Search Results (168)

Background/Objectives:Tinnitus, the perception of sound without an external source, is a prevalent and often distressing condition with complex neurobiological and psychological underpinnings. A growing body of literature suggests a frequent co-occurrence between tinnitus and psychiatric symptoms such as anxiety, depression, and sleep disturbances. However, the extent to which these conditions are associated, and whether treatments targeting one domain impact the other, remains unclear. This scoping review aimed to (1) identify associations between tinnitus and mental health comorbidities, (2) evaluate whether tinnitus treatments affect psychiatric outcomes, and (3) explore whether psychiatric treatments influence tinnitus symptoms. Methods: A comprehensive search of PubMed, MEDLINE, Embase, PsycINFO, Cochrane Database of Systematic Reviews, and Google Scholar was conducted for articles published between January 2014 and May 2025. Eligible studies were written in English, French, or Spanish, focused primarily on tinnitus, included at least one co-occurring psychiatric condition, and described how tinnitus was evaluated. A total of 30 studies were included. Data were extracted and synthesized thematically. Study quality was assessed using the Mixed Methods Appraisal Tool and relevant Joanna Briggs Institute checklists. Results: Most studies reported significant associations between tinnitus and psychiatric symptoms, particularly anxiety, depression, stress, insomnia, and, in some cases, psychosis. Treatments aimed at tinnitus, such as eye movement desensitization and reprocessing and cognitive behavioral therapy, were sometimes associated with secondary improvements in mental health. Conversely, limited evidence suggested that psychiatric treatment, including antipsychotic medication and psychotherapy, may reduce tinnitus severity in selected cases. Conclusions: Tinnitus and psychiatric comorbidities frequently co-occur, and early evidence suggests that addressing one may benefit the other. Given the specific inclusion criteria, this review presents a selected subset of the broader literature, focusing only on studies that evaluated tinnitus alongside clinically measured psychiatric symptoms. Future research should prioritize integrated, longitudinal interventions to better understand these complex interactions. Full article

To optimize the management of groundwater resources in the Bourgogne-Franche-Comté (BFC, France) region, data from the Size-Eaux database were cross-referenced with the French Reference Framework for Groundwater Bodies (GWB). The information contained in this dataset was synthesized using Principal Component Analysis (PCA), followed by Agglomerative Hierarchical Clustering (AHC) of GWBs based on their average coordinates along the main factorial axes. The results reveal 11 distinct GWB groups, each internally homogeneous in terms of chemical composition and ongoing processes responsible for intra-group variability. The distribution of the groups aligns with the region’s structural geology, lithology, and agricultural activity patterns. Livestock farming areas, prone to fecal contamination, and cereal-growing areas, characterized by high nitrate concentrations, stand out distinctly. Furthermore, the analysis of GWB groups highlights regional processes such as denitrification, confirming the existence of spatial structuring of these mechanisms beyond local specificities. The major physicochemical and bacteriological zones show strong contrasts between groups while maintaining significant internal homogeneity. Despite the region’s vast size and diversity, spanning three major watersheds, further subdivision was not necessary to obtain applicable results. These findings confirm observations made in other regions and pave the way for an optimized monitoring and surveillance strategy. Full article

This study, which involved 868 patients, focused on size-dependent features (body size, pinna formation, brachycephaly, overweight) and their associations with the occurrence of canine Otitis externa. Breed, sex, and neuter status were also included. Canine patients diagnosed with Otitis externa presented between 1 January 2019 and 31 July 2022 in a referral small animal hospital were included, while dogs with matching categories presented at the Unit for Reproductive Medicine in the same time period functioned as a randomized control group. Statistical analyses included Pearson–Chi² test, Fisher’s exact test, and Bonferroni correction. p-values of <0.05 were considered statistically significant. Rhodesian Ridgebacks, non-brachycephalic breeds, intact female dogs, dogs with semi-erect ears, and large-sized breeds had a significantly reduced risk of developing Otitis externa. Conversely, Pugs, French Bulldogs, Cocker Spaniels, medium-sized breeds, dogs with erect ears, brachycephalic breeds, neutered female, and neutered male patients were more frequently diagnosed with Otitis externa. The study concluded that large breed dogs showed a reduced risk of developing Otitis externa in our data set as well as meso- and doliocephalic breeds and dogs with semi-erect pinna formation. Particularly, the Rhodesian Ridgeback and intact female dogs showed a significantly low risk of suffering from Otitis in the current study. Full article

This paper argues that Louis-Ferdinand Céline and Georges Bataille use voyeurism as a transgressive mechanism to confront death through the female body, a paradoxical site of life and decay. Though Céline’s clinical, disenchanted gaze contrasts with Bataille’s erotic, metaphysical quest, both employ the act of seeing to reveal death’s presence within vitality. In Céline’s works, voyeurism shifts from erotic curiosity to cold observation, framing the female body as a sterile emblem of mortality. In Bataille’s, it becomes participatory, merging ecstasy with dissolution in a sacred yet destructive form. Drawing on Freud and Sodom motifs, this study shows how their gazes transform the female body into a lens for existential finitude, challenging life–death boundaries in 20th-century French literature. Full article

The continuous use of antibiotics is associated with many complications in the poultry industry. Probiotics have emerged as a viable alternative over the past few decades to counter the adverse effects of antibiotics. No candidate probiotic microorganisms have been fully evaluated in the poultry industry for their effectiveness as potential probiotics in guinea fowls (GFs) compared to chickens. Recently, a metagenome evaluation of GFs in our laboratory revealed a predominance of Lactobacillus reuteri (L. reuteri) and actinobacteria class of bacteria in their gastrointestinal tract. The aim of this study is to evaluate a well-known lactic acid probiotic bacterium (L. reuteri) and a unique probiotic (S. coelicolor) that has not been assessed in any guinea fowl species. In the current study, L. reuteri and Streptomyces coelicolor (S. coelicolor) were selected as probiotic bacteria, encapsulated, and added into French guinea fowl (FGF) feed individually at a concentration of 10⁸ cfu/g or both microorganisms combined each at 10⁴ cfu/g. In an 8-week study, 216-day-old guinea keets were randomly assigned to four dietary treatments as indicated: (1) L. reuteri (10⁸ cfu/g); (2) S. coelicolor (10⁸ cfu/g); (3) mixture of L. reuteri (10⁴ cfu/g) and S. coelicolor (10⁴ cfu/g); and (4) control treatment (no probiotics included). The L. reuteri, S. coelicolor, and L. reuteri + S. coelicolor were added into the feed using wheat middlings as a carrier at a final concentration of 10⁸ cfu/g. The FGFs that were fed diets containing L. reuteri showed improved feed consumption at 3–8 weeks of age (WOA). The guineas fed L. reuteri and S. coelicolor showed a lower feed conversion ratio (FCR), which was significant at 2 and 8 WOA, and a numerically lower 8-week average FCR when compared with other dietary treatments. Differences in body weight gain among all dietary treatments were not significant. This research suggests that L. reuteri and S. coelicolor may have the potential for use as probiotics in FGFs when used in combination or separately. Full article

Background: The obesity epidemic among adolescents significantly impacts not only their physical health but also various psychological factors, including their perception of body image. Thus, this study pursued three main objectives: (1) to update the reference standard values for all the physical fitness tests performed; (2) to examine the impact of overweight and obesity on factors influencing physical fitness in adolescents; and (3) to determine the relationship between the physical fitness level and the body image dissatisfaction among a population of French-Canadian adolescents. Methods: A total of 1862 adolescents aged 12 to 17 (1008 boys and 854 girls) participated in this study. Data were collected from 12 French-language high-schools from different socioeconomic backgrounds and spread across four regions of the province of Québec, Canada. Anthropometric measures (body mass, body height, body mass index (BMI), waist circumference, waist-to-height ratio) and fitness tests (aerobic power, anaerobic power, muscle endurance, muscular power, flexibility) were conducted. To assess adolescents’ body perception, a silhouette scale was used. Results: Standardized normative values were established for each fitness test (Lambda Mu Sigma; LMS method). In boys, performance generally improved with age, except for the V-test and sit-ups, which remained stable, and VO₂peak, which declined during adolescence in both genders (unpaired t-test and Cohen’s d effect size). In girls, only the vertical jump and 30 m sprint improved with age, while the other tests stabilized by age 13. Fitness level was significantly influenced by obesity status. Boys and girls with a normal BMI performed better than those who were overweight or obese (ANOVA = p < 0.001 and effect size F). Girls appeared to be less affected by obesity status, with differences between overweight and obese groups rarely being significant (p > 0.05). Fitness level was also linked to body satisfaction, with satisfied adolescents generally achieving better scores than dissatisfied ones, even among those with a typical BMI. Socioeconomic status did not impact body image perception in boys (p = 0.351). In contrast, girls from lower socioeconomic backgrounds exhibited significantly more negative perceptions (p = 0.002) than their peers from more affluent families. Conclusions: Obesity status is strongly associated with poorer performance on fitness tests. Conversely, higher levels of physical fitness are linked to improved body image satisfaction. This positive relationship between fitness and body image holds true even for individuals with a healthy body weight (typical BMI). Full article

Measuring limb joint angles is crucial for understanding horse conformation, performance, injury diagnosis, and prevention. While Thoroughbred horses have been extensively studied, local Pakistani breeds (e.g., Morna racehorse) have not received scientific attention. This study aimed to quantify normal angles of limb joints in the Morna breed. Limb joint angles of standing horses (n = 50) were quantified using a measuring tape, height stick, protractor scale, and goniometer. The mean and standard deviation (Mean ± SD) values for the forelimb joint angles were 123.02 ± 3.46° for elbow, 171.52 ± 2.39° for knee, and 147.68 ± 5.11° for fetlock. The mean ± SD values for the hindlimb joint angles were 128.62 ± 4.08° for stifle, 160.40 ± 3.89° for hock, and 155.48 ± 2.68° for fetlock. There was a non-significant (p > 0.05) correlation between horse joint angles and, age, body weight, and body condition score (BCS). The elbow and stifle joint angles of Morna align well with characteristics associated with optimal racing performance. However, the hock and fetlock angles differ from jumping Thoroughbred and French trotters. We recommend further research to examine the conformation of the Morna breed, particularly by measuring the lengths of limb segments and correlating it with joint angles. This may provide valuable insights into individual variations within the breed. Full article

Brazilian garimpeiros are a highly hard-to-reach and mobile population, with little access to basic hygiene and health services, and have been crossing the border to work irregularly in gold mines in French Guiana since the 1990s. This study aimed to characterize this population and identify their main health problems. A cross-sectional study was carried out in the municipality of Oiapoque-AP, with two surveys: before (2018) and after (2019) the implementation of Malakit. Individuals were recruited from resting places and given a questionnaire regarding demographic variables, history and knowledge of malaria, and health issues in the mines. Simultaneously, a clinical evaluation was performed. The garimpeiros were mainly men from Maranhão, Pará, and Amapá, with a low educational level and who had worked on average for 10 years in the mining sites. The study population mentioned numerous health problems: malaria, followed by leishmaniasis, flu, body aches, headaches, and digestive problems. Other diseases mentioned were skin diseases, bat bites, hepatitis, and HIV infection. This vulnerable population is constantly subjected to heavy routines and exposed to different diseases and infections that can spread across borders. Knowledge of this is essential for developing public health policies that can be integrated into specific epidemiological situations. Full article

Inequities related to teen pregnancy are a complex social and health problem across the globe. Evaluation of research assumptions can help to move research forward when considering complex public health issues. Drawing on previous critical reviews, this scoping review sought to map not just what teen pregnancy research is available, but how current public health research was orienting to teen pregnancy in Canada. This review included studies focused on general or intended teen pregnancy within a public health Canadian context. Both grey and peer-reviewed literature were searched, with only studies in English and French included. In total 32 studies were analyzed. Taking a multifaceted approach to assessing research orientation this scoping review applied an adapted health equity framework to consider alignment between awareness and action and utilized discourse analysis to explore constructions of pregnancy intention. Results showed although a portion of research fell within the acknowledge and illuminate categories, most of the research utilized public health language rooted in biomedical and individualistic discourses and focused on influencing individual action, rather than greater societal change. Adding to the growing body of teen pregnancy research in Canada, this scoping review revealed potential epistemological barriers related to limited research approaches, applied public health action, and engagement with topic overall, leading to a call for more diverse, critically reflective, and disruptive approaches to teen pregnancy research in Canada to address teen pregnancy-related inequities at the root. Full article

While both French and Spanish have complex onsets, the languages differ in the variety and distribution of clusters allowed as well as in the realization of voiced stops. The present study examines the effects of C1 voicing, place of articulation, and language on the production of word-initial /pl bl kl gl/ using a combination of electropalatographic (C1 and C2 linguopalatal contact and timing) and acoustic measures (duration and relative intensity) from 4 French and 7 Spanish speakers. Certain between-language similarities and differences in the effects of voicing and place on intergestural timing were observed. In particular, (1) both languages showed more overlap in clusters where C1 was velar rather than labial; (2) the effect of voicing (more overlap in clusters with a voiced C1) was restricted to French; and (3) lateral duration was unaffected by C1 place or voicing, while C1 duration was strongly affected by stress and voicing in Spanish alone given the approximantization of voiced stops. These results contribute to a better understanding of the general mechanisms and language-specific patterns of intergestural coordination in onset clusters and add to the growing body of articulatory work on these complex structures in Romance languages. Full article

Gastric lymphofollicular hyperplasia (GLFH) is characterized by large lymphoid nodules in the lamina propria. Its etiology and immunohistochemical characteristics are poorly understood. This study analyzed 41 canine GLFH cases, including clinical, endoscopic, histopathological, and immunohistochemical evaluations. Young French Bulldogs (75.06%) were the most affected. Endoscopically, lymphoid nodules were identified in both the antrum and gastric body. Lymphoid follicle diameters were similar in the gastric body (mean 295.587 μm) and antrum (mean 294.641 μm). Associated lesions included glandular atrophy, lymphoplasmacytic inflammation, and fibrosis. Minimal, moderate, and severe colonization with Helicobacter-like organisms (HLOs) were observed in 20, 6, and 3 cases, respectively. B-cell lymphocytes positive for Bcl6 and Pax5 were localized centrally in large follicles, surrounded by CD3+ T lymphocytes. Small follicles lacked germinal centers and showed mixed T and B lymphocytes. A positive correlation was found between the follicle diameter and both HLOs colonization (p = 0.049) and follicular hyperplasia (p < 0.001). A regression analysis indicated that HLOs colonization and hyperplasia accounted for 42.3% of follicle diameter variance (R² = 0.423, p < 0.001). Additional studies are required to investigate potential correlations between GLFH and HLOs, as well as to assess the role of this lesion in the progression to neoplasia. Full article

COSMOS-France is the French part of the COSMOS project, an international prospective cohort study that investigates whether the use of mobile phones and other wireless technologies is associated with health effects and symptoms (cancers, cardiovascular diseases, neurologic pathologies, tinnitus, headaches, or sleep and mood disturbances). Here, we provide the first descriptive results of COSMOS-France, a cohort nested in the general population-based cohort of adults named Constances. Methods: A total of 39,284 Constances volunteers were invited to participate in the COSMOS-France study during the pilot (2017) and main recruitment phase (2019). Participants were asked to complete detailed questionnaires on their mobile phone use, health conditions, and personal characteristics. We examined the association between mobile phone use, including usage for calls and Voice over Internet Protocol (VoIP), cordless phone use, and Wi-Fi usage with age, sex, education, smoking status, body mass index (BMI), and handedness. Results: The participation rate was 48.4%, resulting in 18,502 questionnaires in the analyzed dataset. Mobile phone use was reported by 96.1% (N = 17,782). Users reported typically calling 5–29 min per week (37.1%, N = 6600), making one to four calls per day (52.9%, N = 9408), using one phone (83.9%, N = 14,921) and not sharing it (80.4% N = 14,295), mostly using the phone on the side of the head of their dominant hand (59.1%, N = 10,300), not using loudspeakers or hands-free kits, and not using VoIP (84.9% N = 15,088). Individuals’ age and sex modified this picture, sometimes markedly. Education and smoking status were associated with ever use and call duration, but neither BMI nor handedness was. Cordless phone use was reported by 66.0% of the population, and Wi-Fi use was reported by 88.4%. Conclusion: In this cross-sectional presentation of contemporary mobile phone usage in France, age and sex were important determinants of use patterns. Full article

François Hotman (1524–1590) was one of the leading Reformed jurisconsults of his time. Past research has stressed his innovative interpretations and practices in the study of Roman, feudal, and French constitutional law. Little has yet been said about his views on canon law, another fundamental legal body in Western history that experienced renewed intellectual scrutiny during the sixteenth century. This paper investigates some of Hotman’s early work on canon law, focusing on his legal–historical reconstruction of the early Church in De statu primitivae Ecclesiae (1553) and his contribution to a budding historical field in Catholic circles: conciliar history. Despite the general lack of interest in the history of councils on the part of some leading Protestant theologians (Luther, Calvin, Bullinger), Hotman clearly believed that the textual tradition of councils provided a prime example of sustained popish efforts to control and deform the historical narrative and the legal structure of the Church. Yet, although he seems to have worked on demonstrating just that over more than forty years, he never again voiced his views on the matter in a dedicated work. Comparing in its conclusion De statu primitivae Ecclesiae with Antitribonian, this paper suggests that, in parallel to his better known ‘complex of Tribonian’ (Pierre Mesnard), Hotman seems to have suffered from a ‘complex of Gratian’: the doctrinal unity and institutional accomplishments of the early Church, as represented by the first councils, may well have dazzled Hotman and kept him from writing some definitive work against Gratian. Full article

In July 2017, a family of three members, a 46-year-old male, a 45-year-old female and their 8-year-old daughter, returned to South Africa from Thailand. They presented symptoms consistent with mosquito-borne diseases, including fever, headache, severe body aches and nausea. Mosquito bites in all family members suggested recent exposure to arthropod-borne viruses. Dengue virus 1 (Genus Orthoflavivirus) was isolated (isolate no. SA397) from the serum of the 45-year-old female via intracerebral injection in neonatal mice and subsequent passage in VeroE6 cells. Phylogenetic analysis of this strain indicated close genetic identity with cosmopolitan genotype 1 DENV1 strains from Southeast Asia, assigned to major lineage K, minor lineage 1 (DENV1I_K.1), such as GZ8H (99.92%) collected in November 2018 from China, and DV1I-TM19-74 isolate (99.72%) identified in Bangkok, Thailand, in 2019. Serum samples from the 46-year-old male yielded a virus isolate that could not be confirmed as DENV1, prompting unbiased metagenomic sequencing for virus identification and characterization. Illumina sequencing identified multiple segments of a mammalian orthoreovirus (MRV), designated as Human/SA395/SA/2017. Genomic and phylogenetic analyses classified Human/SA395/SA/2017 as MRV-3 and assigned a tentative genotype, MRV-3d, based on the S1 segment. Genomic analyses suggested that Human/SA395/SA/2017 may have originated from reassortments of segments among swine, bat, and human MRVs. The closest identity of the viral attachment protein σ1 (S1) was related to a human isolate identified from Tahiti, French Polynesia, in 1960. This indicates ongoing circulation and co-circulation of Southeast Asian and Polynesian strains, but detailed knowledge is hampered by the limited availability of genomic surveillance. This case represents the rare concurrent detection of two distinct viruses with different transmission routes in the same family with similar clinical presentations. It highlights the complexity of diagnosing diseases with similar sequelae in travelers returning from tropical areas. Full article

Ignorance is produced through mechanisms related to power relations and socio-cultural context. This article examines whether the theoretical conceptualisation of agnotology may be useful when exploring intersex and the way it has been erased socially and physically. Specifically, based on the work of a PhD in Sociology and History of Science, it proposes categorising three types of mechanisms of ignorance production—cultural, epistemological and physical—with the aim of providing a greater understanding of how medicine, science and technology participate in a continuous process of erasing intersex bodies and lived experiences. Using medical literature, interviews and observations, the article focuses on a specific area of biomedical knowledge and intervention: the prenatal ‘treatment’ of Congenital Adrenal Hyperplasia (CAH) with dexamethasone or ‘prenatal DEX’. It shows how this procedure was pioneered by French doctors and how it continues to be practised in France despite numerous uncertainties and controversies inside and outside of the medical sphere. Full article