Search Results (437)

Objectives: Borrelia burgdorferi sensu lato, a spirochete bacterium responsible for Lyme borreliosis—the most common tick-borne infection in North America and Europe—can trigger the production of antiphospholipid antibodies. These antibodies target host lipids such as cardiolipin (CL), phosphatidic acid (PA), phosphatidylcholine (PC), and phosphatidylserine (PS), which the spirochete incorporates into its membrane from the surrounding environment. Although antiphospholipid antibodies are typically associated with antiphospholipid syndrome (APS), they may also arise during infections, including Lyme borreliosis. This study aimed to develop and optimize several enzyme-linked immunosorbent assays (ELISAs) for measuring various antiphospholipid antibodies in patients with Lyme borreliosis. Methods: Thirty patients diagnosed with Lyme borreliosis were enrolled: ten with solitary erythema migrans (EM), ten with multiple EM (MEM), and ten with late manifestations known as acrodermatitis chronica atrophicans (ACA). Forty healthy blood donors served as controls. Four distinct antiphospholipid antibody ELISAs were developed, each using a different phospholipid coating: CL, PA, PC, and PS. Serum of APS patient was used as a positive control and for standard curve generation. Results: All four ELISAs were successfully established and demonstrated good measurement precision. Significant differences in antiphospholipid antibody levels and positivity rates were observed between Lyme borreliosis patients and healthy blood donors. Notably, levels of antibodies directed against PA (aPA), PC (aPC), and PS (aPS), both IgG and IgM, were significantly higher in patients with late Lyme borreliosis, manifested as ACA, compared to healthy blood donors. In contrast, anti-CL (aCL) levels did not differ significantly between groups. Patients with ACA also showed the highest frequency of multiple antiphospholipid antibody positivity, with 7 out of 10 patients testing positive for three or more antiphospholipid antibodies. Conclusions: Accurate and precise in-house ELISAs for the detection of aCL, aPA, aPC, and aPS using APS sera as standard material were developed and validated for the analysis of samples of patients with Lyme borreliosis. Our data suggest that antiphospholipid antibody levels—specifically aPA, aPC, and aPS—differ across clinical manifestations of Lyme borreliosis, with the greatest increases observed in patients with ACA. Full article

Background/Objectives: Low-dose atropine eye drops are widely used to slow myopia progression in children, but by reducing accommodation they may affect near ocular alignment and binocular visual function. Evidence on ocular alignment and strabismus-related findings remains insufficiently synthesized. This review examined low-dose atropine for pediatric myopia control in relation to ocular alignment and strabismus-related findings. Methods: PubMed/MEDLINE and Web of Science Core Collection were searched from inception to 16 April 2026. English-language studies addressing low-dose atropine, myopia control, ocular alignment, strabismus, binocular vision, accommodation, and vergence were screened. Of 247 records, 166 underwent screening after duplicate removal. Twenty-three database-derived and four manually identified full-text articles were reviewed. Eleven studies were included. Results: Of eleven included studies, six were clinical or interventional studies and five were case reports or case series. Case-based reports described near-predominant esodeviation, convergence excess-type deviation, elevated accommodative convergence/accommodation (AC/A) ratios, diplopia, reduced fusion, and acquired esotropia during fixed low-dose or escalating atropine use; most fixed low-dose cases improved after discontinuation or treatment modification. Clinical and interventional studies did not show consistent worsening of ocular alignment, near point of convergence (NPC), fusional vergence, or binocular vision. More consistent changes included pupil dilation, receded near point of accommodation (NPA), reduced accommodative amplitude and facility, selected fusional vergence changes, and short-term binocular or accommodative fluctuations. Conclusions: Low-dose atropine appears to be useful for pediatric myopia control and is generally well tolerated. However, selected cases may be temporally associated with ocular alignment abnormalities or strabismus-related findings. Careful monitoring may be warranted in children with unstable binocular systems and during dose escalation. Full article

The aim of this study is to determine the optimal functional size of laser peripheral iridotomy (LPI) for anterior chamber parameter improvement in primary angle-closure disease (PACD). This study evaluated 109 eyes from 62 consecutive phakic patients. Baseline and one-week post-LPI anterior segment OCT were utilized to measure anterior chamber volume (ACV), anterior chamber angle (ACA), and iridotomy dimensions. Data was analyzed using linear mixed-effects models (LMMs), generalized additive models (GAMs), and receiver operating characteristic (ROC) curves. Post-LPI, significant increases occurred in ACA 500 (+7.54°), ACV (+11.09 mm³), and gonioscopic grade. LMMs confirmed a positive association between iridotomy size and anatomical expansion. GAMs demonstrated a saturation effect for ACV improvement, plateauing at 0.1 mm² (narrow area) and 0.25–0.30 mm² (superficial area), while the ACA relationship remained predominantly linear. ROC analysis identified preliminary superficial area cutoffs of 0.14 mm² and 0.12 mm² as discriminators of above-median volumetric and angular response, respectively. These findings suggest that LPI size is an independent determinant of anatomical response, beyond simple patency. As a preliminary, hypothesis-generating target, a superficial iridotomy area of approximately 0.12–0.14 mm² was associated with above-median volumetric and angular response in this cohort. Prospective validation is required before these thresholds can be incorporated into clinical practice. Full article

Maliciously deployed disco intelligent reflecting surfaces (DIRSs) introduce active channel aging (ACA) to achieve fully passive jamming without requiring channel state information or jamming power. To enhance this capability, we propose a distributed DIRS framework for downlink multi-user multiple-input single-output (MU-MISO) systems. By distributing multiple panels, this framework increases independent reflection paths and introduces inter-panel cascaded reflections, severely exacerbating precoder mismatch. We develop a comprehensive near- and far-field cascaded channel model, deriving closed-form expressions for the interference variance and a sum-rate lower bound in the large-antenna regime. Both pilot training (PT) phase-on and phase-off scenarios are investigated to evaluate the jamming impact under different operational states. Analytical and simulation results reveal that DIRS-induced interference scales with transmit power, imposing a strict rate ceiling. Specifically, at 10 dBm transmit power per LU, the proposed framework not only reduces the achievable sum-rate by over 57% relative to the interference-free scenario, but also improves the jamming impact by approximately 36% compared to the conventional single-panel DIRS, demonstrating superior and robust fully passive jamming capability. Full article

Background/Objectives: Acrodermatitis chronica atrophicans (ACA), a late cutaneous manifestation of Lyme borreliosis, presents with a broad clinical spectrum. Most commonly, a characteristic bluish-red patchy rash, but it can also appear as unilateral limb swelling. This study aimed to characterize the clinical manifestations, diagnostic workup, and outcomes of patients with ACA in a tertiary setting in Denmark. Methods: Retrospective cohort study including all patients diagnosed with ACA at Copenhagen University Hospital-Rigshospitalet between 2017 and 2025. Results: Forty patients were included (median age 57 years; 63% female), with a median BMI of 24.5 [range 15.6–36.3]. Symptom duration was long (median 1 year). All patients presented with a skin rash. The most common location was the lower extremity, 26/40 (65%). Local edema and neuropathic pain were common (20/40) 50% and (23/40) 55%, respectively. A total of 13/40 patients underwent lymphoscintigraphy, which was deemed pathological in 7/13 (54%). The patients presenting with edema underwent significantly more imaging procedures, median 3 (range 1–5) vs. 0 (range 0–2), p < 0.005; they were younger, median age 49 years (range 17–76) vs. median 65 (range 30–81), p = 0.03; but did not differ in BMI, median 26.6 (range 19.0–36.2) versus median 23.8 (range 15.6–36.3), p = 0.48. All patients were Borrelia burgdorferi (Bb) IgG seropositive. Borrelia-specific PCR was positive in 6/13 (46%). Histopathology supported the diagnosis in 19/20 (95%). Clinical evaluation of the treatment response at 3 months was good in 33/40 (83%). Conclusions: Edema/swelling due to lymphatic obstruction is a common presentation of ACA in the tertiary setting, resulting in extensive diagnostic workup. The condition is associated with younger age but not BMI, sex, or immunodeficiency. Raised awareness and earlier testing for Bb IgG in serum seem warranted. Full article

This paper presents the electrochemical behavior of stainless steel 304 (SS304), a material often utilized in the wine industry, in the presence of varying concentrations of ascorbic acid (AcAS), introduced in a neutral solution (Na₂SO₄ 0.25 M + 12% (v/v) EtOH). The experimental part of this paper included potentiodynamic polarization and chronoamperometry techniques to evaluate the influence of ascorbic acid on the corrosion processes in the test solutions. Electrochemical impedance spectroscopy (EIS) has been used to investigate the charge transfer at the interface and the formation of a protective film in the absence and presence of AcAS. The Tafel method was employed to determine the kinetic parameters of the corrosion process studied. Additionally, several models of adsorption isotherms were applied to describe the interactions between AcAS and the stainless steel surface, with the Freundlich and Dubinin–Radushkevich isotherms demonstrating the most robust correlation, based on the R² correlation coefficients. Quantum chemical calculations (DFT) were also performed to clarify the molecular mechanism via which AcAS functions as an eco-friendly corrosion inhibitor in winemaking-related environments. Full article

Background: Sensor-based systems and virtual reality (VR) technologies provide new opportunities for the objective, technology-driven assessment and training of visuomotor performance in applied contexts such as sport. Methods: This study examined the effects of an integrated visual training program combining stroboscopic stimulation, VR-based vergence exercises, and instrumented reaction-light tasks in adolescent handball players. Twenty-eight adolescent handball players (under-18 competitive level) completed two baseline assessments separated by six weeks, followed by a six-session training program (approximately 15 min per session) integrated into regular team practice. The intervention targeted visuomotor reaction speed, accommodative dynamics, and peripheral visual responsiveness using sensor-based and virtual reality–assisted stimuli. Results: Compared with both baseline measurements, the intervention produced selective improvements in accommodative facility (cycles per minute, cpm)—particularly near–far focusing speed—and in multiple reaction-time conditions (milliseconds, ms) involving manual and decision-based responses. Specific peripheral-field locations showed increased response scores, whereas binocular alignment, AC/A ratio, near phoria, and stereoscopic acuity remained unchanged. Conclusions: These findings indicate that technology-supported visual training protocols incorporating sensor-based reaction systems and VR stimuli were associated with measurable adaptations in dynamic visuomotor processing while preserving fundamental binocular vision parameters. Full article

Background: Pacemakers enable continuous long-term surveillance of atrial fibrillation detected by implanted devices. Circulating biomarkers reflecting endothelial dysfunction, inflammation, and myocardial stress may help identify patients at risk for atrial fibrillation (AF) progression and higher arrhythmic burden. Methods: This analysis included patients from the prospective ACaSA study (NCT05127720) with a dual chamber pacemaker (Microport^® BOREA DR or TEO DR) and monitored weekly via remote monitoring technology (SMARTVIEW^®). Individuals with permanent AF or single-chamber systems were excluded. Baseline plasma concentrations of angiopoietin-2 (ANGPT2), growth differentiation factor-15 (GDF-15), fibroblast growth factor-23 (FGF-23), bone morphogenetic protein-10 (BMP10), and tumor necrosis factor–related apoptosis-inducing ligand receptor-2 (TRAIL-R2) were quantified using enzyme-linked immunosorbent assays. N-terminal pro-B-type natriuretic peptide (NT-proBNP) was measured using electrochemiluminescence immunoassay. Biomarkers were log₂-transformed, with values below assay detection limits imputed at half the lower limit of detection. Two endpoints were assessed following a 30-day blanking period: (1) progression to persistent AF, defined as ≥7 consecutive days with >99% daily AF burden, analyzed using Cox regression; and (2) AF burden, calculated as total AF time normalized to monitored days and categorized as <25%, 25–75%, or >75%, analyzed using multinomial logistic regression. Multivariable models were adjusted for age, sex, heart failure, diabetes, and prior myocardial infarction; Cox models were limited to age, sex, and heart failure due to fewer events. Results: A total of 223 patients were included (median age 75 years; 37.2% women). During follow-up, 28 patients (13.3%) progressed to persistent AF. Higher baseline ANGPT2 was the strongest predictor of progression (HR per doubling 1.83, 95% CI 1.27–2.66, p = 0.001), followed by GDF-15 (HR 1.52, 95% CI 1.03–2.24, p = 0.036). In the burden analysis, ANGPT2 demonstrated a pronounced graded relationship with arrhythmic load, with markedly increased odds of high (>75%) AF burden (OR 8.31, 95% CI 2.63–26.26, p < 0.001). GDF-15 independently predicted both medium (OR 2.05, p = 0.025) and high burden (OR 2.32, p = 0.037). NT-proBNP displayed a borderline association with high burden (OR 2.02, p = 0.061). No significant associations were observed for FGF-23, BMP10, or TRAIL-R2. Conclusions: In continuously monitored pacemaker patients, ANGPT2 and GDF-15 emerged as key biomarkers associated with AF disease severity. ANGPT2 was strongly linked to both progression to persistent AF and high AF burden, whereas GDF-15 consistently predicted higher AF burden and also contributed to risk of progression. These findings highlight endothelial and inflammatory pathways as potential markers of atrial disease progression. Full article

Arid Central Asia (ACA) is a major source of atmospheric dust in the Northern Hemisphere; however, the evolutionary models and driving mechanisms of Holocene aeolian activity in this region remain debated. Based on 13 reliable AMS ¹⁴C dates from the Sayram Lake SLM2009 sediment core, this study reconstructs the Holocene sequence in aeolian activity through end-member modeling analysis (EMMA). It evaluates its relationship with regional atmospheric circulation. Four end-members were identified from base to top: EM1, with a modal grain size of 7.58 μm, represents low-energy suspension deposition; EM2 (26.30 μm) reflects lacustrine hydrodynamic processes; while EM3 (52.48 μm) and EM4 (416.86 μm) serve as proxies for regional aeolian activity. The results indicate that aeolian activity was relatively strong during the early Holocene (reaching peaks at 11.7–11.2 and 9.2–8.1 cal ka BP), significantly intensified during the mid-Holocene (7.3–5.3 cal ka BP), and gradually weakened in the late Holocene (since 4.0 cal ka BP). Comparison of the aeolian record from Lake Sayram with Greenland ice cores, North Atlantic ice-rafted debris events, and the GISP2 K⁺ record indicates that variations in aeolian activity in arid Central Asia are closely linked to the Northern Hemisphere climate system. We propose that these variations were primarily modulated by large-scale atmospheric circulation, driven by the synergistic interaction between the Siberian High and the mid-latitude westerlies. Full article

Unsupervised video anomaly detection (VAD) methods learn from normal data to identify anomalies by capturing pattern deviations. However, they often struggle to model multi-scale features and distinguish between normal and abnormal instances. To address these limitations, we propose a Multi-scale U-shaped Adaptive Clustering Learning (MS-UACL) framework. Built on the U-Net architecture, we redesign it as a 3D-encoder/2D-decoder autoencoder. In the encoder, we introduce a Dual-scale Feature Cascading Module (IDCN), which adopts a pseudo-branch fusion mechanism to systematically model multi-scale spatiotemporal features, thereby enhancing the model’s representational capability. To further enhance the distinction between normal and anomalous patterns, we propose an MLP-based Adaptive Clustering Algorithm (MLP-ACA). Specifically, MLP-ACA employs an initial mapping mechanism to align cluster centers with the underlying normal data distribution, facilitating more accurate feature reconstruction. Additionally, we introduce an adaptive clustering update strategy that optimizes cluster centers by tuning solely the parameters of the MLP. This enables the cluster centers to autonomously converge toward optimal feature representations, thereby accelerating clustering convergence and enhancing pattern separability. Extensive experiments on three benchmark datasets demonstrate that the proposed MS-UACL framework outperforms most existing methods on small- and medium-scale datasets. Full article

Accurate prediction of hard disk drive (HDD) health states is critical for enabling proactive data maintenance and ensuring data reliability in large-scale data centers. However, conventional models often suffer from semantic entanglement among heterogeneous SMART attributes and from the masking of incipient failure signatures by stochastic noise. To address these challenges, we propose SDGR-Net, a spatiotemporally decoupled learning framework designed to model the complex degradation dynamics of HDDs. SDGR-Net introduces three synergistic innovations: (1) a spatiotemporally decoupled dual-branch encoder that disentangles longitudinal temporal evolution from cross-variable correlations via parameter-isolated branches, thereby reducing representational interference; (2) a parsimonious dual-view temporal extraction mechanism that captures early-stage anomalies through forward–reverse sequence concatenation, enabling high-fidelity preservation of non-stationary pre-failure patterns; and (3) a cross-branch dynamic gated residual fusion module that functions as an adaptive information bottleneck to emphasize failure-critical features while suppressing redundant noise. Extensive experiments conducted on three heterogeneous HDD datasets, ST4000DM000, HUH721212ALN604, and MG07ACA14TA, demonstrate that SDGR-Net consistently outperforms six state-of-the-art baselines. In particular, SDGR-Net achieves a peak fault detection rate (FDR) of 0.9898 and a 69.6% relative reduction in false alarm rate (FAR) under high-reliability operating conditions. These results, corroborated by comprehensive ablation studies, indicate that SDGR-Net effectively balances detection sensitivity and operational robustness, offering a practical solution for intelligent HDD health monitoring. Full article

A sustainable way to recycle used tires and improve the functionality of asphalt pavements is through the use of crumb rubber modified asphalt (CRMA). However, its application during high-temperature construction raises environmental and occupational health concerns due to the release of significant quantities of odorous and potentially harmful gases. Therefore, this study selected α-Amyl cinnamic aldehyde (ACA) as a deodorant and added it to CRMA at proportions of 0.5%, 1.0%, 1.5%, and 2.0% to prepare DCRMA. A number of common tests, such as softening point, ductility, penetration, Brookfield rotational viscosity, and segregation analysis, were used to evaluate the basic characteristics of the modified asphalt. A self-developed asphalt fume monitoring device was used to quantitatively analyze the changes in VOCs, H₂S gas concentration, and solid particle content in the asphalt fumes to assess the deodorization effect of ACA on CRMA. Furthermore, the deodorization mechanism of ACA on CRMA was explored in depth using microscopic methods, such as fluorescence microscopy (FM) and Fourier transform infrared spectroscopy (FTIR). The findings demonstrated that ACA can increase the softening point and viscosity of CRMA while decreasing its penetration and ductility. The storage stability was optimal at a 1.0% ACA addition. Additionally, as the ACA content increased, the concentrations of VOCs, H₂S gas, and solid particles in the asphalt fumes continued to decrease. FM results indicated that when the ACA content did not exceed 1.0%, it promoted the swelling degree of CR in the asphalt. FTIR results showed that ACA can reduce the characteristic peak intensity of CRMA. This study offers important technical references and practical support for the environmentally friendly use of CRMA. Full article

The remain well clear (RWC) function of a detect-and-avoid (DAA) system provides guidance to a remote pilot (RP) of a remotely piloted aircraft to prevent a conflict from developing into a collision hazard. The ACAS Xu standard is a decision support system that uses RWC bands to advise a RP which headings to avoid. A recent A* DAA system is a resolution support system that advises a RP which route to take. The objective of this study is to achieve structured feedback by professional RPs on the horizontal RWC guidance of both systems. Nine RPs participated in on-line experiments, where they were shown videos of DAA displays of encounter scenarios between two aircraft. At various stages the RPs were asked for their opinion about transparency, pilot manoeuvring, situation awareness, display orientation, risk perception, competence, trust, and overall system preference. The results show that the scores for competence, trust and pilot manoeuvring were significantly higher, and the score for perceived risk was significant lower for the RWC route guidance. Overall, 89% of the RPs preferred the RWC route guidance, while one RP had no preference. An implication of the uncertainty in pilot behaviour is that ACAS Xu model-based optimisation may provide suboptimal RWC guidance strategies, while the A* DAA optimisation can be managed effectively. Full article

Background/Objectives: Dental caries remains a global challenge, with high prevalence among five-year-old children and regional inequalities. The aim of this study is to identify factors associated with protection from dental caries in five-year-old children, using Salutogenic Theory as a reference. Methods: Secondary data were analyzed from the Minas Gerais Oral Health Survey. Five-year-old children (n = 1193) were examined. Parents or guardians answered a questionnaire addressing individual variables and the use of dental services. Dependent variables were the absence of caries activity (ACA) and absence of caries experience (ACE), which were extracted from the decayed–missing–filled primary teeth (dmft) index. Logistic regression analysis was used to estimate odds ratios with 95% confidence intervals for each block of variables on the hierarchical levels. The Complex Samples module of the SPSS 19.0 program was used. Results: Five hundred ninety-five children (50.5%) in the overall sample were caries-free. In the final model, white skin color, monthly family income greater than R$1500, having more than six material goods, and not visiting a dentist in the previous year were associated with ACA and ACE. Conclusions: Factors related to socioeconomic conditions were associated with protection from dental caries in early childhood, supporting equity-based public policies to increase the number of children not affected by caries. Full article