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3,297 Results Found

  • Article
  • Open Access
8 Citations
3,458 Views
11 Pages

Mesenchymal stem (MS) cells, embryonic stem (ES) cells, and induced pluripotent stem (iPS) cells are known for their ability to differentiate into different lineages, including chondrocytes in culture. However, the existing protocol for chondrocyte d...

  • Article
  • Open Access
7 Citations
3,127 Views
8 Pages

Association between CSF1 and CSF1R Polymorphisms and Parkinson’s Disease in Taiwan

  • Kuo-Hsuan Chang,
  • Yih-Ru Wu,
  • Yi-Chun Chen,
  • Hsiu-Chuan Wu and
  • Chiung-Mei Chen

24 September 2019

Background: CSF1/CSF1R neuroinflammatory signaling is emerging as an important pathway involved in the pathogenesis of Parkinson’s disease (PD). However, the genetic associations between CSF1/CSF1R and PD have not yet been explored. Methods: We...

  • Feature Paper
  • Article
  • Open Access
7 Citations
4,565 Views
19 Pages

Construction of Recombinant Human GM-CSF and GM-CSF-ApoA-I Fusion Protein and Evaluation of Their Biological Activity

  • Mariya Pykhtina,
  • Svetlana Miroshnichenko,
  • Vladimir Romanov,
  • Antonina Grazhdantseva,
  • Galina Kochneva and
  • Anatoly Beklemishev

In this study, two strains of the yeast P. pastoris were constructed, one of which produced authentic recombinant human granulocyte-macrophage colony-stimulating factor (ryGM-CSF), and the other was a chimera consisting of ryGM-CSF genetically fused...

  • Article
  • Open Access
10 Citations
4,641 Views
22 Pages

21 October 2021

Relapse is a major issue in acute myeloid leukemia (AML) and while the contribution of gene mutations in developing drug resistance is well established, little is known on the role of macrophages (MΦs) in an AML cell microenvironment. We examined whe...

  • Article
  • Open Access
10 Citations
5,738 Views
20 Pages

Cerebrospinal Fluid (CSF) Exchange with Artificial CSF Enriched with Mesenchymal Stem Cell Secretions Ameliorates Experimental Autoimmune Encephalomyelitis

  • Michael Valitsky,
  • Sandrine Benhamron,
  • Keren Nitzan,
  • Dimitrios Karussis,
  • Ezra Ella,
  • Oded Abramsky,
  • Ibrahim Kassis and
  • Hanna Rosenmann

The complexity of central nervous system (CNS) degenerative/inflammatory diseases and the lack of substantially effective treatments point to the need for a broader therapeutic approach to target multiple components involved in the disease pathogenes...

  • Review
  • Open Access
18 Citations
6,361 Views
29 Pages

CSF Dynamics for Shunt Prognostication and Revision in Normal Pressure Hydrocephalus

  • Afroditi Despina Lalou,
  • Marek Czosnyka,
  • Michal M. Placek,
  • Peter Smielewski,
  • Eva Nabbanja and
  • Zofia Czosnyka

15 April 2021

Background: Despite the quantitative information derived from testing of the CSF circulation, there is still no consensus on what the best approach could be in defining criteria for shunting and predicting response to CSF diversion in normal pressure...

  • Article
  • Open Access
45 Citations
4,854 Views
14 Pages

CSF1/CSF1R Axis Blockade Limits Mesothelioma and Enhances Efficiency of Anti-PDL1 Immunotherapy

  • Sophia Fotiou Magkouta,
  • Photene Christou Vaitsi,
  • Apostolos Georgiou Pappas,
  • Marianthi Iliopoulou,
  • Chrysavgi Nikolaou Kosti,
  • Katherina Psarra and
  • Ioannis Theodorou Kalomenidis

22 May 2021

Colony-Stimulating Factor 1 (CSF1)/Colony-Stimulating Factor Receptor 1 (CSF1R) signaling orchestrates tumor-associated macrophage (TAM) recruitment and polarization towards a pro-tumor M2 phenotype, the dominant phenotype of TAMs infiltrating mesoth...

  • Article
  • Open Access
29 Citations
7,207 Views
18 Pages

Macrophage colony-stimulating factor (M-CSF or CSF-1) is known to have a broad range of actions on myeloid cells maturation, including the regulation of macrophage differentiation, proliferation and survival. Macrophages generated by M-CSF stimulus h...

  • Article
  • Open Access
20 Citations
4,543 Views
19 Pages

Prognostic Significance of CSF-1R Expression in Early Invasive Breast Cancer

  • Nazia Riaz,
  • Samantha Burugu,
  • Angela S. Cheng,
  • Samuel C. Y. Leung,
  • Dongxia Gao and
  • Torsten O. Nielsen

18 November 2021

Colony-stimulating factor-1 receptor (CSF-1R) signaling promotes an immune suppressive microenvironment enriched in M2 macrophages. Given that CSF-1R inhibitors are under investigation in clinical trials, including in breast cancer, CSF-1R expression...

  • Article
  • Open Access
2 Citations
1,865 Views
18 Pages

5 August 2024

The yak (Bos grunniens) is a valuable livestock animal endemic to the Qinghai–Tibet Plateau in China with low reproductive rates. Cryptorchidism is one of the primary causes of infertility in male yaks. Compared with normal testes, the tight ju...

  • Article
  • Open Access
44 Citations
8,136 Views
14 Pages

Distinct Properties of Human M-CSF and GM-CSF Monocyte-Derived Macrophages to Simulate Pathological Lung Conditions In Vitro: Application to Systemic and Inflammatory Disorders with Pulmonary Involvement

  • Alain Lescoat,
  • Alice Ballerie,
  • Yu Augagneur,
  • Claudie Morzadec,
  • Laurent Vernhet,
  • Olivier Fardel,
  • Patrick Jégo,
  • Stéphane Jouneau and
  • Valérie Lecureur

Macrophages play a central role in the pathogenesis of inflammatory and fibrotic lung diseases. However, alveolar macrophages (AM) are poorly available in humans to perform in vitro studies due to a limited access to broncho-alveolar lavage (BAL). In...

  • Feature Paper
  • Review
  • Open Access
23 Citations
6,413 Views
13 Pages

CSF-1R in Cancer: More than a Myeloid Cell Receptor

  • Francesca Cersosimo,
  • Silvia Lonardi,
  • Cristina Ulivieri,
  • Paolo Martini,
  • Andrea Morrione,
  • William Vermi,
  • Antonio Giordano and
  • Emanuele Giurisato

9 January 2024

Colony-stimulating factor 1 receptor (CFS-1R) is a myeloid receptor with a crucial role in monocyte survival and differentiation. Its overexpression is associated with aggressive tumors characterized by an immunosuppressive microenvironment and poor...

  • Review
  • Open Access
29 Citations
7,271 Views
25 Pages

Insights into CSF-1R Expression in the Tumor Microenvironment

  • Caterina Tomassetti,
  • Gaia Insinga,
  • Francesca Gimigliano,
  • Andrea Morrione,
  • Antonio Giordano and
  • Emanuele Giurisato

The colony-stimulating factor 1 receptor (CSF-1R) plays a pivotal role in orchestrating cellular interactions within the tumor microenvironment (TME). Although the CSF-1R has been extensively studied in myeloid cells, the expression of this receptor...

  • Article
  • Open Access
1,574 Views
21 Pages

Evaluating Triazole-Substituted Pyrrolopyrimidines as CSF1R Inhibitors

  • Srinivasulu Cherukupalli,
  • Jan Eickhoff,
  • Carsten Degenhart,
  • Peter Habenberger,
  • Anke Unger,
  • Bård Helge Hoff and
  • Eirik Sundby

18 June 2025

6-Aryl-7H-pyrrolo[2,3-d]pyrimidin-4-amines have promising properties as colony-stimulating factor 1 receptor (CSF1R) inhibitors. Inspired by these antagonists, two series of 1,2,3-triazole analogues (28 compounds) were synthesized and evaluated as CS...

  • Article
  • Open Access
50 Citations
7,144 Views
18 Pages

Targeting CSF1R Alone or in Combination with PD1 in Experimental Glioma

  • Justyna M. Przystal,
  • Hannes Becker,
  • Denis Canjuga,
  • Foteini Tsiami,
  • Nicole Anderle,
  • Anna-Lena Keller,
  • Anja Pohl,
  • Carola H. Ries,
  • Martina Schmittnaegel and
  • Ghazaleh Tabatabai
  • + 6 authors

15 May 2021

Glioblastoma is an aggressive primary tumor of the central nervous system. Targeting the immunosuppressive glioblastoma-associated microenvironment is an interesting therapeutic approach. Tumor-associated macrophages represent an abundant population...

  • Article
  • Open Access
33 Citations
5,246 Views
15 Pages

31 December 2019

Background: Recurrent Pregnancy Loss (RPL) is a syndrome recognizing several causes, and in some cases the treatment with Granulocyte Colony Stimulating Factor (G-CSF) may be successful, especially when karyotype of the previous miscarriage showed no...

  • Article
  • Open Access
7 Citations
3,238 Views
14 Pages

Trem2 Enhances Demyelination in the Csf1r+/− Mouse Model of Leukoencephalopathy

  • Fabrizio Biundo,
  • Violeta Chitu,
  • Şölen Gökhan,
  • Edward Chen,
  • Jude Oppong-Asare and
  • E. Richard Stanley

Colony-stimulating factor-1 receptor (CSF-1R)-related leukoencephalopathy (CRL) is a neurodegenerative disease that triggers early demyelination, leading to an adult-onset dementia. Triggering receptor expressed on myeloid cells-2 (TREM2) is a microg...

  • Article
  • Open Access
15 Citations
3,603 Views
16 Pages

Characterization of Postprandial Effects on CSF Metabolomics: A Pilot Study with Parallel Comparison to Plasma

  • Kosuke Saito,
  • Kotaro Hattori,
  • Tomohiro Andou,
  • Yoshinori Satomi,
  • Masamitsu Gotou,
  • Hiroyuki Kobayashi,
  • Shinsuke Hidese and
  • Hiroshi Kunugi

Cerebrospinal fluid (CSF) metabolites reflect biochemical diffusion/export from the brain and possibly serve as biomarkers related to brain disease severity, pathophysiology, and therapeutic efficacy/toxicity. Metabolomic studies using blood matrices...

  • Article
  • Open Access
11 Citations
2,846 Views
14 Pages

Description of a CSF-Enriched miRNA Panel for the Study of Neurological Diseases

  • María Muñoz-San Martín,
  • Imma Gomez,
  • Albert Miguela,
  • Olga Belchí,
  • René Robles-Cedeño,
  • Ester Quintana and
  • Lluís Ramió-Torrentà

22 June 2021

Background: The study of circulating miRNAs in CSF has gained tremendous attention during the last years, as these molecules might be promising candidates to be used as biomarkers and provide new insights into the disease pathology of neurological di...

  • Article
  • Open Access
1 Citations
3,345 Views
12 Pages

Endogenous Expression of G-CSF in Rat Dorsal Root Ganglion Neurons after Nerve Injury

  • Chun-Chang Yeh,
  • Chih-Ping Yang,
  • Kuo-Hsing Ma,
  • Jui-Hu Shih,
  • Ching-San Tseng and
  • Yuahn-Sieh Huang

Granulocyte colony-stimulating factor (G-CSF) has been reported to modulate pain function following nerve injury. However, the expression of endogenous G-CSF in the dorsal root ganglion (DRG) and the response to nerve injury remain unclear. In the pr...

  • Review
  • Open Access
162 Views
10 Pages

Factors Influencing the Use of G-CSF in Drug-Induced Agranulocytosis

  • Emmanuel Andrès,
  • Jean-Edouard Terrade,
  • Xavier Jannot and
  • Noel Lorenzo-Villalba

Drug-induced agranulocytosis is a rare but life-threatening adverse reaction associated with numerous non-chemotherapy drugs. Management relies on immediate drug withdrawal, infection control, and, in selected patients, administration of granulocyte-...

  • Article
  • Open Access
13 Citations
3,725 Views
17 Pages

Inter-Tumor Heterogeneity—Melanomas Respond Differently to GM-CSF-Mediated Activation

  • Adi Moshe,
  • Sivan Izraely,
  • Orit Sagi-Assif,
  • Sapir Malka,
  • Shlomit Ben-Menachem,
  • Tsipi Meshel,
  • Metsada Pasmanik-Chor,
  • Dave S.B. Hoon and
  • Isaac P. Witz

13 July 2020

Granulocyte-monocyte colony stimulating factor (GM-CSF) is used as an adjuvant in various clinical and preclinical studies with contradictory results. These were attributed to opposing effects of GM-CSF on the immune or myeloid systems of the treated...

  • Article
  • Open Access
2,572 Views
17 Pages

Direct Potential Modulation of Neurogenic Differentiation Markers by Granulocyte-Colony Stimulating Factor (G-CSF) in the Rodent Brain

  • Judith Kozole,
  • Rosmarie Heydn,
  • Eva Wirkert,
  • Sabrina Küspert,
  • Ludwig Aigner,
  • Tim-Henrik Bruun,
  • Ulrich Bogdahn,
  • Sebastian Peters and
  • Siw Johannesen

The hematopoietic granulocyte-colony stimulating growth factor (G-CSF, filgrastim) is an approved drug in hematology and oncology. Filgrastim’s potential in neurodegenerative disorders is gaining increasingly more attention, as preclinical and...

  • Review
  • Open Access
63 Citations
9,559 Views
17 Pages

Innate Immune Modulation by GM-CSF and IL-3 in Health and Disease

  • Francesco Borriello,
  • Maria Rosaria Galdiero,
  • Gilda Varricchi,
  • Stefania Loffredo,
  • Giuseppe Spadaro and
  • Gianni Marone

15 February 2019

Granulocyte-macrophage colony-stimulating factor (GM-CSF) and inteleukin-3 (IL-3) have long been known as mediators of emergency myelopoiesis, but recent evidence has highlighted their critical role in modulating innate immune effector functions in m...

  • Article
  • Open Access
3 Citations
3,048 Views
15 Pages

Validation of a New Test for Measuring the Contrast Sensitivity Function (Optopad-CSF) at Near Vision

  • Dolores de Fez,
  • Celia García,
  • Maria Josefa Luque-Cobija,
  • Kevin J. Mena-Guevara,
  • Paula Daudén and
  • David P. Piñero

Our purpose is to develop and validate a new iPad-based contrast sensitivity (CS) test for measuring the contrast sensitivity function at near vision (Optopad-CSF). A total of 200 eyes of 100 healthy subjects (ages 17–63) were evaluated in a co...

  • Article
  • Open Access
4 Citations
2,759 Views
14 Pages

Reversal of CSF HIV-1 Escape during Treatment of HIV-Associated Cryptococcal Meningitis in Botswana

  • Nametso Kelentse,
  • Sikhulile Moyo,
  • Kesaobaka Molebatsi,
  • Olorato Morerinyane,
  • Shatho Bitsang,
  • Ontlametse T. Bareng,
  • Kwana Lechiile,
  • Tshepo B. Leeme,
  • David S. Lawrence and
  • Simani Gaseitsiwe
  • + 5 authors

Cerebrospinal fluid (CSF) viral escape has been poorly described among people with HIV-associated cryptococcal meningitis. We determined the prevalence of CSF viral escape and HIV-1 viral load (VL) trajectories in individuals treated for HIV-associat...

  • Article
  • Open Access
11 Citations
3,517 Views
10 Pages

Endoscopic Skull Base Repair Strategy for CSF Leaks Associated with Pneumocephalus

  • Anda Gâta,
  • Corneliu Toader,
  • Veronica Elena Trombitaș,
  • Annamaria Ilyes and
  • Silviu Albu

25 December 2020

Background: Cerebrospinal (CSF) fluid leaks with associated pneumocephalus (PNC) represent a condition bearing serious risks for the patient, with little data available in the literature. Reported success rates of endoscopic skull base repair are low...

  • Article
  • Open Access
35 Citations
7,514 Views
14 Pages

ACSL1 Regulates TNFα-Induced GM-CSF Production by Breast Cancer MDA-MB-231 Cells

  • Reeby Thomas,
  • Fatema Al-Rashed,
  • Nadeem Akhter,
  • Fahd Al-Mulla and
  • Rasheed Ahmad

1 October 2019

Overexpression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in different types of cancer is associated with tumor growth and progression. Tumor necrosis factor-α (TNFα) is involved in the induction of GM-CSF in different c...

  • Article
  • Open Access
8 Citations
3,723 Views
18 Pages

Transfection of Vitamin D3-Induced Tolerogenic Dendritic Cells for the Silencing of Potential Tolerogenic Genes. Identification of CSF1R-CSF1 Signaling as a Glycolytic Regulator

  • María José Mansilla,
  • Iñigo González-Larreategui,
  • Neus Figa-Martín,
  • Jaume Barallat,
  • Federico Fondelli,
  • Ares Sellés-Rius,
  • Bibiana Quirant-Sánchez,
  • Aina Teniente-Serra and
  • Eva Martínez-Cáceres

The use of autologous tolerogenic dendritic cells (tolDC) has become a promising strategy to re-establish immune tolerance in autoimmune diseases. Among the different strategies available, the use of vitamin D3 for the generation of tolDC (VitD3-tolD...

  • Article
  • Open Access
244 Views
19 Pages

Recombinant G-CSF-ApoAI Fusion Protein Is a Pleiotropic Factor

  • Svetlana Miroshnichenko,
  • Mariya Pykhtina,
  • Kirill Mosalev and
  • Anatoly Beklemishev

29 December 2025

In this study, we report the development of a recombinant human G-CSF fused with apolipoprotein A-I. The chimeric protein was expressed in Pichia pastoris. Using human bone marrow cells, the fusion protein was shown to retain the granulocyte activity...

  • Review
  • Open Access
14 Citations
4,132 Views
17 Pages

28 September 2021

From the World Health Organization’s global TB report for 2020, it is estimated that in 2019 at least 80,000 children (a particularly vulnerable population) developed tuberculous meningitis (TBM)—an invariably fatal disease if untreated—although this...

  • Article
  • Open Access
7 Citations
4,738 Views
15 Pages

Soluble Prokaryotic Overexpression and Purification of Human GM-CSF Using the Protein Disulfide Isomerase b′a′ Domain

  • Thi Kieu Oanh Nguyen,
  • Thi Luong Vu,
  • Minh Quan Nguyen,
  • Huynh Kim Khanh Ta,
  • Kyoung Sun Park,
  • Soo Hyeon Kim,
  • Chong Jai Kim,
  • Yeon Jin Jang and
  • Han Choe

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a member of the colony-stimulating factor (CSF) family, which functions to enhance the proliferation and differentiation of hematopoietic stem cells and other hematopoietic lineages such as...

  • Article
  • Open Access
24 Citations
5,746 Views
24 Pages

Csf1 Deficiency Dysregulates Glial Responses to Demyelination and Disturbs CNS White Matter Remyelination

  • Bartosz Wylot,
  • Jakub Mieczkowski,
  • Sylwia Niedziolka,
  • Bozena Kaminska and
  • Malgorzata Zawadzka

31 December 2019

Remyelination, a highly efficient central nervous system (CNS) regenerative process, is performed by oligodendrocyte progenitor cells (OPCs), which are recruited to the demyelination sites and differentiate into mature oligodendrocytes to form a new...

  • Communication
  • Open Access
2 Citations
2,608 Views
10 Pages

Gene Expression of CSF3R/CD114 Is Associated with Poorer Patient Survival in Glioma

  • Samir Ale Bark,
  • Matheus Dalmolin,
  • Osvaldo Malafaia,
  • Rafael Roesler,
  • Marcelo A. C. Fernandes and
  • Gustavo R. Isolan

Gliomas comprise most cases of central nervous system (CNS) tumors. Gliomas afflict both adults and children, and glioblastoma (GBM) in adults represents the clinically most important type of malignant brain cancer, with a very poor prognosis. The ce...

  • Review
  • Open Access
2,363 Views
26 Pages

12 November 2025

Granulocyte-macrophage colony-stimulating factor (GM-CSF) has emerged as a key cytokine in the pathogenesis of rheumatoid arthritis, an autoimmune disease distinguished by synovial inflammation and progressive joint destruction. GM-CSF orchestrates t...

  • Article
  • Open Access
48 Citations
4,996 Views
8 Pages

19 May 2021

Castration-resistant prostate cancer (CRPC) is an advanced stage of prostate cancer that can progress rapidly even in patients treated with castration. Previously, we found that tumor-associated macrophages (TAM) can be recruited by CSF-1 secreted by...

  • Article
  • Open Access
1,101 Views
18 Pages

The Responsiveness of Breast Cancer Cells to Varied Levels of Vitamin B12, Cisplatin, and G-CSF

  • Volkan Aslan,
  • Duygu Deniz Usta,
  • Atiye Seda Yar Sağlam,
  • Ahmet Özet,
  • Osman Sütcüoglu,
  • Kürşat Dikmen and
  • Nuriye Özdemir

18 September 2025

Supportive agents, such as vitamin B12 (cobalamin, B12) and granulocyte colony-stimulating factor (G-CSF), are widely used during chemotherapy; however, their direct effects on tumor biology are not well understood. We evaluated the impact of pharmac...

  • Article
  • Open Access
11 Citations
3,477 Views
10 Pages

Boron Delivery to Brain Cells via Cerebrospinal Fluid (CSF) Circulation for BNCT in a Rat Melanoma Model

  • Sachie Kusaka,
  • Yuri Morizane,
  • Yugo Tokumaru,
  • Shingo Tamaki,
  • Indah Rosidah Maemunah,
  • Yoko Akiyama,
  • Fuminobu Sato and
  • Isao Murata

3 March 2022

Recently, exploitation of cerebrospinal fluid (CSF) circulation has become increasingly recognized as a feasible strategy to solve the challenges involved in drug delivery for treating brain tumors. Boron neutron capture therapy (BNCT) also faces cha...

  • Article
  • Open Access
10 Citations
3,000 Views
24 Pages

Potential Stereoselective Binding of Trans-(±)-Kusunokinin and Cis-(±)-Kusunokinin Isomers to CSF1R

  • Chompunud Chompunud Na Ayudhya,
  • Potchanapond Graidist and
  • Varomyalin Tipmanee

29 June 2022

Breast cancer cell proliferation and migration are inhibited by naturally extracted trans-(−)-kusunokinin. However, three additional enantiomers of kusunokinin have yet to be investigated: trans-(+)-kusunokinin, cis-(−)-isomer and cis-(+)...

  • Article
  • Open Access
6 Citations
2,181 Views
12 Pages

Application of the AT(N) and Other CSF Classification Systems in Behavioral Variant Frontotemporal Dementia

  • Vasilios C. Constantinides,
  • Fotini Boufidou,
  • Mara Bourbouli,
  • Efstratios-Stylianos Pyrgelis,
  • Apostolia Ghika,
  • Christos Koros,
  • George Liakakis,
  • Sokratis Papageorgiou,
  • Leonidas Stefanis and
  • Elisabeth Kapaki
  • + 1 author

Background: Patients with a frontotemporal lobar degeneration (FTLD) usually manifest with behavioral variant frontotemporal dementia (bvFTD). Alzheimer’s disease (AD) may also manifest with a predominant behavioral-dysexecutive syndrome, simil...

  • Article
  • Open Access
55 Citations
7,522 Views
12 Pages

Neuroinflammation and Alzheimer’s Disease: A Machine Learning Approach to CSF Proteomics

  • Lorenzo Gaetani,
  • Giovanni Bellomo,
  • Lucilla Parnetti,
  • Kaj Blennow,
  • Henrik Zetterberg and
  • Massimiliano Di Filippo

29 July 2021

In Alzheimer’s disease (AD), the contribution of pathophysiological mechanisms other than amyloidosis and tauopathy is now widely recognized, although not clearly quantifiable by means of fluid biomarkers. We aimed to identify quantifiable protein bi...

  • Article
  • Open Access
15 Citations
4,902 Views
14 Pages

24 November 2021

Microglia and astrocytes are the main CNS glial cells responsible for the neuroinflammatory response, where they release a plethora of cytokines into the CNS inflammatory milieu. The TAM (Tyro3, Axl, Mer) receptors and their main ligand Gas6 are regu...

  • Article
  • Open Access
10 Citations
4,397 Views
13 Pages

Effect of Multiple Vaccinations with Tumor Cell-Based Vaccine with Codon-Modified GM-CSF on Tumor Growth in a Mouse Model

  • Jiantai Timothy Qiu,
  • Donia Alson,
  • Ta-Hsien Lee,
  • Ching-Chou Tsai,
  • Ting-Wei Yu,
  • Yu-Sing Chen,
  • Ya-Fang Cheng,
  • Chu-Chi Lin and
  • Scott C. Schuyler

15 March 2019

Ectopic expression of codon-modified granulocyte-macrophage colony-stimulating factor (cGM-CSF) in TC-1 cells (TC-1/cGM-CSF), a model cell line for human papillomavirus (HPV)-infected cervical cancer cells, increased the expression level of GM-CSF an...

  • Article
  • Open Access
1 Citations
1,324 Views
17 Pages

Macrophage-Derived Factors with the Potential to Contribute to the Pathogenicity of HIV-1 and HIV-2: Roles of M-CSF and CXCL7

  • Chunling Gao,
  • Joseph Kutza,
  • Weiming Ouyang,
  • Tobias A. Grimm,
  • Karen Fields,
  • Carla S. R. Lankford,
  • Franziska Schwartzkopff,
  • Mark Paciga,
  • Ana Machuca and
  • Kathleen A. Clouse
  • + 2 authors

Human immunodeficiency virus (HIV) type 2 (HIV-2) is less pathogenic than HIV-1. However, the factors responsible for the differences in pathogenicity are still not well defined. To investigate this issue, we performed infection of primary human mono...

  • Article
  • Open Access
3 Citations
2,611 Views
13 Pages

Activation of the RARα Attenuated CSF Hypersecretion to Inhibit Hydrocephalus Development via Regulating the MAFB/MSR1 Pathway

  • Hanhai Zeng,
  • Kaibo Yu,
  • Junyou Wang,
  • Jingya Ye,
  • Huaijun Chen,
  • Chaoran Xu,
  • Ting Chen,
  • Feng Yan,
  • Gao Chen and
  • Chi Gu

30 January 2023

Hydrocephalus has been observed in rats with spontaneous hypertension (SHRs). It has been demonstrated that activation of the oxidative stress related protein retinoic acid receptor alpha (RARα) has neuroprotective impacts. Our investigation ai...

  • Article
  • Open Access
24 Citations
4,720 Views
12 Pages

Maternal and Neonatal Outcome after the Use of G-CSF for Cancer Treatment during Pregnancy

  • Claudia Berends,
  • Charlotte Maggen,
  • Christianne A. R. Lok,
  • Mathilde van Gerwen,
  • Ingrid A. Boere,
  • Vera E. R. A. Wolters,
  • Kristel Van Calsteren,
  • Heidi Segers,
  • Marry M. van den Heuvel-Eibrink and
  • Frédéric Amant
  • + 2 authors

10 March 2021

Data on the use of Granulocyte colony-stimulating factor (G-CSF) in pregnant cancer patients are scarce. The International Network of Cancer, Infertility and Pregnancy (INCIP) reviewed data of pregnant patients treated with chemotherapy and G-CSF, an...

  • Article
  • Open Access
25 Citations
5,353 Views
18 Pages

Arctigenin Attenuates Breast Cancer Progression through Decreasing GM-CSF/TSLP/STAT3/β-Catenin Signaling

  • Hui Shi,
  • Luping Zhao,
  • Xinlin Guo,
  • Runping Fang,
  • Hui Zhang,
  • Guanjun Dong,
  • Jia Fu,
  • Fenglian Yan,
  • Junfeng Zhang and
  • Huabao Xiong
  • + 6 authors

2 September 2020

Invasive breast cancer is highly regulated by tumor-derived cytokines in tumor microenvironment. The development of drugs that specifically target cytokines are promising in breast cancer treatment. In this study, we reported that arctigenin, a bioac...

  • Article
  • Open Access
11 Citations
3,045 Views
12 Pages

Using CSF Proteomics to Investigate Herpesvirus Infections of the Central Nervous System

  • Saima Ahmed,
  • Patrick van Zalm,
  • Emily A. Rudmann,
  • Michael Leone,
  • Kiana Keller,
  • John A. Branda,
  • Judith Steen,
  • Shibani S. Mukerji and
  • Hanno Steen

10 December 2022

Herpesviruses have complex mechanisms enabling infection of the human CNS and evasion of the immune system, allowing for indefinite latency in the host. Herpesvirus infections can cause severe complications of the central nervous system (CNS). Here,...

  • Article
  • Open Access
4 Citations
2,699 Views
13 Pages

Understanding the Episodic Memory and Executive Functioning Axis Impairment in MCI Patients: A Multicenter Study in Comparison with CSF Biomarkers

  • Brenda Chino,
  • Lucía Torres-Simón,
  • Agnieszka Żelwetro,
  • Inmaculada Concepción Rodríguez-Rojo,
  • Anna Carnes-Vendrell,
  • Gerard Piñol-Ripoll,
  • Raquel Yubero,
  • Nuria Paúl and
  • Fernando Maestú

26 November 2023

Background: This study aimed to explore the association between a verbal learning task that evaluates the potential mutual dependency between memory and executive functions (i.e., the Test of Memory Strategies, TMS) and cerebrospinal fluid (CSF) Alzh...

  • Review
  • Open Access
53 Citations
8,444 Views
14 Pages

CSF Biomarkers in the Early Diagnosis of Mild Cognitive Impairment and Alzheimer’s Disease

  • Vasileios Papaliagkas,
  • Kallirhoe Kalinderi,
  • Patroklos Vareltzis,
  • Despoina Moraitou,
  • Theodora Papamitsou and
  • Maria Chatzidimitriou

Alzheimer’s disease (AD) is a rapidly growing disease that affects millions of people worldwide, therefore there is an urgent need for its early diagnosis and treatment. A huge amount of research studies are performed on possible accurate and r...

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