Search Results (47)

Pulmonary dynamic contrast-enhanced (DCE) MRI is clinically useful for assessing pulmonary perfusion, but its signal-to-noise ratio (SNR) is limited. A self-supervised learning network-based plug-and-play (PnP) denoising model was developed to improve the image quality of pulmonary perfusion MRI. A dataset of patients with suspected pulmonary diseases was used. Asymmetric pixel-shuffle downsampling blind-spot network (AP-BSN) training inputs were two-dimensional background-subtracted perfusion images without clean ground truth. The AP-BSN is incorporated into a PnP model (PnP-BSN) for balancing noise control and image fidelity. Model performance was evaluated by SNR, sharpness, and overall image quality from two radiologists. The fractal dimension and k-means segmentation of the pulmonary perfusion images were calculated for comparing denoising performance. The model was trained on 29 patients and tested on 8 patients. The performance of PnP-BSN was compared to denoising convolutional neural network (DnCNN) and a Gaussian filter. PnP-BSN showed the highest reader scores in terms of SNR, sharpness, and overall image quality as scored by two radiologists. The expert scoring results for DnCNN, Gaussian, and PnP-BSN were 2.25 ± 0.65, 2.44 ± 0.73, and 3.56 ± 0.73 for SNR; 2.62 ± 0.52, 2.62 ± 0.52, and 3.38 ± 0.64 for sharpness; and 2.16 ± 0.33, 2.34 ± 0.42, and 3.53 ± 0.51 for overall image quality (p < 0.05 for all). PnP-BSN outperformed DnCNN and a Gaussian filter for denoising pulmonary perfusion MRI, which led to improved quantitative fractal analysis. Full article

Medical imaging is crucial for disease diagnosis, but noise in CT and MRI scans can obscure critical details, making accurate diagnosis challenging. Traditional denoising methods and deep learning techniques often produce overly smooth images that lack vital diagnostic information. GAN-based approaches also struggle to balance noise removal and content preservation. Existing research has not explored tumor detection after image denoising; instead, it has concentrated on content and noise learning. To address these challenges, this study proposes the Adversarial Content–Noise Complementary Learning (ACNCL) model, which enhances image denoising and tumor detection. Unlike conventional methods focusing solely on content or noise learning, ACNCL simultaneously learns both through dual predictors, ensuring the complementary reconstruction of high-quality images. The model integrates multiple denoising techniques (DnCNN, U-Net, DenseNet, CA-AGF, and DWT) within a GAN framework, using PatchGAN as a local discriminator to preserve fine image textures. The ACNCL separates anatomical details and noise into distinct pathways, ensuring stable noise reduction while maintaining structural integrity. Evaluated on CT and MRI datasets, ACNCL demonstrated exceptional performance compared to traditional models both qualitatively and quantitatively. It exhibited strong generalization across datasets, improving medical image clarity and enabling earlier tumor detection. These findings highlight ACNCL’s potential to enhance diagnostic accuracy and support improved clinical decision-making. Full article

Most existing methods for magnetic resonance imaging (MRI) reconstruction with deep learning use fully supervised training, which assumes that a fully sampled dataset with a high signal-to-noise ratio (SNR) is available for training. In many circumstances, however, such a dataset is highly impractical or even technically infeasible to acquire. Recently, a number of self-supervised methods for MRI reconstruction have been proposed, which use sub-sampled data only. However, the majority of such methods, such as Self-Supervised Learning via Data Undersampling (SSDU), are susceptible to reconstruction errors arising from noise in the measured data. In response, we propose Robust SSDU, which provably recovers clean images from noisy, sub-sampled training data by simultaneously estimating missing k-space samples and denoising the available samples. Robust SSDU trains the reconstruction network to map from a further noisy and sub-sampled version of the data to the original, singly noisy, and sub-sampled data and applies an additive Noisier2Noise correction term upon inference. We also present a related method, Noiser2Full, that recovers clean images when noisy, fully sampled data are available for training. Both proposed methods are applicable to any network architecture, are straightforward to implement, and have a similar computational cost to standard training. We evaluate our methods on the multi-coil fastMRI brain dataset with novel denoising-specific architecture and find that it performs competitively with a benchmark trained on clean, fully sampled data. Full article

This study introduces a non-destructive, quantitative method using low-field MRI to assess moisture mobility and content distribution in cherry tomatoes. This study developed an advanced 3D non-local mean denoising model to enhance tissue feature analysis and applied an optimized TransUNet model for structural segmentation, obtaining multi-echo data from six tissue types. The structural T2 relaxation inversion was refined by integrating an ACS-CIPSO algorithm. This approach addresses the challenge of low signal-to-noise ratios in multi-echo MRI images from low-field equipment by introducing an innovative solution that effectively reduces voxel noise while retaining structural relaxation variability. The study reveals that there are consistent patterns in the changes in moisture mobility and content across different structures of cherry tomatoes during their ripening process. Mono-exponential analysis reveals the patterns of changes in moisture mobility (T2) and content (A) across various structures. Furthermore, tri-exponential analysis elucidates the patterns of changes in bound water (T21), semi-bound water (T22), and free water (T23), along with their respective contents. These insights offer a novel perspective on the changes in moisture mobility throughout the ripening process of tomato fruit, thereby providing a research pathway for the precise assessment of moisture status and ripening expression in fruits. Full article

Super-resolution (SR) techniques have shown significant promise in enhancing the resolution of MRI images, which are often limited by hardware constraints and acquisition time. In this study, we introduce an advanced regularization method for MRI super-resolution that integrates spatially adaptive techniques with a robust denoising process to improve image quality. The proposed method excels in preserving high-frequency details while effectively suppressing noise, addressing common limitations of conventional SR approaches. The validation of clinical MRI datasets demonstrates that our approach achieves superior performance compared to traditional algorithms, yielding enhanced image clarity and quantitative improvements in metrics such as the peak signal-to-noise ratio (PSNR) and structural similarity index (SSIM). Full article

Breast cancer is the most common type of cancer in women and poses a significant health risk to women globally. Developments in computer-aided diagnosis (CAD) systems are focused on specific tasks of classification and segmentation, but few studies involve a completely integrated system. In this study, a comprehensive CAD system was proposed to screen ultrasound, mammograms and magnetic resonance imaging (MRI) of breast cancer, including image preprocessing, breast cancer classification, and tumour segmentation. First, the total variation filter was used for image denoising. Second, an optimised XGBoost machine learning model using EfficicnetB0 as feature extraction was proposed to classify breast images into normal and tumour. Third, after classifying the tumour images, a hybrid CNN deep learning model integrating the strengths of MobileNet and InceptionV3 was proposed to categorise tumour images into benign and malignant. Finally, Attention U-Net was used to segment tumours in annotated datasets while classical image segmentation methods were used for the others. The proposed models in the designed CAD system achieved an accuracy of 96.14% on the abnormal classification and 94.81% on tumour classification on the BUSI dataset, improving the effectiveness of automatic breast cancer diagnosis. Full article

In medical imaging, noise can significantly obscure critical details, complicating diagnosis and treatment. Traditional denoising techniques often struggle to maintain a balance between noise reduction and detail preservation. To address this challenge, we propose an “Efficient Transfer-Learning-Based Fractional Order Image Denoising Approach in Medical Image Analysis (ETLFOD)” method. Our approach uniquely integrates transfer learning with fractional order techniques, leveraging pre-trained models such as DenseNet121 to adapt to the specific needs of medical image denoising. This method enhances denoising performance while preserving essential image details. The ETLFOD model has demonstrated superior performance compared to state-of-the-art (SOTA) techniques. For instance, our DenseNet121 model achieved an accuracy of 98.01%, precision of 98%, and recall of 98%, significantly outperforming traditional denoising methods. Specific results include a 95% accuracy, 98% precision, 99% recall, and 96% F1-score for MRI brain datasets, and an 88% accuracy, 91% precision, 95% recall, and 88% F1-score for COVID-19 lung data. X-ray pneumonia results in the lung CT dataset showed a 92% accuracy, 97% precision, 98% recall, and 93% F1-score. It is important to note that while we report performance metrics in this paper, the primary evaluation of our approach is based on the comparison of original noisy images with the denoised outputs, ensuring a focus on image quality enhancement rather than classification performance. Full article

Background: Silent MRA has shown promising results in evaluating the stents used for intracranial aneurysm treatment. A deep learning-based denoising and deranging algorithm was recently introduced by GE HealthCare. The purpose of this study was to compare the performance of several MRA techniques regarding lumen visibility in silicone models with flow diverter stents. Methods: Two Surpass Evolve stents of different sizes were implanted in two silicone tubes. The tubes were placed in separate boxes in the straight position and in two different curve configurations and connected to a pulsatile pump to construct a flow loop. Using a 3.0T MRI scanner, TOF and silent MRA images were acquired, and deep learning reconstruction was applied to the silent MRA dataset. The intraluminal signal intensity in the stent (SI_in-stent), in the tube outside the stent (SI_vessel), and of the background (SI_bg) were measured for each scan. Results: The SI_in-stent/SI_bg and SI_in-stent/SI_v ratios were higher in the silent scans and DL-based reconstructions than in the TOF images. The stent tips created severe artefacts in the TOF images, which could not be observed in the silent scans. Conclusions: Our study demonstrates that the DL reconstruction algorithm improves the quality of the silent MRA technique in evaluating the flow diverter stent patency. Full article

The inevitable noise generated in the acquisition and transmission process of MRIs seriously affects the reliability and accuracy of medical research and diagnosis. The denoising effect for Rician noise, whose distribution is related to MR image signal, is not good enough. Furthermore, the brain has a complex texture structure and a small density difference between different parts, which leads to higher quality requirements for brain MR images. To upgrade the reliability and accuracy of brain MRIs application and analysis, we designed a new and dedicated denoising algorithm (named VST–MCAATE), based on their inherent characteristics. Comparative experiments were performed on the same simulated and real brain MR datasets. The peak signal-to-noise ratio (PSNR), and mean structural similarity index measure (MSSIM) were used as objective image quality evaluation. The one-way ANOVA was used to compare the effects of denoising between different approaches. p < 0.01 was considered statistically significant. The experimental results show that the PSNR and MSSIM values of VST–MCAATE are significantly higher than state-of-the-art methods (p < 0.01), and also that residual images have no anatomical structure. The proposed denoising method has advantages in improving the quality of brain MRIs, while effectively removing the noise with a wide range of unknown noise levels without damaging texture details, and has potential clinical promise. Full article

This study introduces a hybrid analytical super-resolution (SR) pipeline aimed at enhancing the resolution of medical magnetic resonance imaging (MRI) scans. The primary objective is to overcome the limitations of clinical MRI resolution without the need for additional expensive hardware. The proposed pipeline involves three key steps: pre-processing to re-slice and register the image stacks; SR reconstruction to combine information from three orthogonal image stacks to generate a high-resolution image stack; and post-processing using an artefact reduction convolutional neural network (ARCNN) to reduce the block artefacts introduced during SR reconstruction. The workflow was validated on a dataset of six knee MRIs obtained at high resolution using various sequences. Quantitative analysis of the method revealed promising results, showing an average mean error of 1.40 ± 2.22% in voxel intensities between the SR denoised images and the original high-resolution images. Qualitatively, the method improved out-of-plane resolution while preserving in-plane image quality. The hybrid SR pipeline also displayed robustness across different MRI sequences, demonstrating potential for clinical application in orthopaedics and beyond. Although computationally intensive, this method offers a viable alternative to costly hardware upgrades and holds promise for improving diagnostic accuracy and generating more anatomically accurate models of the human body. Full article

This paper investigates the distribution characteristics of Fourier, discrete cosine, and discrete sine transform coefficients in T1 MRI images. This paper reveals their adherence to Benford’s law, characterized by a logarithmic distribution of first digits. The impact of Rician noise on the first digit distribution is examined, which causes deviations from the ideal distribution. A novel methodology is proposed for noise level estimation, employing metrics such as the Bhattacharyya distance, Kullback–Leibler divergence, total variation distance, Hellinger distance, and Jensen–Shannon divergence. Supervised learning techniques utilize these metrics as regressors. Evaluations on MRI scans from several datasets coming from a wide range of different acquisition devices of 1.5 T and 3 T, comprising hundreds of patients, validate the adherence of noiseless T1 MRI frequency domain coefficients to Benford’s law. Through rigorous experimentation, our methodology has demonstrated competitiveness with established noise estimation techniques, even surpassing them in numerous conducted experiments. This research empirically supports the application of Benford’s law in transforms, offering a reliable approach for noise estimation in denoising algorithms and advancing image quality assessment. Full article

Medical imaging-based biomarkers derived from small objects (e.g., cell nuclei) play a crucial role in medical applications. However, detecting and segmenting small objects (a.k.a. blobs) remains a challenging task. In this research, we propose a novel 3D small blob detector called BlobCUT. BlobCUT is an unpaired image-to-image (I2I) translation model that falls under the Contrastive Unpaired Translation paradigm. It employs a blob synthesis module to generate synthetic 3D blobs with corresponding masks. This is incorporated into the iterative model training as the ground truth. The I2I translation process is designed with two constraints: (1) a convexity consistency constraint that relies on Hessian analysis to preserve the geometric properties and (2) an intensity distribution consistency constraint based on Kullback-Leibler divergence to preserve the intensity distribution of blobs. BlobCUT learns the inherent noise distribution from the target noisy blob images and performs image translation from the noisy domain to the clean domain, effectively functioning as a denoising process to support blob identification. To validate the performance of BlobCUT, we evaluate it on a 3D simulated dataset of blobs and a 3D MRI dataset of mouse kidneys. We conduct a comparative analysis involving six state-of-the-art methods. Our findings reveal that BlobCUT exhibits superior performance and training efficiency, utilizing only 56.6% of the training time required by the state-of-the-art BlobDetGAN. This underscores the effectiveness of BlobCUT in accurately segmenting small blobs while achieving notable gains in training efficiency. Full article

This paper presents a parallel implementation of a non-local transform-domain filter (BM4D). The effectiveness of the parallel implementation is demonstrated by denoising image series from computed tomography (CT) and magnetic resonance imaging (MRI). The basic idea of the filter is based on grouping and filtering similar data within the image. Due to the high level of similarity and data redundancy, the filter can provide even better denoising quality than current extensively used approaches based on deep learning (DL). In BM4D, cubes of voxels named patches are the essential image elements for filtering. Using voxels instead of pixels means that the area for searching similar patches is large. Because of this and the application of multi-dimensional transformations, the computation time of the filter is exceptionally long. The original implementation of BM4D is only single-threaded. We provide a parallel version of the filter that supports multi-core and many-core processors and scales on such versatile hardware resources, typical for high-performance computing clusters, even if they are concurrently used for the task. Our algorithm uses hybrid parallelisation that combines open multi-processing (OpenMP) and message passing interface (MPI) technologies and provides up to 283× speedup, which is a 99.65% reduction in processing time compared to the sequential version of the algorithm. In denoising quality, the method performs considerably better than recent DL methods on the data type that these methods have yet to be trained on. Full article

Chemical Exchange Saturation Transfer (CEST) magnetic resonance imaging (MRI) provides a novel method for analyzing biomolecule concentrations in tissues without exogenous contrast agents. Despite its potential, achieving a high signal-to-noise ratio (SNR) is imperative for detecting small CEST effects. Traditional metrics such as Magnetization Transfer Ratio Asymmetry (MTR_asym) and Lorentzian analyses are vulnerable to image noise, hampering their precision in quantitative concentration estimations. Recent noise-reduction algorithms like principal component analysis (PCA), nonlocal mean filtering (NLM), and block matching combined with 3D filtering (BM3D) have shown promise, as there is a burgeoning interest in the utilization of neural networks (NNs), particularly autoencoders, for imaging denoising. This study uses the Bloch–McConnell equations, which allow for the synthetic generation of CEST images and explores NNs efficacy in denoising these images. Using synthetically generated phantoms, autoencoders were created, and their performance was compared with traditional denoising methods using various datasets. The results underscored the superior performance of NNs, notably the ResUNet architectures, in noise identification and abatement compared to analytical approaches across a wide noise gamut. This superiority was particularly pronounced at elevated noise intensities in the in vitro data. Notably, the neural architectures significantly improved the PSNR values, achieving up to 35.0, while some traditional methods struggled, especially in low-noise reduction scenarios. However, the application to the in vivo data presented challenges due to varying noise profiles. This study accentuates the potential of NNs as robust denoising tools, but their translation to clinical settings warrants further investigation. Full article

Magnetic resonance imaging (MRI) is a technique that is widely used in practice to evaluate any pathologies in the human body. One of the areas of interest is the human brain. Naturally, MR images are low-resolution and contain noise due to signal interference, the patient’s body’s radio-frequency emissions and smaller Tesla coil counts in the machinery. There is a need to solve this problem, as MR tomographs that have the capability of capturing high-resolution images are extremely expensive and the length of the procedure to capture such images increases by the order of magnitude. Vision transformers have lately shown state-of-the-art results in super-resolution tasks; therefore, we decided to evaluate whether we can employ them for structural MRI super-resolution tasks. A literature review showed that similar methods do not focus on perceptual image quality because upscaled images are often blurry and are subjectively of poor quality. Knowing this, we propose a methodology called HR-MRI-GAN, which is a hybrid transformer generative adversarial network capable of increasing resolution and removing noise from 2D T1w MRI slice images. Experiments show that our method quantitatively outperforms other SOTA methods in terms of perceptual image quality and is capable of subjectively generalizing to unseen data. During the experiments, we additionally identified that the visual saliency-induced index metric is not applicable to MRI perceptual quality assessment and that general-purpose denoising networks are effective when removing noise from MR images. Full article