Search Results (183)

China’s power sector is undergoing a complicated transformation characterized by intricate dependence on the dominant coal infrastructure and abundant renewable energy resources. This study assesses China’s carbon-neutral transition pathways for the period of 2024–2060 by using the “Establish Before Breaking” principle within a policy-informed, high-resolution energy system modeling framework. To examine the technological, economic, and environmental trade-offs of various carbon-neutral strategies, four scenarios (Reference (REF), Carbon Capture and Storage (CCS), Renewable-Based (REB), and Integrated (ING)) were developed, and their impacts were assessed through the application of the Low Emission Analysis Platform and the Next Energy Modeling (LEAP–NEMO) model. The results reveal that the ING scenario represents the most feasible and policy-consistent pathway, achieving an 88% renewable electricity share and a total installed capacity of approximately 8000 gigawatts (GW) by 2060. This pathway relies on a dual-track strategy that combines accelerated renewable deployment—supported by geographical complementarity and multi-regional Power-to-X (PtX) systems—with the strategic stabilization of conventional generation assets. The findings further demonstrate that retaining a small but critical share of flexible coal-CCS (0.2–0.5%) and nuclear capacity is necessary to address sub-daily variability, mitigate duck-curve effects, and ensure power system reliability under high renewable penetration. This integrated approach offers a systematic pathway for deep decarbonization within China’s unique energy context, ensuring a just, equitable, and sustainable transition. Full article

ingInfrastructure-as-Code (IaC) is a systems management practice that involves managing and provisioning computing infrastructure through machine-readable definition files, rather than physical hardware configuration or interactive configuration tools. IaC is an essential contribution to the complete automation of the entire software lifecycle in a Development and Operations (DevOps) context. The deployment and management of software through coded configuration, monitoring, and analysis is the IaC solution. In recent times, artificial intelligence (AI)—including generative AI, machine learning, and related techniques—offers opportunities to improve techniques across the IaC life cycle from IaC code generation to its deployment and runtime analysis. We conducted a comprehensive and systematic literature review for all IaC code development and operations phases, considering IaC as a specific software type that we map to the DevOps model. We present the bibliographic review results and investigate in which phases and how AI can enhance IaC techniques by extracting a framework of phase-specific AI contributions and research challenges, contrasting, in particular, generative AI and machine-learning applications across the phases. Key findings include Large Language Models (LLMs) dominating generation and Machine Learning (ML) dominating analysis activities, also showing that operations phases are less studied than IaC development. This review extends previous literature reviews by covering the full DevOps lifecycle, developing a phase-specific taxonomy of AI techniques for IaC, and aligning a comprehensive analysis of research challenges and directions with those that benefit developers by highlighting current innovations and pointing researchers to future directions. Full article

Background and Clinical Significance: Sister Mary Joseph nodules (SMJN) are rare extra-intestinal manifestations of metastatic intra-abdominal and pelvic malignancies, often indicating advanced disease and poor prognosis. Their association with cholangiocarcinoma (CCA) is particularly uncommon, with only a limited number of reported cases. Case Presentation: We present a case report of a 65-year-old previously healthy male who presented for an elective umbilical hernia repair. Additional findings of elevated direct bilirubin and a history of fatigue in the patient prompted further evaluation with biopsy and imaging, which revealed advanced-stage intrahepatic CCA. Following the diagnosis, the patient underwent biliary stenting and chemotherapy. Conclusions: The variable presentation of SMJN, along with its frequent misdiagnosis, often delays recogni-tion and management of the underlying malignancy. This case of SMJN in the setting of CCA highlights the complex interplay between intra-abdominal and pelvic malignancies and their impact on different organ systems. With the rising incidence and mortality rates associated with CCA, early recognition is essential to improving patient outcomes. This underscores the need for increased clinical awareness and further research, thus support-ing the development of this case report. Full article

Cellular senescence, characterized by permanent cell cycle arrest, significantly influences cancer development, immune regulation, and progression. However, the precise mechanisms by which senescence contributes to colorectal cancer prognosis remain to be fully elucidated. By integrating expression profiles of senescence-related and prognostic genes in colon adenocarcinoma (COAD) patients, we formulated and confirmed a nine-gene cellular senescence-related signature (CSRS) that integrates senescence-associated and prognosis-predictive genes using data from the CellAge, The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). A cell senescence-related prognostic formula was developed as follows: CSRS = (CASP2 × 0.2098) + (CDKN2A × 0.1196) + (FOXD1 × 0.1472) + (ING5 × 0.3723) + (OXTR × 0.0786) + (PHGDH × 0.1408) + (SERPINE1 × 0.1127) + (SNAI1 × 0.1034) + (LIMK1 × 0.0747). In a multivariate Cox proportional hazards model, the CSRS score, age and TNM stage were all identified as significant independent indicators for overall survival, affirming their prognostic value in colorectal cancer. The CSRS-high group exhibited significantly up-regulated senescence-associated secretory phenotype (SASP) and immune cell infiltration, whereas the CSRS-low group showed an apparent better response to immune-checkpoint inhibitor therapy. Our findings suggest CSRS score and its constituent genes represent potential biomarkers for prognosis and immunotherapeutic benefit in COAD patients. Extending this nine-gene set into a broader senescence-associated panel should be a next step toward delivering truly individualized treatment plans. Full article

Background/Objectives: Alternative Tobacco and Nicotine Products (ATNPs) have gained widespread popularity. Although they are often promoted as lower-risk alternatives to traditional tobacco products, concerns remain regarding their association with risky behaviors among adolescents and young adults. This study examines the relationship between dietary and lifestyle habits and both ATNP use and intention to use ATNP among Italian participants in the MINERVA (My changINg lifEstyles our Research and eVeryone heAlth) international project. Methods: MINERVA is an observational, international, prospective cohort study. A study-specific questionnaire was administered to participants, who were recruited through informal snowball sampling. The questionnaire collected information on sociodemographic characteristics, lifestyle factors, dietary habits, and the use of both traditional tobacco products and ATNPs. Predictors of ATNP use and intention to use were assessed using logistic regression models. Results: Data from 7535 Italian participants were analyzed. Overall, 48% reported having ever used ATNP, and 14% of non-smokers and non-users expressed an intention to try these products. Significant predictors of ATNP use and intention to use included prior smoking, lower age, and having family members who smoke. Lifestyle factors such as frequent consumption of fast food, junk food, and alcoholic beverages were positively associated with both ATNP use and intention to use. Conversely, daily fruit and vegetable consumption was inversely associated with these outcomes. Conclusions: ATNP use and intention to use were associated with unhealthy dietary and lifestyle patterns. These findings highlight the importance of integrated public health strategies addressing substance use alongside broader lifestyle behaviors among adolescents and young adults. Full article

Fused deposition modeling of polyether ether ketone offers distinct advantages for fabricating complex and lightweight structures. Although three principal build orientations theoretically exist for practical 3D engineering components, research on their effects remains limited, especially regarding the influence of the interaction between build orientation and printing path on mechanical performance. This study investigated the tensile and shear properties, as well as the failure mechanisms, of FDM-fabricated PEEK under the coupled effects of build orientation and printing path through mechanical testing, fracture morphology analysis, and statistical methods. The results indicate that the printing path exerts a dominant influence on anisotropic behavior, while the interaction between printing path and build orientation jointly governs the shear failure modes. Under identical printing paths, the elongation at break varied by up to twofold across different build orientations, reaching a maximum of 96%, whereas samples printed with W or T paths exhibited elongations at break below 5%. Although shear and tensile moduli remained largely consistent across build orientations, other mechanical properties demonstrated significant differences. Variations in cross-sectional dimensions induced by build orientation markedly affected tensile performance: the coupled effect of build orientation and printing path was found to render the path repetition frequency a critical factor in determining temperature uniformity within the printed region and the quality of interlayer interfaces, thereby constituting the core mechanism underlying anisotropic behavior. Furthermore, larger cross-sections re-duced tensile modulus but enhanced yield strength and elongation at break, highlight-ing the regulatory role of cross-sectional geometry on mechanical response. Based on these findings, a synergistic optimization strategy integrating printing path, build orientation, and tensile–shear performance is proposed to achieve tailored mechanical properties in FDM-fabricated PEEK components. This approach enables controlled enhancement of structural performance to meet diverse application requirements. Full article

Technology has historically served as a fundamental driver of human welfare and progress. Contemporary calls for temporary moratoria on technological development, motivated by concerns about existential threats to humanity, represent a misguided approach that may ultimately prove counterproductive to human flourishing. This paper argues that technology itself is not inherently problematic; rather, the issue lies in contemporary society’s fragmented ontological framework. Drawing on African philosophical traditions, particularly Kemetic cosmology and ubuntu philosophy, we examine how ancient Kemetic civilization exemplified transhumanist principles through its integration of technological advancement within a holistic worldview. The Kemetic understanding of Reality as a sacred, differentiated Whole, embodied in their conception of Atum as the self-developing divine principle, always connected to and guided by Shu (life) and Tefnut/Ma’at (order), provided a cosmological foundation that enabled beneficial coexistence with technology as a life-giving human contingency regulated by ma’at. Similarly, the ubuntu cosmo-philosophical vision in contemporary African thought emphasizes Reality as an interconnected totality, with technology being an independent yet connected excitation in this Reality. This study, therefore, contends that the fundamental challenge facing modern society today is not technological or AI development per se, but rather the need to reconstruct our fragmented perception of Reality. Within a properly integrated cosmological vision, technology functions not as a selfish instrument or an object readily available for our exploitative purposes but as an inherently life-affirming, sustaining, and enhancing force indispensable for the well-being of the Whole. The implications suggest that, rather than constraining technological advancement, which could be detrimental to our well-being due to our inherent reliance on it, as it relies on us, efforts should be directed toward cultivating a holistic yet relational understanding of technology, with the cosmos. Full article

The TIP60/NuA4 complex is a large, multifunctional histone acetyltransferase assembly of ~1.7 megadaltons, composed of 17–20 subunits, which plays a central role in epigenetic regulation. Through recognition of H3K4me3 by the ING3 reader, TIP60/NuA4 is recruited to sites of active transcription, where it remodels chromatin to regulate gene expression. Its activities include histone acetylation, histone variant exchange, transcriptional co-activation, and regulation of the cell cycle and apoptosis. In this review, we examine how altered subunit levels or mutations impact the chromatin structure and transcriptional activity, and how these changes influence differentiation across diverse cell types. We emphasize the molecular mechanisms by which TIP60/NuA4 shapes lineage specification, including histone H2A and H4 acetylation by the KAT5 catalytic subunit, H2A.Z incorporation by EP400, and interactions with transcription factors such as MyoD, PPARγ, and Myc. By integrating mechanistic and functional insights, we highlight how TIP60/NuA4 acts as a central epigenetic hub in differentiation and contributes to proper developmental transitions. Full article

The Australian health care system continues to struggle to meet the needs of people experiencing multiple complex chronic conditions. Australians who report poorer health continue to report poorer access to health care. Inequities in access are attributed to a “mistmatch” between the health care system and individuals’ clinical and social needs. To address this misalignment at the interface of access, innovative approaches that consider both individual and system-level barriers to care need to be examined. Nurse navigation models designed to support people negotiating complex care and bridge systems and service gaps have been touted as a method to enhance access, but how nurse navigators work at the interface of access in practice is unclear. This qualitative study examined the mechanisms by which nurse navigators facilitate access to care for people experiencing complex care needs through an exploration of key stakeholder perspectives: nurse navigators, nurse navigator patients, and care professionals. Data collection involved in-depth semi-structured interviews, and analysis included reflexive thematic analysis and data triangulation processes. A conceptual framework of access to health care was used to explore nurse navigators’ roles at both system and patient levels. Nurse navigators supported both patients and care professionals by building relationships across the interface of access, challenging norms of care, and facilitating empowerment. Nurse navigators acted as intermediaries to negotiate access, work made possible through their knowledge of systems and capacity to identify and respond to multidimensional care needs and systems challenges. This research highlights the importance of holistic and relational approaches to overcome issues of access for all involved. Full article

Bacterial nanocellulose (BNC) composite films have emerged as promising candidates for sustainable building materials, yet their practical application in building-integrated photovoltaics (BIPV) facade systems is hindered by insufficient mechanical strength, poor environmental stability, and limited energy efficiency. Here, we developed bacterial nanocellulose/zinc oxide–phenolic resin (BNC/ZnO–PF) composite films with high-strength, stability, and energy efficiency for BIPV facade system through a simple strategy. Specifically, we first prepared BNC films, then in-situ grew ZnO nanoparticles on BNC films via ultrasound assistance, and finally hot-pressed the BNC/ZnO films with PF resin. The BNC/–PF composite films exhibit high mechanical strength (tensile strength of 93.8 MPa), exceptional sturdiness (wet strength of 92.3 MPa), and thermal properties, demonstrating their durability for long-term outdoor applications. Furthermore, the BNC/ZnO–PF composite films show high transparency (86.47%) and haze (82.02%) in the visible light range, enabling effective light propagation and scattering, as well as soft, uniform, and large-area light distribution. Meanwhile, a low thermal conductivity of 21.7 mW·m⁻¹·K⁻¹ can effectively impede the transfer of high outdoor temperatures into the room, significantly reducing the energy consumption demands of heating and cooling systems. Coupled with its ability to en-hance the photovoltaic conversion efficiency of solar cells by 12.9%, this material can serve as the core encapsulation layer for BIPV facades. While enabling build-ing-integrated photovoltaic power generation, through the synergistic effect of light management and thermal insulation, it is expected to reduce comprehensive building energy consumption, providing a new solution for building energy efficiency under carbon neutrality goals. Full article

This paper discusses a special type of complement of perception verbs in Serbian, introduced by kako (‘how’). Via a parallel corpus analysis, I compare the distribution of Serbian kako-clauses and English -ing forms. I show that two types of non-interrogative kako-clauses can be used in translations of English -ing forms, distinguished based on their formal and interpretive properties: ‘eventive’ and propositional kako-clauses. Eventive clauses focus on directly perceived events and cannot be negated or combined with epistemic verbs, while propositional clauses express beliefs or judgments and have a truth value. At a formal level, eventive clauses feature a null subject, while propositional clauses feature an overt nominative subject. I argue that this distinction is captured syntactically through the notion of phasehood, with only propositional clauses merging a full CP domain. Adopting the Form-Copy operation, I propose that eventive clauses lack a phase boundary, allowing for the deletion of a lower subject copy and yielding the observed case alternation and null embedded subject. This analysis offers a unified syntactic account of kako-complements and contributes to the typology of perception-based clause embedding. Full article

Canine mammary tumors (CMTs) are among the most frequently diagnosed neoplasms in female dogs, with complex etiologies involving age, breed, body size, and reproductive status. This retrospective study analyzed 250 cases comprising 361 mammary tumors to evaluate demographic patterns, histopathological subtypes, and their topographical distribution. The majority of tumors (88.64%) were malignant, with complex carcinoma being the most common subtype (24%), followed by intraductal papillary carcinoma (14.95%). The mean age at diagnosis was 9.36 years, with 60.8% of cases occurring in dogs older than 8 years. Mixed-breed dogs were most frequently affected, followed by Bichon-type breeds and German Shepherds. Small-sized dogs (<10 kg) accounted for 43.5% of cases. Regarding the reproductive status, 35.6% of dogs were unspayed, while the remainder were either intact or had an undetermined status, reflecting regional spaying practices. A statistically significant association was identified between histological subtype and mammary gland location, revealing non-random, region-specific tumor distribution. Complex carcinomas were frequently located in the left canial abdominal mammary segment (L.A2), right canial abdominal mammary segment (R.A2), and left inguinal mammary segment (L.ING); mixed and tubular carcinomas were more prevalent in R.A2 and R.ING; and tubulopapillary carcinomas appeared predominantly in L.ING. While no significant overall association was found between tumor grade and gland location, grade III carcinomas showed a possible predilection for the left inguinal gland (L.INGH), indicating a regional tendency that warrants further investigation. These findings underscore the importance of anatomical factors in the development of CMTs and support the integration of gland-specific tumor patterns into diagnostic assessment and surgical decision-making. Full article

People with moderate to severe intellectual disabilities (M/S ID) and behaviour that challenges are still almost exclusively encountered and understood within a highly specialized professional care system context. They are almost invisible in the societal mainstream, where a wider variety of perspectives on (everyday) manners, encounters, relationships and life applies. These (and other) exclusionary dynamics render everyday relations with residents with M/S ID whose behaviours challenge still largely dependent on the interpretative frameworks and actions of professionals. Professionals are trained and socialized within highly specialized professional care system contexts, despite a growing scientific and professional awareness that behaviour that challenges is a multifaceted and contextual phenomenon. In this paper, we report on a pioneering initiative (titled Project WAVE) which aimed to cultivate a fresh and comprehensive approach to behaviours that challenge within stagnant care practices. Our goal was to foster an innovative collaborative paradigm by facilitating an extensive and enduring exchange between “insiders”—professionals of specialized care system contexts—and “outsider-researchers”—individuals socialized through alternative avenues. We present our epistemological and methodological approach, the data collection process (a multiple case-informed community of practice), and the most important lessons learned. Full article

It is a popular assumption that people learn certain practices for handling media in the course of their adolescence and adulthood, which make it difficult for them to develop new patterns for the use of media at a later point in their lives. From this theoretical standpoint, it is a challenge for older people to learn how to handle new media and integrate them into their current living situation. Beyond theoretical assumptions, there has formerly been a lack of exploratory investigations pursuing the conditions under which older adults take up digital media with which they were previously not familiar and incorporate them into their daily lives. Between October 2023 and March 2024, 32 semi-standardised individual interviews were conducted with a group of people between 80 and 93 years of age, who had recently acquired a digital medium and integrated it into their everyday lives. The decisive factor here was the presence of certain motives that generate plausible incentives to make permanent use of new media. The interviewees have purposefully acquired new media. It is notable that acquisition processes were strongly initiated by significant changes in life circumstances. In the case of most interviewees, the intention to acquire an internet-enabled medium was based on the wish to use a few selected functions. New options for online use were only explored after a while. The following patterns were identified regarding the motives and gratifications of acquisition: new media as…(1) hobby extension, (2) support network, (3) compensation tool, (4) connection opportunity, (5) escape from everyday life. It can be assumed that older people experience the use of new media as purposeful if they have specific motives for doing so. Biological, psychological and social correlations as well as ways of coping and dealing with age(ing) are relevant here. If daily use potentials are perceived as beneficial, older people show a high level of adaptability in terms of new media. Against this background, a gratification-orientated model appears to be a promising starting point for explaining the prerequisites for media adoption based on motives that generate plausible incentives for learning how to use new media at an older age. Full article

This study investigates the evolutionary mechanisms and equilibrium character-istics of the China–US trade dispute through an improved ecological competition model. By quantifying tariff policies as competition intensity regulators and introducing trade elasticity parameters, we construct a dynamic system that captures the nonlinear feedback between economic rivals. Key findings are as follows. (1) When both nations implement reciprocal tariff measures with similar economic sensitivities, the system converges to a stable equilibrium where bilateral economic outputs stabilize at reduced levels compared to pre-conflict states, provided the product of adjusted competition coefficients remains below critical thresholds. (2) Excessive tariff escalation beyond identifiable tipping points triggers winner-takes-all outcomes, validating the “Thucydides Trap” hypothesis in eco-nomic conflicts. (3) Empirical simulations using 2018–2023 trade data demonstrate that China’s tit-for-tat tariff strategy effectively maintains competitive balance, while domestic market expansion measures (evidenced by a 6.3% average annual growth in China’s do-mestic consumption) significantly mitigate trade diversion effects. The study establishes theoretical connections with optimal tariff theory and strategic trade policy literature while providing policymakers with quantitative tools to assess trade policy impacts. Our find-ings theoretically validate China’s policy combination of calibrated reciprocity and domestic demand stimulation, offering new insights into managing great-power economic competition. Full article