Search Results (25)

Psychological stress and dietary behavior are interdependent forces that greatly influence mental and physical health. Thus, both what and how we eat impact our well-being. Maladaptive eating patterns, such as eating in response to emotional cues rather than physiological hunger, have become increasingly common amid modern stressors and an ultra-processed food environment. This narrative review synthesizes interdisciplinary findings from nutritional psychiatry, microbiome science, and behavioral nutrition to explore how stress physiology, gut–brain interactions, and dietary quality shape emotional regulation and eating behavior. It highlights mechanisms (e.g., HPA-axis dysregulation, blunted interoception, and inflammatory and epigenetic pathways) and examines the evidence for mindful and intuitive eating; phytochemical-rich, whole-food dietary patterns; and the emerging role of precision nutrition. Trauma-informed approaches, cultural foodways, structural barriers to healthy eating, and clinical implementation strategies (e.g., interprofessional collaboration) are considered in the context of public health equity to support sustainable mental wellness through dietary interventions. Ultimately, restoring a healthy relationship with food positions nutrition not only as sustenance but as a modifiable regulator of affect, cognition, and stress resilience, central to mental and physical well-being. Full article

Prostate cancer cell lines are particularly clinically homogenous, mostly representing metastatic states rather than localized disease. While there has been significant work in the development of additional models, few have been created without oncogenic transformation. We derived a primary prostate cancer cell line from a patient with localized Gleason 7 prostate cancer—designated CaB34—which spontaneously immortalized. We leveraged CaB34 to generate a paired radioresistant subline, CaB34-CF, using a clinically relevant fractionated radiotherapy schedule. These two paired cell lines were investigated extensively to determine their molecular characteristics and therapy responses. Both CaB34 and CaB34-CF express prostate-specific markers, including KRT18, NKX3.1, and AMACR. Multi-omic analyses using RNAseq and shotgun proteomics identified NNMT as the most significantly dysregulated component in CaB34-CF. A bioinformatic analysis determined that NNMT was more abundant within prostate tumors compared to benign prostate, suggesting a role in tumor progression. Knockdown studies of NNMT demonstrated significant radiosensitization of CaB34-CF cells, which was largely a result of increased radiation-induced cellular senescence. Growth as 3D organoids was significantly higher in the CaB34-CF line, and demonstrated a less structured pattern of expression of cytokeratin markers. Radiosensitization with NNMT siRNA was recapitulated in a 3D organoid clonogenic assay in CaB34-CF cells. Our research provides a paired primary model of treatment-naïve and radioresistant disease to address mechanisms of therapy resistance, while expanding the repertoire of localized prostate cancer cell lines for the research community. In addition, our findings present NNMT as a potential therapeutic target for sensitization of radioresistant disease. Full article

As terrestrial resources become increasingly scarce, the exploration and utilization of marine resources have become crucial for ensuring a stable resource supply. A maritime A-Frame is a specialized lifting mechanism mounted on the stern of a vessel, designed for deploying and retrieving heavy loads during subsea exploration. Real-time monitoring of the stress of A-Frames is essential for identifying potential failures and preventing accidents. This paper presents a stress-monitoring campaign conducted on a maritime A-Frame during a deep-sea mining project in the South China Sea. Fiber Bragg Grating (FBG) strain sensors were installed on the A-Frame to measure its stress responses throughout the deep-sea mining operation. The stress variations observed during the deployment and retrieval of a deep-sea mining vehicle were analyzed. The results indicate that the stress caused by the swinging motion of the A-Frame was significantly higher than that generated by the lifting and deployment of the mining equipment. Additionally, a finite element model (FEM) of the A-Frame was developed to estimate the stress of the hot spots by integrating the measured strain data. The analysis confirmed that the maximum stress experienced by the A-Frame was well below the allowable threshold, indicating that the structure had sufficient strength to withstand operational loads. In addition, the swing angle of the A-Frame significantly affects the stress value of the A-Frame, while lifting the mining vehicle has a very slight effect. Thus, it is advisable to accelerate the deployment and retrieval speeds of the mining vehicle and minimize the outward swing angle of the A-Frame. These findings provide valuable insights for optimizing the design and ensuring the safe operation of maritime A-Frames in deep-sea mining exploration. Full article

Background/Purpose: Fractal gait patterns have been shown to be modifiable, but the extent to which they are retained and transferred to new contexts is relatively unknown. This study aimed to close those gaps by enrolling participants (N = 23) in a seven-day fractal gait training program. Methods: Building on related work, the fractal gait training occurred on a treadmill over a 10-min period. Before and after the treadmill training, each participant walked for 10 min overground without the fractal stimulus used during training. The daily post-test was used to examine immediate retention and transfer of the fractal gait patterns from the treadmill to overground. The pre-tests in days 2–7 were used to examine the extent to which the fractal gait patterns from the preceding day were retained 24 h later. Inertial measurement units were used to measure stride time so a consistent measurement method could be employed in the treadmill and overground phases of the study. Results: Our results showed that multiple days of treadmill training led to elevated fractal patterns, indicating a positive training effect. However, the positive training effect observed on the treadmill did not transfer to overground walking. Conclusions: Collectively, the data show that fractal patterns in gait are modifiable across multiple days of training, but the transferability of these patterns to new contexts needs to be further explored. Full article

This study assesses the role of grazing reserves and transhumance corridor systems in enhancing sustainable transhumant pastoralism, drawing on the collaborative planning theory as its theoretical framework. This research aims to understand how these land management strategies impact the sustainability of pastoral practices from the viewpoints of various stakeholders, including farmers, herders, policymakers and local community leaders. This study adopted a mixed-method research design and an exploratory sequential mixed-method approach. Based on the research approach, this study first gathers data through key informant interviews and, subsequently, cross-sectional surveys of 254 crop farmers and 82 herders in the Sekyere Kumawu and Sekyere Afram Plains Districts of Ghana. The findings indicate mixed perceptions among stakeholders regarding delineating grazing reserves and transhumance corridor systems. While most farmers and herders recognise the potential benefits of delineating grazing reserves and corridors in reducing conflict and promoting environmental sustainability, concerns persist about land rights and the flexibility of resource use. While herders see these policies as providing secure grazing territories, farmers fear losing land for agricultural expansion. This study also notes a “paradox of pastoral land tenure”, where herders gain access to grazing resources but face mobility restrictions. Socioeconomic factors like age, education, experience, and association membership significantly influence stakeholders’ perceptions, particularly among herders directly dependent on these resources. These findings underline the complexities in policymaking for land use, emphasising the need for inclusive and well-informed approaches. Full article

Senior high school (SHS) students are at risk of stress and other adverse exposures that may negatively affect their well-being and possibly cause attrition. The concepts of academic resilience and well-being share commonality as psychological attributes linked to positive functioning among students. Despite this connection, there seems to be limited research exploring these concepts across genders among SHS students in developing regions. This study examined the gender difference in academic resilience and well-being among SHS students in Ghana. Using a cross-sectional survey design, 190 SHS students in three schools from Kwahu North and South district (i.e., Afram Plains) of Ghana’s Eastern Region completed the Academic Resilience Scale (ARS-30) and College Student Subjective Wellbeing Questionnaire (CSSWQ). The sample consists of 102 males and 88 females, with a mean age of 17.83 years. The data were analyzed using independent samples t-tests and hierarchical regression. The study established that students have a moderate level of academic resilience and a higher level of well-being, with no statistically significant variation in students’ academic resilience (t = 0.718; p = 0.474) or well-being (t = −1.596; p = 0.112) across gender. Further, the study discovered that resilience significantly predicted academic well-being (B = 0.425; SE = 0.050; t = 8.50; p < 0.001). This study highlights the importance of promoting gender-sensitive intervention strategies that enhance the academic resilience and well-being of SHS students and help boost their educational attainment. Full article

In recent decades, technological advancements have transformed the industry, highlighting the efficiency of automation and safety. The integration of augmented reality (AR) and gesture recognition has emerged as an innovative approach to create interactive environments for industrial equipment. Gesture recognition enhances AR applications by allowing intuitive interactions. This study presents a web-based architecture for the integration of AR and gesture recognition, designed to interact with industrial equipment. Emphasizing hardware-agnostic compatibility, the proposed structure offers an intuitive interaction with equipment control systems through natural gestures. Experimental validation, conducted using Google Glass, demonstrated the practical viability and potential of this approach in industrial operations. The development focused on optimizing the system’s software and implementing techniques such as normalization, clamping, conversion, and filtering to achieve accurate and reliable gesture recognition under different usage conditions. The proposed approach promotes safer and more efficient industrial operations, contributing to research in AR and gesture recognition. Future work will include improving the gesture recognition accuracy, exploring alternative gestures, and expanding the platform integration to improve the user experience. Full article

Accidental crankcase explosions in marine diesel engines are presumably caused by the inflammation of lubricating oil in air followed by flame propagation and pressure buildup. This manuscript deals with the numerical simulation of internal unvented and vented crankcase explosions of lubricating oil mist using the 3D CFD approach for two-phase turbulent reactive flow with finite-rate turbulent/molecular mixing and chemistry. The lubricating oil mist was treated as either monodispersed with a droplet size of 60 μm or polydispersed with a trimodal droplet size distribution (10 $\mathsf{\mu }$m (10 wt%), 250 $\mathsf{\mu }$m (10 wt%), and 500 $\mathsf{\mu }$m (80 wt%)). The mist was partly pre-evaporated with pre-evaporation degrees of 60%, 70%, and 80%. As an example, a typical low-speed two-stroke six-cylinder marine diesel engine was considered. Four possible accidental ignition sites were considered in different linked segments of the crankcase, namely the leakage of hot blow-by gases through the faulty stuffing box, a hot spot on the crankpin bearing, electrostatic discharge in the open space at the A-frame, and a hot spot on the main bearing. Calculations show that the most important parameter affecting the dynamics of crankcase explosion is the pre-evaporation degree of the oil mist, whereas the oil droplet size distribution plays a minor role. The most severe unvented explosion was caused by the hot spot ignition of the oil mist on the main bearing and flame breaking through the windows connecting the crankcase segments. The predicted maximum rate of pressure rise in the crankcase attained 0.6–0.7 bar/s, whereas the apparent turbulent burning velocity attained 7–8 m/s. The rate of heat release attained a value of 13 MW. Explosion venting caused the rate of pressure rise to decrease and become negative. However, vent opening does not lead to an immediate pressure drop in the crankcase: the pressure keeps growing for a certain time and attains a maximum value that can be a factor of 2 higher than the vent opening pressure. Full article

In this review, we explore the potential drivers of heterogeneity in response to Vitamin D (VitD) therapy, such as bioavailability, sex-specific response, and autoimmune pathology, in those at risk for and diagnosed with T2DM. In addition, we propose distinct populations for future interventions with VitD. The literature concerning VitD supplementation in the prevention, treatment, and remission of type 2 diabetes mellitus (T2DM) spans decades, is complex, and is often contradictory with mixed findings upon intervention. By association, VitD status is powerfully predictive with deficient subjects reporting greater risk for T2DM, conversion to T2DM from prediabetes, and enhanced response to VitD therapy. Preclinical models strongly favor intervention with VitD owing to the pleiotropic influence of VitD on multiple systems. Additional research is crucial as there remain many questions unanswered that are related to VitD status and conditions such as T2DM. Future research must be conducted to better understand the potentially spurious relationships between VitD status, supplementation, sun exposure, health behaviors, and the diagnosis and management of T2DM. Public health practice can greatly benefit from a better understanding of the mechanisms by which we can reliably increase VitD status and how this can be used to develop education and improve health behaviors. Full article

The scarcity of land resources and food security challenges have prompted more effective uses of the rooftop as well as façade spaces in the urban city of Singapore. Urban rooftop spaces are used for mechanical and electrical (M&E) amenities such as air-conditioning cooling units and water tanks, so the spacious span of the roof area on HDB flats in Singapore is not available. Urban-metabolic farming modules (UmFm) built on 1.5 to 2 m terrace-step terrains have been modelled using BIM Revit to mimic such constraints in rooftop spaces. CFD simulation was conducted for the structure with consideration of the prevailing wind directions at different months of the year. The airflow with the inclusion of mesh netting and varying tiltings of the polycarbonate side façade was simulated to understand their impact on airflow in the growth envelope of the UmFm units under different prevailing wind directions. The amount of solar irradiance received by the crops at different heights in the UmFm due to the sun’s path, and shading of crops grown on the A-frame, was studied using Climate Studio. A comparative verification was done with a scaffold modular unit mounted with temperature, humidity, airflow, and Photosynthesis Photon Flux Density (PPFD) sensors. The digital model of the UmFm unit enables a prior assessment of site feasibility before actual physical implementation on an existing rooftop. It also facilitates plug and play for the UmFm unit to generate an eco-resilient farmscape for an urban city. Full article

Transportation and installation of a wind turbine system is one of the main factors for business availability of offshore wind power due to its high cost and technical difficulty. The purpose of this study is to develop an innovative transportation and installation method for offshore wind turbines. We refer to this installation process as an All-In-One-Installation (A.I.O.I), and the special vessel used is referred to as a multipurpose mobile base (MMB). In this study, the short-range transportation and penetration and pull-out tests of the entire wind turbine system are performed before field demonstration. All the offshore wind turbine systems were transported and installed safely at one time. Field demonstration was conducted on the installation site approximately 15 km from the harbor in approximately 5 h using the suction method. In the actual A.I.O.I demonstration test, stable values were obtained. The respective changes in inclination at the center of the MMB and the tower were within 0.1° and 0.2° during operation, respectively, because of the reduction of longitudinal and transverse sway of the MMB induced by the self-weight assembly and ballast. The presented method constitutes an innovative transportation and installation method useful for the offshore wind power industry demonstrating single-day installation feasibility. This installation method can be used to configure the fleet in the development of large-scale offshore wind farms, but it is also possible to install turbines in individual units for research or small businesses. With minor A-Frame modifications, it can be applied as a multipurpose vessel to maintain the blades or heavy components, or can be used for pile driving, or for the lifting/installation of offshore structures. Full article

Dog agility is associated with a risk for sport-related injuries, but few risk factors for injury are known. A retrospective online questionnaire was used to collect data on 864 Finnish competition-level agility dogs—including 119 dogs (14%) with agility-related injury during 2019. Data included injury details, health background, experience in agility, and sport and management routines prior to the injury. Risk factors for injury were evaluated with multivariate logistic regression. The rate of competition-related injuries was 1.44 injuries/1000 competition runs. The front limb was injured in 61% of dogs. In 65% of dogs, the injury presented as lameness. The main risk factors for agility-related injury during 2019 were multiple previous agility-related injuries (OR 11.36; 95% CI 6.10–21.13), older age when starting course-like training (OR 2.04 per one year increase; 95% CI 1.36–3.05), high training frequency, diagnosis of lumbosacral transitional vertebra, and physiotherapy every two to three months compared with never. The most important protective factors were moderate competition frequency and A-frame performance technique. These associations do not confirm causality. We identified new risk factors for injury in agility. This information can be used to improve the welfare of agility dogs. Full article

Accurate measurement of physical activity is critical to understand its role in cardiometabolic health and obesity development in children and to monitor trends in behavior and evaluate interventions. An ongoing mixed-longitudinal study of child growth and development in Samoa is collecting physical activity data with both accelerometers and the Netherlands Physical Activity Questionnaire (NPAQ). The aims of our analyses were to (1) describe the response frequency and correlations of individual questions in the NPAQ, (2) develop modified NPAQ scores with selected questions and (3) examine the concordance of modified NPAQ scores with accelerometer outcomes among children aged 2–4 years. We developed two modified NPAQ scores with combinations of questions and assessed concordance of the modified scores with accelerometer data using estimated marginal means adjusted for monitor wear time. Although the evenly distributed tertiles of the modified 15-point NPAQ score showed promising trends of increasing minutes of accelerometer-assessed high-intensity physical activity with increasing tertile, the estimated marginal means were imprecise with high variance, demonstrating that NPAQ score could not accurately assess physical activity levels of preschool-aged children in Samoa. Considering that questionnaires are often considered more cost-effective tools for physical activity measurement than accelerometry, further research is necessary to develop a culturally and age-appropriate physical activity questionnaire in this population. Full article

Nutrition is a foundation of health and one of six pillars of Lifestyle Medicine. The importance of nutrition in clinical care is now widely recognized by health care professionals and the public. However, clinicians are not comfortable counselling their patients on nutrition due to inadequate or lack of training, leaving a significant need in patient care. This gap can be closed with evidence-based curricula in medical schools and in the trainings of other health care professionals. This communication presents the current state of nutrition knowledge in health care, emphasizing nutrition education for physicians, and presents a model of how pre- through post-professional health care providers may become proficient in nutrition counseling including appropriate referral to more specialized providers. With these skills, health care professionals will be able to initiate patient-centered lifestyle plans. This includes improving diet and utilization of team-based medicine and referrals. Full article