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  • Article
  • Open Access
17 Citations
4,149 Views
17 Pages

Antithetic hTERT Regulation by Androgens in Prostate Cancer Cells: hTERT Inhibition Is Mediated by the ING1 and ING2 Tumor Suppressors

  • Sophie Bartsch,
  • Kimia Mirzakhani,
  • Laura Neubert,
  • Alexander Stenzel,
  • Marzieh Ehsani,
  • Mohsen Esmaeili,
  • Thanakorn Pungsrinont,
  • Merve Kacal,
  • Seyed Mohammad Mahdi Rasa and
  • Aria Baniahmad
  • + 5 authors

10 August 2021

The human telomerase is a key factor during tumorigenesis in prostate cancer (PCa). The androgen receptor (AR) is a key drug target controlling PCa growth and regulates hTERT expression, but is described to either inhibit or to activate. Here, we rev...

  • Review
  • Open Access
21 Citations
6,228 Views
19 Pages

24 December 2019

The ING family of tumor suppressor genes is composed of five members (ING1-5) involved in cell cycle regulation, DNA damage response, apoptosis and senescence. All ING proteins belong to various HAT or HDAC complexes and participate in chromatin remo...

  • Review
  • Open Access
41 Citations
5,620 Views
17 Pages

Biological Functions of the ING Proteins

  • Arthur Dantas,
  • Buthaina Al Shueili,
  • Yang Yang,
  • Arash Nabbi,
  • Dieter Fink and
  • Karl Riabowol

19 November 2019

The proteins belonging to the inhibitor of growth (ING) family of proteins serve as epigenetic readers of the H3K4Me3 histone mark of active gene transcription and target histone acetyltransferase (HAT) or histone deacetylase (HDAC) protein complexes...

  • Brief Report
  • Open Access
18 Citations
5,034 Views
13 Pages

Loss of Ing3 Expression Results in Growth Retardation and Embryonic Death

  • Dieter Fink,
  • Tienyin Yau,
  • Arash Nabbi,
  • Bettina Wagner,
  • Christine Wagner,
  • Shiting Misaki Hu,
  • Viktor Lang,
  • Stephan Handschuh,
  • Karl Riabowol and
  • Thomas Rülicke

29 December 2019

The ING3 candidate tumour suppressor belongs to a family of histone modifying proteins involved in regulating cell proliferation, senescence, apoptosis, chromatin remodeling, and DNA repair. It is a stoichiometric member of the minimal NuA4 histone a...

  • Feature Paper
  • Review
  • Open Access
9 Citations
5,211 Views
14 Pages

Exploiting ING2 Epigenetic Modulation as a Therapeutic Opportunity for Non-Small Cell Lung Cancer

  • Alice Blondel,
  • Amine Benberghout,
  • Rémy Pedeux and
  • Charles Ricordel

21 October 2019

Non-small cell lung cancer (NSCLC) has been the leading cause of cancer-related death worldwide, over the last few decades. Survival remains extremely poor in the metastatic setting and, consequently, innovative therapeutic strategies are urgently ne...

  • Review
  • Open Access
15 Citations
3,195 Views
12 Pages

ING Proteins: Tumour Suppressors or Oncoproteins

  • Karine Jacquet and
  • Olivier Binda

27 April 2021

The INhibitor of Growth family was defined in the mid-1990s by the identification of a tumour suppressor, ING1, and subsequent expansion of the family based essentially on sequence similarities. However, later work and more recent investigations demo...

  • Article
  • Open Access
3,188 Views
17 Pages

Loss of ING3 in the Prostate Leads to Activation of DNA Damage Repair Markers

  • Viktor Lang,
  • Lisa Barones,
  • ShiTing Misaki Hu,
  • Fatemeh Hashemi,
  • Karen Blote,
  • Karl Riabowol and
  • Dieter Fink

20 March 2025

Background/Objectives: The inhibitor of growth family member 3 (ING3) acts as an epigenetic reader through physical interactions with histone-modifying enzymes and subsequent chromatin remodelling processes. It is involved in various cellular functio...

  • Review
  • Open Access
6 Citations
3,344 Views
12 Pages

The Biological and Clinical Relevance of Inhibitor of Growth (ING) Genes in Non-Small Cell Lung Cancer

  • Elisabeth Smolle,
  • Nicole Fink-Neuboeck,
  • Joerg Lindenmann,
  • Freyja Smolle-Juettner and
  • Martin Pichler

6 August 2019

Carcinogenic mutations allow cells to escape governing mechanisms that commonly inhibit uncontrolled cell proliferation and maintain tightly regulated homeostasis between cell death and survival. Members of the inhibition of growth (ING) family act a...

  • Article
  • Open Access
32 Citations
12,789 Views
20 Pages

3 July 2020

A singular and modest activist action, a temporary park created in San Francisco, grew into the global urban Park(ing) Day (PD) phenomenon. This tactical urbanism event not only expanded to be annually celebrated in thousands of parking lots all over...

  • Communication
  • Open Access
4 Citations
3,597 Views
7 Pages

4 February 2020

The five members of the family of tumor suppressors ING contain a Plant Homeodomain (PHD) that specifically recognizes histone H3 trimethylated at lysine 4 (H3K4me3) with an affinity in the low micromolar range. Here, we use NMR to show that in the p...

  • Review
  • Open Access
3 Citations
2,587 Views
12 Pages

Inhibitor of Growth Factors Regulate Cellular Senescence

  • Soudeh Ghafouri-Fard,
  • Mohammad Taheri and
  • Aria Baniahmad

24 June 2022

The Inhibitor of Growth (ING) proteins are a group of tumor suppressors with five conserved genes. A common motif of ING factors is the conserved plant homeodomain (PHD), with which they bind to chromatin as readers of the histone mark trimethylated...

  • Article
  • Open Access
14 Citations
3,571 Views
41 Pages

5 November 2021

Human activity and land-use changes have affected the water quality of Kwan Phayao, Upper Ing watershed, due to the associated high sediment load and eutrophication. This study aims to identify suitable LULC allocation scenarios for minimizing sedime...

  • Review
  • Open Access
1 Citations
1,748 Views
17 Pages

Inhibitor of Growth Proteins: Epigenetic Regulators Shaping Neurobiology

  • Ziyue Xu,
  • Hongyu Xu,
  • Jichun Shi,
  • Runming Liu,
  • Xiang Li,
  • Sha Liu and
  • Wei Wei

14 February 2025

The inhibitor of growth (ING) family of proteins is emerging as a pivotal regulator of epigenetic modifications within the nervous system. These proteins are involved in various cellular processes, including apoptosis, cell cycle control, and DNA rep...

  • Review
  • Open Access
12 Citations
4,904 Views
12 Pages

29 September 2021

Prevention and overcoming castration resistance of prostate cancer (PC) remains one of the main unsolved problems in modern oncology. Hence, many studies are focused on the investigation of novel androgen receptor (AR) regulators that could serve as...

  • Article
  • Open Access
7 Citations
3,555 Views
22 Pages

23 April 2023

The impressed current cathodic protection (ICCP) scheme is a more reliable and efficient method of corrosion prevention mechanism than the sacrificial method. Currently, the grid connected transformer rectifier units supported with a battery banks ar...

  • Article
  • Open Access
2,558 Views
24 Pages

This study explores syntactic variation and sociocultural identity in subjectless nonfinite clauses within Philippine English (PhE) and Singaporean English (SgE), focusing on to-infinitive and -ing gerund constructions. Using data from the Internatio...

  • Review
  • Open Access
22 Citations
4,893 Views
14 Pages

1 July 2021

Glycogen synthase kinase-3 beta is a ubiquitously and constitutively expressed molecule with pleiotropic function. It acts as a protooncogene in the development of several solid tumors including pancreatic cancer through its involvement in various ce...

  • Review
  • Open Access
1,494 Views
29 Pages

Functions of TIP60/NuA4 Complex Subunits in Cell Differentiation

  • Fatemeh Hashemi,
  • Aida Nourozi,
  • Mojtaba Shaban Loushab and
  • Karl Riabowol

1 November 2025

The TIP60/NuA4 complex is a large, multifunctional histone acetyltransferase assembly of ~1.7 megadaltons, composed of 17–20 subunits, which plays a central role in epigenetic regulation. Through recognition of H3K4me3 by the ING3 reader, TIP60...

  • Article
  • Open Access
9 Citations
8,785 Views
12 Pages

Within the Australian Indigenous community, it is often said that Aboriginality is a verb. It is a “doing” word, not a noun. As such, identifying actively is at the heart of being Australian Aboriginal. Doing identification, rather than owning a labe...

  • Article
  • Open Access
5 Citations
19,297 Views
18 Pages

Aesthetic Representation of Antisocial Personality Disorder in British Coming-of-Age TV Series

  • Marta Lopera-Mármol,
  • Manel Jiménez-Morales and
  • Mònika Jiménez-Morales

17 March 2022

TV series’ depictions of mental disorders have received considerable scholarly attention. However, few studies have considered the role of aesthetic elements in representing mental disorders. Therefore, in this study, we analysed how aesthetic...

  • Article
  • Open Access
44 Citations
6,369 Views
23 Pages

The Role of Petrimonas mucosa ING2-E5AT in Mesophilic Biogas Reactor Systems as Deduced from Multiomics Analyses

  • Irena Maus,
  • Tom Tubbesing,
  • Daniel Wibberg,
  • Robert Heyer,
  • Julia Hassa,
  • Geizecler Tomazetto,
  • Liren Huang,
  • Boyke Bunk,
  • Cathrin Spröer and
  • Andreas Schlüter
  • + 5 authors

Members of the genera Proteiniphilum and Petrimonas were speculated to represent indicators reflecting process instability within anaerobic digestion (AD) microbiomes. Therefore, Petrimonas mucosa ING2-E5AT was isolated from a biogas reactor sample a...

  • Article
  • Open Access
1 Citations
4,728 Views
19 Pages

Black Deaf Canadians are under-represented in every facet of life. Black Deaf Canadian excellence, history, culture, and language are under-documented and under-reported. Where are we in history? Where are we now? Why are we not being documented? Bla...

  • Proceeding Paper
  • Open Access
2,397 Views
9 Pages

The project VISOSMappING comes from a collaboration based on the sharing of different academic knowledges and is aimed at the development of an educational digital platform dedicated to sustainability, understood broadly: from the traditional meaning...

  • Article
  • Open Access
10 Citations
3,767 Views
17 Pages

JUUL™ing and Heating Lead to a Worsening of Arterial Stiffness

  • Julia Benthien,
  • Moritz Meusel,
  • Silja Cayo Talavera,
  • Ingo Eitel,
  • Daniel Drömann and
  • Klaas F. Franzen

Background: The widespread use of the JUUL™ device ignited a discussion about the effects these products have on harm reduction. Therefore, we conducted a study directly comparing the JUUL™ device with a cigarette, a heated tobacco produc...

  • Article
  • Open Access
28 Citations
5,387 Views
13 Pages

26 February 2022

Lactic acid bacteria (LAB) have gained particular attention among different exopolysaccharide-producing microorganisms due to their safety status and effects on human health and food production. Exopolysaccharide-producing LAB play a crucial role in...

  • Article
  • Open Access
16 Citations
5,672 Views
33 Pages

GSK-3 Inhibitor Elraglusib Enhances Tumor-Infiltrating Immune Cell Activation in Tumor Biopsies and Synergizes with Anti-PD-L1 in a Murine Model of Colorectal Cancer

  • Kelsey E. Huntington,
  • Anna D. Louie,
  • Praveen R. Srinivasan,
  • Christoph Schorl,
  • Shaolei Lu,
  • David Silverberg,
  • Daniel Newhouse,
  • Zhijin Wu,
  • Lanlan Zhou and
  • Wafik S. El-Deiry
  • + 4 authors

Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that has been implicated in numerous oncogenic processes. GSK-3 inhibitor elraglusib (9-ING-41) has shown promising preclinical and clinical antitumor activity across multiple tumor type...

  • Review
  • Open Access
30 Citations
4,420 Views
28 Pages

27 June 2023

The most prominent and highly visible advantage attributed to supercapacitors of any type and application, beyond their most notable feature of high current capability, is their high stability in terms of lifetime, number of possible charge/discharge...

  • Article
  • Open Access
3,144 Views
14 Pages

18 February 2024

In 1996, Helen Lee dubbed the departure of second-generation Asian Americans from the non-English-speaking immigrant churches that they were raised in as the “silent exodus”. This nationwide phenomenon was taking place largely because fir...

  • Article
  • Open Access
22 Citations
3,625 Views
15 Pages

Polyethylenimine-Modified Bombyx mori Silk Fibroin as a Delivery Carrier of the ING4-IL-24 Coexpression Plasmid

  • Longxing Niu,
  • Guo Chen,
  • Yanfei Feng,
  • Xueping Liu,
  • Peng Pan,
  • Linling Huang,
  • Ying Guo and
  • Mingzhong Li

19 October 2021

One of the major challenges for lung cancer gene therapy is to find a gene delivery vector with high efficiency and low toxicity. In this study, low-molecular-weight polyethyleneimine (PEI, 1.8 kDa) was grafted onto the side chains of Bombyx mori sil...

  • Article
  • Open Access
15 Citations
7,410 Views
20 Pages

22 April 2015

Three quinary polar intermetallic compounds in the (Eu1−xCax)9In8(Ge1−ySny)8 (x = 0.66, y = 0.03) and the (Eu1−xCax)3In(Ge3-ySn1+y) (x = 0.66, 0.68; y = 0.13, 0.27) phases have been synthesized using the molten In-metal flux method, and the crystal s...

  • Article
  • Open Access
14 Citations
6,941 Views
15 Pages

Development and Validation of the Vending Evaluation for Nutrient-Density (VEND)ing Audit

  • Tanya M. Horacek,
  • Elif Dede Yildirim,
  • Melissa Matthews Schreiber,
  • Carol Byrd-Bredbenner,
  • Sarah Colby,
  • Adrienne A. White,
  • Karla P. Shelnutt,
  • Melissa D. Olfert,
  • Anne E. Mathews and
  • Kendra Kattelmann
  • + 3 authors

Background: This paper describes the development and validation of the Vending Evaluation for Nutrient-Density (VEND)ing audit to comprehensively evaluate vended products based upon healthfulness, price and promotion, and machine accessibility. Metho...

  • Article
  • Open Access
2,131 Views
11 Pages

17 March 2025

Post-Theoretical “creative–critical” research recently emerged in the discipline of Creative Writing as a collapse of the binaries between practice and Theory. This article shows that using this interdisciplinary methodology in the...

  • Article
  • Open Access
7 Citations
4,541 Views
14 Pages

A Novel Splice Variant of the Inhibitor of Growth 3 Lacks the Plant Homeodomain and Regulates Epithelial–Mesenchymal Transition in Prostate Cancer Cells

  • Anna Melekhova,
  • Mirjam Leeder,
  • Thanakorn Pungsrinont,
  • Tim Schmäche,
  • Julia Kallenbach,
  • Marzieh Ehsani,
  • Kimia Mirzakhani,
  • Seyed Mohammad Mahdi Rasa,
  • Francesco Neri and
  • Aria Baniahmad

4 August 2021

Inhibitor of growth 3 (ING3) is one of five members of the ING tumour suppressor family, characterized by a highly conserved plant homeodomain (PHD) as a reader of the histone mark H3K4me3. ING3 was reported to act as a tumour suppressor in many diff...

  • Article
  • Open Access
2,719 Views
17 Pages

Low-light conditions severely degrade the captured image quality with few details, while deep learning approaches are trending towards low-light image enhancement (LLIE) due to their superior performance. However, few methods face the challenges of l...

  • Communication
  • Open Access
3 Citations
3,578 Views
10 Pages

29 June 2018

Natural gas (NG) is an important input used in the industrial production of South Korea. Therefore, the government requires quantitative information to be provided about the economic benefits of industrial NG (ING) use to decide whether to invest in...

  • Article
  • Open Access
11 Citations
3,964 Views
18 Pages

Semi-Synthetic Ingenol Derivative from Euphorbia tirucalli Inhibits Protein Kinase C Isotypes and Promotes Autophagy and S-Phase Arrest on Glioma Cell Lines

  • Viviane Aline Oliveira Silva,
  • Marcela Nunes Rosa,
  • Aline Tansini,
  • Olga Martinho,
  • Amilcar Tanuri,
  • Adriane Feijó Evangelista,
  • Adriana Cruvinel Carloni,
  • João Paulo Lima,
  • Luiz Francisco Pianowski and
  • Rui Manuel Reis

22 November 2019

The identification of signaling pathways that are involved in gliomagenesis is crucial for targeted therapy design. In this study we assessed the biological and therapeutic effect of ingenol-3-dodecanoate (IngC) on glioma. IngC exhibited dose-time-de...

  • Article
  • Open Access
14 Citations
4,365 Views
9 Pages

Does Adding Standard Systematic Biopsy to Targeted Prostate Biopsy in PI-RADS 3 to 5 Lesions Enhance the Detection of Clinically Significant Prostate Cancer? Should All Patients with PI-RADS 3 Undergo Targeted Biopsy?

  • Enrique Gomez-Gomez,
  • Sara Moreno Sorribas,
  • Jose Valero-Rosa,
  • Ana Blanca,
  • Juan Mesa,
  • Joseba Salguero,
  • Julia Carrasco-Valiente,
  • Daniel López-Ruiz and
  • Francisco José Anglada-Curado

Introduction. Our aim was to assess the value of adding standard biopsy to targeted biopsy in cases of suspicious multiparametric magnetic resonance imaging (mp-MRI) and also to evaluate when a biopsy of a PI-RADS 3 lesion could be avoided. Methods:...

  • Article
  • Open Access
3 Citations
2,343 Views
11 Pages

Features of Thermomechanical Stability of Anionic–Cation Exchange Matrix “Polikon AC” on Viscose Non-Woven Materials

  • Denis Terin,
  • Marina Kardash,
  • Sergey Korchagin,
  • Sergey Tsyplyayev,
  • Vladimir Cherkasov and
  • Tamara Druzhinina

27 September 2021

The thermomechanical stability of the anion–cation exchange matrix “Polikon AC” on viscose nonwoven materials is investigated. In this work, a molecular model of a solvation environment for experimentally obtained “Polikon AC” mosaic membranes is ref...

  • Article
  • Open Access
53 Citations
8,402 Views
19 Pages

CRISPR/Cas9-Mediated Mutagenesis of Carotenoid Cleavage Dioxygenase 8 (CCD8) in Tobacco Affects Shoot and Root Architecture

  • Junping Gao,
  • Tong Zhang,
  • Bingxin Xu,
  • Ling Jia,
  • Bingguang Xiao,
  • He Liu,
  • Lijing Liu,
  • Hao Yan and
  • Qingyou Xia

Strigolactones (SLs) are a class of phytohormones that regulate plant architecture. Carotenoid cleavage dioxygenase (CCD) genes are involved in the biosynthesis of SLs and are identified and characterized in many plants. However, the function of CCD...

  • Proceeding Paper
  • Open Access
1 Citations
3,600 Views
6 Pages

The expansion of mining activities around the world due to the increasing population and demand for metals are transforming mining methods. Mining is going deeper and deeper, and deposits of small thicknesses and large inclinations are becoming inter...

  • Article
  • Open Access
1 Citations
2,709 Views
18 Pages

3 October 2023

Virtual fences for livestock facilitated by a GPS shock collar (GPS-SC) and phone app were introduced to the UK in cattle herd trials in 2020. Technology which uses aversive shocks to control livestock movement on farms and in other settings poses a...

  • Article
  • Open Access
9 Citations
3,199 Views
13 Pages

20 May 2024

A high-sensitivity silicon microring (Si MRR) optical biosensor for detecting the nucleocapsid protein of SARS-CoV-2 is proposed and demonstrated. In the proposed biosensor, the surface of a Si MRR waveguide is modified with antibodies, and the targe...

  • Article
  • Open Access
1,605 Views
17 Pages

3 November 2025

Technology has historically served as a fundamental driver of human welfare and progress. Contemporary calls for temporary moratoria on technological development, motivated by concerns about existential threats to humanity, represent a misguided appr...

  • Article
  • Open Access
4 Citations
2,639 Views
9 Pages

Trace Mineral Leaching from Equine Compost

  • Ashley L. Fowler,
  • Mieke Brummer-Holder and
  • Karl A. Dawson

2 September 2020

Mineral leaching from compost can be environmentally disruptive. Little information is available regarding trace mineral leaching from equine-sourced compost. The objective of this study was to quantify the mineral content and leaching potential of c...

  • Article
  • Open Access
15 Citations
10,282 Views
24 Pages

19 June 2012

The application of the Maximum Entropy (ME) principle leads to a minimum of the Mutual Information (MI), I(X,Y), between random variables X,Y, which is compatible with prescribed joint expectations and given ME marginal distributions. A sequence of s...

  • Article
  • Open Access
4 Citations
3,293 Views
12 Pages

11 December 2019

Minerals excreted in feces have the potential to leach or runoff to water-ways, negatively impacting water quality. This study examined the effect of dietary trace mineral levels, and their source, on the leaching potential of minerals from equine fe...

  • Article
  • Open Access
17 Citations
8,009 Views
18 Pages

Fish Oil Enriched in EPA, but Not in DHA, Reverses the Metabolic Syndrome and Adipocyte Dysfunction Induced by a High-Fat Diet

  • Roberta Dourado Cavalcante da Cunha de Sá,
  • Jussara de Jesus Simão,
  • Viviane Simões da Silva,
  • Talita Mendes de Farias,
  • Maysa Mariana Cruz,
  • Vitor Jacó Antraco,
  • Lucia Armelin-Correa and
  • Maria Isabel Alonso-Vale

26 February 2021

This study aimed to investigate the effects of two commercially available fish oils (FOs) containing different proportions of two omega-3 fatty acids (FA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on the metabolic and endocrine dys...

  • Article
  • Open Access
49 Citations
17,445 Views
25 Pages

30 January 2024

This study examines the adoption and institutionalization of Green Human Resource Management (Green HRM) in Malaysian SMEs, focusing on the influence of Perceived Organizational Green Readiness (POG) and Perceived External Green Readiness (PEG) on th...

  • Article
  • Open Access
7 Citations
4,115 Views
13 Pages

28 November 2023

Obesity is a risk factor for many chronic diseases related to the overexpansion of adipose tissue during obesity, leading to metabolic dysfunction and ectopic lipids. Previous studies reported a close relationship between succinate and obesity and it...

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