Search Results (345)

Background/Objectives: Psychological barriers, particularly kinesiophobia and diminished psychological readiness, represent critical yet undertreated obstacles to a successful return to sport following anterior cruciate ligament reconstruction (ACLR). Scalable, preference-aligned educational interventions capable of addressing these barriers during early rehabilitation are lacking. We aimed to evaluate the effectiveness of structured educational content delivered via Snapchat, as an adjunct to standard ACLR rehabilitation, in reducing kinesiophobia (primary outcome) and improving psychological readiness and perceived knee function (secondary outcomes). Methods: A total of 120 adults with clinically elevated kinesiophobia (TSK-17 > 37) undergoing post-operative ACLR rehabilitation were enrolled in a quasi-experimental, two-arm study with non-randomized allocation at the clinic-branch level at two branches of the same sports rehabilitation clinic (Joint Clinics, Riyadh, Saudi Arabia). Branch allocation assigned 60 participants to each group (intervention and control). The intervention group received 12 weekly structured educational videos via Snapchat alongside standard rehabilitation; the control group received standard rehabilitation alongside general ACLR information videos via Snapchat. TSK-17, ACL-RSI, and IKDC were assessed at baseline and at 12 weeks. Primary analysis used ANCOVA covarying baseline scores, complemented by mixed repeated measures ANOVA and intent-to-treat analysis. Results: Both groups improved across all outcomes; the intervention group demonstrated significantly greater gains. ANCOVA revealed significant between-group differences favoring the intervention for TSK-17 (adjusted mean difference = −2.82; d = 0.54; p < 0.001; d represents Cohen’s d calculated from adjusted mean differences and pooled SD), ACL-RSI (+8.06; d = 0.77; p < 0.001), and IKDC (+8.90; d = 0.54; p = 0.002). Mean video completion was 82.8% among intervention participants. Intent-to-treat analyses using Multiple Imputation confirmed all findings. Conclusions: Snapchat-based structured education was associated with improvements in kinesiophobia, psychological readiness, and perceived knee function among the 102 analyzed participants (control n = 52; intervention n = 50) of the 120 enrolled. High engagement supports preference-based digital delivery as a scalable adjunct to standard rehabilitation. Full article

Background: The necessity of cyclic graft loading during anterior cruciate ligament (ACL) reconstruction remains debated. This study aimed to compare clinical outcomes between patients undergoing ACL reconstruction with and without cyclic graft loading. Methods: A retrospective comparative study was conducted involving 216 patients who underwent ACL reconstruction between 2021 and 2022. Patients were divided into two groups: those whose grafts were cyclically loaded intraoperatively (n = 104) and those who did not undergo cyclic loading (n = 112). All surgeries used hamstring autografts and similar fixation techniques. Outcomes, including graft re-rupture rates, knee laxity (measured by arthrometer, Rolimeter^®), and patient-reported outcomes, were evaluated at a minimum follow-up of two years. Results: The demographics of both groups were comparable. Re-rupture rates were 2.5% in the cyclic loading group and 2.9% in the non-cyclic loading group (p = 0.78). Mean side-to-side laxity difference in anterior tibial translation measured by Rolimeter^® was 1.1 mm ± 0.6 in the cyclic loading group and 1.2 mm ± 0.7 in the non-cyclic loading group (p = 0.39). No significant differences in Lysholm or IKDC scores were observed between groups. Conclusion: In this retrospective, non-randomized cohort, no statistically significant differences were detected between ACL reconstruction performed with or without cyclic graft loading. These findings should be interpreted with caution, given the potential for temporal confounding. Further prospective, randomized studies are required to confirm these results. Full article

Background/Objectives: The optimal management of anterior cruciate ligament (ACL) rupture remains debated, especially regarding long-term outcomes after early ACL reconstruction (ACLR) versus rehabilitation-first with optional delayed ACLR. The interpretation of randomized evidence is complicated by frequent treatment crossover. This review synthesized evidence from randomized controlled trial (RCT) cohorts comparing surgical versus rehabilitation-first management strategies across available follow-up durations. Methods: A structured review based on a systematic literature search and narrative synthesis was conducted, with study identification and reporting guided by PRISMA 2020. MEDLINE (via PubMed) and Google Scholar were searched in February 2026 for English-language human RCTs (2000–2026) comparing early ACLR plus rehabilitation with rehabilitation-first management allowing delayed ACLR for persistent instability. A linked-report PubMed search using the KANON trial registration number (ISRCTN84752559) was additionally performed to identify cohort-derived follow-up publications. Reports were grouped by underlying RCT cohort. Data were extracted on crossover, follow-up, and clinical outcomes. Risk of bias for primary RCT reports was assessed with Cochrane RoB 2. Results: Twenty-seven reports representing three RCT cohorts (KANON, COMPARE, ACL SNNAP) were included; six index reports were prioritized for synthesis. In acute ACL rupture (KANON, COMPARE), early ACLR did not show a consistent long-term superiority in patient-reported outcomes versus rehabilitation-first with optional delayed ACLR, although COMPARE reported a statistically significant 2-year subjective functional difference favoring early ACLR; early ACLR more consistently improved mechanical stability and reduced instability episodes. Crossover from rehabilitation to delayed ACLR was common. In non-acute ACL injury with persistent symptomatic instability (ACL SNNAP), surgery-first improved 18-month patient-reported outcomes. Meniscal procedure rates and osteoarthritis-related outcomes did not consistently favor early ACLR. Conclusions: In acute ACL rupture, rehabilitation-first with timely access to delayed ACLR appears to provide long-term patient-reported outcomes comparable to an early ACLR strategy in many patients, while early ACLR more consistently improves knee stability. In non-acute symptomatic ACL deficiency, a surgery-first strategy appears more effective in the mid-term. These randomized trials should be interpreted as comparisons of management strategies rather than of “pure” operative versus nonoperative treatment approaches. Full article

Background and Objectives: The assessment of neuromuscular recovery after ACL reconstruction is crucial for safe return to sport (RTS) in professional soccer players. This retrospective cross-sectional study aimed to compare squat jump (SJ), bilateral countermovement jump (CMJ), and single-leg CMJ performance in three distinct groups: players at 6 months post-ACL reconstruction, players at 9 months post-ACL reconstruction, and healthy controls. Materials and Methods: Seventy-two male players (24 at 6 months post-ACL, 24 at 9 months post-ACL, 24 healthy controls) performed squat jump, bilateral countermovement jump, and single-leg CMJ tests using contact platforms following a controlled warm-up protocol. Results: Significant group differences were observed in all jump tests. At 6 months post-ACL reconstruction, players demonstrated significantly lower squat jump (45.13 ± 6.20 cm) and bilateral countermovement jump (49.67 ± 6.80 cm) heights compared to both 9-month players (SJ: 50.03 ± 5.30 cm; CMJ: 53.79 ± 4.85 cm) and controls (SJ: 51.12 ± 4.97 cm; CMJ: 55.49 ± 5.54 cm) (p ≤ 0.016, η² = 0.187 and η² = 0.156, respectively). No significant differences between 9-month and control groups were observed for the squat jump and the bilateral countermovement jump. Regarding the unilateral countermovement jump, the injured leg showed significant performance deficits compared to controls in both the 6-month and 9-month groups (p = 0.001, η² = 0.378). However, the non-injured leg exhibited deficits only in the 6-month group. Conclusions: Compared to the 6-month post-ACL reconstruction group, the 9-month group showed a marked improvement in bilateral jump performance, indicating substantial neuromuscular recovery over time. However, persistent unilateral deficits in the injured leg remained even at 9 months, underscoring the need for a routine and comprehensive jumping evaluation to identify residual neuromuscular impairments that may require targeted rehabilitation before returning to sport. Full article

Purpose: To critically evaluate the role or effect of platelet-rich plasma (PRP) in anterior cruciate ligament (ACL) reconstruction in terms of clinical and radiological outcomes. Method: We conducted a systematic search of PubMed, Embase, the Cochrane Library, and Web of Science to identify relevant studies. Clinical outcomes included the Visual Analogue Scale (VAS), International Knee Documentation Committee (IKDC) subjective and objective evaluations, Lysholm score, Tegner score, anterior knee laxity, Knee Injury and Osteoarthritis Outcome Score (KOOS), Kujala score, Victorian Institute of Sport Assessment (VISA) scale, proprioception, isokinetic strength, and physical examination tests (anterior drawer, Lachman, and pivot-shift tests). Radiological outcomes encompassed measures obtained via magnetic resonance imaging (MRI), computed tomography (CT), X-ray, and ultrasound. Statistical significance was defined as a p value < 0.05, and all analyses were performed using R software (version 4.1.3). Results: A total of 23 studies, including 19 randomized controlled trials, met the inclusion criteria, encompassing 1072 patients overall. The meta-analysis showed significant differences between PRP group and non-PRP group with regard to VAS score at 6- and 12-month follow-up, Lysholm score at 6-month follow-up, and Tegner score at 6-month follow-up. Meta-regression showed that the two group differences in VAS score changed significantly with follow-up time (p < 0.01). In terms of radiological findings, about half of the assessments favored PRP to facilitate the graft maturation and integration at 6-month follow-up. Conclusions: PRP application in ACL reconstruction compared with non-PRP, may produce short-term but not long-term clinical outcomes such as VAS score, Lysholm score and Tegner score. While some short-term statistical differences exist, their magnitude and durability do not yet justify routine clinical adoption of PRP in ACL reconstruction. Larger samples and higher-quality studies are needed to support our results and further explore the advantages of PRP in other aspects. Level of evidence: Level II. Full article

The rising popularity of sports practiced without adequate preparation has increased the incidence of anterior cruciate ligament (ACL) injuries, particularly among young individuals. Because the ACL has a very limited intrinsic healing capacity, surgical reconstruction—most often using autologous grafts—remains the standard of care. However, current techniques frequently lead to donor-site morbidity and do not consistently restore long-term joint stability, contributing to early post-traumatic osteoarthritis in active patients. Over the past decades, tissue engineering (TE) has opened promising avenues for developing biological substitutes capable of overcoming these limitations. Despite substantial progress, no strategy has yet demonstrated reliable and clinically validated functional regeneration of the human ACL. Meanwhile, artificial intelligence is emerging as a complementary tool for diagnosis, surgical planning, biomechanical assessment, and personalized reconstruction strategies. This review aims to provide a comprehensive overview of current TE-based approaches for ACL repair and reconstruction, analyzes their biological and biomechanical limitations, and discusses emerging concepts that may enhance future clinical outcomes. We first summarize the fundamental principles of tissue engineering, then examine the major strategies proposed for ACL regeneration—highlighting their respective strengths and shortcomings—and finally outline perspectives for a novel approach currently under development. Full article

Background/Objectives: Objective, non-invasive biomarkers are needed to track anterior cruciate ligament (ACL) graft maturation and support individualized return-to-sport decisions. This study evaluated a single-session multiparametric quantitative MRI (qMRI) protocol for longitudinal assessment of ACL graft microstructural evolution and its association with patient-reported outcomes. Methods: Twenty-eight patients undergoing primary ACL reconstruction with hamstring autografts underwent multiparametric qMRI (T1, T2*, R2*, and PD mapping) at 1, 3, 6, and 12 months. The contralateral native ACL served as a within-subject control. IKDC, Lysholm, and VAS scores were recorded at each visit. Linear mixed-effects models were used to test longitudinal changes. Correlations of baseline-normalized changes between adjacent visits were used to evaluate imaging–clinical associations. Results: All qMRI parameters changed significantly over time (all p < 0.001). At 1 month, T1, PD, and T2* were lower and R2* higher than the contralateral native ACL (all p < 0.001). Thereafter, T1, PD, and T2* increased and R2* decreased, with most metrics approaching contralateral values by 3–6 months (all p < 0.05), and changes entered a plateau after 6 months (all p > 0.05). IKDC, Lysholm, and VAS improved over time (all p < 0.001), mainly before 6 months. Greater early T2* increases and R2* decreases (1–3 months) were associated with less pain relief and smaller Lysholm improvement (p < 0.05); no significant associations were observed from 6–12 months. Conclusions: Single-session multiparametric qMRI sensitively captures ACL graft maturation and highlights 3–6 months as a critical remodeling window, providing objective biomarkers to complement clinical assessment for individualized rehabilitation monitoring and return-to-sport timing. Full article

Background: Lateral extra-articular tenodesis (LET) is a surgical procedure that is additionally implemented in concurrent anterior cruciate ligament reconstruction (ACLR). Although numerous articles have addressed the use of LET in conjunction with ACLR, few definitive contraindications were identified. Given the scarcity of literature evaluating contraindications for LET modality, this study aimed to systematically review the reported contraindications of this procedure in the context of concurrent ACLR. Methods: The searched key terms: (extra-articular OR extraarticular) AND (tenodesis OR plasty OR augmentation OR procedure or reconstruction OR reconstructive OR surgical OR surgery OR technique) AND (ACL OR anterior cruciate ligament), with no publication date restrictions in PubMed, ScienceDirect, Cochrane Central, Web of Science, and Embase databases. We included clinical human studies, with levels of evidence I–III and in the English language. Results: The analysis evaluated fourteen articles published between 2012 and 2024. Level III evidence was found in the majority of studies (n = 9) and Level I evidence was found in the rest (n = 5). The majority of the included articles were retrospective (n = 8) and there were also prospective studies (n = 6). The articles reviewed showed that articular cartilage damage and concomitant injuries to other knee ligaments, alongside ACL injury, are the most frequently mentioned. Conclusions: This is the first study that systematized the contraindications for the LET procedure in ACLR. The contraindications remain unclear; however, the following may be highlighted: articular cartilage damage and injury to another ligament in the knee, in addition to ACL injury. Full article

Background: Musculoskeletal disorders (MSDs) are a major contributor to global disability. Exercise-based rehabilitation is widely recommended as first-line management; however, in clinical practice, it is frequently combined with adjunct therapeutic modalities, and the incremental effectiveness of these approaches remains unclear. The present review addressed the research question: Do adjunct modalities provide additional benefits beyond exercise-based rehabilitation alone in individuals with musculoskeletal disorders? Methods: This systematic review was conducted according to PRISMA 2020 guidelines and prospectively registered in the PROSPERO database (registration number CRD420261309183). Electronic searches were performed in PubMed/MEDLINE, Scopus, Web of Science, and the Cochrane Central Register of Controlled Trials to identify controlled clinical trials evaluating exercise-based rehabilitation delivered alone or combined with adjunct modalities. Outcomes included pain, functional disability, physical performance, strength, structural or imaging-based measures, biomechanical variables, injury risk, and work-related outcomes. Due to methodological heterogeneity across studies, a structured narrative and tabular synthesis were performed. Results: Twenty-one controlled clinical trials were included, encompassing tendinopathies (n = 7), knee osteoarthritis (n = 5), post-ACL reconstruction (n = 2), chronic spinal pain (n = 3), sarcopenia (n = 2), low bone mass (n = 2), and occupational musculoskeletal conditions (n = 1), with sample sizes ranging from 22 to 823 participants. Pain outcomes were reported in 18 studies (86%) and functional outcomes in 16 studies (76%). Exercise-based rehabilitation consistently produced clinically meaningful improvements across studies, whereas adjunct modalities demonstrated short-term advantages in a limited number of trials but rarely showed sustained long-term superiority. Conclusions: Evidence from controlled clinical trials indicates that exercise-based rehabilitation is an effective primary intervention for improving pain, functional capacity, and physical performance across diverse musculoskeletal conditions. Adjunct modalities may provide condition-specific or short-term benefits but do not consistently enhance long-term outcomes beyond structured exercise programs. Full article

Background/Objectives: Restoring lower-limb strength and symmetry is crucial after ACL injury and reconstruction. The limb symmetry index (LSI) is often used to assess strength symmetry for return-to-sport decisions, but various assessment methods can influence outcomes. This study aimed to compare LSI across common knee flexor testing methods in healthy male athletes and to examine associations between absolute strength outcomes, thereby establishing baseline reference values for LSI in a healthy population. Methods: Twenty-two healthy recreationally active males participated in this prospective cross-sectional study. Knee flexor strength was assessed bilaterally using three force plate isometric tests, a static dynamometer-based test (isometric), and isokinetic dynamometer-based tests. Absolute strength values were normalized to body mass. LSI values were calculated for each testing condition. Differences in LSI across modalities were analyzed with repeated-measures ANOVA, and associations between normalized strength outcomes were assessed using Pearson correlation coefficients. Results: LSI values ranged from 96.69 to 101.83 across the testing conditions, with no significant differences observed between measures. Normalized absolute strength outcomes demonstrated very strong correlations within the same measurement category (r = 0.86–0.94 for force plate tests and r = 0.88–0.96 for isokinetic tests). In contrast, correlations between isometric and isokinetic strength outcomes were moderate (r = 0.41–0.67). Conclusions: LSI values were consistent across knee flexor strength testing modalities, suggesting that symmetry assessment was relatively consistent across different measurement methods in the studied group. In contrast, normalized absolute strength outcomes showed only moderate and variable associations across modalities, indicating that different testing approaches assess related but not interchangeable aspects of muscle strength. Full article

Background and Objectives: Present assessment methods have not effectively mitigated the risk of recurrent anterior cruciate ligament (ACL) injury following reconstruction (ACLR), suggesting that critical neuromuscular deficits may be underdiagnosed. This study aimed to compare limb asymmetries across strength, concentric and eccentric power, and deceleration metrics during return-to-sport (RTS) testing in professional athletes post-ACLR. Materials and Methods: Forty-four participants (33 males, 11 females; age 22.5 ± 5.8 years, body mass 75.9 ± 13.0 kg, height 180.5 ± 8.38 cm) (mean ± SD) with a unilateral reconstructed ACL (BTB = 33, HT = 11 graft) were included. They underwent isokinetic testing of knee flexor and extensor strength and bilateral countermovement jump (CMJ) assessments to measure concentric and eccentric peak power and deceleration metrics. Limb symmetry indices (LSI) were calculated for each parameter. Welch’s ANOVA and Games–Howell post hoc tests were used to compare LSIs among parameters. Results: Welch’s ANOVA showed that limb symmetry differed significantly across the measured neuromuscular parameters (F = 12,59, p < 0.001). Knee flexor strength LSI was significantly higher than knee extensor strength LSI (p = 0.003; d = 1.18), concentric peak power LSI (p < 0.001, d = 1.44), eccentric peak power LSI (p = 0.001, d = 1.71), and deceleration LSI (p = 0.001, d = 2.09). In addition, deceleration LSI was significantly lower than knee extensor strength LSI (p = 0.001, d = 1.34) and concentric peak power LSI (p = 0.007, d = 1.10). No significant difference was found between concentric and eccentric peak power, nor between knee extensor strength and either concentric or eccentric peak power LSIs. Conclusions: The findings of this study revealed significantly greater asymmetries in load absorption capacity compared to strength and concentric power measures at return-to-sport time frame in professional athletes post-ACLR. Full article

Background/Objectives: Anterior cruciate ligament reconstruction (ACLR) is a common orthopedic procedure; however, successful return to sport (RTS) remains a major challenge influenced by both physical and psychological factors. Kinesiophobia and psychological readiness are crucial yet inadequately studied components of rehabilitation that may change across distinct phases. This study aimed to examine longitudinal, phase-specific changes in kinesiophobia, psychological readiness, and patient-reported knee function across standardized ACLR rehabilitation phases. Methods: A retrospective longitudinal cohort design was employed. Data were extracted from 45 patients who completed ACLR rehabilitation at a specialized musculoskeletal center in Riyadh, Saudi Arabia. Participants were assessed across four rehabilitation phases: Phase One (0–1 month), Phase Two (>1–3 months), Phase Three (>3–6 months), and Phase Four (>6 months post-ACLR). Outcomes included the Tampa Scale of Kinesiophobia (TSK-17), the ACL–Return to Sport after Injury scale (ACL-RSI), and the International Knee Documentation Committee subjective knee form (IKDC), administered using validated Arabic versions. Linear mixed-effects models with Bonferroni-adjusted pairwise comparisons were used to evaluate phase-related changes. Results: Significant fixed effects of rehabilitation phase were observed for all outcomes (p < 0.001). Kinesiophobia declined substantially from Phase One (mean 51.5) to Phase Three (34.7), with the greatest reduction between Phases Two and Three, followed by stabilization in Phase Four. Psychological readiness increased progressively across all phases (ACL-RSI: 37.1 to 61.8). Knee function demonstrated the greatest improvement during late rehabilitation (IKDC: 37.6 to 75.8). Conclusions: Psychological and functional recovery following ACLR follow distinct temporal trajectories rather than improving synchronously. Kinesiophobia declines most markedly during mid-rehabilitation, while functional gains peak in late rehabilitation. These findings support integrating structured psychological screening into phase-specific ACLR rehabilitation protocols. Full article

Tibial torsion significantly influences knee biomechanics, yet its interaction with ACL reconstruction history in elite alpine skiers remains under-investigated. In this cross-sectional observational study, we analyzed 20 elite alpine skiers (7 ACL-reconstructed, 13 non-injured) using a markerless motion capture system during dynamic tasks (Squat, Single-Leg Squat, Lunge). Static tibial torsion was assessed via the Transmalleolar Axis and Thigh–Foot Angle. The results revealed a critical divergence in biomechanical strategies based on tibial alignment (p < 0.05). Skiers with rotational deformity adopted a pattern we describe as a “Stiffness Strategy”, characterized by suppressed knee valgus and hip rotation, but relied on excessive ankle dorsiflexion (39.5°)—a compensatory mechanism that may become limited when constrained by rigid ski boots. In contrast, ACL-reconstructed skiers with normal alignment exhibited what we term an “Instability Strategy”, showing dynamic valgus collapse and persistent asymmetry. These findings suggest that “one-size-fits-all” rehabilitation may be insufficient. We propose that injury prevention protocols may benefit from incorporating anatomical screening, focusing on decoupling mobility for skiers with tibial torsion and enhancing dynamic stability for those with normal alignment. Full article

Anterior cruciate ligament (ACL) injuries frequently lead to persistent gait asymmetries, posing challenges for early rehabilitation and functional status. Comprehensive monitoring of pelvic gait symmetry during rehabilitation remains underexplored. This study evaluated post-operative functional status using an integrated monitoring approach combining pelvic-mounted inertial measurement unit (IMU) sensors with standardized clinical assessments in 32 individuals (9 women, 23 men; aged 19–64) following ACL reconstruction with patellar tendon autografts. IMU recordings captured pelvic oscillations in the sagittal, frontal, and transverse planes during standardized 10 m walking tests, providing objective digital biomarkers of gait symmetry. Clinical assessments included knee range of motion, thigh circumference, swelling, and pain using a modified 0–20 visual analogue scale (VAS). Across the early rehabilitation period, VAS scores decreased from 13.6 to 3.0, knee swelling from 2.88 cm to 1.09 cm, knee extension deficit from −9.38° to −2.03°, and knee flexion improved from 61.56° to 98.75°. Thigh hypotrophy increased from 1.13 cm to 2.53 cm. Pelvic oscillations improved in all planes (sagittal: 36.2 to 49.2; frontal: 71.9 to 92.2; transverse: 73.4 to 90.9), reflecting progressive restoration of gait control as patients transitioned from crutch-assisted to independent walking. The integration of wearable sensor data with clinical metrics enabled sensitive tracking of pelvic gait symmetry and functional status, demonstrating the utility of technology-supported monitoring to support individualized clinical assessment and early-phase monitoring following ACL reconstruction. Full article

Background/Objectives: The aim of this study was to report first experiences with dynamic intraligamentary stabilization (DIS) technique for anterior cruciate ligament (ACL) rupture in children and adolescents. Methods: A case series of 22 children and adolescents with a mean age of 13.3 years underwent primary repair of an ACL rupture using the DIS technique as an off-label use in skeletally immature patients. Patients were evaluated for laxity, strength, range of motion (ROM), and functional tests, as well as Tegner, Lysholm, International Knee Documentation Committee (IKDC), and PedsQL scores after 3 years. A follow up after 11 years was conducted to analyze long-term results, rerupture rates and reinterventions. Results: Three years after surgery, there was no significant difference in laxity, strength, ROM, and in the functional tests comparing the injured to the contralateral knee. The Tegner Index after surgery showed a slight drop of 0.8 points, from 7.1 preoperatively to 6.3. Mean IKDC, Lysholm, and peds-QL scores were 91.17 (range 62.64–98.85, median 94.25), 88.27 (range 58–100, median 93), and 88.78 (range 58.15–100, median 91.30). Overall failure rate of the DIS-repaired knees was 55% (12 of 22 patients). In ten patients, reruptures happened at an average time of 3.2 years after initial surgery; additionally, two patients with chronic instability had to undergo revision ACL reconstruction. Conclusions: DIS repair might help ACL healing with satisfactory functional outcomes. However, given the high failure and reintervention rates, further studies need to show non-inferiority of the DIS technique in children and adolescents before being considered a valid treatment option. Full article