4.14 × 10⁻⁶, and MAE of 0.0015. The results of the machine learning algorithms were compared to the tectonic characteristics of the area, indicating the potential for utilizing the ANN algorithm in similar investigations. This approach offers a novel way to assess watershed morphometry using ML techniques, which may have advantages over other approaches. Full article

The river sediments in the eastern Makran were investigated to determine the influence of climate, tectonics, and source rocks based on the geochemistry of sediment delivery to the offshore marine basin. Samples were collected at the outlets of four major drainage basins. The specimens were analyzed by XRF, ICP–MS, and ICP–AES. The geochemical concentrations of major, trace, and rare earth elements show great variation among the four outlets. The Rakhshan Kaur (RK), Shadi Kaur (SK), and Dasht Kaur (DK) represent more sorted and matured detrital sediments than those of the Hingol Kaur (HK). The detrital sediments at all outlets represent mostly humid climates except for the DK which falls at the junction of humid and semi-arid conditions. The studied samples show a low level of source area weathering. The sedimentary provenance of the RK and DK is due to the heterogeneous sources of detritus from Iran in the west and the older Eocene-Holocene sedimentary successions in the east. The sediment carried by SK is probably from the late Oligocene–Holocene succession from central and coastal Makran. The HK represents a heterogeneous provenance from the Kirthar-Sulaiman Belt, Bela Ophiolites, and sedimentary successions of central and coastal Makran. The tectonic environments of all river sediments signify a continental arc rather than an active continental margin. Full article

The purpose of this study is the fabrication and performance evaluation of a new type of solar humidification–dehumidification (HD) desalination unit to supply sufficient fresh water for a seawater greenhouse in the MAKRAN coast in southeast Iran. In the proposed design, a particular type of air-to-air condenser is used. The cold air coming out of the greenhouse ventilation system (fan and pad) in summer and the cold ambient air in winter is used to supply the required cooling of the system. In this way, when cold air passes over the pipes in air-to-air condensers, condensation of water vapor occurs in the moist air inside the pipes, and fresh water is produced. Greenhouse fans, which have an air flow rate of around 20,000 m³/hr, are used to create this air flow. By fabricating two condensers, each using 42 rows of PVC pipes with a diameter of 75 mm, it is possible to produce 400 L of fresh water per day in a 400 m² greenhouse. The required heating is provided by the solar farm, which includes 96 square meters of flat plate collectors. The steps of unit fabrication are described in detail in this research. However, the effect of greenhouse air temperature and circulating seawater flow rate on freshwater production, energy consumption, and energy intensity are also investigated. By increasing the flow rate of circulating seawater and decreasing the greenhouse air temperature, the production rate of the system increases. When the hot seawater and greenhouse air temperature are 61.7 °C and 26 °C, respectively, the maximum instantaneous production is estimated to be 80 L/h. The energy intensity of the HD desalination unit is varied between 3192 and 4382 kJ/L, and the gain output ratio of the system is around 0.6. The proposed system can be easily paired with conventional greenhouses employing a fan and pad cooling system and produces around 1.25 (L/m²·day) fresh water. Full article

Bread is one of the staple foods of many countries, and its enrichment with bioactive compounds is trending. This phenomenon is focused on breads with a good nutritional profile, such as wholemeal rye bread (WRB), in which enrichment with plant sterols (PSs) is allowed in accordance with European regulations. The objective of the present study was to optimize the production of a WRB enriched with PS (PS-WRB) and to evaluate the proximate composition and starch digestibility as an indicator of nutritional quality. The rheological analysis showed that the bread dough presents satisfactory farinographic properties (dough development time 6 min; stability 4 min; degree of softening 100 Brabender units) but high water absorption (67%). The PS-WRB is high in dietary fiber and low in protein (20.4 and 7.7% w/w, dry basis, respectively) compared with other cereals reported in the scientific literature. In turn, a low starch proportion was hydrolyzed during the simulated digestion (59.9% of total starch), being also slowly hydrolyzed, as deduced from the rapidly digestible starch value (56.5% of total starch). In conclusion, WRB is a suitable matrix for PS enrichment, which allows for obtaining a product with a good nutritional profile and potential health benefits. Full article

The fortification of foods with cholesterol-lowering agents such as plant sterols (PS) is allowed in Europe and could be of interest to the elderly since aging may lead to higher cardiovascular risk. To date, no studies have analyzed how the gastrointestinal conditions of the elderly affect PS bioaccessibility. Thus, this study evaluates the impact of adapting the standardized INFOGEST 2.0 method for adult to elderly physiological conditions on the bioaccessibility (BA) of PS-enriched wholemeal rye bread. For this purpose, changes in gastric or gastric and intestinal phase conditions (enzyme activity, pH, digestion time, or agitation) were made. Compared to adults, only when gastric and intestinal phase conditions were modified, the BA (%) decreased for individual (10.9–20.5 vs. 19.5–36.3) and total PSs (11.4 ± 1.7 vs. 20.5 ± 1.0), demonstrating that this reduction is due to intestinal phase modifications. However, the order of BA was not modified under any of the conditions tested, following the increasing rank: β-sitosterol, campesterol, Δ7-stigmasterol, sitostanol, Δ5,24, stigmastadienol, Δ5-avenasterol, Δ7avenasterol, stigmasterol, and campestanol. This complex matrix, very rich in fiber, such as wholemeal rye bread, may be responsible for the enzymatic reduction affecting PS solubility in the adapted digestion elderly model. Full article