Search Results (247)

In China, crude phenols, mixtures commonly produced in the coal industry, are inexpensive and abundant in supply, but their valorization is hindered by high energy consumption in the separation process. It is of great academic and commercial significance to improve the separation process of crude phenols to achieve energy efficiency and cost reduction. In this study, a heat pump-assisted distillation (HPD) system for crude phenol separation was developed. External vapor recompression was adopted due to the strong corrosiveness, high toxicity, heat sensitivity, and easy polymerization of crude phenols. Compared with conventional distillation (CD), HPD showed clear advantages in lowering operating costs. The effects of design variables including pressure, the number of theoretical plates and temperature differences between the condenser and reboiler on reflux ratios, kettle temperature, equipment costs, operating costs, and total annual cost (TAC) were investigated and optimized in detail. The effect of steam prices on process economic feasibility was also studied. It was found that HPD reduced at least 55% of the operational cost compared to CD when the steam price was higher than 10.8 USD/GJ. Carbon emission evaluation indicated that CO₂ generated by the HPD process was 56.3% lower than CD. Full article

To address the challenges faced by license plate recognition systems in certain scenarios—such as complex plate backgrounds, plate tilt, and the large model size that hinders deployment on resource-constrained devices—this paper proposes a compact and computation-efficient license plate detection algorithm that maintains the required recognition accuracy while being easy to deploy on edge computing devices. Experimental results show that the optimized detection model reduces network parameters by approximately 32% without compromising accuracy, while the model file size is similarly reduced by about 32%, significantly conserving device resources. For the recognition stage, LPRNet is further optimized. Experiments demonstrate that the improved recognition network achieves a 1.2% higher accuracy compared to the baseline, with almost no increase in model size, thereby delivering better license plate recognition performance. The combined detection and recognition models occupy less than 6 MB of storage, offering clear advantages in recognition rate, robustness, and resource-efficient design, making them well-suited for deployment on edge devices. Full article

This paper presents an original approach through Transfer-Matrix Method applied for the calculus of the continuous circular plate embedded at the exterior circumference, charged with asymmetrical uniform load on the entire upper surface of the plate. Continuous circular plates are elements often found in practice, in the machine building, aeronautics, chemical industries (the bottoms of chemical reactors), and in petrochemical, mechanical, robotic, medical, military, nuclear, and aerospace industries. The calculus of continuous circular plates is a special problem both from the point of view of the theory of elasticity and from the point of view of the mathematical approach. The results obtained with Transfer-Matrix Method were compared and validated with those obtained from classical analytical calculation, the Theory of Elasticity. Transfer-Matrix Method is an elegant method and relatively easy to program. In future research, we want to validate our results with those given by the Finite Elements Method and those measured experimentally. Full article

Acoustic Emission tomography (AET) has the potential to visualize damage in existing structures, contributing to structural health monitoring. Further, AET requires only the arrival times of elastic waves at sensors to identify velocity distributions, as source localization based on ray-tracing is integrated into its algorithm. Thus, AET offers the advantage of easy acquisition of measurement data. However, accurate source localization requires a large number of elastic wave source candidate points, and increasing these candidates significantly raises the computational resource demand. Lagrange Interpolation has the potential to reduce the number of candidate points, optimizing computational resources, and this potential has been validated numerically. In this study, AET incorporating Lagrange Interpolation is applied to identify the velocity distribution in a defective concrete plate, validating its effectiveness using measured wave data. The validation results show that the defect location in the concrete plate is successfully identified using only 36 source candidates, compared to the 121 candidates required in conventional AET. Furthermore, when using 36 source candidates, the percentage error in applying Lagrange Interpolation is 8.4%, which is significantly more accurate than the 25% error observed in conventional AET. Therefore, it is confirmed that AET with Lagrange Interpolation has the potential to identify velocity distributions in existing structures using optimized resources, thereby contributing to the structural health monitoring of concrete infrastructure. Full article

Background: The importance of understanding dietary habits during working hours is becoming increasingly evident. As demonstrated, dietary habits have been shown to exert a considerable influence on the productivity of workers and the creation of a healthier workplace. Objective: The aim of this study is to assess the nutritional quality and self-perception of lunches consumed by workers in Piedmont (Italy). Methods: A questionnaire, supported by the EasyDietWeb 4.3.0 software, was used to assess the macronutrient composition of the meals and to evaluate adherence to the “Healthy Eating Plate” (HEP) guidelines. The basal metabolic rate and total daily energy expenditure of the subjects were calculated. Results: The survey results, which included 189 participants, revealed that a notable proportion of the respondents consumed homemade meals at their place of work. The majority of meals reported by the participants did not align with the HEP composition due to the absence of one or more components, especially vegetables. The participants’ perceptions of meal balance frequently diverged from the actual nutritional quality of the meals. Finally, overweight participants exhibited a higher risk of reporting diseases (OR = 4.4, 95% CI = 1.6–12.0). Conclusions: This study provides insight into the dietary habits of a specific group of workers regarding their lunch consumption. This underscores the significance of enhancing public awareness regarding dietary choices and nutritional intakes, as adhering to proper dietary routines is paramount for preserving a state of well-being and sustaining a healthy lifestyle. Full article

Impedance-based cellular assays allow determination of biological functions of cell populations in real-time by measuring electrical impedance. As compared to end-point assays, such as trans-epithelial electrical resistance assays, for example, they enable fast, non-invasive, and easy detection of cell kinetics—their growth, attachment, and interaction can be monitored over time. In our experiment, Caco-2 cells were cultured on E-plates 16. Next, fully differentiated cells were treated with either TNF-α or 3,4-dihydroxy-L-phenylalanine (L-DOPA). We aimed to verify the possibility of real-time testing of the viability, monolayer formation, and integrity (i.e., the presence of a functional and polarized monolayer) of Caco-2 cells by the xCELLigence real-time cell analyzer (RTCA) S16 system (Agilent Technologies). Full article

Study design: The advent of the Matrix Wave^TM System (Depuy-Synthes)—a bone-anchored Mandibulo-Maxillary Fixation (MMF) System—merits closer consideration because of its peculiarities. Objective: This study alludes to two preliminary stages in the evolution of the Matrix Wave^TM MMF System and details its technical and functional features. Results: The Matrix Wave^TM System (MWS) is characterized by a smoothed square-shaped Titanium rod profile with a flexible undulating geometry distinct from the flat plate framework in Erich arch bars. Single MWS segments are Omega-shaped and carry a tie-up cleat for interarch linkage to the opposite jaw. The ends at the throughs of each MWS segment are equipped with threaded screw holes to receive locking screws for attachment to underlying mandibular or maxillary bone. An MWS can be partitioned into segments of various length from single Omega-shaped elements over incremental chains of interconnected units up to a horseshoe-shaped bracing of the dental arches. The sinus wave design of each segment allows for stretch, compression and torque movements. So, the entire MWS device can conform to distinctive spatial anatomic relationships. Displaced fragments can be reduced by in-situ-bending of the screw-fixated MWS/Omega segments to obtain accurate realignment of the jaw fragments for the best possible occlusion. Conclusion: The Matrix Wave^TM MMF System is an easy-to-apply modular MMF system that can be assembled according to individual demands. Its versatility allows to address most facial fracture scenarios in adults. The option of “omnidirectional” in-situ-bending provides a distinctive feature not found in alternate MMF solutions. Full article

The aim of this work is to present an original, relatively simple, and elegant approach to the analysis of long rectangular plates subjected to uniformly distributed vertical loads acting on various surfaces. Plate analysis is important in many fields, especially where components are either rectangular plates or can be approximated as such. The Transfer Matrix Method is increasingly used in research, as evidenced by the references cited. The advantages of this method lie in the simplicity of its algorithm, the ease of implementation in programming, and its straightforward integration into optimization software. The approach consists of discretizing the rectangular plate by sectioning it with planes parallel to the short sides—i.e., perpendicular to the two long edges. This results in a set of beams, each with a length equal to the width of the plate, a height equal to the plate’s thickness, and a unit width. Each unit beam has support at its ends that replicate the edge conditions of the plate along its long sides. In the study presented, the rectangular plate is embedded along its two long edges, meaning the unit beam is considered embedded at both ends. The Transfer Matrix Method is particularly valuable because it lends itself well to iterative calculations, making it easy to develop software capable of analyzing long rectangular plates quickly. This makes it especially useful for shape optimization applications, which we intend and hope to pursue in future studies. Full article

(1) Background: When implementing new biomechanical and technology-based assessments, such as the jump assessment in Multiple Sclerosis (MS), into clinical routine, it is important to ensure that they are based on the real needs of patients and to identify and adapt to potential barriers early on. (2) Methods: In the present cross-sectional study, 157 pwMS performed a sensor-based jump assessment on a force plate consisting of three jump tests: 10 s jump test (10SHT), countermovement jumps (CMJ), and single-leg countermovement jumps (SLCMJ). After the jump assessment, the patient experience measures (PREM) were recorded using a paper-based questionnaire on an 11-point scale from 0 (positive) to 10 (negative). (3) Results: PwMS showed an overall positive experience with the sensor-based jump assessment. “Staff support performance”, “acceptance required time”, “usefulness” of the results, and “integration of results in therapy” were the best rated items with a median of 0 (positive). The CMJ was perceived as the easy (p < 0.05) and less exhausting (p < 0.05). PwMS who experienced CMJ as easy, not exhausting, and safe were associated with higher CMJ performance, especially in peak power, flight time, and jump height (r > −0.4). Significant associations were found between PREMs and age, sex, BMI, physical activity, and disability degree. (4) Conclusions: The study findings support the feasibility of jump assessment in clinical practice and highlight the need for patient-centered integration of innovative technologies to optimize precision neuromuscular function evaluation in MS. Full article

The three-dimensional inversion of geophysical data is an effective method for analyzing underground structures. The seismic method is widely used due to its high resolution. However, the uneven distribution of seismic stations, especially in offshore areas, increases the uncertainty of inversion results. Gravity data are easy to obtain and offer high lateral resolution. For the influence of the Earth’s curvature in large-scale inversion, we first developed the joint inversion method of seismic ambient noise and gravity data in the ellipsoidal coordinate system, achieving the acquisition of large-scale and high-precision underground density and velocity structures. Experiments were conducted to address the uneven distribution of seismic stations, which proved the accuracy of the method. The proposed method was applied to the Jiaodong Peninsula (China) to obtain the transcrustal property distribution, further revealing that gold deposits are formed by the upwelling and condensation of hydrothermal materials, which causes the destruction of the North China Craton caused by the subduction of the Western Pacific Plate. Furthermore, we inverted the high-precision gravity anomaly of Sanshan Island, obtaining the structural distribution and predicting the distribution of offshore gold deposits. Full article

Many ozone-based products that promote the healing process of wounds have been released in recent years. In this study, we evaluate a new spray dressing preparation based on stable ozonides with Vitamin E Acetate in children operated for distal hypospadias. Methods: We included all patients with distal hypospadias, who underwent Tubularized Incised Plate Urethroplasty (TIPU) over a 12-month period. The patients were randomized in two groups according to the type of medication: ozonide spray with Vitamin E Acetate (G1); hyaluronic acid cream (G2). After discharge, parents changed the dressing twice a day for 2–3 weeks postoperatively. The patients were evaluated at 7, 14, 21, 30, 60, and 180 postoperative days and thereafter annually. At the end of the treatment, we submitted a satisfaction questionnaire to parents. Results: Eighty-six patients (median age 18 months) were included. The wound healing was significantly faster in G1 compared with G2 (p = 0.001). No adverse skin reactions occurred in either group. Foreskin dehiscence and re-operation rates were lower in G1. Postoperative foreskin retractability was better in G1, with a significantly higher incidence of secondary phimosis in G2. The median treatment costs were significantly lower in G1 compared with G2 (p = 0.001). Group 1 found the spray dressing easy to use, improving patient management and adherence. Conclusions: The new preparation of ozonide-based product adopted promoted faster wound healing compared to conventional dressing. Furthermore, this spray preparation is easy to apply, economical, and simpler to preserve. This is better for parents who do not have to touch the wound to apply the product. Full article

Porous 316L stainless steel has a low density and high specific surface area, and is easy to process due to the large number of pores within it, making it ideal for applications such as piping in the chemical and food industries, as a medical tool, or as a fuel cell pole plate material. Nitriding treatment can further improve the hardness and strength of porous stainless steel. In this paper, a method combining vacuum sintering and nitriding treatment was proposed, i.e., 316L stainless steel powder was used as the raw material, and porous 316L was sintered in a vacuum tube furnace, in which the porous stainless steel was nitrided with nitrogen gas during the cooling process. In the research process, thermodynamic calculation and differential thermal analysis were used to determine the optimum nitriding temperature range of 700 °C~850 °C and nitriding pressure of 0.4 MPa~0.8 MPa. With the increase in nitriding temperature and pressure, the nitrogen content in the sample increased, and the nitrogen content of porous 316L stainless steel after nitriding was 0.03%~0.86%. The results show that nitrogen exists exclusively in solid solution at nitriding temperatures of 700 °C and 750 °C. At nitriding temperatures of 800 °C and 850 °C, the nitrogen existed in both solid solution and chromium nitride (CrN), and the Vickers hardness at 0.08 MPa and 850 °C was 135 HV, which was 2.82 times higher than that before nitriding. The compressive strength of the specimens was maximum at a nitriding pressure of 0.04 MPa and 850 °C. The corrosion resistance of the specimens is optimized when the nitriding pressure is 0.04 MPa and the temperature is 800 °C. Full article

Continuous perfusion is necessary to sustain microphysiological systems and other microfluidic cell cultures. However, most of the established microfluidic perfusion systems, such as syringe pumps, peristaltic pumps, and rocker plates, have several operational challenges and may be cost-prohibitive, especially for laboratories with no microsystems engineering expertise. Here, we address the need for a cost-efficient, easy-to-implement, and reliable microfluidic perfusion system. Our solution is a modular pumpless perfusion assembly (PPA), which is constructed from commercially available, interchangeable, and aseptically packaged syringes and syringe filters. The total cost for the components of each assembled PPA is USD 1–2. The PPA retains the simplicity of gravity-based pumpless flow systems but incorporates high resistance filters that enable slow and sustained flow for extended periods of time (hours to days). The perfusion characteristics of the PPA were determined by theoretical calculations of the total hydraulic resistance of the assembly and experimental characterization of specific filter resistances. We demonstrated that the PPA enabled reliable long-term culture of engineered endothelialized 3-D microvessels for several weeks. Taken together, our novel PPA solution is simply constructed from extremely low-cost and commercially available laboratory supplies and facilitates robust cell culture and compatibility with current microfluidic setups. Full article

Capillary electrophoresis based on laser-induced fluorescence (CE-LIF) plays an important role in the analysis of nucleic acids. However, the commercial CE-LIF is not only quite expensive but also inflexible, thus hindering its widespread use in the lab. Herein, we proposed a compact, low-cost, and flexible CE-LIF system. We also investigated its stability by separating the DNA ladders. Experiments demonstrated that the relative standard error of the relative fluorescence intensity and migration time was lower than 6.2% and 1.1%, respectively. The aperture size of the light source illuminating the capillary can affect the separation performance. Smaller apertures offer higher resolution length for the adjacent DNA fragments but may reduce the number of theoretical plates. Various fluorescent dyes (e.g., SYBR Green I, Gel Green, EvaGreen) can be employed in the self-built system. The limit of detection of dsDNA was as low as 0.05 ng/μL. The working range for DNA was 0.05 ng/μL~10 ng/μL. Finally, we have successfully separated the PCR products of the target gene of Porphyromonas gingivalis and Candida albicans in the home-built CE system. Such a robust CE-LIF system is easy to assemble in the lab. The total cost of the assembled CE system did not exceed 1100 USD. We believe this work can advance the application of CE and hope it will facilitate the easy assembly of flexible CE instruments in labs. Full article

Background: Systemic therapy is frequently utilized because of its easy accessibility, low cost, and high efficacy. However, it can be linked with systemic adverse effects and drug–drug interactions, especially in immunocompromised and poly-medicated patients. Topical antifungals, associated with a low risk of systemic adverse effects and drug–drug interactions, have emerged as the most suitable treatment option for patients with diabetic foot disease. However, the duration of topical treatment can extend up to 12 months. Consequently, there is a need to bolster these topical treatments with complementary therapies. Methods: The current study acquired approval from an ethics committee (code 24/241-E) and Clinical Trials (code NCT06485050). No patients were excluded, irrespective of comorbidities or the severity of onychomycosis. Patients included in the study were administered Ciclopirox 8% (consisting of ethyl acetate, 96% ethanol, ketostearyl alcohol, hydroxypropyl chitosan, and purified water) once daily for 6 months. This was supplemented with photodynamic therapy (three sessions in the first 2 months) using toluidine blue gel and a 635 nm diode laser lasting 10 min, as well as monthly debridement of the nail plate. Results: All patients (10/10) included in the study exhibited negative microbiological culture results 6 months after the study began. Of these, 90% (9/10) were clinically cured, and thus, fully cured. No adverse effects or complications secondary to the treatments were observed in any of the cases. The average Onychomycosis Severity Index (OSI) value was initially 18.50 ± 8.947, reduced to 10.30 ± 6.129 at 3 months, and finally fell to 4.10 ± 4.08 at the end of the treatment. Conclusions: The current study demonstrated the clinical improvement, mycological cure, effectiveness, and safety of combination therapy of ciclopirox 8% and photodynamic therapy over 6 months. Full article