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Keywords = Integrated Management Systems (IMS)

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14 pages, 1110 KB  
Article
Modular System for High-Precision Irrigation with Nutrients Addition
by Elena Serea, Codrin Donciu and Marinel Costel Temneanu
Appl. Sci. 2025, 15(16), 8819; https://doi.org/10.3390/app15168819 - 10 Aug 2025
Viewed by 404
Abstract
Precision agriculture necessitates irrigation systems capable of adapting to spatial variability and dynamic crop requirements. Existing systems often rely on costly infrastructures or lack the fine-grained control and integration of fertigation. This paper presents the development and experimental validation of a cost-effective, modular [...] Read more.
Precision agriculture necessitates irrigation systems capable of adapting to spatial variability and dynamic crop requirements. Existing systems often rely on costly infrastructures or lack the fine-grained control and integration of fertigation. This paper presents the development and experimental validation of a cost-effective, modular Irrigation Modular System (IMS) designed for deployment on pivot or linear movement automated irrigation infrastructure. The system enables high-precision irrigation with nutrient addition, supported by real-time environmental sensing and Power Line Communication (PLC) for data transfer. The IMS comprises five main components: electrovalve-controlled irrigation modules, soil and atmospheric sensor nodes, nutrient supply units, a PLC-based communication layer, and a centralized decision-making platform. Field trials on early tomatoes and autumn cauliflower demonstrated improved water and nutrient use efficiency, reduced input consumption, and increased yields. The IMS presents a scalable, retrofit-ready solution for efficient resource management in precision agriculture. Full article
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36 pages, 2939 KB  
Systematic Review
A Systematic Review and Bibliometric Analysis for the Design of a Traceable and Sustainable Model for WEEE Information Management in Ecuador Based on the Circular Economy
by Marlon Copara, Angel Pilamunga, Fernando Ibarra, Silvia-Melinda Oyaque-Mora, Diana Morales-Urrutia and Patricio Córdova
Sustainability 2025, 17(14), 6402; https://doi.org/10.3390/su17146402 - 12 Jul 2025
Viewed by 744
Abstract
The rapid increase in waste electrical and electronic equipment (WEEE) creates major environmental and governance issues in developing countries like Ecuador struggle because they with minimal formal collection and recycling rates. This research presents a potential sustainable management approach that tracks products through [...] Read more.
The rapid increase in waste electrical and electronic equipment (WEEE) creates major environmental and governance issues in developing countries like Ecuador struggle because they with minimal formal collection and recycling rates. This research presents a potential sustainable management approach that tracks products through their life cycles while following circular economy principles that include product extension and material extraction and waste minimization. A systematic literature review (SLR) using the PRISMA methodology combined with a bibliometric analysis found essential global strategies and technological frameworks and regulatory frameworks. The analysis of articles demonstrates that information management systems (IMSs) together with digital technologies and consistent regulations serve as essential elements for enhancing traceability and material recovery and formal recycling processes. A WEEE management IMS model was developed for the Ecuadorian market through an analysis of the findings; it follows a five-stage development process, starting from the technological infrastructure setup to complete data visualization integration. The proposed model is designed to enable public–private–community partnerships using digital tools that promote sustainable practices. The combination of circular strategies with traceability technologies and strong regulatory frameworks leads to improved WEEE governance, which supports sustainable system transitions in emerging economies. Full article
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46 pages, 2891 KB  
Article
Integrated Quality and Environmental Management in Healthcare: Impacts, Implementation, and Future Directions Toward Sustainability
by Dana-Gabriela Simion Ludușanu, Daniela-Ionela Fertu, Grigore Tinică and Maria Gavrilescu
Sustainability 2025, 17(11), 5156; https://doi.org/10.3390/su17115156 - 4 Jun 2025
Viewed by 1643
Abstract
Healthcare institutions are under increasing pressure to deliver high-quality, patient-centered care while reducing their environmental footprint. Integrating quality and environmental management systems (ISO 9001 and ISO 14001) into a unified integrated management system (IMS) offers a potential pathway to meet these dual imperatives. [...] Read more.
Healthcare institutions are under increasing pressure to deliver high-quality, patient-centered care while reducing their environmental footprint. Integrating quality and environmental management systems (ISO 9001 and ISO 14001) into a unified integrated management system (IMS) offers a potential pathway to meet these dual imperatives. This study investigates the effects of IMS implementation in three European hospitals through a comparative qualitative analysis of institutional reports, audit documentation, and performance indicators. The methodology combines a literature-informed conceptual framework with a multi-case analysis guided by four domains: environmental impact, care quality, process efficiency, and stakeholder engagement. The data were collected from institutional documentation over a six-year period (three years before and after IMS implementation), covering key indicators such as energy and water consumption, medical waste recycling, audit compliance, and patient satisfaction. The findings show that IMS adoption was associated with a 20–28% improvement in resource efficiency, increased recycling rates, and consistent gains in compliance and satisfaction metrics. These results were supported by strategic leadership, cross-functional training, and digital monitoring tools. The study concludes that IMS enhances institutional performance and sustainability while aligning healthcare operations with broader governance and policy goals. Further research is recommended to explore the long-term impacts and generalize the findings across healthcare systems. Full article
(This article belongs to the Section Health, Well-Being and Sustainability)
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33 pages, 1925 KB  
Systematic Review
Impression Management Tactics in the Chairperson’s Statement: A Systematic Literature Review and Avenues for Future Research
by Masibulele Phesa, Mabutho Sibanda, Frank Ranganai Matenda and Zamanguni Gumede
J. Risk Financial Manag. 2025, 18(5), 270; https://doi.org/10.3390/jrfm18050270 - 16 May 2025
Viewed by 1093
Abstract
The chairperson’s statement (CS) has evolved into a key component of corporate reporting, offering an authoritative, high-level summary of a company’s activities, initiatives, operations, financial performance, and achievements over the preceding financial year, along with insights into future outlooks. Recognised for its informative [...] Read more.
The chairperson’s statement (CS) has evolved into a key component of corporate reporting, offering an authoritative, high-level summary of a company’s activities, initiatives, operations, financial performance, and achievements over the preceding financial year, along with insights into future outlooks. Recognised for its informative value, the CS is consistently ranked by stakeholders as the most read and most influential section of the integrated report. Despite its importance, the CS is also a platform where corporate management often engages in impression management (IM) to portray a biased and overly positive image of the company. This study conducted a systematic literature review to examine the IM tactics employed within the CS. Based on the findings, an integrative conceptual framework was developed. Identified IM tactics include readability, textual characteristics, the influence of culture, legal systems and capital markets, paratext and intertextuality, the tone of language, forward-looking statements, retrospective sense-making, ambiguous language, the use of photographs and graphs, impersonalisation and evaluative language, and self-serving attributions. The results highlight that the study of IM strategies in CSs represents a rich and relevant research domain that warrants deeper exploration. Given its qualitative complexity and underexplored dimensions, this area offers several promising avenues for future investigation. Full article
(This article belongs to the Special Issue Financial Management)
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33 pages, 2689 KB  
Review
Management Frameworks and Management System Standards in the Context of Integration and Unification: A Review and Classification of Core Building Blocks for Consilience
by Yalcin Gerek and Mehmet Nafiz Aydin
Systems 2025, 13(4), 234; https://doi.org/10.3390/systems13040234 - 28 Mar 2025
Cited by 2 | Viewed by 2133
Abstract
Management frameworks (MFs) and management system standards (MSSs) are essential tools for improving organisational management practises. They inherently include a range of fundamental building blocks that facilitate the creation of structured management systems. However, these building blocks have not yet been holistically identified [...] Read more.
Management frameworks (MFs) and management system standards (MSSs) are essential tools for improving organisational management practises. They inherently include a range of fundamental building blocks that facilitate the creation of structured management systems. However, these building blocks have not yet been holistically identified or unified into a consilient taxonomy. Addressing this research gap, this study conducts a comprehensive review of 415 academic papers and theses, 47 ISO MSSs, and 79 MFs sourced from scholarly databases and official publications. Utilising a novel heuristic methodology, this study integrates a literature review, clustering, text mining analytics, and an expert review to develop a Consilient Building Block Taxonomy (CBBT). This taxonomy categorises the foundational components of MFs and MSSs, presenting them as a structured framework that unifies these elements into a cohesive system. By providing a systematic classification, the CBBT serves as a foundation for the development of a Unified Singular Management System (USMS). The proposed taxonomy enhances operational coherence, strategic alignment, and efficiency by consolidating the core aspects of diverse management systems. This study concludes with insights into how the CBBT can be leveraged to achieve integration and unification in management practises, offering significant potential for both research and practical applications. Full article
(This article belongs to the Section Systems Theory and Methodology)
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25 pages, 9075 KB  
Article
Optimization of Intelligent Maintenance System in Smart Factory Using State Space Search Algorithm
by Nuttawan Thongtam, Sukree Sinthupinyo and Achara Chandrachai
Appl. Sci. 2024, 14(24), 11973; https://doi.org/10.3390/app142411973 - 20 Dec 2024
Viewed by 1784
Abstract
With the continuous growth of Industry 4.0 (I4.0), the industrial sector has transformed into smart factories, enhancing business competitiveness while aiming for the sustainable development of organizations. Machinery is a critical component and key to the success of production in a smart industrial [...] Read more.
With the continuous growth of Industry 4.0 (I4.0), the industrial sector has transformed into smart factories, enhancing business competitiveness while aiming for the sustainable development of organizations. Machinery is a critical component and key to the success of production in a smart industrial factory. Minimizing unplanned downtime (UPDT) poses a significant challenge in designing an effective maintenance system. In the era of Industry 4.0, the most widely adopted maintenance frameworks are intelligent maintenance systems (IMSs), which integrate predictive maintenance with computerized systems. IMSs are intelligent tools designed to efficiently plan maintenance cycles for each machine component in a smart factory. This research presents the application of a search algorithm named state space search (SSS) in conjunction with a newly designed IMS, aimed at optimizing maintenance routines by identifying the optimal timing for maintenance cycles. The design began with the development of a new IMS concept that incorporates three key elements: the automation pyramid standard, Industrial Internet of Things (IIoT) sensors, and a computerized maintenance management system (CMMS). The CMMS collects machine data from the maintenance database, while real-time parameters are gathered via IIoT sensors from the supervisory control and data acquisition (SCADA) system. The new IMS concept provides a summary of the total maintenance cost and the remaining lifetime of the equipment. By integrating with SSS algorithms, the IMS presents optimized maintenance cycle solutions to the maintenance manager, focusing on minimizing costs while maximizing the remaining lifetime of the equipment. Moreover, the SSS algorithms take into account the risks associated with maintenance routines, following factory standards such as failure mode and effects analysis (FMEA). This approach is well suited to smart factories and helps to reduce UPDT. Full article
(This article belongs to the Special Issue Advancement in Smart Manufacturing and Industry 4.0)
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30 pages, 22040 KB  
Article
Optimal Driving Torque Control Strategy for Front and Rear Independently Driven Electric Vehicles Based on Online Real-Time Model Predictive Control
by Hang Yin, Chao Ma, Haifeng Wang, Zhihao Sun and Kun Yang
World Electr. Veh. J. 2024, 15(11), 533; https://doi.org/10.3390/wevj15110533 - 18 Nov 2024
Cited by 1 | Viewed by 2239
Abstract
This paper presents a novel driving torque control strategy for the front and rear independently driven electric vehicle (FRIDEV) to reduce energy consumption and enhance vehicle stability. The strategy is built on a comprehensive vehicle model that integrates vertical load transfer, tire slip [...] Read more.
This paper presents a novel driving torque control strategy for the front and rear independently driven electric vehicle (FRIDEV) to reduce energy consumption and enhance vehicle stability. The strategy is built on a comprehensive vehicle model that integrates vertical load transfer, tire slip dynamics, and an electric system model that accounts for losses in induction motors (IMs), permanent magnet synchronous motors (PMSMs), inverters, and batteries. The torque control problem is framed with a nonlinear model predictive control (MPC) method, utilizing state-space equations as representations of vehicle dynamics. The optimization targets adjust in real-time based on road traction conditions, with the slip rate of front and rear wheels determining the torque control strategy. Active slip control is applied when slip rates exceed critical thresholds, while under normal conditions, torque distribution is optimized to minimize energy losses. To enable online real-time implementation, an improved sparrow search algorithm (SSA) is designed. Simulations in MATLAB/Simulink confirm that the proposed online strategy reduces energy consumption by 2.3% under the China light-duty vehicle test cycle-passenger cars (CLTC-P) compared to a rule-based strategy. Under low-adhesion conditions, the proposed online strategy effectively manages slip ratios, ensuring stability and performance. Improved SSA also enhances computational efficiency by approximately 44%–52%, making the online strategy viable for real-time applications. Full article
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15 pages, 5787 KB  
Review
A Review of Ku-Band GaN HEMT Power Amplifiers Development
by Jihoon Kim
Micromachines 2024, 15(11), 1381; https://doi.org/10.3390/mi15111381 - 15 Nov 2024
Cited by 3 | Viewed by 3287
Abstract
This review article investigates the current status and advances in Ku-band gallium nitride (GaN) high-electron mobility transistor (HEMT) high-power amplifiers (HPAs), which are critical for satellite communications, unmanned aerial vehicle (UAV) systems, and military radar applications. The demand for high-frequency, high-power amplifiers is [...] Read more.
This review article investigates the current status and advances in Ku-band gallium nitride (GaN) high-electron mobility transistor (HEMT) high-power amplifiers (HPAs), which are critical for satellite communications, unmanned aerial vehicle (UAV) systems, and military radar applications. The demand for high-frequency, high-power amplifiers is growing, driven by the global expansion of high-speed data communication and enhanced national security requirements. First, we compare the main GaN HEMT process technologies employed in Ku-band HPA development, categorizing the HPAs into monolithic microwave integrated circuits (MMICs) and internally matched power amplifier modules (IM-PAMs) and examining their respective characteristics. Then, by reviewing the literature, we explore design topologies, major issues like oscillation prevention and bias circuits, and heat sink technologies for thermal management. Our findings indicate that silicon carbide (SiC) substrates with gate lengths of 0.25 μm and 0.15 μm are predominantly used, with ongoing developments enabling MMICs and IM-PAMs to achieve up to 100 W output power and 30% power-added efficiency. Notably, the performance of MMIC power amplifiers is advancing more rapidly than that of IM-PAMs, highlighting MMICs as a promising direction for achieving higher efficiency and integration in future Ku-band applications. This paper can provide insights into the overall key technologies for Ku-band GaN HPA design and future development directions. Full article
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22 pages, 7238 KB  
Article
Application of Hydrochemical Parameters as Tool for Sustainable Management of Water Supply Network
by Nikolina Novotni-Horčička, Tamara Marković, Igor Karlović and Ivan Kovač
Sustainability 2024, 16(21), 9558; https://doi.org/10.3390/su16219558 - 2 Nov 2024
Viewed by 1099
Abstract
Effective management of Water Supply Systems (WSSs) is crucial for ensuring safe drinking water. The WSS of Varaždin County is a complex network involving three groundwater sources: Bartolovec and Vinokovščak wellfields (alluvial aquifers) and Bela karstic spring. To achieve a comprehensive characterization of [...] Read more.
Effective management of Water Supply Systems (WSSs) is crucial for ensuring safe drinking water. The WSS of Varaždin County is a complex network involving three groundwater sources: Bartolovec and Vinokovščak wellfields (alluvial aquifers) and Bela karstic spring. To achieve a comprehensive characterization of WSSs, routine laboratory data was integrated with stable isotopes and geochemical modeling. Within this study, all measured parameters remain below the Maximum Contaminant Level (MCL), ensuring water safety for human consumption. The Piper diagram identified variations in water sources based on their chemical composition, providing a simplified overview of mixing patterns within WSSs. Among the modeling approaches, inverse modeling (IM) was found to be more reliable than forward modeling (FM) and mass balance modeling (MB). Despite the limited capacity of δ18O to provide accurate mixing results, it was revealed that the reservoir water was in equilibrium with the air (no evaporation effects), indicating well-sealed reservoirs. Mixing modeling showed that the western, southwestern, and northern parts of the WSS mixed all three sources, whereas the eastern and southeastern areas primarily relied on the deeper aquifer of the Bartolovec source, indicating potential vulnerability. Strict validation criteria ensured the reliability of results, demonstrating the effectiveness and applicability of geochemical modeling in water security management plans. Full article
(This article belongs to the Section Sustainable Water Management)
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24 pages, 22696 KB  
Article
Sustainability Performance Differences of Industrial Heritage Regeneration Implementation Modes
by Tong Chu, Minghao Zhou and Jiang Wu
Buildings 2024, 14(11), 3489; https://doi.org/10.3390/buildings14113489 - 31 Oct 2024
Cited by 1 | Viewed by 1549
Abstract
In high-density cities around the world, the contradiction of sustaining development and limited resources has become more evident. Transforming historic industrial buildings, through both functional and spatial adjustments, has emerged as a key strategy to manage these challenges effectively. There is a significant [...] Read more.
In high-density cities around the world, the contradiction of sustaining development and limited resources has become more evident. Transforming historic industrial buildings, through both functional and spatial adjustments, has emerged as a key strategy to manage these challenges effectively. There is a significant demand for the quick regeneration of industrial heritage districts, resulting in the emergence of various implementation modes (IMs). While the Sustainable Development Goals (SDGs) have gained widespread acceptance, the integration of sustainability principles into urban regeneration practices has strengthened globally. However, in many regions, approaches to achieving sustainable regeneration are still unclear, with a lack of evaluation and adjustment of sustainability performance (SP). This paper combines qualitative analysis and a quantitative assessment of indicators to compare three representative case studies with different IMs. It explores whether there is a connection between the chosen IM and SP, examines the mechanisms of impact, and discusses how to select the most suitable IM for industrial heritage regeneration. The study confirms the practicality of an SP evaluation system and identifies key factors within IMs that affect SP. Future research is expected to produce tools that support the promotion of sustainability in industrial heritage regeneration efforts. Full article
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24 pages, 8816 KB  
Article
Distributed Secondary Control of DC Microgrid with Power Management Based on Time-of-Use Pricing and Internal Price Rate
by Muhammad Alif Miraj Jabbar, Dat Thanh Tran and Kyeong-Hwa Kim
Sustainability 2024, 16(19), 8705; https://doi.org/10.3390/su16198705 - 9 Oct 2024
Viewed by 1479
Abstract
This paper presents a novel approach to manage distributed DC microgrids (DCMG) by integrating a time-of-use (ToU) electricity pricing scheme and an internal price rate calculation mechanism. The proposed power-management system is designed to effectively handle uncertainties such as utility grid (UG) availability, [...] Read more.
This paper presents a novel approach to manage distributed DC microgrids (DCMG) by integrating a time-of-use (ToU) electricity pricing scheme and an internal price rate calculation mechanism. The proposed power-management system is designed to effectively handle uncertainties such as utility grid (UG) availability, fluctuating electricity prices, battery state of charge (SOC) levels, and frequent plug-ins and plug-outs of electric vehicles (EVs). Uncertainties in DCMG systems often lead to inefficiencies, power imbalances, and inexact voltage regulation issues within DCMGs. In addition, to maintain the power balance and constant voltage regulation under various operational states, the proposed scheme also incorporates secondary control into the DCMG power-management system. Unlike the existing approaches that often fail to adapt dynamically to changing conditions, the proposed method is the first approach to consider the concept of internal price rate in designing the DCMG power management. To address this challenge, this approach proposes a more resilient power-management strategy to enhance the efficiency and adaptability of DCMG systems. Extensive simulations and experimental validations demonstrate the practicality and adaptability of the proposed control strategy under diverse test conditions, including operation transitions between grid-connected mode (GCM) and islanded mode (IM), low battery SOC condition, operation transition from the current control mode (CCM) to distributed secondary control mode (DSCM), and EV plug-in scenarios. The test results confirm that the proposed method enhances the reliability, efficiency, and economic viability of DCMG systems, making it a promising solution for future smart grid and renewable energy integrations. Full article
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16 pages, 2220 KB  
Review
Review of Integrated Management Systems to Re-Engineer Existing Nonconformances Troubleshooting System
by Matshidiso Moso and Oludolapo Akanni Olanrewaju
Safety 2024, 10(3), 58; https://doi.org/10.3390/safety10030058 - 5 Jul 2024
Viewed by 1826
Abstract
Total quality management (TQM) is a strategic philosophy that has adopted kaizen activities which drives the business to carry out activities effectively to yield the best desired output, hence, a profitable organization. The kaizen philosophy acts as a catalyst in productivity rate and [...] Read more.
Total quality management (TQM) is a strategic philosophy that has adopted kaizen activities which drives the business to carry out activities effectively to yield the best desired output, hence, a profitable organization. The kaizen philosophy acts as a catalyst in productivity rate and integrated management systems (IMS) which results in drastic improvements. When the nonconformity arises within the process, the accuracy of the problem solving determines quality of preventive action, therefore the preventive action should be accompanied by the opportunity of improvement from the raised nonconformance. This research seeks to add more knowledge and upgrade technology of problem-solving models relating to the integrated management systems by examining various troubleshooting models for problem solving and preventive action related to quality nonconformances, safety incidents and engineering breakdowns. Hence, the aim of this research is for troubleshooting model technique enhancement for issues related to process engineering, quality management systems and occupational health and safety by creating a model which analyses kaizen projects from the corrective and preventive action analysis of nonconformances. The proposed troubleshooting model was developed using lean techniques and risk rating tools; it was then applied to the case study company for simulation and the outcomes resulted in the closure of nonconformances and continual improvement of future projects. The proposed model is more advantageous to the manufacturing industries seeking to improve their Corrective Action and Preventive Action (CAPA) systems. Full article
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14 pages, 557 KB  
Review
Imaging Flow Cytometry: Development, Present Applications, and Future Challenges
by Savvas Dimitriadis, Lefkothea Dova, Ioannis Kotsianidis, Eleftheria Hatzimichael, Eleni Kapsali and Georgios S. Markopoulos
Methods Protoc. 2024, 7(2), 28; https://doi.org/10.3390/mps7020028 - 23 Mar 2024
Cited by 6 | Viewed by 7046
Abstract
Imaging flow cytometry (ImFC) represents a significant technological advancement in the field of cytometry, effectively merging the high-throughput capabilities of flow analysis with the detailed imaging characteristics of microscopy. In our comprehensive review, we adopt a historical perspective to chart the development of [...] Read more.
Imaging flow cytometry (ImFC) represents a significant technological advancement in the field of cytometry, effectively merging the high-throughput capabilities of flow analysis with the detailed imaging characteristics of microscopy. In our comprehensive review, we adopt a historical perspective to chart the development of ImFC, highlighting its origins and current state of the art and forecasting potential future advancements. The genesis of ImFC stemmed from merging the hydraulic system of a flow cytometer with advanced camera technology. This synergistic coupling facilitates the morphological analysis of cell populations at a high-throughput scale, effectively evolving the landscape of cytometry. Nevertheless, ImFC’s implementation has encountered hurdles, particularly in developing software capable of managing its sophisticated data acquisition and analysis needs. The scale and complexity of the data generated by ImFC necessitate the creation of novel analytical tools that can effectively manage and interpret these data, thus allowing us to unlock the full potential of ImFC. Notably, artificial intelligence (AI) algorithms have begun to be applied to ImFC, offering promise for enhancing its analytical capabilities. The adaptability and learning capacity of AI may prove to be essential in knowledge mining from the high-dimensional data produced by ImFC, potentially enabling more accurate analyses. Looking forward, we project that ImFC may become an indispensable tool, not only in research laboratories, but also in clinical settings. Given the unique combination of high-throughput cytometry and detailed imaging offered by ImFC, we foresee a critical role for this technology in the next generation of scientific research and diagnostics. As such, we encourage both current and future scientists to consider the integration of ImFC as an addition to their research toolkit and clinical diagnostic routine. Full article
(This article belongs to the Special Issue Feature Papers in Methods and Protocols 2024)
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26 pages, 2269 KB  
Article
Design of a Novel Chaotic Horse Herd Optimizer and Application to MPPT for Optimal Performance of Stand-Alone Solar PV Water Pumping Systems
by Rabeh Abbassi and Salem Saidi
Mathematics 2024, 12(4), 594; https://doi.org/10.3390/math12040594 - 17 Feb 2024
Cited by 13 | Viewed by 2356
Abstract
A significant part of agricultural farms in the Kingdom of Saudi Arabia (KSA) are in off-grid sites where there is a lack of sufficient water supply despite its availability from groundwater resources in several regions of the country. Since abundant agricultural production is [...] Read more.
A significant part of agricultural farms in the Kingdom of Saudi Arabia (KSA) are in off-grid sites where there is a lack of sufficient water supply despite its availability from groundwater resources in several regions of the country. Since abundant agricultural production is mainly dependent on water, farmers are forced to pump water using diesel generators. This investigation deals with the increase in the effectiveness of a solar photovoltaic water pumping system (SPVWPS). It investigated, from a distinct perspective, the nonlinear behavior of photovoltaic modules that affects the induction motor-pump because of the repeated transitions between the current and the voltage. A new chaotic Horse Herd Optimization (CHHO)-based Maximum Power Point Tracking technique (MPPT) is proposed. This algorithm integrates the capabilities of chaotic search methods to solve the model with a boost converter to maximize power harvest while managing the nonlinear and unpredictable dynamical loads. The analytical modeling for the proposed SPVWPS components and the implemented control strategies of the optimal duty cycle of the DC–DC chopper duty cycle and the Direct Torque Control (DTC) of the Induction Motor (IM) has been conducted. Otherwise, the discussions and evaluations of the proposed model performance in guaranteeing the maximum water flow rate and the operation at MPP of the SPVWPS under partial shading conditions (PSC) and changing weather conditions have been carried out. A comparative study with competitive algorithms was conducted, and the proposed control system’s accuracy and its significant appropriateness to improve the tracking ability for SPVWPS application have been proven in steady and dynamic operating climates and PSC conditions. Full article
(This article belongs to the Special Issue Mathematical Modeling and Optimization of Energy Systems)
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21 pages, 3972 KB  
Review
Delving into Molecular Pathways: Analyzing the Mechanisms of Action of Monoclonal Antibodies Integrated in IMGT/mAb-DB for Myasthenia Gravis
by Rebecca Golfinopoulou, Véronique Giudicelli, Taciana Manso and Sofia Kossida
Vaccines 2023, 11(12), 1756; https://doi.org/10.3390/vaccines11121756 - 26 Nov 2023
Cited by 3 | Viewed by 3753
Abstract
Background: Myasthenia Gravis (MG) is a rare autoimmune disease presenting with auto-antibodies that affect the neuromuscular junction. In addition to symptomatic treatment options, novel therapeutics include monoclonal antibodies (mAbs). IMGT®, the international ImMunoGeneTics information system®, extends the characterization of [...] Read more.
Background: Myasthenia Gravis (MG) is a rare autoimmune disease presenting with auto-antibodies that affect the neuromuscular junction. In addition to symptomatic treatment options, novel therapeutics include monoclonal antibodies (mAbs). IMGT®, the international ImMunoGeneTics information system®, extends the characterization of therapeutic antibodies with a systematic description of their mechanisms of action (MOA) and makes them available through its database for mAbs and fusion proteins, IMGT/mAb-DB. Methods: Using available literature data combined with amino acid sequence analyses from mAbs managed in IMGT/2Dstructure-DB, the IMGT® protein database, biocuration allowed us to define in a standardized way descriptions of MOAs of mAbs that target molecules towards MG treatment. Results: New therapeutic targets include FcRn and molecules such as CD38, CD40, CD19, MS4A1, and interleukin-6 receptor. A standardized graphical representation of the MOAs of selected mAbs was created and integrated within IMGT/mAb-DB. The main mechanisms involved in these mAbs are either blocking or neutralizing. Therapies directed to B cell depletion and plasma cells have a blocking MOA with an immunosuppressant effect along with Fc-effector function (MS4A1, CD38) or FcγRIIb engager effect (CD19). Monoclonal antibodies targeting the complement also have a blocking MOA with a complement inhibitor effect, and treatments targeting T cells have a blocking MOA with an immunosuppressant effect (CD40) and Fc-effector function (IL6R). On the other hand, FcRn antagonists present a neutralizing MOA with an FcRn inhibitor effect. Conclusion: The MOA of each new mAb needs to be considered in association with the immunopathogenesis of each of the subtypes of MG in order to integrate the new mAbs as a viable and safe option in the therapy decision process. In IMGT/mAb-DB, mAbs for MG are characterized by their sequence, domains, and chains, and their MOA is described. Full article
(This article belongs to the Special Issue Advances in Immunogenetics: From Genetics to Immune Responses)
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