Search Results (160)

The objective of this study was to evaluate the feasibility and efficacy of the ultrasound-guided thoracolumbar erector spinae plane (TL-ESP) block in standing horses. A total of 24 injections (n = 12) were performed at the L1 level using either 0.1 mL/kg of saline solution (SS group) or 2% lidocaine (LID group). The block feasibility was assessed based on needle visualization and injection time, while efficacy was evaluated through craniocaudal and dorsoventral (DV) spread using the pinprick technique over 270 min. Desensitization was observed at least once in 100% of horses in the LID group and in 75% in the SS group (p = 0.001). However, in the SS group, desensitization was primarily limited to the Th18 metamer at the 2 cm DV position, with a shorter duration compared to the LID group. The block onset occurred at 22.5 (11.25–60) min in the LID group and at 5 (5–30) min in the SS group (p = 0.069). The number of affected metamers was significantly higher in the LID group (2 [¹,²,³]) compared to the SS group (1 [1–2.25], p = 0.014). At the 2 cm DV point, the end of the block effect occurred at 135 (120–210) min in the LID group and at 60 (3.75–60) min in the SS group (p = 0.001). Needle visualization was excellent in 95.8% of cases, and the mean injection time was 2.5 (2–3) min. These findings confirm that the TL-ESP block is a feasible technique in standing horses. However, its effect is predominantly localized to dorsal dermatomes with a limited ventral spread. Future studies evaluating larger volumes and multiple injection sites are warranted to enhance its clinical applicability. Full article

The structural analysis of shelterbelts forms the foundation of their planning and management, yet the scientific and effective quantification of shelterbelt structures requires further investigation. This study developed an innovative heterogeneous analytical framework, integrating three key methodologies: the LeWoS algorithm for wood–leaf separation, TreeQSM for structural reconstruction, and 3D alpha-shape spatial quantification, using terrestrial laser scanning (TLS) technology. This framework was applied to three typical farmland shelterbelts in the Ulan Buh Desert oasis, enabling the first precise quantitative characterization of structural components during the leaf-on stage. The results showed the following to be true: (1) The combined three-algorithm method achieved ≥90.774% relative accuracy in extracting structural parameters for all measured traits except leaf surface area. (2) Branch length, diameter, surface area, and volume decreased progressively from first- to fourth-order branches, while branch angles increased with ascending branch order. (3) The trunk, branch, and leaf components exhibited distinct vertical stratification. Trunk volume and surface area decreased linearly with height, while branch and leaf volumes and surface areas followed an inverted U-shaped distribution. (4) Horizontally, both surface area density (Scd) and volume density (Vcd) in each cube unit exhibited pronounced edge effects. Specifically, the Scd and Vcd were greatest between 0.33 and 0.60 times the shelterbelt’s height (H, i.e., mid-canopy). In contrast, the optical porosity (Op) was at a minimum of 0.43 H to 0.67 H, while the volumetric porosity (Vp) was at a minimum at 0.25 H to 0.50 H. (5) The proposed volumetric stratified porosity (Vsp) metric provides a scientific basis for regional farmland shelterbelt management strategies. This three-dimensional structural analytical framework enables precision silviculture, with particular relevance to strengthening ecological barrier efficacy in arid regions. Full article

The accurate measurement of the tree diameter is vital for forest inventories, urban tree quality assessments, the management of roadside and railway vegetation, and various other applications. It also plays a crucial role in evaluating tree growth dynamics, which are closely linked to tree health, structural stability, and vulnerability. Although a range of devices and methodologies are currently under investigation, the widespread adoption of laser scanners remains constrained by their high cost. This study therefore aimed to compare high-end laser scanners (Trimble TX8 and GeoSLAM ZEB Horizon) with cost-effective alternatives, represented by the Apple iPhone 14 Pro and the LA03 scanner developed by mapry Co., Ltd. (Tamba, Japan). It further sought to evaluate the feasibility of employing these more affordable devices, even for small-scale forest owners or managers. Given the growing availability of 3D-based forest inventory algorithms, a selection of such processing pipelines was used to assess the practical potential of the scanning devices. The tested low-cost device produced moderate results, achieving a tree detection rate of up to 78% and a relative root mean square error (rRMSE) of 19.7% in diameter at breast height (DBH) estimation. However, performance varied depending on the algorithms applied. In contrast, the high-end mobile laser scanning (MLS) and terrestrial laser scanning (TLS) systems outperformed the low-cost alternative across all metrics, with tree detection rates reaching up to 99% and DBH estimation rRMSEs as low as 5%. Nevertheless, the low-cost device may still be suitable for scanning small sample plots at a reduced cost and could potentially be deployed in larger quantities to support broader forest inventory initiatives. Full article

This paper outlines a structural qualification process to assess the use of newly developed high-modulus (HM) glass fiber-reinforced polymer (GFRP) bars with headed ends in the joint between concrete bridge barriers and decks. The main goals of the study are to evaluate the structural performance of GFRP-reinforced TL-5 barrier–deck systems under transverse loading and to determine the pullout capacity of GFRP anchorage systems for both new construction and retrofit applications. The research is divided into two phases. In the first phase, six full-scale Test-Level 5 (TL-5) barrier wall–deck specimens, divided into three systems, were constructed and tested up to failure. The first system used headed-end GFRP bars to connect the barrier wall to a non-deformable thick deck slab. The second system was similar to the first but had a deck slab overhang for improved anchorage. The third system utilized postinstalled GFRP bars in a non-deformable thick deck slab, bonded with a commercial epoxy adhesive as a solution for deteriorated barrier replacement. The second phase involves an experimental program to evaluate the pullout strength of the GFRP bar anchorage in normal-strength concrete. The experimental results from the tested specimens were then compared to the factored applied moments in existing literature based on traffic loads in the Canadian Highway Bridge Design Code. Experimental results confirmed that GFRP-reinforced TL-5 barrier–deck systems exceeded factored design moments, with capacity-to-demand ratios above 1.38 (above 1.17 with the inclusion of an environmental reduction factor of 0.85). A 195 mm embedment length proved sufficient for both pre- and postinstalled bars. Headed-end GFRP bars improved pullout strength compared to straight-end bars, especially when bonded. Failure modes occurred at high loads, demonstrating structural integrity. Postinstalled bars bonded with epoxy performed comparably to preinstalled bars. A design equation for the barrier resistance due to a diagonal concrete crack at the barrier–deck corner was developed and validated using experimental findings. This equation offers a conservative and safe design approach for evaluating barrier–deck anchorage. Full article

Background: Tetanus toxin, produced by Clostridium tetani, is the second deadliest known toxin. Antibodies capable of neutralizing tetanus toxin (TeNT) are vital for preventing and treating tetanus disease. Methods: Herein, we screened thirty-six single variable domains on a heavy chain (VHHs) binding to the light chain (L) and the translocation domain (HN) (L-HN) fragment of TeNT from a phage-display library. Then, the L-HN-specific clones were identified, humanized, and fused with a human fragment crystallizable region (hFc) to form humanized VHH-hFc fusion proteins. Results: The humanized VHH-hFc fusion proteins TL-16-h1-hFc, TL-25-h1-hFc, and TL-34-h1-hFc possessed potent efficacy with high binding affinity, specificity, and neutralizing activity. Only 0.3125 μg was required for TL-16-h1-hFc or TL-25-h1-hFc, and 0.625 μg was required for TL-34-h1-hFc to provide full protection against 10 × Lethal Dose 50 (LD₅₀) TeNT. In the prophylactic setting, 125 μg/kg of TL-16-h1-hFc or TL-25-h1-hFc provided full protection even when they were injected 12 days before exposure to 10 × LD₅₀ TeNT, while TL-34-h1-hFc was less effective. In the therapeutic setting, 25 μg/kg of TL-16-h1-hFc or TL-25-h1-hFc could provide complete protection when administered 24 h after exposure to 5 × LD₅₀ TeNT, while TL-34-h1-hFc required 50 μg/kg. Conclusion: Our results suggest that TL-16-h1-hFc, TL-25-h1-hFc, and TL-34-h1-hFc provide a bright future for the development of anti-TeNT preventive or therapeutic drugs. Full article

The emergence of large-scale quantum computing presents an imminent threat to contemporary public-key cryptosystems, with quantum algorithms such as Shor’s algorithm capable of efficiently breaking RSA and elliptic curve cryptography (ECC). This vulnerability has catalyzed accelerated standardization efforts for post-quantum cryptography (PQC) by the U.S. National Institute of Standards and Technology (NIST) and global security stakeholders. While theoretical security analysis of these quantum-resistant algorithms has advanced considerably, comprehensive real-world performance benchmarks spanning diverse computing environments—from high-performance cloud infrastructure to severely resource-constrained IoT devices—remain insufficient for informed deployment planning. This paper presents the most extensive cross-platform empirical evaluation to date of NIST-selected PQC algorithms, including CRYSTALS-Kyber and NTRU for key encapsulation mechanisms (KEMs), alongside BIKE as a code-based alternative, and CRYSTALS-Dilithium and Falcon for digital signatures. Our systematic benchmarking framework measures computational latency, memory utilization, key sizes, and protocol overhead across multiple security levels (NIST Levels 1, 3, and 5) in three distinct hardware environments and various network conditions. Results demonstrate that contemporary server architectures can implement these algorithms with negligible performance impact (<5% additional latency), making immediate adoption feasible for cloud services. In contrast, resource-constrained devices experience more significant overhead, with computational demands varying by up to 12× between algorithms at equivalent security levels, highlighting the importance of algorithm selection for edge deployments. Beyond standalone algorithm performance, we analyze integration challenges within existing security protocols, revealing that naive implementation of PQC in TLS 1.3 can increase handshake size by up to 7× compared to classical approaches. To address this, we propose and evaluate three optimization strategies that reduce bandwidth requirements by 40–60% without compromising security guarantees. Our investigation further encompasses memory-constrained implementation techniques, side-channel resistance measures, and hybrid classical-quantum approaches for transitional deployments. Based on these comprehensive findings, we present a risk-based migration framework and algorithm selection guidelines tailored to specific use cases, including financial transactions, secure firmware updates, vehicle-to-infrastructure communications, and IoT fleet management. This practical roadmap enables organizations to strategically prioritize systems for quantum-resistant upgrades based on data sensitivity, resource constraints, and technical feasibility. Our results conclusively demonstrate that PQC is deployment-ready for most applications, provided that implementations are carefully optimized for the specific performance characteristics and security requirements of target environments. We also identify several remaining research challenges for the community, including further optimization for ultra-constrained devices, standardization of hybrid schemes, and hardware acceleration opportunities. Full article

This study aims to enhance our understanding of the marbled spinefoot (Siganus rivulatus) population along the Red Sea coast of Saudi Arabia. It investigates whether the stock is subject to overfishing and tests the hypothesis that current fishing mortality exceeds sustainable thresholds. A total of 6192 specimens were sampled during a comprehensive survey conducted from 2022 to 2024, utilizing a range of fishing methods, including handline, trap, gillnet, and demersal trawl fisheries. The sampled fish ranged in total length (TL) from 100 to 335 mm and in total weight (W) from 17 to 470 g. The length–weight relationship was W = 0.0175 × TL^2.92. Growth parameters derived from the von Bertalanffy model were TL_∞ = 43.5 cm, K = 1.12 year⁻¹, and t₀ = −0.18 year. The median size at first maturity was estimated at 14.83 cm TL for both sexes. Virtual Population Analysis revealed fishing mortality rates ranging from 0.01 year⁻¹ to 0.89 year⁻¹ across age classes 1 to 5 years, with exploitation levels of 0.6, 0.55, and 0.5 at ages 3, 4, and 5, respectively, indicating slight overfishing. The annual average catch of marbled spinefoot along the Saudi Arabian Red Sea coast was approximately 211 tonnes, contributing an estimated 1.8 million USD to the national economy. Maintaining the current fishing effort at sustainable levels is essential to ensure the long-term viability of this stock. Full article

Eocene magmatic systems contemporaneous with world-class Carlin-type Au deposits in Nevada (USA) have been proposed by some researchers as a key ingredient for Au mineralization, though evidence conclusively demonstrating their genetic relationship remains tenuous. This study provides the first direct evidence of the pre-eruptive metal budget of volatile- and metal-charged silicic magmas coincident in time (~41 to 34 Ma) and space (within 5 km) with Carlin-type Au deposits. We characterize the pre-eruptive metal fingerprints of these diverse magmatic systems to assess their potential as sources of metals for Carlin-type Au mineralization. Metal abundances from quartz-hosted melt inclusions (Au, Te, Ag, Sb, Tl, Mo, W, Sn, As, Pb, Co, Cu, Ni, and Zn) characterized in situ by SHRIMP-RG and LA-ICP-MS represent our best (and only) estimates for the pre-eruptive metal budget in these systems. Median metal concentrations are generally within one order of magnitude of average upper crust and average continental rhyolite values. But there are two notable exceptions, with median Au contents extending >1 order of magnitude higher than average upper crust and median Cu contents ranging >1 order of magnitude lower than upper crust. Despite this, melts contain lower Au/Cu (<0.1), Au/Ag (<5), and Au/Tl (<0.3) than most ore-grade Carlin-type rock samples and quartz-hosted fluid inclusions, regardless of their age and timing relative to nearby Carlin-type Au mineralization. The metal fingerprints of these magmatic systems, defined both by traditional and multivariate compositional data analysis techniques, are distinct from one another. Yet none are particularly specialized, e.g., high Au/Cu, in terms of being ideal ingredients as postulated by magmatic models for Carlin-type Au mineralization. Magmatic Au contents do not appear to be correlated with rhyolite “flavors” in the way that Cu, Sn, and Nb contents are. Fluid/melt partitioning modeling and magma volume estimates support the idea that a diverse array of non-specialized silicic magmas could feasibly contribute some or potentially all of the Au, Ag, and Cu in Carlin-type systems. The compositional diversity among contemporaneous magmatic systems could possibly contribute to some of the diversity observed across Carlin-type Au districts in Nevada. Full article

To conduct an environmental risk assessment for metals in the groundwater of a site in Jiujiang City, Jiangxi Province, we analyzed seven metals (Cr, Zn, Pb, Ni, Sb, Cu, and Tl) that exhibited higher detection rates among the elements we measured. For example, in our measurement data, the average concentration of the element cobalt (Co) is less than 2 × 10^–3 μg/L, and the average concentration of the element cadmium (Cd) is less than 5 × 10^–3 μg/L. The purpose of this environmental risk assessment was to provide a scientific basis for site remediation and subsequent construction. The risk assessment was carried out using the single-factor pollution index, the Nemerow comprehensive pollution index (Pn), and potential ecological hazard index methods. Principal component analysis and correlation analyses were used to investigate the sources of metal pollution in the groundwater. The results indicated the following: (1) The average concentrations of the seven metals in the groundwater of the study area did not exceed the Class IV groundwater quality standard limits. The highest average concentration was for Zn (38.08 μg/L), indicating that metal concentrations in the groundwater were relatively low. (2) The Pn for the seven metals was below 0.7, indicating that the study area was at a non-polluted level. (3) The correlation and principal component analyses of the metals indicate that the sources of these metals may be residues from material stored in the raw material warehouse of the former iron smelting plant at the site. The results show that the level of groundwater contamination at the site falls within an extremely low range; thus, the focus on groundwater pollution can be reduced in subsequent site remediation and construction activities. Full article

The continuous monitoring of radioactivity in a cabled subsea network in the North Sea Observatory was performed to test the performance of a medium-resolution underwater spectrometer, as well as to identify and to assess potential anthropogenic and/or natural hazards. The effectiveness of continuous monitoring was tested together with the operability of the underwater sensor, and quantification methods were optimized to identify the type of radioactivity as well as the activity concentration of radionuclides in the seawater. In the frame of the RADCONNECT project, a medium-resolution underwater radioactivity system named GeoMAREA was integrated into an existing cabled ocean observatory placed on Helgoland Island (COSYNA network). The system could be operated via an online mode controlled by the operational centre (AWI), as well as remotely by the end-user (HCMR). The system provided gamma-ray spectra and activity concentrations of key radionuclides that were enriched in seawater during the monitoring period. As concerns the quantification method of natural radioactivity, the average activity concentrations (in terms of the total monitoring period) of ²¹⁴Bi, ²⁰⁸Tl, ²²⁸Ac and ⁴⁰K were found to be 108 ± 30, 57 ± 14, 40 ± 5 and 9800 ± 500 Bqm⁻³, respectively. As concerns the quantification of ¹³⁷Cs, the average activity concentration in terms of the total monitoring period (although it is uncertain) was found to be 6 ± 4 Bqm⁻³. The data analysis proved that the system had a stable operation in terms of voltage stability, so all acquired spectra could be summed up efficiently in time to produce statistically optimal gamma-ray spectra for further analysis. Full article

When volumes of mining excavations change, rock mass is displaced. Convergence in a salt mine may lead to substantial deformations. The displacement may, in turn, cause an inrush of water from the rock mass into the mine, which is a catastrophic event. Hence, salt excavation convergence is regularly monitored. Traditionally, convergence is measured at monitoring stations. The measurements were first performed with rigid instruments (such as a wire extensometer), then with manual laser rangefinders, and now attempts are made to employ terrestrial laser scanning (TLS). This article presents the evolution of TLS surveys in the mine. The method is demonstrated with multiple scans of a heritage chamber at the Wieliczka salt mine. The analyses indicate that TLS streamlines measurements and offers copious results. The main aim of this study was to identify the most effective and reliable determination of geometric changes in the excavation using TLS data from several years. The differences represented by the models adjusted to a common coordinate system with an error of 5 mm can be considered correct and reflecting the actual changes in the excavation. This gives significant opportunities for the use of TLS data in monitoring the behavior of mine workings in the future. However, considering the insufficient accuracy, the technology must not be the sole source of insight into mining excavation convergence. Full article

This article focuses on modern methods of documentation and visualization for a historic object. Digital photogrammetry and terrestrial laser scanning (TLS), which are essential tools for documenting cultural heritage in view of their rapid development in recent years, were used, compared, and analyzed. Furthermore, the use of available 3D computer graphics technologies for visualization is described and an optimal procedure for converting the object into VR and AR is proposed and implemented. The technologies presented in this article were tested within the context of a project on the reconstruction of the shrine of the Prophet Nahum in the city of Alqosh in northern Iraq, taking the shrine as a case study. Funded by ARCH Int. and provided by GemaArt Int., the restoration project started in 2018 and was completed in 2021. The ongoing documentation was prepared by the CTU and it used the materials for research purposes. Accurate documentation using photogrammetry, drones, and TLS was key to the restoration. Leica BLK360, Faro Focus S150, and GeoSlam laser scanners were used, as well as photogrammetric methods. In particular, the documentation process involved the creation of 3D textured models from the photogrammetry, which were compared to the TLS data to ensure accuracy. These models were necessary to track changes during the reconstruction phases and to calculate the volumes of rubble removed and materials added. Our data analysis revealed significant differences between the construction logs and the analysis of the accurate 3D models; the results showed an underestimation of the displaced material statements by 13.4% for removed material and 4.6% for added material. The use of heat maps and volumetric analyses helped to identify areas of significant change that guided the reconstruction and documented significant changes to the building for the investor. These findings are important for use in the construction industry with respect to historic sites as well as for further research focused on visualization using VR (virtual reality) and AR (augmented reality). The conversion of existing 3D models into VR and AR is rapidly evolving and significant progress was made during this project. The Unreal Engine (UE) game engine was used. Despite the significantly improved performance of the new UE 5 version, the data for conversion to VR and AR needs to be decimated to reduce the amount—in our case, this was by up to 90%. The quality appearance of the objects is then ensured by textures. An important outcome of this part of the research was the debugged workflow developed to optimize the 3D models for VR, which was essential for creating a virtual museum that shows the restoration process. Full article

Terrestrial laser scanners (TLS) are portable dimensional measurement instruments used to obtain 3D point clouds of objects in a scene. While TLSs do not require the use of cooperative targets, they are sometimes placed in a scene to fuse or compare data from different instruments or data from the same instrument but from different positions. A contrast target is an example of such a target; it consists of alternating black/white squares that can be printed using a laser printer. Because contrast targets are planar as opposed to three-dimensional (like a sphere), the center of the target might suffer from errors that depend on the orientation of the target with respect to the TLS. In this paper, we discuss a low-cost method to characterize such errors and present results obtained from a short-range TLS and a long-range TLS. Our method involves comparing the center of a contrast target against the center of spheres and, therefore, does not require the use of a reference instrument or calibrated objects. For the short-range TLS, systematic errors of up to 0.5 mm were observed in the target center as a function of the angle for the two distances (5 m and 10 m) and resolutions (30 points-per-degree (ppd) and 90 ppd) considered for this TLS. For the long-range TLS, systematic errors of about 0.3 mm to 0.8 mm were observed in the target center as a function of the angle for the two distances (5 m and 10 m) at low resolution (28 ppd). Errors of under 0.3 mm were observed in the target center as a function of the angle for the two distances at high resolution (109 ppd). Full article

Global awareness of the harmful effects of heavy metal contamination in soil has increased significantly. Understanding the vertical distribution of oxides and elements is vital for tracing the history of potential contamination. Thus, this study focuses on deep sediment cores primarily composed of quartz and clay minerals from a small village in the western Tamnava Basin of Serbia. The aim was to assess the vertical distribution of 11 oxides and 21 elements and the ecological risks of eight heavy metals by analyzing 250 sediment samples from 18 boreholes at depths ranging from 5 to 58.5 m. Deep sediment core samples were analyzed using energy-dispersive X-ray fluorescence spectrometry (ED-XRF). Potential contamination levels were evaluated within the study area. Additionally, samples were analyzed for total carbonate and organic carbon contents and particles retained on a 0.063 mm sieve. Higher than permitted concentrations of vanadium (V), thallium (Tl), and barium (Ba) were found. Notably, this zone is located above a proposed lithium and boron mine in Gornje Nedeljice, making it crucial for monitoring efforts. Even if mining operations do not commence, examining the deep sediment layers in this rural area remains important. This study offers novel and valuable data on the concentrations of potentially toxic elements in undisturbed deep sediment, serving as a benchmark for future comparisons. Full article

The contamination of farmland soil with cadmium (Cd) poses a significant threat to the safety and quality of agricultural products. Herbivorous pests may develop adaptations to survive in Cd-contaminated farmland over time, potentially leading to population outbreaks. The gut microbiota plays a crucial role in this adaptation process, though the mechanisms involved remain unclear. This study examined the effects of two pepper cultivars of Capsicum annuum (Chiyan, CY, and Tianlanse, TLS) under Cd contamination on larval growth, development, food utilization, and gut microbiota of Spodoptera litura larvae. The inherent toxicity of TLS is higher than that of CY, as evidenced by a significant reduction in larvae survival rate in the control. In CY, Cd had a positive effect on larvae at low concentrations and a negative effect at high concentrations. Briefly, 5 mg/kg Cd of CY increased the efficiency of conversion of ingested food (ECI) and relative growth rate (RGR), whereas 10 mg/kg Cd decreased larvae growth and nutritional indices [higher relative consumption rate (RCR), approximate digestibility (AD), and lower efficiency of conversion of digested food (ECD)]. In TLS, Cd had a significant, dose-dependent, negative effect on larvae weight, ECD, and relative growth rate (RGR). Cd thus increased the negative effects of the plant toxins on the larvae. Meta-barcode sequencing of the 16S rRNA gene revealed that microbial diversity was affected by pepper cultivar but not Cd concentration. In larvae fed on CY, the most frequent bacterial genera were Enterococcus and Pluralibacte, whereas Enterococcus was the predominant genus in TLS larvae. Our findings reveal variations in how Cd impacts S. litura larvae across different pepper cultivars and imply that alterations in gut microbial communities could play a role in the joint detoxification of Cd and plant-derived toxins. Full article