Search Results (167)

It is a popular assumption that people learn certain practices for handling media in the course of their adolescence and adulthood, which make it difficult for them to develop new patterns for the use of media at a later point in their lives. From this theoretical standpoint, it is a challenge for older people to learn how to handle new media and integrate them into their current living situation. Beyond theoretical assumptions, there has formerly been a lack of exploratory investigations pursuing the conditions under which older adults take up digital media with which they were previously not familiar and incorporate them into their daily lives. Between October 2023 and March 2024, 32 semi-standardised individual interviews were conducted with a group of people between 80 and 93 years of age, who had recently acquired a digital medium and integrated it into their everyday lives. The decisive factor here was the presence of certain motives that generate plausible incentives to make permanent use of new media. The interviewees have purposefully acquired new media. It is notable that acquisition processes were strongly initiated by significant changes in life circumstances. In the case of most interviewees, the intention to acquire an internet-enabled medium was based on the wish to use a few selected functions. New options for online use were only explored after a while. The following patterns were identified regarding the motives and gratifications of acquisition: new media as…(1) hobby extension, (2) support network, (3) compensation tool, (4) connection opportunity, (5) escape from everyday life. It can be assumed that older people experience the use of new media as purposeful if they have specific motives for doing so. Biological, psychological and social correlations as well as ways of coping and dealing with age(ing) are relevant here. If daily use potentials are perceived as beneficial, older people show a high level of adaptability in terms of new media. Against this background, a gratification-orientated model appears to be a promising starting point for explaining the prerequisites for media adoption based on motives that generate plausible incentives for learning how to use new media at an older age. Full article

This study investigates the evolutionary mechanisms and equilibrium character-istics of the China–US trade dispute through an improved ecological competition model. By quantifying tariff policies as competition intensity regulators and introducing trade elasticity parameters, we construct a dynamic system that captures the nonlinear feedback between economic rivals. Key findings are as follows. (1) When both nations implement reciprocal tariff measures with similar economic sensitivities, the system converges to a stable equilibrium where bilateral economic outputs stabilize at reduced levels compared to pre-conflict states, provided the product of adjusted competition coefficients remains below critical thresholds. (2) Excessive tariff escalation beyond identifiable tipping points triggers winner-takes-all outcomes, validating the “Thucydides Trap” hypothesis in eco-nomic conflicts. (3) Empirical simulations using 2018–2023 trade data demonstrate that China’s tit-for-tat tariff strategy effectively maintains competitive balance, while domestic market expansion measures (evidenced by a 6.3% average annual growth in China’s do-mestic consumption) significantly mitigate trade diversion effects. The study establishes theoretical connections with optimal tariff theory and strategic trade policy literature while providing policymakers with quantitative tools to assess trade policy impacts. Our find-ings theoretically validate China’s policy combination of calibrated reciprocity and domestic demand stimulation, offering new insights into managing great-power economic competition. Full article

Hydrogel patches have gained significant attention in wound healing applications as they are similar to hydrogel dressings due to their moisture-retentive properties, biocompatibility, and ability to promote tissue regeneration. In this study, gelatin-based hydrogels crosslinked with genipin and incorporated with hyaluronic acid (HA) were developed to enhance mechanical stability, swelling behavior, and structural integrity. Fourier transform infrared (FTIR), thermogravimetric (TGA), and energy-dispersive X-ray (EDX) analyses were conducted and confirmed successful crosslinking and good thermal stability, ensuring hydrogel durability under physiological conditions. The optimized hydrogel (GE_HA_GNP) exhibited a sufficient water vapor transmission rate (WVTR), swelling ratio, and contact angle, allowing for effective wound exudate absorption and hydration maintenance, which is essential for accelerated healing. The findings demonstrate that the crosslinked hydrogels were able to maintain a WVTR of 500 to 1500 gm⁻² day⁻¹, a contact angle of >40°, and a swelling ratio of 700–1000%. The combination of genipin as a crosslinker and the addition of HA significantly improved the mechanical properties and biocompatibility of the hydrogels, making them promising candidates for an alternative treatment for atopic dermatitis and a potential wound dress-ing. Furthermore, the hydrogel patches show potential for future drug delivery appli-cations, with further studies required to evaluate their antimicrobial properties and long-term clinical performance. Full article

Despite the exponential rise in cybersecurity incidents worldwide, existing analytical approaches often fail to detect subtle temporal dynamics in cyber threats, particularly on a quarterly scale. This paper addresses a critical research gap in the domain of temporal cyber risk analysis by introducing a mathematically rigorous and AI-augmented framework capable of identifying, validating, and forecasting quarterly shifts in global cyber-attack patterns. The methodology integrates a hybrid data acquisition pipeline with GPT-based AI classification to construct a structured, high-dimensional dataset comprising 11,497 cybersecurity incidents spanning from October 2023 to March 2025. These incidents cover 106 attack types, 29 industries, and 257 countries. The framework decomposes the dataset into quarterly intervals and applies mathematical formulations to compute frequency shifts across categorical variables (attack types, industries, countries) and numerical variables (attack significance), followed by robust statistical validations (Chi-square and ANOVA tests), time-series forecasting via ARIMA, and the computation of a Quarterly Composite Index (QCI). Key results reveal dominant attack types—Social Engineering (ing1733) and Zero-Day Exploits (1657)—and highlight sectoral vulnerabilities in IT (5959) and Government (2508). Statistically significant quarterly variations were confirmed (${\chi }^2=2319.13$, $F=3.78$, $p<0.001$). ARIMA forecasts predict 1782–2080 incidents per quarter for 2025–2026, while QCI trends average around 0.75, signifying sustained volatility. The research delivers both theoretical and practical advancements by combining generative AI, temporal segmentation, and statistical modeling to create an operationalizable intelligence system. This contribution enhances strategic cybersecurity preparedness and policymaking in a complex, evolving threat landscape. Full article

Non-EU international students encounter considerable challenges in social integration, cultural adaptation, and emotional well-being within UK higher education. Despite this, the role of internet memes as a form of participatory digital media in mediating these experiences has not been extensively studied. This paper examines how non-EU students at a British university utilise memes to manage cross-cultural identity and daily stressors. Employing an Experience-Centred Design (ECD) approach, our qualitative research involved 20 participants through digital cultural probes, semi-structured interviews, and co-design workshop. We discovered that memes serve a dual role: they provide emotional bridges that foster a sense of belonging through shared humour, yet they also risk exclusion due to cultural opacity. We introduce the concept of “negotiated humour”, which requires cross-cultural explanation and reduces comedic spontaneity but enhances intercultural understanding. Furthermore, we identify a continuum of meme usage that reflects different phases of acculturation, ranging from expressing frustrations to creating hybrid cultural expressions. This study contributes to cross-cultural adaptation theory by highlighting memes as boundary objects in identity negotiation. We suggest design implications for culturally sensitive platforms, such as contextual footnotes, and institutional interventions like meme-based orientation activities to exploit humour’s potential for fostering inclusive dialogue. Our research highlights how transient digital humour can provide deep insights into identity, community, and the complex dynamics of cross-cultural adaptation. Full article

Soil total phosphorus plays an important role in soil fertility, plant growth, and bioge-ochemical cycles. This study aims to determine the spatial distribution characteristics of soil total phosphorus and identify its main influencing factors in the study area, thereby providing a basis for the scientific management of soil total phosphorus. Here, we conducted a comprehensive analysis by combining classical statistical analysis, ge-ostatistics methods, Pearson correlation analysis, one-way analysis of variance (ANOVA), and structural equation modeling (SEM) to explore the spatial distribution patterns of soil total phosphorus and its influencing factors. The results showed that soil total phosphorus in the study area ranged from 161.00 to 991.00 mg/kg, with an average of 495.71 mg/kg. Spatially, soil total phosphorus exhibited a patchy distribu-tion pattern, with high values primarily concentrated in cultivated areas along rivers and low values mainly located in forested areas in the southeastern and central re-gions. Additionally, the nugget effect of soil total phosphorus was 71.5%, indicating a moderate level of spatial variability. The Pearson correlation analysis revealed that soil total phosphorus content was significantly correlated with multiple factors, including land use types, soil parent material, distance from settlements, slope, and soil pH. Based on these findings, we employed ANOVA to analyze the impacts of various fac-tors. The results indicated that soil total phosphorus content showed significant differences under the influence of different factors. Subsequently, we further explored in depth the action paths through which these factors affect soil total phosphorus us-ing SEM. The SEM results showed that the absolute values of the total effects of the influencing factors on soil total phosphorus, ranked from highest to lowest, were as follows: land use types (0.499) > soil parent material (0.240) > distance from settle-ments (0.178) > slope (0.161) > elevation (0.127) > soil pH (0.114) > normalized differ-ence vegetation index (0.103). These findings provide a scientific foundation for the effective management of soil total phosphorus in similar study areas. Full article

Background/Objective: Cyclosporine A and other calcineurin inhibitors have been identified as prospective treatments for preventing Alzheimer’s disease. We previously found that calcineurin inhibitors elicit a unique behavioral profile in zebrafish larvae, characterized by increased activity, acoustic hyperexcitability, and reduced visually guided behaviors. Screening a large library of FDA-approved compounds using Z-LaP Tracker revealed that some heart medications produce a similar behavioral profile, suggesting these drugs may exert calcineurin-inhibitor-like effects relevant to prevent-ing or ameliorating Alzheimer’s disease. Methods: Screening a large library of FDA-approved drugs using Z-LaP Tracker, a neural network model, revealed a cluster of 65 drugs demonstrating a cyclosporine A-like behavioral profile. Fourteen of these drugs were heart medications, including angiotensin receptor blockers, beta blockers, al-pha-adrenergic receptor antagonists, and a statin. Results: Dual administration of the heart medications with cyclosporine A in Z-LaP Tracker revealed synergistic effects: lower doses of each heart medication could be delivered in conjunction with a lower dose of cyclosporine A to evoke a similar or larger behavioral effect than higher doses of each drug independently. Other studies have shown that many of these heart medica-tions drugs directly or indirectly inhibit the calcineurin–NFAT pathway, like cyclo-sporine A, providing a potential mechanism. Conclusions: Co-administering a low dose of cyclosporine A with select cardiac drugs could be a potentially effective treatment strategy for preventing Alzheimer’s disease occurrence and simultaneously treating cardiovascular dysfunction, while mitigating the side effects associated with higher doses of cyclosporine A. Given that heart disease precedes Alzheimer’s disease in many patients, physicians may be able to create a treatment regimen that addresses both con-ditions. Our results suggest that a calcineurin inhibitor combined with simvastatin, irbesartan, cilostazol, doxazosin, or nebivolol is the most promising candidate for future exploration. Full article

Background: The Jinwu pig is a novel breed created by crossbreeding Jinhua and Duroc pigs, displaying superior meat quality, strong adaptability to coarse feed, high production performance, and a rapid growth rate. However, research on its reproductive traits and genomic characteristics has not been systematically reported. Methods: In this study, we investigated the genetic basis of reproductive traits in Jinwu pigs us-ing a genome-wide association study. We analyzed 2831 breeding records from 516 Jinwu sows to evaluate the effects of fixed factors (farrowing season, parity, and mated boar) on six reproductive traits: the total number of births (TNB), number born alive (NBA), number of healthy offspring produced (NHOP), weak litter size (WLS), number of stillbirths (NS), and number of mummies (NM). Results: A total of 771 genome-wide significant single-nucleotide polymorphisms (SNPs) and ten potential candidate genes associated with pig reproductive traits were identified: VOPP1, PGAM2, TNS3, LRFN5, ORC1, CC2D1B, ZFYYE9, TUT4, DCN, and FEZF1. TT-genotype-carrier individuals of the pleiotropic SNP rs326174997 exhibited significantly higher TNB, NBA, and NHOP trait-related phenotypic values. Conclusions: These findings provide a foundation for the reproductive breeding of Jinwu pigs and offer new insights into molecular genetic breeding in pigs. Full article

Background/Objectives: Poly (ADP-ribose) polymerase (PARP) inhibitors have shown significant efficacy in treating BRCA-mutated cancers; however, a significant proportion of patients fail to respond. Emerging evidence highlights the role of PARP in lipid metabolism, suggest-ing its modulation as a novel strategy to regulate tumor progression. Methods: In this study, lipidomics and transcriptomics analyses were conducted to elucidate the mechanisms underlying PARP inhibitor-induced ferroptosis and immune modulation in triple-negative breast cancer (TNBC). Results: We demonstrated that the PARP inhibitor Niraparib significantly reprograms lipid metabolism in TNBC cells, marked by elevated phosphatidylethanolamine (PE) and cholesterol ester (ChE) levels. This metabolic shift was mechanistically linked to upregulation of the cholesterol transporter NPC1L1 via the PARP1-RELA-NPC1L1 signaling axis, which subsequently activated the AKT pathway. Combinatorial treatment with Niraparib and either Ezetimibe (an NPC1L1 inhibitor) or AZD5363 (an AKT inhibitor) synergistically enhanced TNBC cell death by promoting ferroptosis through glutathione depletion and lipid peroxidation. Furthermore, NPC1L1 inhibition amplified PARP inhibitor-induced immune responses, increasing CD8⁺ T cell infiltration and cytotoxicity in tumors. Conclusions: In conclusion, our findings establish NPC1L1 as a critical mediator of PARP inhibitor efficacy and propose dual targeting of lipid metabolism, providing a new therapeutic approach for the combination treatment of TNBC. Full article

Despite the growing importance of human-centered design and ergonomics in various fields, a significant gap exists in applying these principles to robotic systems in airport environments. This paper focuses on a real-time baggage handling monitoring system by proposing a computational ergo-design approach. It presents the optimal system architecture for real-time baggage handling. The proposed architecture, called ARTEMIS (ARchitecture for real-TimE baggage handling and MonitorIng System), is designed for real-time baggage handling and monitoring. The circuit modeling is carried out using a directed graph. Five strategies are simulated to test their effectiveness and evaluate their performance within the system. A simulation that generates key indicators enables preliminary visualization and analysis of AGV behavior through predefined scenarios. These results are presented through an intuitive and ergonomic user interface, designed with a focus on user–computer interaction as a problem-solving process centered on the user’s experience. The results show that, if the goal is to balance energy efficiency with effective baggage handling, the Mixed Advance/Delay Strategy appears to be the best overall choice, as it optimizes both energy consumption and baggage handling while maintaining relatively low waiting times. However, if minimizing queue time and maximizing baggage collection are the highest priorities (with less emphasis on energy efficiency), the Turnstile Strategy remains a solid option. In addition, the simulations show that the operator plays a central role in minimizing delays and ensuring the smooth operation of the system. Both local and global system failures depend heavily on the operator’s response time, decision-making, and overall efficiency. Therefore, operator efficiency and a well-designed support system are critical to maintaining a smooth and effective baggage handling process. Full article

Background: The wound healing process presents notable challenges for nursing teams, requiring extensive knowledge of wound care materials. A nanoparticle-free, bioabsorbable pol-yvinyl alcohol (PVA) with citric acid (CA) dressing produced by simple electrospin-ning was evaluated to treat acute wound healing in rats. This PVA-CA combination promotes crosslinking, increases the dressing capacity of absorption and confers heal-ing properties due to the citric acid antioxidant action. Methods: The dressing was tested in a quantitative experiment on 1.9 cm acute dermatological lesions in rats (n = 12), com-paring the PVA-CA-treated group with the untreated control group (CG). Samples were collected at 3, 7 and 14 days after lesion induction to evaluate the inflammatory process and tissue healing. Results: The macroscopic and histological data on the third day showed similar characteristics in both groups; however, after fourteen days, the PVA-CA group exhibited complete healing, accompanied by recomposition of the skin layers, whereas the wounds in the CG did not close completely. Conclusions: The results highlight that electrospun PVA-AC dressings improve healing outcomes and constitute a prom-ising and affordable solution, providing a suitable environment for tissue repair, re-ducing inflammatory cell infiltration, blood vessel formation, and restoration of epi-thelial tissue, reducing the time of the healing process of acute wounds. Full article

This study explores syntactic variation and sociocultural identity in subjectless nonfinite clauses within Philippine English (PhE) and Singaporean English (SgE), focusing on to-infinitive and -ing gerund constructions. Using data from the International Corpus of English for the Philippines (ICE-PHI) and Singapore (ICE-SIN), it examines the distribution of these constructions across spoken and written registers to uncover their sociocultural underpinnings. The findings reveal a shared preference for to-infinitive constructions in both varieties, reflecting their role in expressing intention and purpose. PhE’s adherence to prescriptive norms stems from colonial history and formal education, while SgE’s multilingual and pragmatic linguistic ecology fosters greater syntactic flexibility, exemplified by the innovative want + -ing construction absent in PhE. Although gerunds are less frequent overall, they consistently occur with verbs like enjoy in both varieties, signaling habitual or ongoing actions. Sociolinguistic distinctions also emerge in constructions like [Negator] + try + Nonfinite Clause, where PhE employs elaborative commentary aligned with its expressive narrative tendencies, contrasting with SgE’s concise, context-driven usage. By investigating this underexplored syntactic phenomenon, the study demonstrates how localized Englishes adapt grammatical structures to reflect sociocultural priorities, advancing the understanding of World Englishes and their sociolinguistic diversity. Full article

Background/Objectives: The inhibitor of growth family member 3 (ING3) acts as an epigenetic reader through physical interactions with histone-modifying enzymes and subsequent chromatin remodelling processes. It is involved in various cellular functions, such as cell cycle control, cell growth, and apoptosis. Although ING3 was assigned tumour suppressor candidate status in some types of cancers, including prostate cancer, some studies suggest it acts to promote growth. To address these contradictory reports regarding its role in the initiation and progression of prostate cancer, we specifically addressed the question of whether ablation of ING3 in the mouse prostate is sufficient to initiate malignant transformation of the prostate and support its (candidate) tumour suppressor status. Methods: To generate the prostate-specific Ing3 knockout mouse, paternal inheritance of the PB-Cre4 transgene was used, while for the generation of a global knockout control, a female mouse harbouring the PB-Cre4 transgene was utilized. To determine the recombination efficiency of the Cre-LoxP system in the prostate at the Ing3 locus, a duplex probe-based digital PCR assay capable of counting undisrupted Ing3 copies was designed. The impact of DNA recombination on the protein level was investigated by immunohistochemical staining of prostate tissue samples. Results: In the prostate-specific knockout, digital PCR analysis revealed mosaic gene deletion. We found recombination efficiencies in the anterior, dorsolateral, and ventral prostate lobes ranging from approximately 15 to 30%. ING3 staining in the prostate was faint with no detectable differences in signal intensity between the knockout specimen and wild-type controls. This low ING3 expression in the prostate is consistent with observations of X-gal staining of an Ing3-LacZ reporter allele. Immunohistochemistry showed increased expression of DNA-damage-associated markers γH2AX and 53BP1. However, no gross anatomical abnormalities or prostate intraepithelial neoplasia (PIN) lesions in the prostate of tissue-specific knockout animals compared to wild-type controls were observed. Conclusions: Altogether, our data provide evidence that disruption of ING3 expression in prostate cells does not lead to malignant transformation and challenges the idea that ING3 acts primarily in a tumour-suppressive manner. Furthermore, this work supports the crucial role of ING3 in maintaining genomic stability, and we confirmed the embryonic lethal phenotype of homozygous Ing3 null mice that is rescued by ectopic expression of ING3. Full article

Post-Theoretical “creative–critical” research recently emerged in the discipline of Creative Writing as a collapse of the binaries between practice and Theory. This article shows that using this interdisciplinary methodology in the study of mysticism is a natural fit, illustrating its efficacy in a case study with the reflexive writing of the medieval Christian mystic Julian of Norwich. As a creative–critical writer and researcher, I explored the junctures where Julian’s poetics intersect with trauma-informed theology. Writing through these intersections formed a literary trauma-informed framework for the holding and processing of loss and grief through Julian’s nuanced modelling of mystical union with God. This case study shows how the framework came together critically and its application to contemporary ecological grief in the writing of a performative long poem, Blue: a lament for the sea. The “theopoetic” making process with two images from Julian’s texts, Christ’s “wounds” and “one-ing”, developed new language for liminal and spiritual experience. Insights from creative–critical research can be shared in artistic performance and publication in the academy and beyond in public impact. Bringing the whole self through theopoetics to the scholarly research of mysticism has the potential to form fresh insights, revealing new dimensions. Full article

Ground-Level Enhancements (GLEs) pose a potential hazard for crew and passengers on polar routes. The accurate estimation of the integral proton flux of Solar Energetic Particle (SEP) events is crucial for assessing the expected radiation dose. This paper describes a new approach that predicts the occurrence of GLEs and the associated >500 MeV intensity using proton and electron data. The new approach utilizes the Geostationary Operational Environmental Satellites (GOESs) for proton observations and the Advanced Composition Explorer (ACE) satellite for electron observations. Núñez et al. proposed a GLE occurrence predictor called the High Energy Solar Particle Events foRecastIng and Analysis (HESPERIA) University of Málaga Solar particle Event Predictor (UMASEP-500), which did not include a model for predicting the >500 MeV integral proton intensity. This paper presents a comparison in terms of the GLE event occurrence between the HESPERIA UMASEP-500 and a new approach called UMASEP-500. Although the new approach shows a slightly better critical success index (CSI), which combines the probability of detection (POD) and false alarm ratio (FAR), the difference is not statistically significant. The main advantage of the new UMASEP-500 is its ability to predict the expected >500 MeV proton intensity. This study provides initial insight into a new era of electron and proton telescopes that will be available at L1 in the coming years. Full article