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  • Article
  • Open Access
25 Citations
4,890 Views
20 Pages

IGF1R Deficiency Modulates Brain Signaling Pathways and Disturbs Mitochondria and Redox Homeostasis

  • Susana Cardoso,
  • Icíar P. López,
  • Sergio Piñeiro-Hermida,
  • José G. Pichel and
  • Paula I. Moreira

Insulin-like growth factor 1 receptor (IGF1R)-mediated signaling pathways modulate important neurophysiological aspects in the central nervous system, including neurogenesis, synaptic plasticity and complex cognitive functions. In the present study,...