In the search for molecular candidates for targeted meningioma therapies, increasing attention has been paid to the role of signaling pathways in the development and progression of intracranial meningiomas. Although it is well known that the Wnt sign...
The susceptibility of brain to secondary formation from lung cancer primaries is a well-known phenomenon. In contrast, the molecular basis for invasion and metastasis to the brain is largely unknown. In the present study, 31 brain metastases that ori...
Undetected micrometastasis plays a key role in the metastasis of cancer in colorectal cancer (CRC) patients. The aim of this study is to identify a biomarker of CRC patients with liver metastasis through the detection of circulating tumor cells (CTCs...
Introduction: Neuroendocrine tumors are a diverse group of tumors predominantly found in the gastrointestinal tract or respiratory system. Methods: This retrospective study aimed to measure the serum concentrations of LRP6 (low-density lipoprotein re...
Aiming at the problem that complex underwater environments induce outliers in Doppler Velocity Log (DVL) measurements, which degrade the navigation accuracy of the Strapdown Inertial Navigation System (SINS)/DVL integrated system, this paper proposes...
It is difficult for autonomous underwater vehicles (AUVs) to obtain accurate aided position information in many locations because of underwater conditions. The velocity accuracy from the Doppler velocity log (DVL) is a key element in deciding the AUV...
The Technion autonomous underwater vehicle (TAUV) is an ongoing project aiming to develop and produce a small AUV to carry on research missions, including payload dropping, and to demonstrate acoustic communication. Its navigation system is based on...
For an underwater Strapdown Inertial Navigation System/Doppler velocity log (SINS/DVL) integrated navigation system, the short-term failure of DVL may lead to the loss of reliable external velocity information from DVL, which will cause the SINS erro...
As the exploration of marine resources continues to deepen, the utilization of Autonomous Underwater Vehicles (AUVs) for conducting marine resource surveys and underwater environmental mapping has become a common practice. In order to successfully ac...
This article proposes a novel initial bias estimation method using a trajectory generator (TG). The accuracy of attitude and position estimation in navigation after using the inertial navigation system/Doppler velocity log (INS/DVL) and INS/DVL/gyroc...
Inertial navigation system (INS)/Doppler velocity log (DVL) integration is the most common navigation solution for underwater vehicles. Due to the complex underwater environment, the velocity information provided by DVL always contains some errors. T...
To address the problem of the bottom velocity being directly affected by the time-varying ocean currents when DVL operates in the water observation mode, it cannot be directly used for combined SINS/DVL navigation. Existing methods generally approxim...
As a common device for underwater integrated navigation systems, Doppler velocity log (DVL) has the risk of malfunction. To improve the reliability of navigation systems, a hybrid approach is presented to forecast the measurements of the DVL while it...
Primary cilia are nonmotile cellular signal-sensing antenna-like structures composed of microtubule-based structures that distinguish them from motile cilia in structure and function. Primary ciliogenesis is regulated by various cellular signals, suc...
The navigation performance of an autonomous underwater vehicle (AUV) as the main tool for exploring the ocean greatly affects its work efficiency. Under the circumstance that high-precision GNSS positioning signals cannot be obtained, the role of the...
Autonomous Underwater Vehicles (AUVs) are widely employed for deep sea exploration and underwater operations, but their navigation performance is often degraded in complex environments due to time-varying measurement noise, abnormal observations, and...
DVL is one of the small polypeptides which plays an important role in regulating plant growth and development, tissue differentiation, and organ formation in the process of coping with stress conditions. So far, there has been no comprehensive analys...
Because of the complex task environment, long working distance, and random drift of the gyro, the positioning error gradually diverges with time in the design of a strapdown inertial navigation system (SINS)/Doppler velocity log (DVL) integrated posi...
Background/Objectives: Chronic venous insufficiency (CVI) is a progressive vascular disorder characterized by sustained venous hypertension leading to structural and functional alterations of the venous wall. Despite its clinical significance, the mo...
Navigation is a precondition for ocean space vehicles to work safely in polar regions. The traditional polar algorithms employ the grid strapdown inertial navigation system (SINS) as the backbone and Doppler velocity log (DVL) output velocity as meas...
Autonomous underwater vehicles (AUVs) play an increasingly essential role in the field of polar ocean exploration, and the Doppler velocity log (DVL)-aided strapdown inertial navigation system (SINS) is widely used for it. Due to the rapid convergenc...
As an important means of underwater navigation and positioning, the accuracy of SINS/DVL integrated navigation system greatly affects the efficiency of underwater work. Considering the complexity and change of the underwater environment, it is necess...
Underwater vehicles heavily depend on the integration of inertial navigation with Doppler Velocity Log (DVL) for fusion-based localization. Given the constraints imposed by sensor costs, ensuring the optimization ability and robustness of fusion algo...
Neuroglobin is an endogenous neuroprotective protein, but the underlying neuroprotective mechanisms remain to be elucidated. Our previous yeast two-hybrid screening study identified that Dishevelled-1, a key hub protein of Wnt/β-Catenin signalin...
Disease recurrence and metastasis lead to poor prognosis in patients with advanced endometrial carcinoma (EC). RNA-binding proteins (RBPs) are closely associated with tumor initiation and metastasis, but the function and molecular mechanisms of RBPs...
The Autonomous Underwater Vehicle (AUV) is usually equipped with multiple sensors, such as an inertial navigation system (INS), ultra-short baseline system (USBL), and Doppler velocity log (DVL), to achieve autonomous navigation. Multi-source informa...
In-motion alignment of Strapdown Inertial Navigation Systems (SINS) without any geodetic-frame observations is one of the toughest challenges for Autonomous Underwater Vehicles (AUV). This paper presents a novel scheme for Doppler Velocity Log (DVL)...
The escalating development of Maritime Autonomous Surface Ships (MASS) has imposed rigorous demands on the precision, continuity, and resilience of onboard integrated navigation systems. However, in complicated marine settings, data from the Global N...
To address the problem of low accuracy for the regular filter algorithm in SINS/DVL integrated navigation, a square-root unscented information filter (SR-UIF) is presented in this paper. The proposed method: (1) adopts the state probability approxima...
Wnt/β-catenin signaling is hyper-activated in several cancer cells and cancer stem cells. Dishevelled/Dvl is a key adapter protein that acts as a bridge between the Wnt receptor Frizzled (Fzd) and other cytosolic factors. In detail, the C-termin...
The spatiotemporal expression of α-tubulin, inversin and dishevelled-1 (DVL-1) proteins associated with the Wnt-signaling pathway, and primary cilia morphology were analyzed in developing kidneys (14th–38th developmental weeks), healthy postnatal (1....
Wingless/integrase-11 (WNT)/β-catenin pathway is a crucial upstream regulator of a huge array of cellular functions. Its dysregulation is correlated to neoplastic cellular transition and cancer proliferation. Members of the Dishevelled (DVL) fam...
For seabed mapping, the prevalence of autonomous underwater vehicles (AUVs) employing side-scan sonar (SSS) necessitates robust navigation solutions. However, the positioning errors of traditional strapdown inertial navigation system (SINS) and Doppl...
The strap-down inertial navigation system (SINS) and Doppler velocity log (DVL) integrated navigation system are widely used for autonomous underwater vehicles (AUVs). Whereas DVL works in the water tracking mode, the velocity provided by DVL is rela...
Aripiprazole, a dopamine D2 receptor (D2R) partial agonist, possesses a unique clinical profile. Glycogen synthase kinase 3β (GSK3β)-dependent signalling pathways have been implicated in the pathophysiology of schizophrenia and antipsychotic drug act...
Global navigation satellite system (GNSS) spoofing poses a significant threat to maritime logistics. Many maritime electronic devices rely on GNSS time, positioning, and speed for safe vessel operation. In this study, inertial measurement unit (IMU)...
Autonomous underwater vehicles (AUVs) are extensively utilized in various autonomous underwater missions, encompassing ocean environment monitoring, underwater searching, and geological exploration. Owing to their profound underwater capabilities and...
Researchers are currently conducting several studies in the field of navigation systems and sensors. Even in the past, there was a lot of research regarding the field of velocity sensors for unmanned underwater vehicles (UUVs). UUVs have various serv...
In most autonomous underwater vehicles (AUVs), the navigation system is based on an inertial navigation system (INS) aided by a Doppler velocity log (DVL). In several INSs, only the velocity vector, provided by the DVL, can be used as input for assis...
Underwater vehicles are key carriers for underwater inspection and operation tasks, and the successful implementation of these tasks depends on the positioning and navigation equipment with corresponding accuracy. In practice, multiple positioning an...
The Inertial Navigation System (INS) and Doppler Velocity Log (DVL) combination navigation system has been widely used in Autonomous Underwater Vehicles (AUVs) due to its independence, stealth, and high accuracy. Compared to the standalone INS or DVL...
Due to the influence of the complex underwater environment, the initial alignment method for Doppler velocity log (DVL)-aided strap-down inertial navigation systems (SINS) often suffer from performance degradation, especially when DVL measurements ar...
Navigation and positioning of autonomous underwater vehicles (AUVs) in the complex and changeable marine environment are crucial and challenging. For the positioning of AUVs, the integrated navigation of the strap-down inertial navigation system (SIN...
To improve the ability of autonomous navigation for Unmanned Surface Vehicles (USVs), multi-sensor integrated navigation based on Inertial Navigation System (INS), Celestial Navigation System (CNS) and Doppler Velocity Log (DVL) is proposed. The CNS...
Initial alignment of the strapdown inertial navigation system (SINS) is intended to determine the initial attitude matrix in a short time with certain accuracy. The alignment accuracy of the quaternion filter algorithm is remarkable, but the converge...
Breast cancer stem cells (BCSCs) drive tumor progression, metastasis, and therapeutic resistance. Sirtuin 1 (SIRT1) has been implicated in stem cell regulation, but its context-dependent role in BCSC maintenance and the underlying molecular mechanism...
Integrated navigation algorithms under the grid frame have been proposed based on the Kalman filter (KF) to solve the problem of navigation in some special regions. However, in the existing study of grid strapdown inertial navigation system (SINS)/Do...
Congenital and breed-associated vertebral anomalies in dogs and cats encompass a heterogeneous group of abnormalities affecting vertebral formation, segmentation, regional identity, and number. Their interpretation requires integration of postnatal a...
Here, we present a rarely seen example of bilateral meningiomas exhibiting different malignancy grades, I (meningothelial) and II (atypical), recorded in a 72-year-old patient. The presence of two separated lesions of different grades in a single pat...
An accurate observation model and statistical model are critical in underwater integrated navigation. However, it is often the case that the statistical characteristics of noise are unknown through the ultra-short baseline (USBL) system/Doppler veloc...
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